Harry J Flint

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. pmc Abundance and diversity of dockerin-containing proteins in the fiber-degrading rumen bacterium, Ruminococcus flavefaciens FD-1
    Marco T Rincon
    Microbial Ecology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 5:e12476. 2010
  2. pmc Some are more equal than others: the role of "keystone" species in the degradation of recalcitrant substrates
    Xiaolei Ze
    Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    Gut Microbes 4:236-40. 2013
  3. doi request reprint The role of the gut microbiota in nutrition and health
    Harry J Flint
    Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, UK
    Nat Rev Gastroenterol Hepatol 9:577-89. 2012
  4. pmc Microbial degradation of complex carbohydrates in the gut
    Harry J Flint
    Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen UK
    Gut Microbes 3:289-306. 2012
  5. doi request reprint The impact of nutrition on the human microbiome
    Harry J Flint
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, Scotland, UK
    Nutr Rev 70:S10-3. 2012
  6. doi request reprint Obesity and the gut microbiota
    Harry J Flint
    Rowett Institute of Nutrition and Health, University of Aberdeen, UK
    J Clin Gastroenterol 45:S128-32. 2011
  7. pmc Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth
    Mireia Lopez-Siles
    Grup de Microbiologia Clínica i Malalties Infeccioses, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, Girona, Spain
    Appl Environ Microbiol 78:420-8. 2012
  8. pmc A new tetracycline efflux gene, tet(40), is located in tandem with tet(O/32/O) in a human gut firmicute bacterium and in metagenomic library clones
    Katarzyna A Kazimierczak
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, United Kingdom
    Antimicrob Agents Chemother 52:4001-9. 2008
  9. doi request reprint The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities
    Alan W Walker
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, UK
    Environ Microbiol 10:3275-83. 2008
  10. doi request reprint Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene
    Petra Louis
    Microbial Ecology Group, Gut Health Division, Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Environ Microbiol 12:304-14. 2010

Collaborators

Detail Information

Publications64

  1. pmc Abundance and diversity of dockerin-containing proteins in the fiber-degrading rumen bacterium, Ruminococcus flavefaciens FD-1
    Marco T Rincon
    Microbial Ecology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 5:e12476. 2010
    ..More than two-hundred dockerin-containing proteins have been identified in the R. flavefaciens genome, yet the reason for the expansion of these crucial cellulosomal components is yet unknown...
  2. pmc Some are more equal than others: the role of "keystone" species in the degradation of recalcitrant substrates
    Xiaolei Ze
    Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    Gut Microbes 4:236-40. 2013
    ..The concept of keystone species can be equally relevant to other activities, e.g., those involved in stabilizing the community...
  3. doi request reprint The role of the gut microbiota in nutrition and health
    Harry J Flint
    Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, UK
    Nat Rev Gastroenterol Hepatol 9:577-89. 2012
    ..This Review considers the complex interplay between the gut microbiota, diet and health...
  4. pmc Microbial degradation of complex carbohydrates in the gut
    Harry J Flint
    Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen UK
    Gut Microbes 3:289-306. 2012
    ..The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs...
  5. doi request reprint The impact of nutrition on the human microbiome
    Harry J Flint
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, Scotland, UK
    Nutr Rev 70:S10-3. 2012
    ..As a better understanding is gained of the impact of different groups of bacteria on host metabolism, the ability to manipulate the microbiota through diet should provide a route for delivering health benefits...
  6. doi request reprint Obesity and the gut microbiota
    Harry J Flint
    Rowett Institute of Nutrition and Health, University of Aberdeen, UK
    J Clin Gastroenterol 45:S128-32. 2011
    ....
  7. pmc Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth
    Mireia Lopez-Siles
    Grup de Microbiologia Clínica i Malalties Infeccioses, Departament de Biologia, Facultat de Ciencies, Universitat de Girona, Girona, Spain
    Appl Environ Microbiol 78:420-8. 2012
    ..These attributes help to explain the abundance of F. prausnitzii in the colonic community but also suggest factors in the gut environment that may limit its distribution...
