Research Topics
Species | Paul C FletcherSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficitsPaul C Fletcher
Box 189, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
Trends Cogn Sci 10:167-74. 2006..We suggest that close attention to these deficits can offer insights into core pathophysiology of schizophrenia...- Disrupted prediction-error signal in psychosis: evidence for an associative account of delusionsP R Corlett
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Brain 130:2387-400. 2007..Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs... - Sense of agency in health and disease: a review of cue integration approachesJ W Moore
Institute of Cognitive Neuroscience, University College London, Queen Square, London, UK
Conscious Cogn 21:59-68. 2012..We extend this to consider how alterations in cue integration may lead to aberrant experiences of agency... - From drugs to deprivation: a Bayesian framework for understanding models of psychosisP R Corlett
Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, Cambridge
Psychopharmacology (Berl) 206:515-30. 2009..This helps us to understand the similarities and differences across the common models of psychosis... - Regional brain activations predicting subsequent memory success: an event-related fMRI study of the influence of encoding tasksPaul C Fletcher
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Cortex 39:1009-26. 2003..They provide more evidence, too, for a less consistent finding: the interaction between the encoding task and the success of subsequent recognition... - Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatumPaul C Fletcher
Department of Psychiatry, University of Cambridge, GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Centre for Clinical Investigations, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
J Neurosci 30:14346-55. 2010..Furthermore, they support a regionally specific effect on brain function through which sibutramine exerts its clinical effect... - Responses of human frontal cortex to surprising events are predicted by formal associative learning theoryP C Fletcher
Brain Mapping Unit, Box 189, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
Nat Neurosci 4:1043-8. 2001..In short, the physiological response properties of right DLPFC satisfied specific predictions made by associative learning theory... - Frontal lobes and human memory: insights from functional neuroimagingP C Fletcher
Research Department of Psychiatry, Cambridge University, Addenbrooke s Hospital, Cambridge, UK
Brain 124:849-81. 2001..We expect that the neuroimaging techniques will provide an important part of this enterprise... - "Sculpting the response space"--an account of left prefrontal activation at encodingP C Fletcher
Wellcome Department of Cognitive Neurology, 12 Queen Square, London, WC1N 3BG, United Kingdom
Neuroimage 12:404-17. 2000..A crucial feature of such associative processing lies in selecting appropriate, and inhibiting inappropriate, semantic attributes of the study material... - On the benefits of not trying: brain activity and connectivity reflecting the interactions of explicit and implicit sequence learningP C Fletcher
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Cereb Cortex 15:1002-15. 2005..The findings demonstrate a neural basis for a well-known behavioural effect: the deleterious impact of an explicit search upon implicit learning... - The influence of explicit instructions and stimulus material on lateral frontal responses to an encoding taskP C Fletcher
Institut fur Medizin, Forschungszentrum, Julich, Germany
Neuroimage 17:780-91. 2002..The complex patterns of frontal effect counsel against any simple dichotomy of frontal function at the level of either material or task type... - Individual differences in psychotic effects of ketamine are predicted by brain function measured under placeboGarry D Honey
Department of Psychiatry, Brain Mapping Unit and Behavioural and Clinical Neurosciences Institute, University of Cambridge, School of Clinical Medicine, Cambridge CB2 2QQ, United Kingdom
J Neurosci 28:6295-303. 2008..These results demonstrate precise and predictive brain markers for individual profiles of vulnerability to drug-induced psychosis... - Functional dysconnectivity in schizophrenia associated with attentional modulation of motor functionGarry D Honey
University of Cambridge, Department of Psychiatry, Cambridge, UK
Brain 128:2597-611. 2005..Furthermore, these data show evidence of additional functional deficits in patients with negative symptoms, deficits which may explain the accompanying attentional impairment... - The neural underpinnings of associative learning in health and psychosis: how can performance be preserved when brain responses are abnormal?Graham K Murray
Brain Mapping Unit, University of Cambridge, Box 189, Cambridge CB2 0QQ, UK
Schizophr Bull 36:465-71. 2010..The findings suggest that a combination of these factors may resolve the question of why performance is sometimes preserved when brain patterns are disrupted... - Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eatersChris M Dodds
Experimental Medicine, GlaxoSmithKline Pharmaceuticals, Clinical Unit Cambridge, Addenbrooke s Centre for Clinical Investigation, Box 128, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
Appetite 59:27-33. 2012..However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D(3) receptor manipulation does not modulate brain responses to food images in overweight and obese subjects... - Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning taskMischa De Rover
MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Neuropsychologia 49:2060-70. 2011..The findings suggest that performance on PAL might be a useful cognitive biomarker for early detection of Alzheimer's disease, especially when used in conjunction with neuroimaging... - Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosisPhilip R Corlett
Brain Mapping Unit, Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, England
Arch Gen Psychiatry 63:611-21. 2006..They are consistent with a model of delusion formation positing disruptions in error-dependent learning... - Separable forms of reality monitoring supported by anterior prefrontal cortexJon S Simons
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
J Cogn Neurosci 20:447-57. 2008..The observation of significant correlations between reduced medial anterior prefrontal signal and scores on such measures corroborates these theoretical links... - The effects of a subpsychotic dose of ketamine on recognition and source memory for agency: implications for pharmacological modelling of core symptoms of schizophreniaGarry D Honey
Department of Psychiatry, University of Cambridge, UK
Neuropsychopharmacology 31:413-23. 2006..This difference may account for the pattern of psychopathology induced by ketamine... - A study of visuospatial working memory pre- and post-Gonadotropin Hormone Releasing Hormone agonists (GnRHa) in young womenMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
Horm Behav 54:47-59. 2008..Our study suggests that acute ovarian hormone withdrawal following GnRHa, and perhaps at other times, (e.g. following surgical menopause and postpartum) alters the neural circuitry underlying performance of VWM... - Exploring the impact of ketamine on the experience of illusory body ownershipHannah L Morgan
Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, United Kingdom
Biol Psychiatry 69:35-41. 2011..Given the evidence that ketamine, a noncompetitive N-methyl-D-aspartate antagonist reproduces symptoms of schizophrenia, we sought to determine whether the rubber-hand illusion is augmented by ketamine... - Impairment of specific episodic memory processes by sub-psychotic doses of ketamine: the effects of levels of processing at encoding and of the subsequent retrieval taskGarry D Honey
Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, P.O. Box 255, Hills Road, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 181:445-57. 2005..The observed effects are compatible with memory deficits seen in schizophrenia and thus provide some support for the ketamine model of the disease... - Prediction error during retrospective revaluation of causal associations in humans: fMRI evidence in favor of an associative model of learningPhilip R Corlett
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
Neuron 44:877-88. 2004..Our results support a modified associative account of retrospective revaluation and demonstrate the potential of functional neuroimaging as a tool for evaluating competing learning models... - Distinct roles for lateral and medial anterior prefrontal cortex in contextual recollectionJon S Simons
Institute of Cognitive Neuroscience and Department of Pyschology, University College London, United Kingdom
J Neurophysiol 94:813-20. 2005..Lateral regions seem to be more involved in the early retrieval specification stages of recollection, with medial regions contributing to later stages (e.g., monitoring and verification)... - Anterior prefrontal cortex and the recollection of contextual informationJon S Simons
Institute of Cognitive Neuroscience, Department of Psychology, University College London, 17 Queen Square, London WC1N 3AR, UK
Neuropsychologia 43:1774-83. 2005..These results suggest different roles for lateral and medial anterior prefrontal cortex in recollection... - Is the parietal lobe necessary for recollection in humans?Jon S Simons
Brain Mapping Unit, University of Cambridge, Cambridge, UK
Neuropsychologia 46:1185-91. 2008..Thus, although the processes subserved by the human parietal lobe appear to be recruited to support memory function, they are not a necessary requirement for accurate remembering to occur... - Appetitive and aversive taste conditioning in a computer game influences real-world decision making and subsequent activation in insular cortexJonathan A McCabe
Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
J Neurosci 29:1046-51. 2009.... - Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteersKaren D Ersche
Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Brain Mapping Unit, Addenbrooke s Hospital, Cambridge, UK
Psychopharmacology (Berl) 188:364-73. 2006..One possible explanation for this behaviour is that methadone users were less sensitive to punishment on immediately preceding unsuccessful trials... - The hippocampal region is involved in successful recognition of both remote and recent famous facesFrederic A Bernard
Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Neuroimage 22:1704-14. 2004.... - The role of the lateral frontal cortex in causal associative learning: exploring preventative and super-learningDanielle C Turner
Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, CB2 2QQ, UK
Cereb Cortex 14:872-80. 2004..Furthermore, its activity is not directly explicable in terms of novelty or response errors and appears directly related to the learning that arises out of prediction error... - Sense of agency, associative learning, and schizotypyJames W Moore
Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, Cambridge, United Kingdom
Conscious Cogn 20:792-800. 2011..These results are discussed in terms of models of SoA, and our understanding of disrupted SoA in certain disorders... - Does the brain have a baseline? Why we should be resisting a restAlexa M Morcom
