John Fisher

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint A stratified approach to pre-clinical tribological evaluation of joint replacements representing a wider range of clinical conditions advancing beyond the current standard
    John Fisher
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK
    Faraday Discuss 156:59-68; discussion 87-103. 2012
  2. ncbi request reprint Tribology of alternative bearings
    John Fisher
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    Clin Orthop Relat Res 453:25-34. 2006
  3. doi request reprint Bioengineering reasons for the failure of metal-on-metal hip prostheses: an engineer's perspective
    J Fisher
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Bone Joint Surg Br 93:1001-4. 2011
  4. ncbi request reprint Wear of surface engineered metal-on-metal hip prostheses
    J Fisher
    Institute of Medical and Biological Engineering Research Group iMBE, School of Mechanical Engineering, The University of Leeds, Leeds LS2 9JT, UK
    J Mater Sci Mater Med 15:225-35. 2004
  5. pmc 2009 Knee Society Presidential Guest Lecture: Polyethylene wear in total knees
    John Fisher
    Institute for Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    Clin Orthop Relat Res 468:12-8. 2010
  6. ncbi request reprint Influences of sterilising techniques on polyethylene wear
    J Fisher
    Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    Knee 11:173-6. 2004
  7. doi request reprint Wear of 36-mm BIOLOX(R) delta ceramic-on-ceramic bearing in total hip replacements under edge loading conditions
    Mazen Al-Hajjar
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 227:535-42. 2013
  8. doi request reprint Wear of surface-engineered metal-on-metal bearings for hip prostheses under adverse conditions with the head loading on the rim of the cup
    Ian Leslie
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 227:345-9. 2013
  9. doi request reprint Surface engineering: a low wearing solution for metal-on-metal hip surface replacements
    Ian J Leslie
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    J Biomed Mater Res B Appl Biomater 90:558-65. 2009
  10. ncbi request reprint Biomechanical characterization of decellularized and cross-linked bovine pericardium
    Dilip Oswal
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    J Heart Valve Dis 16:165-74. 2007

Detail Information

Publications152 found, 100 shown here

  1. ncbi request reprint A stratified approach to pre-clinical tribological evaluation of joint replacements representing a wider range of clinical conditions advancing beyond the current standard
    John Fisher
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK
    Faraday Discuss 156:59-68; discussion 87-103. 2012
    ..The stratified approach to pre-clinical tribological simulation of joint replacements has the potential to support the development of robust designs and improve safety and reliability of joint replacements in the future...
  2. ncbi request reprint Tribology of alternative bearings
    John Fisher
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    Clin Orthop Relat Res 453:25-34. 2006
    ..Bedding in wear is also lower with reduced radial clearance. Differential hardness ceramic-on-metal bearings and the application of ceramic-like coatings reduce metal wear and ion levels...
  3. doi request reprint Bioengineering reasons for the failure of metal-on-metal hip prostheses: an engineer's perspective
    J Fisher
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Bone Joint Surg Br 93:1001-4. 2011
    ..This may cause adverse tissue reactions, loosening of components and failure of the prosthesis...
  4. ncbi request reprint Wear of surface engineered metal-on-metal hip prostheses
    J Fisher
    Institute of Medical and Biological Engineering Research Group iMBE, School of Mechanical Engineering, The University of Leeds, Leeds LS2 9JT, UK
    J Mater Sci Mater Med 15:225-35. 2004
    ..The extremely low volume of wear debris and concentration of metal ions released by these surface engineered systems, especially with CrN and CrCN coatings, have considerable potential for the clinical application of this technology...
  5. pmc 2009 Knee Society Presidential Guest Lecture: Polyethylene wear in total knees
    John Fisher
    Institute for Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    Clin Orthop Relat Res 468:12-8. 2010
    ....
  6. ncbi request reprint Influences of sterilising techniques on polyethylene wear
    J Fisher
    Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    Knee 11:173-6. 2004
    ..Reducations in polyethylene wear were found with both stabilised polyethylene and cross-linked polyethylene, and with rotating platform mobile bearing designs...
  7. doi request reprint Wear of 36-mm BIOLOX(R) delta ceramic-on-ceramic bearing in total hip replacements under edge loading conditions
    Mazen Al-Hajjar
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 227:535-42. 2013
    ..25 mm(3)/million cycles) compared to earlier generation ceramic-on-ceramic bearings (BIOLOX forte, 1.84 mm(3)/million cycles) and other bearing materials such as metal-on-metal bearings (2-8 mm(3)/million cycles)...
  8. doi request reprint Wear of surface-engineered metal-on-metal bearings for hip prostheses under adverse conditions with the head loading on the rim of the cup
    Ian Leslie
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 227:345-9. 2013
    ....
