Adrienne M Flanagan

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression
    N Presneau
    UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK
    Br J Cancer 108:964-72. 2013
  2. pmc Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway
    N Presneau
    UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
    Br J Cancer 100:1406-14. 2009
  3. doi request reprint Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2
    M Fernanda Amary
    Histopathology Unit, Royal National Orthopaedic Hospital National Health Service Trust, Stanmore, UK
    Nat Genet 43:1262-5. 2011
  4. pmc A molecular map of mesenchymal tumors
    Stephen R Henderson
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK
    Genome Biol 6:R76. 2005
  5. doi request reprint Benefits of molecular pathology in the diagnosis of musculoskeletal disease : Part II of a two-part review: bone tumors and metabolic disorders
    Adrienne M Flanagan
    Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK
    Skeletal Radiol 39:213-24. 2010
  6. doi request reprint The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target
    Asem Shalaby
    UCL Cancer Institute, 72 Huntley Street, London WC1 6BT, UK
    J Pathol 223:336-46. 2011
  7. doi request reprint IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
    M Fernanda Amary
    Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK
    J Pathol 224:334-43. 2011
  8. doi request reprint GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma
    David Delaney
    Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK
    Mod Pathol 22:718-24. 2009
  9. doi request reprint Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study
    Nadege Presneau
    UCL Cancer Institute, 72 Huntley Street, London WC1 6BT, UK
    J Pathol 223:327-35. 2011
  10. doi request reprint Clear cell sarcoma of the mediastinum
    Roberto Tirabosco
    Department of Histopathology, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
    Ann Diagn Pathol 13:197-200. 2009

