Simon E Fisher

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Eur J Hum Genet 17:1354-8. 2009
  2. pmc Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits
    Matthias Groszer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Curr Biol 18:354-62. 2008
  3. pmc Generation of mice with a conditional Foxp2 null allele
    Catherine A French
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genesis 45:440-6. 2007
  4. ncbi request reprint The eloquent ape: genes, brains and the evolution of language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Genet 7:9-20. 2006
  5. ncbi request reprint Tangled webs: tracing the connections between genes and cognition
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    Cognition 101:270-97. 2006
  6. ncbi request reprint Molecular windows into speech and language disorders
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Folia Phoniatr Logop 59:130-40. 2007
  7. ncbi request reprint Genes, cognition and dyslexia: learning to read the genome
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Cogn Sci 10:250-7. 2006
  8. ncbi request reprint Deciphering the genetic basis of speech and language disorders
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    Annu Rev Neurosci 26:57-80. 2003
  9. ncbi request reprint Developmental dyslexia: genetic dissection of a complex cognitive trait
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Neurosci 3:767-80. 2002
  10. doi request reprint FOXP2 as a molecular window into speech and language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Genet 25:166-77. 2009

Detail Information

Publications37

  1. pmc Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Eur J Hum Genet 17:1354-8. 2009
    ..However, this was also found in a random control sample. Analyses of non-coding SNP changes did not find any correlation with affection status. We conclude that FOXP1 mutations are unlikely to represent a major cause of DVD...
  2. pmc Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits
    Matthias Groszer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Curr Biol 18:354-62. 2008
    ....
  3. pmc Generation of mice with a conditional Foxp2 null allele
    Catherine A French
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genesis 45:440-6. 2007
    ....
  4. ncbi request reprint The eloquent ape: genes, brains and the evolution of language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Genet 7:9-20. 2006
    ..We argue that language should be viewed not as a wholesale innovation, but as a complex reconfiguration of ancestral systems that have been adapted in evolutionarily novel ways...
  5. ncbi request reprint Tangled webs: tracing the connections between genes and cognition
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    Cognition 101:270-97. 2006
    ..I propose that it is necessary for us to fully embrace the complexity of biological systems, if we are ever to untangle the webs that link genes to cognition...
  6. ncbi request reprint Molecular windows into speech and language disorders
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Folia Phoniatr Logop 59:130-40. 2007
    ..I demonstrate ways of bridging the gaps between molecules, neurons and the brain, which will provide a new understanding of the aetiology of speech and language impairments...
  7. ncbi request reprint Genes, cognition and dyslexia: learning to read the genome
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Cogn Sci 10:250-7. 2006
    ..Dissection of cognitive mechanisms that subserve reading will ultimately depend on an integrated approach, uniting data from genetic investigations, behavioural studies and neuroimaging...
  8. ncbi request reprint Deciphering the genetic basis of speech and language disorders
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    Annu Rev Neurosci 26:57-80. 2003
    ..The molecular genetic approach has potential for dissecting neurological pathways underlying speech and language disorders, but such investigations are only just beginning...
  9. ncbi request reprint Developmental dyslexia: genetic dissection of a complex cognitive trait
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Neurosci 3:767-80. 2002
  10. doi request reprint FOXP2 as a molecular window into speech and language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Genet 25:166-77. 2009
    ..This body of research represents the first functional genetic forays into neural mechanisms contributing to human spoken language...
  11. pmc A genomewide linkage screen for relative hand skill in sibling pairs
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 70:800-5. 2002
    ..13. Relative hand skill therefore is probably a complex multifactorial phenotype with a heterogeneous background, but nevertheless is amenable to QTL-based gene-mapping approaches...
  12. pmc A functional genetic link between distinct developmental language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    N Engl J Med 359:2337-45. 2008
    ..Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. We hypothesized that neural pathways downstream of FOXP2 influence more common phenotypes, such as specific language impairment...
  13. ncbi request reprint Familial and genetic effects on motor coordination, laterality, and reading-related cognition
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Am J Psychiatry 160:1970-7. 2003
    ..With a large sample, the authors aimed to investigate genetic relationships between measures of reading-related cognition, hand motor skill, and hand skill lateralization...
  14. pmc A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 75:1046-58. 2004
    ..In addition, the QTL effect may be largely limited to the severe range of reading disability...
  15. pmc A genomewide scan for loci involved in attention-deficit/hyperactivity disorder
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom
    Am J Hum Genet 70:1183-96. 2002
    ..Two of the regions highlighted in the present study, 2q24 and 16p13, coincided with the top linkage peaks reported by a recent genome-scan study of autistic sib pairs...
  16. ncbi request reprint Functional genetic analysis of mutations implicated in a human speech and language disorder
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Hum Mol Genet 15:3154-67. 2006