  9. doi request reprint Surface engineering: a low wearing solution for metal-on-metal hip surface replacements
    Ian J Leslie
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    J Biomed Mater Res B Appl Biomater 90:558-65. 2009
    ..The CrN coating could provide a reduction in the wear and ion release of MoM surface replacements, thereby reducing the perceived risks to the patient associated with these prostheses...
  10. ncbi request reprint Biomechanical characterization of decellularized and cross-linked bovine pericardium
    Dilip Oswal
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    J Heart Valve Dis 16:165-74. 2007
    ..The study aims were to decellularize bovine pericardium and to compare the biomechanical properties of fresh and decellularized bovine pericardia to those treated with different concentrations of glutaraldehyde (GA)...
  11. ncbi request reprint Wear of crosslinked polyethylene under different tribological conditions
    Alison Galvin
    Institute of Medical and Biological Engineering, University of Leeds
    J Mater Sci Mater Med 17:235-43. 2006
    ..These findings are relevant to the consideration of the use of crosslinked polyethylene in the knee, where the kinematics have lower levels of cross shear and in the hip and knee against roughened metallic counterfaces...
  12. doi request reprint Effect of simplifications of bone and components inclination on the elastohydrodynamic lubrication modeling of metal-on-metal hip resurfacing prosthesis
    Qingen Meng
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 227:523-34. 2013
    ..Moreover, the combined effect of material properties and structures of bones was negligible. Future studies should focus on higher inclination angles, smaller coverage angle and microseparation related to the occurrences of edge loading...
  13. pmc Effect of femoral head size on the wear of metal on metal bearings in total hip replacements under adverse edge-loading conditions
    Mazen Al-Hajjar
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom
    J Biomed Mater Res B Appl Biomater 101:213-22. 2013
    ..Preclinical simulation testing should be undertaken with translational and rotational malpositioning conditions as well as standard walking cycle conditions defined by the ISO standard...
  14. ncbi request reprint Quantification of the effect of cross-shear and applied nominal contact pressure on the wear of moderately cross-linked polyethylene
    Abdellatif Abdelgaied
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 227:18-26. 2013
    ..This study provided independent wear data for inputs into computational models for moderately cross-linked polyethylene and supported the application of wear coefficient-based computational wear models...
  15. ncbi request reprint The effect of cup orientation and coverage on contact mechanics and range of motion of metal-on-metal hip resurfacing arthroplasty
    Ling Wang
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 226:877-86. 2012
    ..This study enables both sets of variable to be considered in the design of metal-on-metal bearings in hip...
  16. ncbi request reprint Tissue engineering of cardiac valve prostheses II: biomechanical characterization of decellularized porcine aortic heart valves
    Sotiris A Korossis
    School of Mechanical Engineering, University of Leeds, UK
    J Heart Valve Dis 11:463-71. 2002
    ..This study investigated the effect of 0.03% (w/v) and 0.1% (w/v) sodium dodecyl sulfate (SDS) on the mechanical integrity of porcine aortic valve leaflets...
  17. ncbi request reprint The influence of clearance on friction, lubrication and squeaking in large diameter metal-on-metal hip replacements
    Claire L Brockett
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Mater Sci Mater Med 19:1575-9. 2008
    ..This study suggests that increasing the bearing clearance results in reduced lubricant film thickness, increased friction and an increased incidence of squeaking...
  18. doi request reprint Effect of bearing size on the long-term wear, wear debris, and ion levels of large diameter metal-on-metal hip replacements-An in vitro study
    Ian Leslie
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    J Biomed Mater Res B Appl Biomater 87:163-72. 2008
    ..The ion levels measured suggest both bearing sizes have similar initial wear rates; however, the 55 mm bearings reach steady state wear more rapidly...
  19. doi request reprint Comparison of ceramic-on-metal and metal-on-metal hip prostheses under adverse conditions
    Sophie Williams
    Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Biomed Mater Res B Appl Biomater 101:770-5. 2013
    ....
  20. doi request reprint Biocompatibility and potential of acellular human amniotic membrane to support the attachment and proliferation of allogeneic cells
    Stacy Paul Wilshaw
    Faculty of Biological Sciences, Institute of Medical and Biological Engineering, University of Leeds, Leeds, West Yorkshire, United Kingdom
    Tissue Eng Part A 14:463-72. 2008
    ..Cell-seeded acellular amniotic membrane has the potential for delivering autologous or allogeneic cells to treat a variety of conditions, including diabetic foot ulcers, corneal defects, and severe skin burns...