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
Neuroimage 37:1073-82. 2007..In doing so, we challenge the utility of studies of the resting state in a number of important domains of research... - Physiological variation in estradiol and brain function: a functional magnetic resonance imaging study of verbal memory across the follicular phase of the menstrual cycleMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, Kings College, London, SE5 8AF, UK
Horm Behav 53:503-8. 2008..Although we did not find a significant relationship between plasma estradiol concentration and verbal recall performance, we report a positive correlation between brain function and estradiol concentration at the LIFG... - Leptin regulates striatal regions and human eating behaviorI Sadaf Farooqi
University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
Science 317:1355. 2007.... - Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humansAdam R Aron
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
Nat Neurosci 6:115-6. 2003 - Acute ketamine administration alters the brain responses to executive demands in a verbal working memory task: an FMRI studyR A E Honey
Department of Psychiatry, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 29:1203-14. 2004..Furthermore, we have shown that ketamine's effects may be elucidated by fMRI even when overt behavioral measures show no evidence of impairment... - The functional roles of prefrontal cortex in episodic memory. I. EncodingP C Fletcher
Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK
Brain 121:1239-48. 1998..Activity in more ventral and anterior left PFC regions would appear to reflect a less specific component of episodic memory encoding... - The effects of the dopamine D? receptor antagonist GSK598809 on attentional bias to palatable food cues in overweight and obese subjectsPradeep J Nathan
Clinical Unit Cambridge, Medicines Discovery and Development, GlaxoSmithKline R and D, Cambridge, UK
Int J Neuropsychopharmacol 15:149-61. 2012.... - Consistency and interpretation of changes in millimeter-scale cortical intrinsic curvature across three independent datasets in schizophreniaLisa Ronan
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
Neuroimage 63:611-21. 2012..The results suggest that reduced gyrification in schizophrenia is driven by a reduction in the expansion of upper cortical layers. This may plausibly be related to a reduction in short-range connectivity... - Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophreniaPaul C Fletcher
University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
Nat Rev Neurosci 10:48-58. 2009..We suggest that it is possible to understand these symptoms in terms of a disturbed hierarchical Bayesian framework, without recourse to separate considerations of experience and belief... - Learning-related human brain activations reflecting individual financesPhilippe N Tobler
Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
Neuron 54:167-75. 2007..The inverse relationship of behavioral and neuronal learning speed with personal finances is compatible with the general concept of decreasing marginal utility with increasing wealth... - Deficits in sensory prediction are related to delusional ideation in healthy individualsChristoph Teufel
Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, University of Cambridge, Cambridge, UK
Neuropsychologia 48:4169-72. 2010..Rather they appear to be stable, trait-like characteristics of an individual, a finding that has important implications for our understanding of the neurocognitive basis of delusions... - The origin of pharmacopsychology: Emil Kraepelin's experiments in Leipzig, Dorpat and Heidelberg (1882-1892)Ulrich Muller
Department of Experimental Psychology, University of Cambridge, Downing Site, CB2 3EB, Cambridge, UK
Psychopharmacology (Berl) 184:131-8. 2006..Kraepelin's contributions to psychopharmacology and clinical neuropsychology were far ahead of his time and his conceptual achievements have been largely neglected by modern psychiatry and cognitive neuroscience... - Reinforcement and reversal learning in first-episode psychosisG K Murray
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Schizophr Bull 34:848-55. 2008..Abnormalities in reinforcement learning and reversal learning have been reported in psychosis, possibly secondary to subcortical dopamine abnormalities... - Inhibition of subliminally primed responses is mediated by the caudate and thalamus: evidence from functional MRI and Huntington's diseaseA R Aron
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
Brain 126:713-23. 2003.... - Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteersA R Absalom
University Division of Anaesthesia, Addenbrooke s Hospital, and University of Cambridge School of Clinical Medicine, CB2 2QQ, UK
Br J Anaesth 98:615-23. 2007..The aim of the current study was to assess the predictive performance of the Domino model during these studies, and compare it with that of three other ketamine models... - Ketamine disrupts frontal and hippocampal contribution to encoding and retrieval of episodic memory: an fMRI studyG D Honey
University of Cambridge, Department of Psychiatry, Cambridge, UK
Cereb Cortex 15:749-59. 2005..Our findings show that, even when overt behaviour is unimpaired, ketamine has an impact upon the recruitment of key regions in episodic memory task performance... - Substantia nigra/ventral tegmental reward prediction error disruption in psychosisG K Murray
Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
