C M Fitzsimmons

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, United Kindgdom
    Infect Immun 80:4264-70. 2012
  2. pmc The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS Negl Trop Dis 6:e1593. 2012
  3. pmc Changes in IgE- and antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantel
    Mohamed Z Satti
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    BMC Immunol 5:6. 2004
  4. ncbi request reprint Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Biochem Parasitol 144:123-7. 2005
  5. ncbi request reprint Human IgE response to the Schistosoma haematobium 22.6 kDa antigen
    C M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, UK
    Parasite Immunol 26:371-6. 2004
  6. ncbi request reprint Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposure
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, UK
    Int Arch Allergy Immunol 142:40-50. 2007
  7. doi request reprint Survival of the fittest: allergology or parasitology?
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, UK, CB2 1QP
    Trends Parasitol 25:447-51. 2009
  8. pmc Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Infect Immun 72:4023-30. 2004
  9. ncbi request reprint Applied and basic research on the epidemiology, morbidity, and immunology of schistosomiasis in fishing communities on Lake Albert, Uganda
    David W Dunne
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 100:216-23. 2006
  10. pmc Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel
    Claus M Reimert
    DBL, Institute for Health Research and Development, Jaegersborg Alle 1 D, 2720 Charlottenlund, Denmark
    Clin Vaccine Immunol 13:584-93. 2006

Collaborators

Detail Information

Publications10

  1. pmc Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, United Kindgdom
    Infect Immun 80:4264-70. 2012
    ..g., TAL3) and that this leads to increasing cross-reactivity with antigens of invading larvae (e.g., TAL5). Progressive accumulation of worm/larvae cross-reactivity could explain the age-dependent immunity observed in areas of endemicity...
  2. pmc The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS Negl Trop Dis 6:e1593. 2012
    ..In addition to containing dynein-light-chain domains, these TALs also contain EF-hand domains similar to those found in numerous EF-hand allergens...
  3. pmc Changes in IgE- and antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantel
    Mohamed Z Satti
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    BMC Immunol 5:6. 2004
    ..mansoni infection, before and 1-day and 21-days after PZQ treatment...
  4. ncbi request reprint Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Biochem Parasitol 144:123-7. 2005
  5. ncbi request reprint Human IgE response to the Schistosoma haematobium 22.6 kDa antigen
    C M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, UK
    Parasite Immunol 26:371-6. 2004
    ..These results demonstrate that like related molecules in other species, Sh22.6 is a target for the human IgE response. The data also indicate that changes in the IgE response occur with age or with progressive exposure to key antigens...
  6. ncbi request reprint Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposure
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, UK
    Int Arch Allergy Immunol 142:40-50. 2007
    ..Here we compare human IgE and IgG responses to other family members, Sm20.8 and Sm21.7, as well as to SmDLC1, relating these to antigen structure and expression in parasite life stages...
  7. doi request reprint Survival of the fittest: allergology or parasitology?
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, UK, CB2 1QP
    Trends Parasitol 25:447-51. 2009
    ..This suggests that at least part of the secret of what allows some proteins to be allergens may actually lie in the long co-evolutionary relationship between worms and their vertebrate (and latterly human) hosts...
  8. pmc Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Infect Immun 72:4023-30. 2004
    ....
  9. ncbi request reprint Applied and basic research on the epidemiology, morbidity, and immunology of schistosomiasis in fishing communities on Lake Albert, Uganda
    David W Dunne
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trans R Soc Trop Med Hyg 100:216-23. 2006
    ..Such information and operational capacity are needed to facilitate much needed schistosomiasis control programmes, such as the Schistosomiasis Control Initiative that was launched in Uganda in 2003...
  10. pmc Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel
    Claus M Reimert
    DBL, Institute for Health Research and Development, Jaegersborg Alle 1 D, 2720 Charlottenlund, Denmark
    Clin Vaccine Immunol 13:584-93. 2006
    ..Moreover, it is possible that infection intensity-dependent levels of plasma IL-10 may be involved in the prevention of treatment-induced anaphylactic reactions...