Paul C Fletcher

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficits
    Paul C Fletcher
    Box 189, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Trends Cogn Sci 10:167-74. 2006
  2. pmc Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
    P R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 130:2387-400. 2007
  3. pmc Is food addiction a valid and useful concept?
    H Ziauddeen
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Obes Rev 14:19-28. 2013
  4. pmc Sense of agency in health and disease: a review of cue integration approaches
    J W Moore
    Institute of Cognitive Neuroscience, University College London, Queen Square, London, UK
    Conscious Cogn 21:59-68. 2012
  5. pmc From drugs to deprivation: a Bayesian framework for understanding models of psychosis
    P R Corlett
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, Cambridge
    Psychopharmacology (Berl) 206:515-30. 2009
  6. pmc On the benefits of not trying: brain activity and connectivity reflecting the interactions of explicit and implicit sequence learning
    P C Fletcher
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Cereb Cortex 15:1002-15. 2005
  7. pmc Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum
    Paul C Fletcher
    Department of Psychiatry, University of Cambridge, GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Centre for Clinical Investigations, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 30:14346-55. 2010
  8. ncbi Regional brain activations predicting subsequent memory success: an event-related fMRI study of the influence of encoding tasks
    Paul C Fletcher
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Cortex 39:1009-26. 2003
  9. ncbi The influence of explicit instructions and stimulus material on lateral frontal responses to an encoding task
    P C Fletcher
    Institut fur Medizin, Forschungszentrum, Julich, Germany
    Neuroimage 17:780-91. 2002
  10. ncbi Frontal lobes and human memory: insights from functional neuroimaging
    P C Fletcher
    Research Department of Psychiatry, Cambridge University, Addenbrooke s Hospital, Cambridge, UK
    Brain 124:849-81. 2001

Collaborators

Detail Information

Publications78

  1. ncbi Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficits
    Paul C Fletcher
    Box 189, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Trends Cogn Sci 10:167-74. 2006
    ..We suggest that close attention to these deficits can offer insights into core pathophysiology of schizophrenia...
  2. pmc Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
    P R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 130:2387-400. 2007
    ..Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs...
  3. pmc Is food addiction a valid and useful concept?
    H Ziauddeen
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Obes Rev 14:19-28. 2013
    ..We argue the current evidence is preliminary and suggest directions for future work that may provide more useful tests of the concept...
  4. pmc Sense of agency in health and disease: a review of cue integration approaches
    J W Moore
    Institute of Cognitive Neuroscience, University College London, Queen Square, London, UK
    Conscious Cogn 21:59-68. 2012
    ..We extend this to consider how alterations in cue integration may lead to aberrant experiences of agency...
  5. pmc From drugs to deprivation: a Bayesian framework for understanding models of psychosis
    P R Corlett
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, Cambridge
    Psychopharmacology (Berl) 206:515-30. 2009
    ..This helps us to understand the similarities and differences across the common models of psychosis...
  6. pmc On the benefits of not trying: brain activity and connectivity reflecting the interactions of explicit and implicit sequence learning
    P C Fletcher
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Cereb Cortex 15:1002-15. 2005
    ..The findings demonstrate a neural basis for a well-known behavioural effect: the deleterious impact of an explicit search upon implicit learning...
  7. pmc Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum
    Paul C Fletcher
    Department of Psychiatry, University of Cambridge, GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Centre for Clinical Investigations, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 30:14346-55. 2010
    ..Furthermore, they support a regionally specific effect on brain function through which sibutramine exerts its clinical effect...
  8. ncbi Regional brain activations predicting subsequent memory success: an event-related fMRI study of the influence of encoding tasks
    Paul C Fletcher
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Cortex 39:1009-26. 2003
    ..They provide more evidence, too, for a less consistent finding: the interaction between the encoding task and the success of subsequent recognition...
  9. ncbi The influence of explicit instructions and stimulus material on lateral frontal responses to an encoding task
    P C Fletcher
    Institut fur Medizin, Forschungszentrum, Julich, Germany
    Neuroimage 17:780-91. 2002
    ..The complex patterns of frontal effect counsel against any simple dichotomy of frontal function at the level of either material or task type...
