S M Fitzjohn

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity
    S M Fitzjohn
    Department of Anatomy, University of Bristol, UK
    Neuropharmacology 37:1445-58. 1998
  2. ncbi request reprint DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists
    S M Fitzjohn
    Department of Anatomy, School of Medical Sciences, MRC Centre for Synaptic Plasticity, University of Bristol, UK
    Neuropharmacology 38:1577-83. 1999
  3. ncbi request reprint Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranes
    L Pickard
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK
    Neuropharmacology 41:700-13. 2001
  4. pmc A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro
    S M Fitzjohn
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Physiol 537:421-30. 2001
  5. ncbi request reprint Similar levels of long-term potentiation in amyloid precursor protein -null and wild-type mice in the CA1 region of picrotoxin treated slices
    S M Fitzjohn
    MRC Centre for Synaptic Plasticity and Department of Anatomy, University of Bristol, UK
    Neurosci Lett 288:9-12. 2000
  6. ncbi request reprint Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus
    Z A Bortolotto
    Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Curr Opin Neurobiol 9:299-304. 1999
  7. ncbi request reprint Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
    S M Fitzjohn
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, United Kingdom
    J Neurosci 21:4691-8. 2001
  8. ncbi request reprint An electrophysiological characterisation of long-term potentiation in cultured dissociated hippocampal neurones
    S M Fitzjohn
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK
    Neuropharmacology 41:693-9. 2001

Collaborators

Detail Information

Publications8

  1. ncbi request reprint The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity
    S M Fitzjohn
    Department of Anatomy, University of Bristol, UK
    Neuropharmacology 37:1445-58. 1998
    ..Since in the same inputs these forms of LTP were blocked by (S)-MCPG, a novel type of mGlu receptor may be involved in their induction...
  2. ncbi request reprint DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists
    S M Fitzjohn
    Department of Anatomy, School of Medical Sciences, MRC Centre for Synaptic Plasticity, University of Bristol, UK
    Neuropharmacology 38:1577-83. 1999
    ..In conclusion, DHPG, probably via activation of mGlu5 receptors, is able to induce a robust form of LTD in the CA1 region of the young rat hippocampus that is mechanistically distinct from NMDA receptor-dependent homosynaptic LTD...
  3. ncbi request reprint Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranes
    L Pickard
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK
    Neuropharmacology 41:700-13. 2001
    ..Our data indicate that the transient synaptic activation of NMDARs can lead to the insertion of native AMPARs at sites on the neuronal membrane that initially lacks AMPARs...
  4. pmc A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro
    S M Fitzjohn
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Physiol 537:421-30. 2001
    ..Furthermore, when synaptic transmission was blocked by perfusing with Ca2+-free medium, DHPG application reliably induced LTD. 8. These data suggest that DHPG-induced LTD is Ca2+ independent and is expressed presynaptically...
  5. ncbi request reprint Similar levels of long-term potentiation in amyloid precursor protein -null and wild-type mice in the CA1 region of picrotoxin treated slices
    S M Fitzjohn
    MRC Centre for Synaptic Plasticity and Department of Anatomy, University of Bristol, UK
    Neurosci Lett 288:9-12. 2000
    ..These results suggest that the LTP process per se is not altered by the absence of APP. The deficit may therefore be an indirect consequence of other changes in the hippocampus that occur in the APP-null animal...
  6. ncbi request reprint Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus
    Z A Bortolotto
    Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Curr Opin Neurobiol 9:299-304. 1999
    ....
  7. ncbi request reprint Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein
    S M Fitzjohn
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, BS8 1TD, United Kingdom
    J Neurosci 21:4691-8. 2001
    ..We conclude that increased susceptibility to excitotoxicity rather than a specific effect on LTP is the primary cause of cognitive deficits in APP(695)SWE mice...
  8. ncbi request reprint An electrophysiological characterisation of long-term potentiation in cultured dissociated hippocampal neurones
    S M Fitzjohn
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK
    Neuropharmacology 41:693-9. 2001
    ..This form of LTP is prevented by NMDA receptor antagonists and by chelating Ca2+ in the postsynaptic neurone. It is manifest primarily as an increase in the frequency of mEPSCs...