Collaborators

Detail Information

Publications22

  1. pmc MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression
    N Presneau
    UCL Cancer Institute, 72 Huntley Street, London WC1E 6BT, UK
    Br J Cancer 108:964-72. 2013
    ..These are benign nerve sheath tumours, which can transform into malignant peripheral nerve sheath tumours (MPNST)...
  2. pmc Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway
    N Presneau
    UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
    Br J Cancer 100:1406-14. 2009
    ....
  3. doi request reprint Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2
    M Fernanda Amary
    Histopathology Unit, Royal National Orthopaedic Hospital National Health Service Trust, Stanmore, UK
    Nat Genet 43:1262-5. 2011
    ..The findings are compatible with a model in which IDH1 or IDH2 mutations represent early post-zygotic occurrences in individuals with these syndromes...
  4. pmc A molecular map of mesenchymal tumors
    Stephen R Henderson
    Cancer Research UK, Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London, WC1E 6BT, UK
    Genome Biol 6:R76. 2005
    ..Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy...
  5. doi request reprint Benefits of molecular pathology in the diagnosis of musculoskeletal disease : Part II of a two-part review: bone tumors and metabolic disorders
    Adrienne M Flanagan
    Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK
    Skeletal Radiol 39:213-24. 2010
    ..It also addresses the importance of phosphate metabolism in skeletal disorders including phosphaturic mesenchymal tumor, vitamin D-resistant rickets, and tumoral calcinosis...
  6. doi request reprint The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target
    Asem Shalaby
    UCL Cancer Institute, 72 Huntley Street, London WC1 6BT, UK
    J Pathol 223:336-46. 2011
    ..There was no reduction of T as assessed by western blotting. These data implicate aberrant EGFR signalling in the pathogenesis of chordoma. This study provides a strategy for patient stratification for treatment with EGFR antagonists...
  7. doi request reprint IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
    M Fernanda Amary
    Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK
    J Pathol 224:334-43. 2011
    ..We speculate that a mosaic pattern of IDH-mutation-bearing cells explains the reports of diverse tumours (gliomas, AML, multiple cartilaginous neoplasms, haemangiomas) occurring in the same patient...
  8. doi request reprint GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma
    David Delaney
    Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK
    Mod Pathol 22:718-24. 2009
    ....
  9. doi request reprint Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study
    Nadege Presneau
    UCL Cancer Institute, 72 Huntley Street, London WC1 6BT, UK
    J Pathol 223:327-35. 2011
    ..In conclusion, chromosomal aberrations resulting in gain of the T locus are common in sporadic chordomas and expression of this gene is critical for proliferation of chordoma cells in vitro...
  10. doi request reprint Clear cell sarcoma of the mediastinum
    Roberto Tirabosco
    Department of Histopathology, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
    Ann Diagn Pathol 13:197-200. 2009
    ..To the best of our knowledge, primary mediastinal clear cell sarcoma has not been previously reported in the literature. We present the case and discuss the differential diagnosis...
  11. doi request reprint A common single-nucleotide variant in T is strongly associated with chordoma
    Nischalan Pillay
    Cancer Institute, University College London, UK
    Nat Genet 44:1185-7. 2012
    ..1, 95% confidence interval (CI) = 3.1-12.1; P = 4.4 × 10(-9)), a finding that is exceptional in cancers with a non-Mendelian mode of inheritance...
  12. ncbi request reprint Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation
    Roberto Tirabosco
    Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK
    Skeletal Radiol 36:59-65. 2007
    ..Brachyury can be employed as a marker of notochordal differentiation and help identify confidently, for the first time, extra-axial bone and soft tissue chordomas, and tumours which may show focal notochordal differentiation...
  13. ncbi request reprint Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas
    Asem A E Shalaby
    UCL Cancer Institute, London, UK
    Mod Pathol 22:996-1005. 2009
    ..The key genetic events responsible for the initiation and progression of chordomas remain to be discovered...
  14. doi request reprint Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma: characterization of five cases
    M Fernanda Amary
    Departments of Histopathology, Radiology and Surgery, Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK
    Skeletal Radiol 42:947-57. 2013
    ..To describe the imaging and histopathology of pseudomyogenic hemangioendothelioma...
  15. pmc Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
    Paul Guilhamon
    Medical Genomics, UCL Cancer Institute, University College London, London, UK
    Nat Commun 4:2166. 2013
    ....
  16. doi request reprint Nonbacterial osteitis: a clinical, histopathological, and imaging study with a proposal for protocol-based management of patients with this diagnosis
    Panagiotis D Gikas
    Bone Tumour Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
    J Orthop Sci 14:505-16. 2009
    ..We present our clinical experience as the largest reported series of children with NBO to date...
  17. doi request reprint The benefits of molecular pathology in the diagnosis of musculoskeletal disease : part I of a two-part review: soft tissue tumors
    Adrienne M Flanagan
    Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, HA7 4LP, UK
    Skeletal Radiol 39:105-15. 2010
    ..Finally, a brief practical guide of how to use and provide a molecular pathology service is given...
  18. doi request reprint Liposarcomatous differentiation in malignant peripheral nerve sheath tumor: a case report
    Roberto Tirabosco
    Department of Histopathology, Institute of Orthopaedics and Musculoskeletal Science, The Royal National Orthopaedic Hospital, Stanmore, HA7 4LP Middlesex, UK
    Pathol Res Pract 206:138-42. 2010
    ..The diagnosis of MPNST with rhabdomyoblastic and lipoblastic differentiation was made. We are not aware of previously reported lipoblastic differentiation in MPNST. Herein, we present details of the case...
  19. doi request reprint MRI characteristics of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma: retrospective comparison with histology and MDM2 gene amplification
    Mélanie Brisson
    Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK
    Skeletal Radiol 42:635-47. 2013
    ..To review the reliability of MR imaging features for the purpose of distinguishing lipoma and atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL)...
  20. doi request reprint Primary myxoid liposarcoma of the ovary in an adolescent girl: a case report
    Roberto Tirabosco
    Department of Histopathology, The Royal National Orthopaedic Hospital, Stanmore, HA7 4LP, Middlesex, UK
    Int J Gynecol Pathol 29:256-9. 2010
    ..To the best of our knowledge, primary ovarian myxoid liposarcoma has not been previously reported in the English literature. We present the case and briefly discuss the differential diagnosis...
  21. doi request reprint Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis
    Nicholas S Kalson
    The London Bone and Soft Tissue Sarcoma Unit, Brockley Hill, Stanmore, Middlesex, United Kingdom
    J Arthroplasty 26:339.e15-20. 2011
    ..This case, unique in the literature, demonstrates the destructive capacity and diagnostic pitfalls of synovial hemangioma...
  22. doi request reprint Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue
    Roberto Tirabosco
    Department of Histopathology, The Royal National Orthopaedic Hospital, UK
    Am J Surg Pathol 32:572-80. 2008
    ....