  10. ncbi Frontal lobes and human memory: insights from functional neuroimaging
    P C Fletcher
    Research Department of Psychiatry, Cambridge University, Addenbrooke s Hospital, Cambridge, UK
    Brain 124:849-81. 2001
    ..We expect that the neuroimaging techniques will provide an important part of this enterprise...
  11. ncbi Responses of human frontal cortex to surprising events are predicted by formal associative learning theory
    P C Fletcher
    Brain Mapping Unit, Box 189, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Nat Neurosci 4:1043-8. 2001
    ..In short, the physiological response properties of right DLPFC satisfied specific predictions made by associative learning theory...
  12. ncbi "Sculpting the response space"--an account of left prefrontal activation at encoding
    P C Fletcher
    Wellcome Department of Cognitive Neurology, 12 Queen Square, London, WC1N 3BG, United Kingdom
    Neuroimage 12:404-17. 2000
    ..A crucial feature of such associative processing lies in selecting appropriate, and inhibiting inappropriate, semantic attributes of the study material...
  13. pmc Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo
    Garry D Honey
    Department of Psychiatry, Brain Mapping Unit and Behavioural and Clinical Neurosciences Institute, University of Cambridge, School of Clinical Medicine, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 28:6295-303. 2008
    ..These results demonstrate precise and predictive brain markers for individual profiles of vulnerability to drug-induced psychosis...
  14. pmc The neural underpinnings of associative learning in health and psychosis: how can performance be preserved when brain responses are abnormal?
    Graham K Murray
    Brain Mapping Unit, University of Cambridge, Box 189, Cambridge CB2 0QQ, UK
    Schizophr Bull 36:465-71. 2010
    ..The findings suggest that a combination of these factors may resolve the question of why performance is sometimes preserved when brain patterns are disrupted...
  15. pmc Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
    Garry D Honey
    University of Cambridge, Department of Psychiatry, Cambridge, UK
    Brain 128:2597-611. 2005
    ..Furthermore, these data show evidence of additional functional deficits in patients with negative symptoms, deficits which may explain the accompanying attentional impairment...
  16. ncbi Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis
    Philip R Corlett
    Brain Mapping Unit, Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, England
    Arch Gen Psychiatry 63:611-21. 2006
    ..Establishing a neurobiological account of delusion formation that links cognitive processes, brain activity, and symptoms is important to furthering our understanding of psychosis...
  17. ncbi Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters
    Chris M Dodds
    Experimental Medicine, GlaxoSmithKline Pharmaceuticals, Clinical Unit Cambridge, Addenbrooke s Centre for Clinical Investigation, Box 128, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Appetite 59:27-33. 2012
    ..However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D(3) receptor manipulation does not modulate brain responses to food images in overweight and obese subjects...
  18. doi Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning task
    Mischa De Rover
    MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychologia 49:2060-70. 2011
    ..The findings suggest that performance on PAL might be a useful cognitive biomarker for early detection of Alzheimer's disease, especially when used in conjunction with neuroimaging...
  19. pmc The effects of a subpsychotic dose of ketamine on recognition and source memory for agency: implications for pharmacological modelling of core symptoms of schizophrenia
    Garry D Honey
    Department of Psychiatry, University of Cambridge, UK
    Neuropsychopharmacology 31:413-23. 2006
    ..This difference may account for the pattern of psychopathology induced by ketamine...
  20. pmc Separable forms of reality monitoring supported by anterior prefrontal cortex
    Jon S Simons
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    J Cogn Neurosci 20:447-57. 2008
    ..The observation of significant correlations between reduced medial anterior prefrontal signal and scores on such measures corroborates these theoretical links...
  21. pmc Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people
    Victoria C Cambridge
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, Cambridge Biomedical Campus, University of Cambridge, United Kingdom
    Biol Psychiatry 73:887-94. 2013
    ..Moreover, relatively few studies have used pharmacologic functional magnetic resonance imaging to probe the underlying basis of altered eating behaviors...
  22. doi A study of visuospatial working memory pre- and post-Gonadotropin Hormone Releasing Hormone agonists (GnRHa) in young women
    Michael C Craig
    Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    Horm Behav 54:47-59. 2008
    ..Our study suggests that acute ovarian hormone withdrawal following GnRHa, and perhaps at other times, (e.g. following surgical menopause and postpartum) alters the neural circuitry underlying performance of VWM...