  21. ncbi request reprint Friction of total hip replacements with different bearings and loading conditions
    Claire Brockett
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biomed Mater Res B Appl Biomater 81:508-15. 2007
    ..Increased serum concentration resulted in increased friction factor in all material combinations, except MoM, where increased serum concentration produced a significant reduction in friction factor...
  22. ncbi request reprint Effect of swing phase load on metal-on-metal hip lubrication, friction and wear
    Sophie Williams
    School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds, LS2 9JT, UK
    J Biomech 39:2274-81. 2006
    ..This may explain some of the variations that have been observed with clinical wear rates...
  23. ncbi request reprint In vitro analysis of the wear, wear debris and biological activity of surface-engineered coatings for use in metal-on-metal total hip replacements
    S Williams
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 217:155-63. 2003
    ..The reduced wear volumes coupled with the reduced cytotoxicity per unit volume of wear indicate the potential for the clinical application of this technology...
  24. pmc Development of methods for studying the differentiation of human mesenchymal stem cells under cyclic compressive strain
    Efstathios Michalopoulos
    Faculty of Biological Sciences, Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    Tissue Eng Part C Methods 18:252-62. 2012
    ..A combination of a composite viscoelastic scaffold and controlled cyclic compressive strain may be useful for study of the differentiation of MSC...
  25. ncbi request reprint In-vitro assessment of the functional performance of the decellularized intact porcine aortic root
    Sotirios A Korossis
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    J Heart Valve Dis 14:408-21; discussion 422. 2005
    ..25% (w/v) trypsin and 0.1% (w/v) SDS on the biomechanics and hydrodynamics of the aortic root. This treatment has been shown to produce decellularization of both the aorta and valve leaflets...
  26. ncbi request reprint The 2007 Otto Aufranc Award. Ceramic-on-metal hip arthroplasties: a comparative in vitro and in vivo study
    Sophie Williams
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Clin Orthop Relat Res 465:23-32. 2007
    ..Short-term studies in 31 patients at 6 months revealed lower metal ion levels (cobalt and chromium) in those with ceramic-on-metal compared with metal-on-metal bearings...
  27. doi request reprint Squeaking hip arthroplasties: a tribological phenomenon
    Claire L Brockett
    Institute of Medical and Biological Engineering, University of Leeds, School of Mechanical Engineering, Leeds, United Kingdom
    J Arthroplasty 28:90-7. 2013
    ..There are numerous factors that may cause the suboptimal lubrication, and therefore, it is unlikely that an individual cause for squeaking will be identified...
  28. doi request reprint Development and characterization of an acellular porcine cartilage bone matrix for use in tissue engineering
    Ehab Kheir
    Institude of Medical and Biological Engineering, The University of Leeds, Leeds, UK
    J Biomed Mater Res A 99:283-94. 2011
    ..To our knowledge, this is the first study that has successfully removed whole cells and α-gal from xenogeneic cartilage and bone tissue...
  29. ncbi request reprint Computational simulation of oxygen diffusion in aortic valve leaflet for tissue engineering applications
    Ling Wang
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    J Heart Valve Dis 17:700-9. 2008
    ..The study aim was to investigate the effect of tissue thickness and thickness variation on oxygen diffusion in a three-dimensional (3D) aortic valve leaflet model...
  30. ncbi request reprint Severe wear and fracture of zirconia heads against alumina inserts in hip simulator studies with microseparation
    Todd D Stewart
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, United Kingdom
    J Arthroplasty 18:726-34. 2003
    ..The results further raise concerns over the suitability of conventional simulators in evaluating the wear of ceramic hip prostheses...
  31. ncbi request reprint Biocompatibility of acellular human pericardium
    Saeed Mirsadraee
    The Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    J Surg Res 143:407-14. 2007
    ..The aim of this study was to assess the biocompatibility and reseeding potential of the acellular human pericardial scaffold...
  32. ncbi request reprint The influence of molecular weight, crosslinking and counterface roughness on TNF-alpha production by macrophages in response to ultra high molecular weight polyethylene particles
    Joanne Helen Ingram
    Department of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Biomaterials 25:3511-22. 2004
    ..This study has demonstrated that molecular weight, crosslinking and counterface roughness are important factors in determining the biological activity of polyethylene...
  33. doi request reprint Development and characterization of an acellular porcine medial meniscus for use in tissue engineering
    Thomas W Stapleton
    Institute of Molecular and Cellular Biology, The University of Leeds, Leeds, United Kingdom
    Tissue Eng Part A 14:505-18. 2008
    ..In conclusion, this study has generated data on the production of a biocompatible, biomechanically functional scaffold for use in meniscal repair...