  8. pmc A new tetracycline efflux gene, tet(40), is located in tandem with tet(O/32/O) in a human gut firmicute bacterium and in metagenomic library clones
    Katarzyna A Kazimierczak
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, United Kingdom
    Antimicrob Agents Chemother 52:4001-9. 2008
    ..At least 10 of the metagenomic inserts that carried tet(O/32/O) also carried tet(40), suggesting that tet(40), although previously undetected, may be an abundant efflux gene...
  9. doi request reprint The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities
    Alan W Walker
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, UK
    Environ Microbiol 10:3275-83. 2008
    ..The abundance of such primary degraders may often be underestimated because of the difficulty in recovering these bacteria and their nucleic acids from the insoluble substrate...
  10. doi request reprint Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene
    Petra Louis
    Microbial Ecology Group, Gut Health Division, Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Environ Microbiol 12:304-14. 2010
    ..This type of analysis therefore provides an excellent source of information on functionally important groups within the colonic microbial community...
  11. pmc Molecular diversity, cultivation, and improved detection by fluorescent in situ hybridization of a dominant group of human gut bacteria related to Roseburia spp. or Eubacterium rectale
    Rustam I Aminov
    Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Appl Environ Microbiol 72:6371-6. 2006
    ..Most of the diversity within this important group of butyrate-producing gut bacteria can apparently be retrieved through cultivation...
  12. pmc A novel cell surface-anchored cellulose-binding protein encoded by the sca gene cluster of Ruminococcus flavefaciens
    Marco T Rincon
    Microbial Ecology Group, The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, United Kingdom
    J Bacteriol 189:4774-83. 2007
    ....
  13. ncbi request reprint Selective colonization of insoluble substrates by human faecal bacteria
    E Carol McWilliam Leitch
    Microbial Ecology Group, Aberdeen, UK
    Environ Microbiol 9:667-79. 2007
    ..This study suggests that a specific subset of bacteria is likely to be the primary colonizers of particular insoluble colonic substrates. For a given substrate, however, the primary colonizing species may vary between host individuals...
  14. pmc Unconventional mode of attachment of the Ruminococcus flavefaciens cellulosome to the cell surface
    Marco T Rincon
    Microbial Ecology Group, Rowett Research Institute, Aberdeen, UK
    J Bacteriol 187:7569-78. 2005
    ..This sortase-mediated mechanism for covalent cell-wall anchoring of the cellulosome in R. flavefaciens differs from those reported thus far for any other cellulosome system...
  15. ncbi request reprint Organization of butyrate synthetic genes in human colonic bacteria: phylogenetic conservation and horizontal gene transfer
    Petra Louis
    Rowett Research Institute, Gut Health Division, Microbial Ecology Group, Bucksburn, Aberdeen, UK
    FEMS Microbiol Lett 269:240-7. 2007
    ..The newly identified gene for butyryl-CoA CoA-transferase, which performs the final step in butyrate formation in most known human colonic bacteria, was not closely linked to these central pathway genes...
  16. pmc Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system
    Sylvia H Duncan
    Gut Microbiology and Immunology Division, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Appl Environ Microbiol 69:1136-42. 2003
    ..Thus, considerable caution is necessary when workers attempt to predict the in vivo effects of probiotics and prebiotics from their effects in vitro...
  17. ncbi request reprint A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria
    Cédric Charrier
    Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Microbiology 152:179-85. 2006
    ..A2-183. This suggests strongly that the newly identified group of CoA-transferases described here plays a key role in butyrate formation in the human colon...
  18. pmc Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria
    Katarzyna A Kazimierczak
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Antimicrob Agents Chemother 50:2632-9. 2006
    ..Several different mechanisms, including mechanisms involving plasmids and conjugative transposons, appear to be involved in the horizontal transfer of tet(W) genes, but small core regions that may function as minielements are conserved...