  23. pmc Exploring the impact of ketamine on the experience of illusory body ownership
    Hannah L Morgan
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, United Kingdom
    Biol Psychiatry 69:35-41. 2011
    ..Given the evidence that ketamine, a noncompetitive N-methyl-D-aspartate antagonist reproduces symptoms of schizophrenia, we sought to determine whether the rubber-hand illusion is augmented by ketamine...
  24. ncbi Prediction error during retrospective revaluation of causal associations in humans: fMRI evidence in favor of an associative model of learning
    Philip R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    Neuron 44:877-88. 2004
    ..Our results support a modified associative account of retrospective revaluation and demonstrate the potential of functional neuroimaging as a tool for evaluating competing learning models...
  25. pmc Distinct roles for lateral and medial anterior prefrontal cortex in contextual recollection
    Jon S Simons
    Institute of Cognitive Neuroscience and Department of Pyschology, University College London, United Kingdom
    J Neurophysiol 94:813-20. 2005
    ..Lateral regions seem to be more involved in the early retrieval specification stages of recollection, with medial regions contributing to later stages (e.g., monitoring and verification)...
  26. ncbi Anterior prefrontal cortex and the recollection of contextual information
    Jon S Simons
    Institute of Cognitive Neuroscience, Department of Psychology, University College London, 17 Queen Square, London WC1N 3AR, UK
    Neuropsychologia 43:1774-83. 2005
    ..These results suggest different roles for lateral and medial anterior prefrontal cortex in recollection...
  27. ncbi Impairment of specific episodic memory processes by sub-psychotic doses of ketamine: the effects of levels of processing at encoding and of the subsequent retrieval task
    Garry D Honey
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, P O Box 255, Hills Road, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 181:445-57. 2005
    ..The precise nature of the impact of the N-methyl-D-aspartate antagonist, ketamine, upon human episodic memory, has yet to be elucidated fully...
  28. ncbi Is the parietal lobe necessary for recollection in humans?
    Jon S Simons
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Neuropsychologia 46:1185-91. 2008
    ..Thus, although the processes subserved by the human parietal lobe appear to be recruited to support memory function, they are not a necessary requirement for accurate remembering to occur...
  29. doi Appetitive and aversive taste conditioning in a computer game influences real-world decision making and subsequent activation in insular cortex
    Jonathan A McCabe
    Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 29:1046-51. 2009
    ....
  30. ncbi The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects
    Hisham Ziauddeen
    Medicines Discovery and Development, GlaxoSmithKline, Clinical Unit Cambridge, Addenbrooke s Centre for Clinical Investigations, Cambridge, UK Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK Cambridgeshire and Peterborough NHS Foundation Trust CPFT, Cambridge, UK
    J Clin Pharmacol 53:1078-90. 2013
    ..There were no effects of GSK1521498 on reaction time, hedonic or consummatory responses. These findings provide encouraging safety and PK data to support continued development of GSK1521498 for the treatment of alcohol addiction. ..
  31. pmc Ketamine administration in healthy volunteers reproduces aberrant agency experiences associated with schizophrenia
    James W Moore
    a Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Cogn Neuropsychiatry 16:364-81. 2011
    ..Previous research has found that the magnitude of binding is exaggerated in patients with schizophrenia. We therefore investigated whether ketamine administration to otherwise healthy adults induced a similar pattern of binding...
  32. pmc Consistency and interpretation of changes in millimeter-scale cortical intrinsic curvature across three independent datasets in schizophrenia
    Lisa Ronan
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuroimage 63:611-21. 2012
    ..The results suggest that reduced gyrification in schizophrenia is driven by a reduction in the expansion of upper cortical layers. This may plausibly be related to a reduction in short-range connectivity...
  33. pmc The role of the lateral frontal cortex in causal associative learning: exploring preventative and super-learning
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, CB2 2QQ, UK
    Cereb Cortex 14:872-80. 2004
    ..Furthermore, its activity is not directly explicable in terms of novelty or response errors and appears directly related to the learning that arises out of prediction error...