  34. doi request reprint Hemiarthroplasty of hip joint: An experimental validation using porcine acetabulum
    Sainath Shrikant Pawaskar
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biomech 44:1536-42. 2011
    ..This was lower than that observed in conforming contact problems involving biphasic cartilage and was due to a smaller local contact area and variable clearance making fluid exudation easier...
  35. ncbi request reprint Regional cartilage properties of three quadruped tibiofemoral joints used in musculoskeletal research studies
    Stewart W D McLure
    The School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 226:652-6. 2012
    ..The results highlight the importance of considering the interspecies and regional variation in quadruped tissue properties when selecting animal joints for musculoskeletal investigations...
  36. ncbi request reprint Prediction of oxygen distribution in aortic valve leaflet considering diffusion and convection
    Ling Wang
    Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Heart Valve Dis 20:442-8. 2011
    ..The aims of this study were to investigate the effect of interstitial fluid flow within the aortic valve leaflet, induced by the cyclic loading of the leaflet, on oxygen transport...
  37. ncbi request reprint Characterisation of wear particles produced by metal on metal and ceramic on metal hip prostheses under standard and microseparation simulation
    Christopher Brown
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, Woodhouse Lane, West Yorkshire, UK
    J Mater Sci Mater Med 18:819-27. 2007
    ..The wear particles isolated from all simulations had a mean size of less than 50 nm with a rounded and irregular morphology. No significant difference was found between the size of wear particles generated under any conditions...
  38. pmc Quantification of the effect of cross-shear on the wear of conventional and highly cross-linked UHMWPE
    Lu Kang
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Biomech 41:340-6. 2008
    ..Cross-shear increased the apparent wear factor for both polyethylenes by more than fivefold compared to unidirectional wear...
  39. doi request reprint Contact mechanics and elastohydrodynamic lubrication in a novel metal-on-metal hip implant with an aspherical bearing surface
    Qingen Meng
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, UK
    J Biomech 43:849-57. 2010
    ....
  40. ncbi request reprint Wear and deformation of ceramic-on-polyethylene total hip replacements with joint laxity and swing phase microseparation
    S Williams
    Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    Proc Inst Mech Eng H 217:147-53. 2003
    ..These findings may have significant implications for the choice of fixation systems to be used for different types of bearing couples...
  41. ncbi request reprint Comparison of wear, wear debris and functional biological activity of moderately crosslinked and non-crosslinked polyethylenes in hip prostheses
    M Endo
    Medical and Biological Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 216:111-22. 2002
    ..However, this study did not reveal any advantage in terms of predicted FBA for moderately crosslinked UHMWPE compared with non-crosslinked UHMWPE...
  42. ncbi request reprint A hip joint simulator study using new and physiologically scratched femoral heads with ultra-high molecular weight polyethylene acetabular cups
    P S Barbour
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 214:569-76. 2000
    ..A greater than twofold increase in wear rate is reported for these heads when compared with smooth heads. This increased wear rate is, however, still within the limits of data from clinical wear studies...
  43. doi request reprint Biological effects of cobalt-chromium nanoparticles and ions on dural fibroblasts and dural epithelial cells
    Bharat Behl
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    Biomaterials 34:3547-58. 2013
    ..The data contributes to a greater understanding of the potential biological consequences of the use of metal-on-metal total disc prostheses...
  44. pmc High cup angle and microseparation increase the wear of hip surface replacements
    Ian J Leslie
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, West Yorkshire, LS2 9JT, UK
    Clin Orthop Relat Res 467:2259-65. 2009
    ..The data suggest both head and cup position influence the wear of surface replacements; we believe it likely bearings with high wear either have a high cup inclination angle, an offset deficient head, or a combination of both...
  45. ncbi request reprint Biocompatibility and recellularization potential of an acellular porcine heart valve matrix
    Helen E Wilcox
    Institute of Medical and Biological Engineering, School of Biochemistry and Microbiology, University of Leeds, Leeds, UK
    J Heart Valve Dis 14:228-36; discussion 236-7. 2005
    ..Tissue-engineered heart valves have the potential to overcome the limitations of present heart valve replacements. The study aim was to investigate the biocompatibility and recellularization potential of an acellular porcine valve matrix...
  46. ncbi request reprint Long-term wear of ceramic matrix composite materials for hip prostheses under severe swing phase microseparation
    Todd D Stewart
    School of Mechanical Engineering, The University of Leeds, LS2 9JT, United Kingdom
    J Biomed Mater Res B Appl Biomater 66:567-73. 2003
    ....
  47. doi request reprint Tribology and wear of metal-on-metal hip prostheses: influence of cup angle and head position
    Sophie Williams
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Bone Joint Surg Am 90:111-7. 2008
    ..The aim of this study was to test the hypothesis that both a steep cup angle and a lateralized position of the head can increase head contact on the superior rim of the cup, with the consequence of increased wear...