  19. pmc Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut
    Alvaro Belenguer
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Appl Environ Microbiol 72:3593-9. 2006
    ..adolescentis and butyrate-forming bacteria may operate in gut ecosystems, one due to consumption of fermentation end products (lactate and acetate) and the other due to cross-feeding of partial breakdown products from complex substrates...
  20. doi request reprint Phylogenetic distribution of genes encoding β-glucuronidase activity in human colonic bacteria and the impact of diet on faecal glycosidase activities
    Freda M McIntosh
    Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK
    Environ Microbiol 14:1876-87. 2012
    ..By comparison, in three of five isolates that possessed only the gus gene, β-glucuronidase activity was induced...
  21. ncbi request reprint Growth requirements and fermentation products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. nov., comb. nov
    Sylvia H Duncan
    Division of Gut Microbiology and Immunology, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen A821 9SB, UK
    Int J Syst Evol Microbiol 52:2141-6. 2002
    ..nov., comb. nov. ATCC 27768(T) (= NCIMB 13872(T)) (formerly Fusobacterium prausnitzii) as the type species together with ATCC 27766 and the newly isolated strains A2-165 and L2-6...
  22. doi request reprint Rates of production and utilization of lactate by microbial communities from the human colon
    Alvaro Belenguer
    The Rowett Institute of Nutrition and Health, Bucksburn, Aberdeen, UK
    FEMS Microbiol Ecol 77:107-19. 2011
    ..5, although volunteer and temporal variability existed. Under healthy gut environmental conditions, bacterial lactate disposal seems to exceed production markedly...
  23. ncbi request reprint Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon
    Alan G Ramsay
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, UK
    Microbiology 152:3281-90. 2006
    ..2.1.1). These major starch-degrading enzymes thus appear to be anchored to the cell wall in this important group of human gut bacteria...
  24. ncbi request reprint Interactions and competition within the microbial community of the human colon: links between diet and health
    Harry J Flint
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB219SB, UK
    Environ Microbiol 9:1101-11. 2007
    ..Oligosaccharides used as dietary prebiotics must inevitably have complex effects upon the bacterial community that include non-target organisms and the consequences of metabolic cross-feeding and changes in the gut environment...
  25. ncbi request reprint Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and Roseburia inulinivorans sp. nov., based on isolates from human faeces
    Sylvia H Duncan
    Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Int J Syst Evol Microbiol 56:2437-41. 2006
    ..nov. (type strain A2-183(T)=DSM 16839(T)=NCIMB 14029(T)), Roseburia inulinivorans sp. nov. (type strain A2-194(T)=DSM 16841(T)=NCIMB 14030(T)) and Roseburia faecis sp. nov. (type strain M72/1(T)=DSM 16840(T)=NCIMB 14031(T))...
  26. pmc Substrate-driven gene expression in Roseburia inulinivorans: importance of inducible enzymes in the utilization of inulin and starch
    Karen P Scott
    Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Proc Natl Acad Sci U S A 108:4672-9. 2011
    ..The latter response may be concerned with improving bacterial access to insoluble starch particles...
  27. pmc ScaC, an adaptor protein carrying a novel cohesin that expands the dockerin-binding repertoire of the Ruminococcus flavefaciens 17 cellulosome
    Marco T Rincon
    Microbial Genetics Group, The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom
    J Bacteriol 186:2576-85. 2004
    ....
  28. pmc Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon
    Xiaolei Ze
    Microbial Ecology Group, Rowett Institute of Nutrition and Health, Greenburn Road, Bucksburn, Aberdeen, UK
    ISME J 6:1535-43. 2012
    ..This work also indicates that R. bromii possesses an exceptional ability to colonize and degrade starch particles when compared with previously studied amylolytic bacteria from the human colon...
  29. doi request reprint Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein
    Wendy R Russell
    Molecular Nutrition Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    Mol Nutr Food Res 57:523-35. 2013
    ..Although they have the potential to be derived from diets rich in plant-based foods, evidence suggests that these compounds can be derived from the microbial fermentation of aromatic amino acids (AAAs) in the colon...