Mol Psychiatry 13:239, 267-76. 2008..This study provides the first evidence linking abnormal mesolimbic activity, reward learning and psychosis... - Investigating principles of human brain function underlying working memory: what insights from schizophrenia?G D Honey
University of Cambridge, Department of Psychiatry, Brain Mapping Unit, Downing Site, Downing Street, Cambridge CB2 3EB, UK
Neuroscience 139:59-71. 2006..The increasing use of psychopharmacological models of disease in healthy human subjects is therefore considered as an attempt to address, or to some extent circumvent these issues... - Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individualsK D Ersche
Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
Psychopharmacology (Berl) 180:612-23. 2005..We sought to investigate this possibility using functional neuroimaging... - Cingulate control of fronto-temporal integration reflects linguistic demands: a three-way interaction in functional connectivityE A Stamatakis
Department of Experimental Psychology, University of Cambridge, UK
Neuroimage 28:115-21. 2005..These findings suggest a monitoring role for the ACC which, in the context of processing regular inflected words, is associated with greater engagement of an integrated fronto-temporal language system... - Changing human behavior to prevent disease: the importance of targeting automatic processesTheresa M Marteau
Behaviour and Health Research Unit, Institute of Public Health, University of Cambridge, Cambridge CB2 0SR, UK
Science 337:1492-5. 2012..We discuss specific interventions and suggest ways to determine whether and how interventions that target automatic processes can enhance global efforts to prevent disease... - Intrinsic curvature: a marker of millimeter-scale tangential cortico-cortical connectivity?Lisa Ronan
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
Int J Neural Syst 21:351-66. 2011..Thus, the degree of cortical intrinsic curvature may have implications for short-range connectivity... - Seeing other minds: attributed mental states influence perceptionChristoph Teufel
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
Trends Cogn Sci 14:376-82. 2010..This hypothesis has far-reaching implications for our understanding of both the healthy social brain and characteristic social failures in psychopathology... - Right prefrontal cortex responds to item familiarity during a memory encoding taskP C Fletcher
Institute of Neurology, London, UK
Memory 7:703-13. 1999.... - Decision-making in mania: a PET studyJ S Rubinsztein
Department of Psychiatry, University of Cambridge, Cambridge, UK
Brain 124:2550-63. 2001.... - The functional roles of prefrontal cortex in episodic memory. II. RetrievalP C Fletcher
Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK
Brain 121:1249-56. 1998..The results provide evidence for functional specialization of the right prefrontal cortex for discrete cognitive processes during episodic memory retrieval... - Dopaminergic drug effects on physiological connectivity in a human cortico-striato-thalamic systemG D Honey
University of Cambridge, Brain Mapping Unit, Department of Psychiatry, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
Brain 126:1767-81. 2003.... - The interactive effect of acute ovarian suppression and the cholinergic system on visuospatial working memory in young womenM C Craig
Department of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom
Psychoneuroendocrinology 35:987-1000. 2010..Overall, our findings point to a neural network by which acute loss of ovarian function may interact to negatively impact encoding... - Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memoryRebekah A E Honey
Department of Psychiatry, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 28:2037-44. 2003..The specificity of this ketamine effect suggests that the earliest effect of NMDA receptor blockade is in higher order control of executive function rather than in more basic maintenance processes... - From prediction error to psychosis: ketamine as a pharmacological model of delusionsP R Corlett
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, UK
J Psychopharmacol 21:238-52. 2007.... - Obesity and the brain: how convincing is the addiction model?Hisham Ziauddeen
Department of Psychiatry, University of Cambridge, Herchel Smith Building, Addenbrooke s Hospital, Cambridge CB2 0SZ, UK
Nat Rev Neurosci 13:279-86. 2012.... - Functional neuroimaging of schizophrenia: from a genetic predisposition to the emergence of symptomsPaul C Fletcher
Brain 127:457-9. 2004 - Functional brain mapping of psychopathologyG D Honey
University of Cambridge, Department of Psychiatry, Brain Mapping Unit, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
J Neurol Neurosurg Psychiatry 72:432-9. 2002..Parallel advances in each of these questions will be required before imaging techniques can impact on clinical decisions in psychiatry... - The interactive effect of the cholinergic system and acute ovarian suppression on the brain: an fMRI studyM C Craig
Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, Kings College London, Denmark Hill, London, UK
Horm Behav 55:41-9. 2009..Furthermore, this interaction may provide a useful model to help explain reports of increased risk for cognitive decline and AD in women following ovariectomy... - Gonadotropin hormone releasing hormone agonists alter prefrontal function during verbal encoding in young womenMichael C Craig
Section of Brain Maturation PO50, Department of Psychological Medicine, Institute of Psychiatry, 16 De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Psychoneuroendocrinology 32:1116-27. 2007....