  48. doi request reprint Factors influencing the oxygen consumption rate of aortic valve interstitial cells: application to tissue engineering
    Ling Wang
    Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom
    Tissue Eng Part C Methods 15:355-63. 2009
    ....
  49. ncbi request reprint Development and characterization of an acellular human pericardial matrix for tissue engineering
    Saeed Mirsadraee
    The Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    Tissue Eng 12:763-73. 2006
    ..In summary, successful decellularization of the human pericardium was achieved producing a biocompatible matrix that retained the major structural components and strength of the native tissue...
  50. doi request reprint Influence of acetabular cup rim design on the contact stress during edge loading in ceramic-on-ceramic hip prostheses
    Mathew Mak
    School of Mechanical Engineering, The University of Leeds, Leeds, United Kingdom
    J Arthroplasty 26:131-6. 2011
    ..Introducing a 2.5-mm radius chamfer should reduce the maximum tensile stress in the region of 60%...
  51. ncbi request reprint A comparison of the wear and physical properties of silane cross-linked polyethylene and ultra-high molecular weight polyethylene
    H Sakoda
    Department of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom
    J Arthroplasty 16:1018-23. 2001
    ..New cross-linked polyethylenes differ considerably from XLPE. This study indicates that it is prudent to examine the wear of new polyethylenes under a range of conditions that may occur in vivo...
  52. ncbi request reprint Biological reactions to wear debris in total joint replacement
    E Ingham
    Department of Microbiology, University of Leeds, UK
    Proc Inst Mech Eng H 214:21-37. 2000
    ..It is concluded that the pre-clinical testing of any new materials for joint replacement must include an analysis of the wear particle characteristics and their biological reactivity in addition to the usual assessment of wear...
  53. ncbi request reprint Comparative wear and wear debris under three different counterface conditions of crosslinked and non-crosslinked ultra high molecular weight polyethylene
    M M Endo
    School of Mechanical Engineering, University of Leeds, UK
    Biomed Mater Eng 11:23-35. 2001
    ..This has important implications for its osteolytic potential...
  54. ncbi request reprint A simple fully integrated contact-coupled wear prediction for ultra-high molecular weight polyethylene hip implants
    L Kang
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 220:33-46. 2006
    ..Furthermore, if the head diameter increases beyond 42 mm, a rapid increase in the contact pressure was predicted, owing to the decrease in the wall thickness of the cross-linked UHMWPE cup...
  55. ncbi request reprint Biphasic surface amorphous layer lubrication of articular cartilage
    Simon Graindorge
    Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    Med Eng Phys 27:836-44. 2005
    ..The increase in lubrication effectiveness is shown to be greatest during short duration loading scenarios, such as shock loads...
  56. doi request reprint Wear of ceramic-on-carbon fiber-reinforced poly-ether ether ketone hip replacements
    Claire L Brockett
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    J Biomed Mater Res B Appl Biomater 100:1459-65. 2012
    ..The mean volumetric wear rate was 0.3 mm(3)/Mc, indicating the ceramic-on-CFR-PEEK bearing to be a very low wearing option for total hip replacement...
  57. ncbi request reprint Wear of moderately cross-linked polyethylene in fixed-bearing total knee replacements
    Claire L Brockett
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 226:529-35. 2012
    ..This study indicates the use of a moderately cross-linked polyethylene in a fixed-bearing total knee replacement may provide a low wearing option for total knee replacement...
  58. pmc The effect of anterior-posterior shear on the wear of CHARITÉ total disc replacement
    Rachel Vicars
    Institute of Medical and Biological Engineering, University of Leeds, UK
    Spine (Phila Pa 1976) 37:E528-34. 2012
    ..An in vitro study of the wear rates of the CHARITÉ lumbar total disc replacement (TDR)...
  59. doi request reprint Enhanced computational prediction of polyethylene wear in hip joints by incorporating cross-shear and contact pressure in additional to load and sliding distance: effect of head diameter
    Lu Kang
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9J7, UK
    J Biomech 42:912-8. 2009
    ..The effect of increasing the femoral head size was subsequently considered and was shown to increase wear, as a result of increased sliding distance and reduced contact pressure...
  60. doi request reprint Robust and general method for determining surface fluid flow boundary conditions in articular cartilage contact mechanics modeling
    Sainath Shrikant Pawaskar
    Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Biomech Eng 132:031001. 2010
    ..It was then extended to include two cartilages in contact. The results were in excellent agreement with the previous studies reported in the literature...