  30. pmc Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product
    Sylvia H Duncan
    Microbial Genetics Group, Rowett Research Institute, Greenburn Rd, Bucksburn, Aberdeen AB21 9SB, UK
    Appl Environ Microbiol 70:5810-7. 2004
    ..The abundance of E. hallii in particular in the colonic ecosystem suggests that these bacteria play important roles in preventing lactate accumulation...
  31. pmc Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon
    Petra Louis
    Division of Gut Microbiology and Immunology, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    J Bacteriol 186:2099-106. 2004
    ....
  32. pmc pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon
    Alan W Walker
    Microbial Genetics Group, Rowett Research Institute, Greenburn Rd, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Appl Environ Microbiol 71:3692-700. 2005
    ....
  33. doi request reprint High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health
    Wendy R Russell
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom
    Am J Clin Nutr 93:1062-72. 2011
    ..However, the effect of such diets on microbiota-derived metabolites that influence colonic health has not been established...
  34. pmc Transfer of conjugative elements from rumen and human Firmicutes bacteria to Roseburia inulinivorans
    Karen P Scott
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, Scotland AB21 9SB, United Kingdom
    Appl Environ Microbiol 74:3915-7. 2008
    ..Here the human colonic anaerobe Roseburia inulinivorans A2-194 was shown to be a transfer recipient for two conjugative transposons, Tn1545 from Eubacterium cellulosolvens and TnK10 from Clostridium saccharolyticum K10...
  35. ncbi request reprint Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro
    Karen P Scott
    Microbial Ecology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, UK
    FEMS Microbiol Ecol 87:30-40. 2014
    ..XOS was a more selective growth substrate than FOS, with only six of the 11 Firmicutes strains able to use XOS for growth. These results illustrate the selectivity of different prebiotics and help to explain why some are butyrogenic...
  36. doi request reprint Plant cell wall breakdown by anaerobic microorganisms from the Mammalian digestive tract
    Harry J Flint
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Ann N Y Acad Sci 1125:280-8. 2008
    ..The true complexity, both at a single organism and community level, of the microbial enzyme systems that allow animals to digest plant material is beginning to become apparent...
  37. pmc Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces
    Sylvia H Duncan
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Appl Environ Microbiol 73:1073-8. 2007
    ..1%, and 1.9%, respectively; P = 0.026) decreased as carbohydrate intake decreased. The abundance of butyrate-producing bacteria related to Roseburia spp. and E. rectale correlated well with the decline in fecal butyrate...
  38. pmc Development of a semiquantitative degenerate real-time pcr-based assay for estimation of numbers of butyryl-coenzyme A (CoA) CoA transferase genes in complex bacterial samples
    Petra Louis
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    Appl Environ Microbiol 73:2009-12. 2007
    ..This pathway is present in numerically important groups of butyrate producers within the human colon, and thus this assay estimates the butyrate-producing ability of the microbiota...
  39. ncbi request reprint Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves
    Sylvia H Duncan
    Gut Microbiology and Immunology Division, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    Br J Nutr 91:749-55. 2004
    ..Coumarin compounds that occur naturally in dietary plants or when supplemented in the diet probably inhibit the survival of E. coli O157 in the gut...
  40. doi request reprint Nutritional influences on the gut microbiota and the consequences for gastrointestinal health
    Karen P Scott
    Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Aberdeen AB21 9SB, Scotland, UK
    Biochem Soc Trans 39:1073-8. 2011
    ..Since bacterial species have different metabolic activities, specific diets have various consequences for health, dependent on the effect exerted on the bacterial population...
  41. ncbi request reprint Contribution of acetate to butyrate formation by human faecal bacteria
    Sylvia H Duncan
    Gut Microbiology and Immunology Division, Rowett Research Institute, Aberdeen, UK
    Br J Nutr 91:915-23. 2004
    ..Variations in the dominant metabolic type of butyrate producer between individuals or with variations in diet are not ruled out, however, and could influence butyrate supply in the large intestine...
  42. ncbi request reprint The microbiology of butyrate formation in the human colon
    Susan E Pryde
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    FEMS Microbiol Lett 217:133-9. 2002
    ....