  34. pmc Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Brain Mapping Unit, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 188:364-73. 2006
    ..One possible explanation for this behaviour is that methadone users were less sensitive to punishment on immediately preceding unsuccessful trials...
  35. ncbi The hippocampal region is involved in successful recognition of both remote and recent famous faces
    Frederic A Bernard
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neuroimage 22:1704-14. 2004
    ....
  36. ncbi Does the brain have a baseline? Why we should be resisting a rest
    Alexa M Morcom
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
    Neuroimage 37:1073-82. 2007
    ..In doing so, we challenge the utility of studies of the resting state in a number of important domains of research...
  37. pmc Sense of agency, associative learning, and schizotypy
    James W Moore
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, Cambridge, United Kingdom
    Conscious Cogn 20:792-800. 2011
    ..These results are discussed in terms of models of SoA, and our understanding of disrupted SoA in certain disorders...
  38. pmc Differential tangential expansion as a mechanism for cortical gyrification
    Lisa Ronan
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 3EB, UK
    Cereb Cortex 24:2219-28. 2014
    ..We conclude that differential expansion is a plausible primary mechanism for gyrification, and propose that this perspective offers a compelling mechanistic account of the co-localization of cytoarchitecture and cortical folds. ..
  39. doi Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia
    Paul C Fletcher
    University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Nat Rev Neurosci 10:48-58. 2009
    ..We suggest that it is possible to understand these symptoms in terms of a disturbed hierarchical Bayesian framework, without recourse to separate considerations of experience and belief...
  40. pmc Underestimating calorie content when healthy foods are present: an averaging effect or a reference-dependent anchoring effect?
    Suzanna E Forwood
    Behaviour and Health Research Unit, Department for Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e71475. 2013
    ..The current study aimed to replicate and extend these findings to test the hypothesized mediating effect of ratings of healthiness of foods on calorie estimates...
  41. ncbi Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
    Adam R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Neurosci 6:115-6. 2003
  42. doi Physiological variation in estradiol and brain function: a functional magnetic resonance imaging study of verbal memory across the follicular phase of the menstrual cycle
    Michael C Craig
    Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, Kings College, London, SE5 8AF, UK
    Horm Behav 53:503-8. 2008
    ..Although we did not find a significant relationship between plasma estradiol concentration and verbal recall performance, we report a positive correlation between brain function and estradiol concentration at the LIFG...
  43. pmc Leptin regulates striatal regions and human eating behavior
    I Sadaf Farooqi
    University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Science 317:1355. 2007
    ....
  44. ncbi The functional roles of prefrontal cortex in episodic memory. I. Encoding
    P C Fletcher
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK
    Brain 121:1239-48. 1998
    ..Activity in more ventral and anterior left PFC regions would appear to reflect a less specific component of episodic memory encoding...
  45. pmc Acute ketamine administration alters the brain responses to executive demands in a verbal working memory task: an FMRI study
    R A E Honey
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 29:1203-14. 2004
    ..Furthermore, we have shown that ketamine's effects may be elucidated by fMRI even when overt behavioral measures show no evidence of impairment...
  46. ncbi The effects of the dopamine D₃ receptor antagonist GSK598809 on attentional bias to palatable food cues in overweight and obese subjects
    Pradeep J Nathan
    Clinical Unit Cambridge, Medicines Discovery and Development, GlaxoSmithKline R and D, Cambridge, UK
    Int J Neuropsychopharmacol 15:149-61. 2012
    ....
  47. pmc Deficits in sensory prediction are related to delusional ideation in healthy individuals
    Christoph Teufel
    Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuropsychologia 48:4169-72. 2010
    ..Rather they appear to be stable, trait-like characteristics of an individual, a finding that has important implications for our understanding of the neurocognitive basis of delusions...
  48. ncbi Learning-related human brain activations reflecting individual finances
    Philippe N Tobler
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    Neuron 54:167-75. 2007
    ..The inverse relationship of behavioral and neuronal learning speed with personal finances is compatible with the general concept of decreasing marginal utility with increasing wealth...