    ..We hypothesize that expression of alternative isoforms of FOXP2 may provide mechanisms for post-translational regulation of transcription factor function...
  17. pmc Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
    Kay D Macdermot
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:1074-80. 2005
    ..This endeavor will be crucial for gaining insight into the role of FOXP2 in human cognition...
  18. pmc Use of multivariate linkage analysis for dissection of a complex cognitive trait
    Angela J Marlow
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 72:561-70. 2003
    ..The approach employed here may aid positional cloning of susceptibility genes in a wide spectrum of complex traits...
  19. ncbi request reprint Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Mol Genet 12:3225-30. 2003
    ..The linkages may be due to a single maternally imprinted influence on lateralized brain development that contains common functional polymorphisms...
  20. pmc High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, The University of Oxford, Oxford, OX3 7BN, UK
    Am J Hum Genet 81:1232-50. 2007
    ..The identified targets suggest roles in modulating synaptic plasticity, neurodevelopment, neurotransmission, and axon guidance and represent novel entry points into in vivo pathways that may be disturbed in speech and language disorders...
  21. ncbi request reprint Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia
    Nuala H Simpson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Dev Med Child Neurol 56:346-53. 2014
    ..We assess the frequency of sex chromosome aneuploidies in individuals with language impairment or dyslexia...
  22. pmc Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 7:e1002145. 2011
    ..Our data indicate that Foxp2 modulates neuronal network formation, by directly and indirectly regulating mRNAs involved in the development and plasticity of neuronal connections...
  23. ncbi request reprint Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1
    Clyde Francks
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Psychiatr Genet 12:35-41. 2002
    ..Our study outlines the approach necessary for the identification of genetic variants causing dyslexia susceptibility in an epidemiological population of dyslexics...
  24. doi request reprint Unravelling neurogenetic networks implicated in developmental language disorders
    Sonja C Vernes
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochem Soc Trans 37:1263-9. 2009
    ..Thus, through ongoing identification of regulated targets and interacting co-factors, this gene is providing the first molecular entry points into neural mechanisms that go awry in language-related disorders...
  25. pmc CMIP and ATP2C2 modulate phonological short-term memory in language impairment
    Dianne F Newbury
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Am J Hum Genet 85:264-72. 2009
    ..This work therefore implicates CMIP and ATP2C2 in the etiology of SLI and provides molecular evidence for the importance of phonological short-term memory in language acquisition...
  26. ncbi request reprint Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Nat Genet 30:86-91. 2002
    ..This is the first report of QTL-based genome-wide scanning for a human cognitive trait...
  27. ncbi request reprint On genes, speech, and language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England
    N Engl J Med 353:1655-7. 2005
  28. pmc Recent advances in the genetics of language impairment
    Dianne F Newbury
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Genome Med 2:6. 2010
    ..We discuss how characterization of these genes, and the pathways in which they are involved, may enhance our understanding of language disorders and improve our understanding of the biological foundations of language acquisition...
  29. pmc Common variants in left/right asymmetry genes and pathways are associated with relative hand skill
    William M Brandler
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 9:e1003751. 2013
    ..Our findings lead us to propose that handedness is a polygenic trait controlled in part by the molecular mechanisms that establish LR body asymmetry early in development...
  30. pmc A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11
    Matthew N Ogdie
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA
    Am J Hum Genet 72:1268-79. 2003
    ..Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism...
  31. pmc Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language
    Stephanie A White
    Department of Physiological Science, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:10376-9. 2006
    ..Below, we describe genetic through behavioral techniques used currently to investigate FoxP2 in birds, rodents, and humans for discovery of the neural bases of vocal learning and language...
  32. ncbi request reprint Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution...
  33. ncbi request reprint FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder
    Cecilia S L Lai
    Neural Development Unit, Institute of Child Health, University College London, UK
    Brain 126:2455-62. 2003
    ..Overall, this study provides support for the hypothesis that impairments in sequencing of movement and procedural learning might be central to the FOXP2-related speech and language disorder...
  34. pmc Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain
    Elizabeth Spiteri
    Program in Neurogenetics, Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 81:1144-57. 2007
    ....
  35. pmc Confirmatory evidence for linkage of relative hand skill to 2p12-q11
    Clyde Francks
    Am J Hum Genet 72:499-502. 2003
  36. pmc Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism
    Susan L Smalley
    Center for Neurobehavioral Genetics and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024USA
    Am J Hum Genet 71:959-63. 2002
    ..These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism...
  37. pmc Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11
    Matthew N Ogdie
    Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
    Am J Hum Genet 75:661-8. 2004
    ..The refinement of linkage within each of these regions lays the foundation for subsequent investigations using association methods to detect risk genes of moderate effect size...