  61. doi request reprint Effect of conformity and contact stress on wear in fixed-bearing total knee prostheses
    Alison L Galvin
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biomech 42:1898-902. 2009
    ..Current designs of fixed-bearing knees do not offer this low wear solution due to their medium cross shear, moderate conformity and medium contact stress...
  62. ncbi request reprint The osteolytic response of macrophages to challenge with particles of Simplex P, Endurance, Palacos R, and Vertebroplastic bone cement particles in vitro
    Joanne H Ingram
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, LS2 9JT, United Kingdom
    J Biomed Mater Res B Appl Biomater 75:210-20. 2005
    ..Hence, compared with the same volumetric concentrations, particles of Palacos R and Endurance were the most, and particles of Vertebroplastic were the least biologically reactive...
  63. doi request reprint Biotribology of articular cartilage--a review of the recent advances
    Jayanth Katta
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK
    Med Eng Phys 30:1349-63. 2008
    ..The importance of developing in vitro models as tools not only to understand the cartilage tribological characteristics, but to evaluate current and future cartilage substitution and treatment therapies is discussed...
  64. ncbi request reprint The pulmonary bioprosthetic heart valve: its unsuitability for use as an aortic valve replacement
    Louise M Jennings
    School of Mechanical Engineering, University of Leeds, UK
    J Heart Valve Dis 11:668-78; discussion 679. 2002
    ..The study aim was to investigate the suitability of the porcine pulmonary bioprosthetic valve for AVR...
  65. ncbi request reprint Metal-on-metal bearings surfaces: materials, manufacture, design, optimization, and alternatives
    G H Isaac
    DePuy International Ltd, Leeds, UK
    Proc Inst Mech Eng H 220:119-33. 2006
    ....
  66. ncbi request reprint A novel method for the prediction of functional biological activity of polyethylene wear debris
    J Fisher
    School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    Proc Inst Mech Eng H 215:127-32. 2001
    ..The application of the model is demonstrated through comparison of the functional biological activity of wear debris from polyethylene acetabular cups articulating under three different conditions in a hip joint simulator...
  67. ncbi request reprint An in vitro study of the reduction in wear of metal-on-metal hip prostheses using surface-engineered femoral heads
    J Fisher
    Medical and Biological Engineering Research Group, School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 216:219-30. 2002
    ..The substantially lower ion concentration released by these surface-engineered components provides important evidence to support the clinical application of this technology...
  68. ncbi request reprint Changes in the contact area during the bedding-in wear of different sizes of metal on metal hip prostheses
    X Q Hu
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, The University of Leeds, Leeds LS2 9JT, UK
    Biomed Mater Eng 14:145-9. 2004
    ..As the radial clearance was reduced, the bedding-in wear volume to reach an optimal contact area also reduced. For a fixed radial clearance, increasing the head diameter also reduced the bedding-in wear volume...
  69. ncbi request reprint The influence of design, materials and kinematics on the in vitro wear of total knee replacements
    H M J McEwen
    School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Biomech 38:357-65. 2005
    ..In knee simulator studies, wear of TKR bearings was dependent on kinematics at the articulating surfaces and the prosthesis design, as well as the type of material...
  70. ncbi request reprint A two-dimensional model of cyclic strain accumulation in ultra-high molecular weight polyethylene knee replacements
    E A Reeves
    School of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 212:189-98. 1998
    ....
  71. ncbi request reprint Comparison of human and animal femoral head chondral properties and geometries
    Simon D Taylor
    Institute of Medical and Biological Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 226:55-62. 2012
    ..Significant differences in geometry and mechanical properties of articular cartilage were found between all species tested. It is necessary to consider these variations when choosing animal tissue to represent human...
  72. doi request reprint Development and characterization of acellular allogeneic arterial matrices
    Stacy Paul Wilshaw
    Faculty of Biological Sciences, Institute of Medical and Biological Engineering, The University of Leeds, Leeds, United Kingdom
    Tissue Eng Part A 18:471-83. 2012
    ..These properties indicate the potential use for acellular human common femoral arteries for vascular bypass or arteriovenous access...
  73. doi request reprint Investigation of the antiadhesive properties of human mesothelial cells cultured in vitro on implantable surgical materials
    Stacy Paul Wilshaw
    Institute of Medical and Biological Engineering, Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom
    J Biomed Mater Res B Appl Biomater 88:49-60. 2009
    ..This in vitro study indicated that Permacol and Surgisis Gold supported the growth and fibrinolytic activity of human mesothelial cells; however, Permacol was shown to be superior in this respect...
  74. doi request reprint Computational wear prediction of artificial knee joints based on a new wear law and formulation
    Abdellatif Abdelgaied
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Biomech 44:1108-16. 2011
    ....