  49. ncbi The origin of pharmacopsychology: Emil Kraepelin's experiments in Leipzig, Dorpat and Heidelberg (1882-1892)
    Ulrich Muller
    Department of Experimental Psychology, University of Cambridge, Downing Site, CB2 3EB, Cambridge, UK
    Psychopharmacology (Berl) 184:131-8. 2006
    ..Kraepelin's contributions to psychopharmacology and clinical neuropsychology were far ahead of his time and his conceptual achievements have been largely neglected by modern psychiatry and cognitive neuroscience...
  50. pmc Inhibition of subliminally primed responses is mediated by the caudate and thalamus: evidence from functional MRI and Huntington's disease
    A R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
    Brain 126:713-23. 2003
    ....
  51. pmc Ketamine disrupts frontal and hippocampal contribution to encoding and retrieval of episodic memory: an fMRI study
    G D Honey
    University of Cambridge, Department of Psychiatry, Cambridge, UK
    Cereb Cortex 15:749-59. 2005
    ..Our findings show that, even when overt behaviour is unimpaired, ketamine has an impact upon the recruitment of key regions in episodic memory task performance...
  52. pmc Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Mol Psychiatry 13:239, 267-76. 2008
    ..This study provides the first evidence linking abnormal mesolimbic activity, reward learning and psychosis...
  53. ncbi Cingulate control of fronto-temporal integration reflects linguistic demands: a three-way interaction in functional connectivity
    E A Stamatakis
    Department of Experimental Psychology, University of Cambridge, UK
    Neuroimage 28:115-21. 2005
    ..These findings suggest a monitoring role for the ACC which, in the context of processing regular inflected words, is associated with greater engagement of an integrated fronto-temporal language system...
  54. pmc Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
    K D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:612-23. 2005
    ..We sought to investigate this possibility using functional neuroimaging...
  55. ncbi Investigating principles of human brain function underlying working memory: what insights from schizophrenia?
    G D Honey
    University of Cambridge, Department of Psychiatry, Brain Mapping Unit, Downing Site, Downing Street, Cambridge CB2 3EB, UK
    Neuroscience 139:59-71. 2006
    ..The increasing use of psychopharmacological models of disease in healthy human subjects is therefore considered as an attempt to address, or to some extent circumvent these issues...
  56. pmc Reinforcement and reversal learning in first-episode psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Schizophr Bull 34:848-55. 2008
    ..Abnormalities in reinforcement learning and reversal learning have been reported in psychosis, possibly secondary to subcortical dopamine abnormalities...
  57. pmc Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers
    A R Absalom
    University Division of Anaesthesia, Addenbrooke s Hospital, and University of Cambridge School of Clinical Medicine, CB2 2QQ, UK
    Br J Anaesth 98:615-23. 2007
    ..The aim of the current study was to assess the predictive performance of the Domino model during these studies, and compare it with that of three other ketamine models...
  58. pmc Attribution of intentional causation influences the perception of observed movements: behavioral evidence and neural correlates
    James W Moore
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge Cambridge, UK Department of Psychology, Goldsmiths, University of London London, UK
    Front Psychol 4:23. 2013
    ..Intriguingly, these brain regions have previously been implicated in the sense of agency over one's own movements. We discuss the implications of these results for intentional binding specifically, and the sense of agency more generally...
  59. ncbi Changing human behavior to prevent disease: the importance of targeting automatic processes
    Theresa M Marteau
    Behaviour and Health Research Unit, Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK
    Science 337:1492-5. 2012
    ..We discuss specific interventions and suggest ways to determine whether and how interventions that target automatic processes can enhance global efforts to prevent disease...
  60. pmc Intrinsic curvature: a marker of millimeter-scale tangential cortico-cortical connectivity?
    Lisa Ronan
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Int J Neural Syst 21:351-66. 2011
    ..Thus, the degree of cortical intrinsic curvature may have implications for short-range connectivity...
  61. doi Seeing other minds: attributed mental states influence perception
    Christoph Teufel
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Trends Cogn Sci 14:376-82. 2010
    ..This hypothesis has far-reaching implications for our understanding of both the healthy social brain and characteristic social failures in psychopathology...
  62. ncbi The functional roles of prefrontal cortex in episodic memory. II. Retrieval
    P C Fletcher
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK
    Brain 121:1249-56. 1998
    ..The results provide evidence for functional specialization of the right prefrontal cortex for discrete cognitive processes during episodic memory retrieval...