  43. doi request reprint Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis
    Harry J Flint
    Microbial Ecology Group, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    Nat Rev Microbiol 6:121-31. 2008
    ..Genomic analyses of the gut microbiota could revolutionize our understanding of these mechanisms and provide new biotechnological tools for the conversion of polysaccharides, including lignocellulosic biomass, into monosaccharides...
  44. pmc Whole-genome transcription profiling reveals genes up-regulated by growth on fucose in the human gut bacterium "Roseburia inulinivorans"
    Karen P Scott
    Gut Health Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    J Bacteriol 188:4340-9. 2006
    ..inulinivorans during growth on fucose. Despite the lack of genome sequence information for this commensal bacterium, microarray analysis has provided a powerful tool for obtaining new information on its metabolic capabilities...
  45. pmc Oligonucleotide probes that detect quantitatively significant groups of butyrate-producing bacteria in human feces
    Georgina L Hold
    Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    Appl Environ Microbiol 69:4320-4. 2003
    ..Bacteria related to E. hallii and the genera Roseburia and Faecalibacterium are therefore among the most abundant known butyrate-producing bacteria in human feces...
  46. doi request reprint The influence of diet on the gut microbiota
    Karen P Scott
    Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Pharmacol Res 69:52-60. 2013
    ....
  47. doi request reprint The role of pH in determining the species composition of the human colonic microbiota
    Sylvia H Duncan
    Microbial Ecology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, UK
    Environ Microbiol 11:2112-22. 2009
    ..5, but were not detected at pH 6.7. Inhibition of the growth of a major group of gram-negative bacteria at mildly acidic pH apparently creates niches that can be exploited by more low pH-tolerant microorganisms...
  48. pmc Novel organization and divergent dockerin specificities in the cellulosome system of Ruminococcus flavefaciens
    Marco T Rincon
    Gut Microbiology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, United Kingdom
    J Bacteriol 185:703-13. 2003
    ..flavefaciens...
  49. pmc Mosaic tetracycline resistance genes are widespread in human and animal fecal samples
    Andrea J Patterson
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Antimicrob Agents Chemother 51:1115-8. 2007
    ..The nonmosaic tet(32) gene was isolated from a human saliva bacterium...
  50. pmc Phylogenetic distribution of three pathways for propionate production within the human gut microbiota
    Nicole Reichardt
    1 Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, UK 2 Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    ISME J 8:1323-35. 2014
    ..A better understanding of the microbial ecology of short-chain fatty acid formation may allow modulation of propionate formation by the human gut microbiota. ..
  51. doi request reprint Colonic bacterial metabolites and human health
    Wendy R Russell
    Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Curr Opin Microbiol 16:246-54. 2013
    ..In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention. ..
  52. doi request reprint The gut microbial metabolome: modulation of cancer risk in obese individuals
    Wendy R Russell
    Lifelong Health Division, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 72:178-88. 2013
    ..It is clear that only if the link between microbial diversity and metabolic functionality is firmly established, will the mechanism by which gut microbiota maintains health or contributes to disease development be elucidated...
  53. pmc Characterization of XYN10B, a modular xylanase from the ruminal protozoan Polyplastron multivesiculatum, with a family 22 carbohydrate-binding module that binds to cellulose
    Estelle Devillard
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Biochem J 373:495-503. 2003
    ..The phylogenetic relationships between the XYN10B CBM22 or catalytic domain and related sequences from ruminal and non-ruminal bacteria and eukaryotes are reported. The xyn10B gene is shown to lack introns...
  54. doi request reprint Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine
    Petra Louis
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    FEMS Microbiol Lett 294:1-8. 2009
    ..Populations of F. prausnitzii are reported to be decreased in Crohn's disease, for example, while populations of Roseburia relatives appear to be particularly sensitive to the diet composition in human volunteer studies...