  75. ncbi request reprint Comparative wear under different conditions of surface-engineered metal-on-metal bearings for total hip arthroplasty
    Sophie Williams
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK
    J Arthroplasty 19:112-7. 2004
    ..CrN-on-CrN bearings produced similar nanometer-sized particles to metal-on-metal bearings, however, CrN wear particles were less cytotoxic when cocultured with macrophage and fibroblast cells...
  76. ncbi request reprint Tissue engineering of cardiac valves: re-seeding of acellular porcine aortic valve matrices with human mesenchymal progenitor cells
    Richard L Knight
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    J Heart Valve Dis 14:806-13. 2005
    ..This study investigated the potential for re-seeding an acellular porcine heart valve matrix using human mesenchymal progenitor cells (MPC)...
  77. doi request reprint Regional biomechanical and histological characterisation of the passive porcine urinary bladder: Implications for augmentation and tissue engineering strategies
    Sotirios Korossis
    Institute of Medical and Biological Engineering, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, United Kingdom
    Biomaterials 30:266-75. 2009
    ....
  78. doi request reprint Effect of cup inclination angle during microseparation and rim loading on the wear of BIOLOX® delta ceramic-on-ceramic total hip replacement
    Mazen Al-Hajjar
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom, LS2 9JT
    J Biomed Mater Res B Appl Biomater 95:263-8. 2010
    ..84 mm(3)/million cycles). BIOLOX® delta has shown lower wear than previous ceramic materials used in THR under adverse conditions...
  79. ncbi request reprint A multi-directional in vitro investigation into friction, damage and wear of innovative chondroplasty materials against articular cartilage
    Ewen Northwood
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    Clin Biomech (Bristol, Avon) 22:834-42. 2007
    ..The aim of this study was to investigate potential chondroplasty biomaterials when sliding against natural articular cartilage under uniaxial reciprocating and multi-directional rotation/reciprocating motions...
  80. doi request reprint Cement mantle stress under retroversion torque at heel-strike
    B Afsharpoya
    School of Mechanical Engineering, The University of Leeds, West Yorkshire, UK
    Med Eng Phys 31:1323-30. 2009
    ....
  81. ncbi request reprint Investigation into the tribological condition of acetabular tissue after bipolar joint replacement hip surgery
    J Pickard
    Biomedical Engineering Research Group, School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 214:361-70. 2000
    ..It was therefore predicted that the motion of the bipolar prosthesis should occur at the inner bearing...
  82. ncbi request reprint A novel low wearing differential hardness, ceramic-on-metal hip joint prosthesis
    P J Firkins
    Medical and Biological Engineering (MBE, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    J Biomech 34:1291-8. 2001
    ..The extremely low wearing differential hardness COM bearings presented in this study produced far smaller volumetric particle loads compared to MOM prostheses currently used clinically...
  83. ncbi request reprint Prediction of plastic strains in ultra-high molecular weight polyethylene due to microscopic asperity interactions during sliding wear
    C McNie
    School of Mechanical Engineering, University of Leeds
    Proc Inst Mech Eng H 212:49-56. 1998
    ..The high plastic strains predicted offer an explanation for the highly elevated wear rates in scratched counterface tests and the aspect ratio of scratch lips is therefore a critical determinant of plastic strain...
  84. ncbi request reprint Self-assembling peptides as injectable lubricants for osteoarthritis
    Carol J Bell
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, West Yorkshire, LS2 9JT, United Kingdom
    J Biomed Mater Res A 78:236-46. 2006
    ..The results indicate that de novo self-assembling peptides could be developed as an alternate therapeutic lubricant for early stage OA...
  85. ncbi request reprint Comparison of the biological activity of grade GUR 1120 and GUR 415HP UHMWPE wear debris
    Joanne Ingram
    Department of Microbiology, University of Leeds, Old Medical School, Thoresby Place, Leeds, West Yorkshire, LS2 9NL, UK
    Biomed Mater Eng 12:177-88. 2002
    ....
  86. pmc Investigation of the regenerative capacity of an acellular porcine medial meniscus for tissue engineering applications
    Thomas W Stapleton
    Institute of Molecular and Cellular Biology, The University of Leeds, Leeds, United Kingdom
    Tissue Eng Part A 17:231-42. 2011
    ..In conclusion, acellular porcine meniscal tissue exhibits excellent immunocompatibility and potential for cellular regeneration in the longer term...
  87. ncbi request reprint The use of ultrasonication to aid recellularization of acellular natural tissue scaffolds for use in anterior cruciate ligament reconstruction
    Joanne Helen Ingram
    Faculties of Engineering and Biological Sciences, Institute of Medical and Biological Engineering, University of Leeds, Leeds, West Yorkshire, United Kingdom
    Tissue Eng 13:1561-72. 2007
    ..This study has shown that an acellular biocompatible tendon scaffold can be produced using 0.1% (w/v) SDS and that ultrasonication can provide a novel method to enhance the recellularization of decellularized natural tissues...
