David M Flavell

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease
    David M Flavell
    Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College of London Medical School, London, UK
    Circulation 105:1440-5. 2002
  2. ncbi Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes
    David M Flavell
    Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK
    Diabetes 54:582-6. 2005
  3. ncbi A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies
    Mohamed A Elrayess
    The Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, UK
    Atherosclerosis 168:131-8. 2003
  4. ncbi The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease
    Philippa J Talmud
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Department of Medicine, Royal Free and University College Medical School, London, UK
    Clin Sci (Lond) 112:617-24. 2007
  5. ncbi Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University St, London WC1E 6JF, UK
    Arterioscler Thromb Vasc Biol 23:644-9. 2003
  6. ncbi Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth
    David M Flavell
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, University College London, London, UK
    J Mol Med (Berl) 84:126-31. 2006
  7. ncbi Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension
    Yalda Jamshidi
    Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK
    Circulation 105:950-5. 2002
  8. ncbi Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training
    Peter T E Wootton
    Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College London Medical School, 5 University Street, London WC1E 6JF, UK
    Nutr Metab Cardiovasc Dis 17:24-31. 2007
  9. ncbi Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II
    Wendy Putt
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK
    Hum Mol Genet 13:1587-97. 2004
  10. pmc IP receptor-dependent activation of PPARgamma by stable prostacyclin analogues
    Emilia Falcetti
    BHF Laboratories, Department of Medicine, Rayne Building, University College London, London WC1E 6JF, UK
    Biochem Biophys Res Commun 360:821-7. 2007

Detail Information

Publications15

  1. ncbi Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease
    David M Flavell
    Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College of London Medical School, London, UK
    Circulation 105:1440-5. 2002
    ..Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the expression of genes involved in lipid metabolism and inflammation, making it a candidate gene for atherosclerosis and ischemic heart disease (IHD)...
  2. ncbi Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes
    David M Flavell
    Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK
    Diabetes 54:582-6. 2005
    ..4 +/- 1.5 and AC + CC 5.3 +/- 1.1 years, P = 0.002). These data indicate that PPARalpha gene variation influences the onset and progression of type 2 diabetes...
  3. ncbi A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies
    Mohamed A Elrayess
    The Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, UK
    Atherosclerosis 168:131-8. 2003
    ..These data demonstrate that the PECAM-1 gene is responsive to shear stress in vitro and that decreased PECAM-1 gene expression in 53A carriers may influence reduced progression of vessel stenosis in patients with coronary artery disease...
  4. ncbi The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease
    Philippa J Talmud
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Department of Medicine, Royal Free and University College Medical School, London, UK
    Clin Sci (Lond) 112:617-24. 2007
    ..007). In conclusion, hypertensive LPL X447 carriers have increased risk of LVH and CHD, suggesting that altered FA delivery constitutes a mechanism through which LVH and CHD are associated in hypertensive subjects...
  5. ncbi Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University St, London WC1E 6JF, UK
    Arterioscler Thromb Vasc Biol 23:644-9. 2003
    ..Alpha1-Antitrypsin (AAT) protects elastic tissue and may play a role in atherogenesis. The association of atherosclerosis progression with common AAT variants was considered in 2 clinical trials...
  6. ncbi Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth
    David M Flavell
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, University College London, London, UK
    J Mol Med (Berl) 84:126-31. 2006
    ..Change in blood pressure accounted for a proportion of LV growth. These data suggest that increased myocardial FA availability may reduce exercise-induced LV growth...
  7. ncbi Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension
    Yalda Jamshidi
    Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK
    Circulation 105:950-5. 2002
    ....
  8. ncbi Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training
    Peter T E Wootton
    Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College London Medical School, 5 University Street, London WC1E 6JF, UK
    Nutr Metab Cardiovasc Dis 17:24-31. 2007
    ..51+/-1.17%) in percentage lean mass, compared to AV (1.64+/-0.38%) and AA (1.10+/-0.24%) recruits (p=0.02). The association of this genotype with changes in body composition after training suggests a novel role for Lp-PLA2...
  9. ncbi Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II
    Wendy Putt
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK
    Hum Mol Genet 13:1587-97. 2004
    ..0002) on AUC TG and APOC3 -482C>T on plasma apoE levels (P=0.0012). Thus, in these healthy young men, variation in USF1 was the influencing feature of both glucose and lipid homeostasis showing case-control heterogeneity...
  10. pmc IP receptor-dependent activation of PPARgamma by stable prostacyclin analogues
    Emilia Falcetti
    BHF Laboratories, Department of Medicine, Rayne Building, University College London, London WC1E 6JF, UK
    Biochem Biophys Res Commun 360:821-7. 2007
    ..We conclude that PPARgamma is activated through the IP receptor via a cyclic AMP-independent mechanism and contributes to the anti-growth effects of prostacyclin analogues...
  11. ncbi Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes
    Christelle Foucher
    Laboratoires Fournier S A Centre de Recherches, Department of Clinical Research and Medical Affairs, Daix, France
    Pharmacogenetics 14:823-9. 2004
    ....
  12. ncbi Identification of the PPARA locus on chromosome 22q13.3 as a modifier gene in familial combined hyperlipidemia
    Petra M H Eurlings
    Department of Internal Medicine, Laboratory of Molecular Metabolism and Endocrinology, Cardiovascular Research Institute Maastricht, University of Maastricht, PO Box 616, Maastricht, NL 6200 MD, The Netherlands
    Mol Genet Metab 77:274-81. 2002
    ..98%) compared to that in spouses (4.84%). These results clearly demonstrate the genetically complex nature of FCHL and identify the PPARA gene as a modifier of the FCHL phenotype...
  13. pmc Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight
    Alex Doney
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
    BMC Genet 3:21. 2002
    ..Both rare alleles are in linkage disequilibrium and the independent associations of these two polymorphisms have not been addressed...
  14. ncbi Characterization of the human PPARalpha promoter: identification of a functional nuclear receptor response element
    Ines Pineda Torra
    U 545 Institut National de la Santé et de la Recherche Médicale, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
    Mol Endocrinol 16:1013-28. 2002
    ..Furthermore, these data demonstrate that the hPPARalpha gene is regulated by nuclear receptors, such as HNF-4, COUP-TFII, and PPARalpha...
  15. ncbi PPARalpha gene variation and physical performance in Russian athletes
    Ildus I Ahmetov
    Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia
    Eur J Appl Physiol 97:103-8. 2006
    ..In conclusion, PPARalpha intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPARalpha genotype and muscle fiber type composition...