  55. doi request reprint Proposal of a neotype strain (A1-86) for Eubacterium rectale. Request for an opinion
    Sylvia H Duncan
    Microbial Ecology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, UK
    Int J Syst Evol Microbiol 58:1735-6. 2008
    ..It is therefore proposed that strain A1-86 (=DSM 17629=NCIMB 14373), isolated from human adult faeces, be formally recognized as the neotype strain of Eubacterium rectale...
  56. doi request reprint Probiotics and prebiotics and health in ageing populations
    Sylvia H Duncan
    Microbial Ecology Group, Rowett Institute of Nutrition and Health, Greenburn Road, Bucksburn, Aberdeen, Scotland, UK
    Maturitas 75:44-50. 2013
    ..Here we review gut microbial changes associated with aging and how diet, prebiotics and probiotics may modulate the gut microbiota to maintain health in the elderly...
  57. pmc Expression of cellulosome components and type IV Pili within the extracellular proteome of Ruminococcus flavefaciens 007
    Masa Vodovnik
    Chair for Microbiology and Microbial Biotechnology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 8:e65333. 2013
    ..The ability was recovered after serial subculture to give the cotton-degrading strain 007C. This has allowed us to investigate the factors required for degradation of this particularly recalcitrant form of cellulose...
  58. ncbi request reprint Phylogeny, culturing, and metagenomics of the human gut microbiota
    Alan W Walker
    Microbiology Group, Rowett Institute of Nutrition and Health, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK
    Trends Microbiol 22:267-74. 2014
    ..As such, culture and phylogeny will continue to have crucially important roles in human microbiota research, and will be required for the development of novel therapeutics. ..
  59. ncbi request reprint Lack of flagella disadvantages Salmonella enterica serovar Enteritidis during the early stages of infection in the rat
    Jeanette M C Robertson
    Gut Microbiology and Immunology Division, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    J Med Microbiol 52:91-9. 2003
    ..Enteritidis infection in the rat. Deletion of flagella did, however, disadvantage the bacterium. This may be due to the inability to produce or release the potent immunomodulating protein flagellin...
  60. ncbi request reprint Polysaccharide breakdown by anaerobic microorganisms inhabiting the Mammalian gut
    Harry J Flint
    Microbial Genetics Group Rowett Research Institute Bucksburn, Aberdeen, AB21 9SB, United Kingdom
    Adv Appl Microbiol 56:89-120. 2004
  61. doi request reprint How our gut microbes influence our behaviour
    Petra Louis
    Microbiology Group, Rowett Institute, University of Aberdeen, Bucksburn, UK
    J Neuroendocrinol 25:517-8. 2013
    ..Bacteria and their metabolites can interact with the host via routes involving the immune, nervous and endocrine system...
  62. pmc The Butyrivibrio fibrisolvens tet(W) gene is carried on the novel conjugative transposon TnB1230, which contains duplicated nitroreductase coding sequences
    Claire M Melville
    Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, United Kingdom
    J Bacteriol 186:3656-9. 2004
    ..tet(W) is flanked by directly repeated sequences with significant homology to oxygen-insensitive nitroreductases. The 340 nucleotides upstream of tet(W) are strongly conserved and are required for tetracycline resistance...
  63. doi request reprint Microbiota of de-novo pediatric IBD: increased Faecalibacterium prausnitzii and reduced bacterial diversity in Crohn's but not in ulcerative colitis
    Richard Hansen
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK
    Am J Gastroenterol 107:1913-22. 2012
    ..The majority of studies to date are however potentially confounded by the effect of treatment and a reliance on established rather than de-novo disease...
  64. ncbi request reprint Roseburia intestinalis sp. nov., a novel saccharolytic, butyrate-producing bacterium from human faeces
    Sylvia H Duncan
    Gut Microbiology and Immunology Division, Rowett Research Institute, Bucksburn, Aberdeen, UK
    Int J Syst Evol Microbiol 52:1615-20. 2002
    ..It is proposed that a novel species, Roseburia intestinalis sp. nov., be created, with strain L1-82T (= DSM 14610T = NCIMB 13810T) as the type strain...