  88. ncbi request reprint Wear-simulation analysis of rotating-platform mobile-bearing knees
    John Fisher
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom
    Orthopedics 29:S36-41. 2006
    ..This resulted in a substantially reduced functional biological activity or osteolytic potential for the rotating-platform mobile-bearing knees due to the lower wear rates...
  89. pmc Long-term radiographic assessment of cemented polyethylene acetabular cups
    Sophie Williams
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    Clin Orthop Relat Res 466:366-72. 2008
    ..The effect of progressive oxidation in vivo does not appear to affect wear in vivo...
  90. ncbi request reprint Metal-on-metal bearing wear with different swing phase loads
    Sophie Williams
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, United Kingdom
    J Biomed Mater Res B Appl Biomater 70:233-9. 2004
    ..Additionally elevated positive swing phase loads may also increase wear. Variable swing phase load conditions in vivo may contribute to variations in clinical wear rates...
  91. ncbi request reprint Effects of clinically relevant alumina ceramic wear particles on TNF-alpha production by human peripheral blood mononuclear phagocytes
    A Hatton
    Division of Microbiology, Department of Biochemistry and Molecular Biology, Institute of Medical and Biological Engineering, University of Leeds, LS2 9JT, Leeds, UK
    Biomaterials 24:1193-204. 2003
    ....
  92. ncbi request reprint Influence of simulator kinematics on the wear of metal-on-metal hip prostheses
    P J Firkins
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 215:119-21. 2001
    ..The motion and kinematic conditions in the contact are critical determinants of wear in metal-on-metal bearings...
  93. ncbi request reprint A hip joint simulator study using simplified loading and motion cycles generating physiological wear paths and rates
    P S Barbour
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 213:455-67. 1999
    ..The in vitro wear rates were found to be highly dependent on the shape of these paths and similarities could be drawn between the shape of the physiological paths and the simplified elliptical paths...
  94. ncbi request reprint The influence of continuous sliding and subsequent surface wear on the friction of articular cartilage
    H Forster
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 213:329-45. 1999
    ..Although laser profilometry did reveal surface wear which was consistent with a small increase in friction, the primary variable controlling the friction coefficient was the period of loading...
  95. ncbi request reprint Quantitative analysis of UHMWPE wear debris isolated from the periprosthetic femoral tissues from a series of Charnley total hip arthroplasties
    J Bell
    Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK
    Biomed Mater Eng 12:189-201. 2002
    ....
  96. ncbi request reprint Quantification of third body damage to the tibial counterface in mobile bearing knees
    V C Jones
    School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    Proc Inst Mech Eng H 215:171-9. 2001
    ..It may be possible in future knee designs to reduce this type of wear damage by introducing alternative materials or coatings which are more resistant to scratching and surface roughening...
  97. ncbi request reprint Quantitative analysis of wear and wear debris from metal-on-metal hip prostheses tested in a physiological hip joint simulator
    P J Firkins
    Medical and Biological Engineering (MBE) Research Group, School of Mechanical Engineering, University of Leeds, UK
    Biomed Mater Eng 11:143-57. 2001
    ..However, particle size and morphology was not affected by method of particle characterisation, the carbon content of the alloy or material combination...
  98. doi request reprint Fluid load support and contact mechanics of hemiarthroplasty in the natural hip joint
    Sainath Shrikant Pawaskar
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK
    Med Eng Phys 33:96-105. 2011
    ..Lower fluid load support was found when the contact area was nearer the edges where the fluid drained easily...
  99. doi request reprint Tissue engineering small-diameter vascular grafts: preparation of a biocompatible porcine ureteric scaffold
    Chris Derham
    Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK
    Tissue Eng Part A 14:1871-82. 2008
    ..This study has demonstrated the potential of acellular porcine ureteric scaffolds in tissue engineering small-diameter living vascular grafts...
  100. ncbi request reprint Review: tissue engineering of the urinary bladder: considering structure-function relationships and the role of mechanotransduction
    Sotiris Korossis
    Biomedical Engineering Research Centre, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom
    Tissue Eng 12:635-44. 2006
    ....
  101. doi request reprint Chondroitin sulphate: an effective joint lubricant?
    J Katta
    Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK
    Osteoarthritis Cartilage 17:1001-8. 2009
    ..The effect of chondroitin sulphate (CS) treatment on the friction and deformation characteristics of native and glycosaminoglycan (GAG) deficient articular cartilage was investigated...