  63. ncbi Decision-making in mania: a PET study
    J S Rubinsztein
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Brain 124:2550-63. 2001
    ....
  64. ncbi The interactive effect of acute ovarian suppression and the cholinergic system on visuospatial working memory in young women
    M C Craig
    Department of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom
    Psychoneuroendocrinology 35:987-1000. 2010
    ..Overall, our findings point to a neural network by which acute loss of ovarian function may interact to negatively impact encoding...
  65. ncbi From prediction error to psychosis: ketamine as a pharmacological model of delusions
    P R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    J Psychopharmacol 21:238-52. 2007
    ....
  66. pmc Dopaminergic drug effects on physiological connectivity in a human cortico-striato-thalamic system
    G D Honey
    University of Cambridge, Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 126:1767-81. 2003
    ....
  67. ncbi Right prefrontal cortex responds to item familiarity during a memory encoding task
    P C Fletcher
    Institute of Neurology, London, UK
    Memory 7:703-13. 1999
    ....
  68. pmc Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memory
    Rebekah A E Honey
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 28:2037-44. 2003
    ..The specificity of this ketamine effect suggests that the earliest effect of NMDA receptor blockade is in higher order control of executive function rather than in more basic maintenance processes...
  69. pmc What is social about social perception research?
    Christoph Teufel
    Brain Mapping Unit, Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge Cambridge, UK
    Front Integr Neurosci 6:128. 2012
    ..Finally, we discuss the potential of this approach to inform studies of clinical conditions such as autism...
  70. ncbi Obesity and the brain: how convincing is the addiction model?
    Hisham Ziauddeen
    Department of Psychiatry, University of Cambridge, Herchel Smith Building, Addenbrooke s Hospital, Cambridge CB2 0SZ, UK
    Nat Rev Neurosci 13:279-86. 2012
    ....
  71. pmc Functional neuroimaging of schizophrenia: from a genetic predisposition to the emergence of symptoms
    Paul C Fletcher
    Brain 127:457-9. 2004
  72. pmc Cortisol shifts financial risk preferences
    Narayanan Kandasamy
    Institute of Metabolic Science, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    Proc Natl Acad Sci U S A 111:3608-13. 2014
    ..Physiology-induced shifts in risk preferences may thus be an underappreciated cause of market instability. ..
  73. pmc The skinny on cocaine: insights into eating behavior and body weight in cocaine-dependent men
    Karen D Ersche
    University of Cambridge, Department of Psychiatry, Cambridge CB2 0SZ, UK University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge CB2 0SZ, UK Electronic address
    Appetite 71:75-80. 2013
    ..Weight changes in cocaine users reflect fundamental perturbations in fat regulation. These are likely to be overlooked in clinical practice but may produce significant health problems when cocaine use is discontinued during recovery. ..
  74. pmc Central nervous system biomarkers for antiobesity drug development
    Hisham Ziauddeen
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, Cambridge Biomedical Campus, University of Cambridge, UK Wellcome Trust MRC Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK Cambridgeshire and Peterborough NHS Foundation Trust CPFT, Cambridge, UK Electronic address
    Drug Discov Today 18:1282-91. 2013
    ..In this review, we examine potential biomarkers for effects on metabolism and satiety, hedonics and motivation, and eating behaviour. We also review biomarkers for early detection of neuropsychiatric adverse effects. ..
  75. pmc Functional brain mapping of psychopathology
    G D Honey
    University of Cambridge, Department of Psychiatry, Brain Mapping Unit, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 72:432-9. 2002
    ..Parallel advances in each of these questions will be required before imaging techniques can impact on clinical decisions in psychiatry...
  76. doi The interactive effect of the cholinergic system and acute ovarian suppression on the brain: an fMRI study
    M C Craig
    Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, Kings College London, Denmark Hill, London, UK
    Horm Behav 55:41-9. 2009
    ..Furthermore, this interaction may provide a useful model to help explain reports of increased risk for cognitive decline and AD in women following ovariectomy...
  77. ncbi Gonadotropin hormone releasing hormone agonists alter prefrontal function during verbal encoding in young women
    Michael C Craig
    Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, 16 De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Psychoneuroendocrinology 32:1116-27. 2007
    ....