Michael J Firbank

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Validation of automated white matter hyperintensity segmentation
    Sean D Smart
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    J Aging Res 2011:391783. 2011
  2. pmc Neuroimaging predictors of death and dementia in a cohort of older stroke survivors
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 83:263-7. 2012
  3. ncbi request reprint Partial volume effects in MRI studies of multiple sclerosis
    M J Firbank
    University Department of Radiology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Magn Reson Imaging 17:593-601. 1999
  4. pmc Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year
    M J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 76:1448-51. 2005
  5. ncbi request reprint Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle, Wolfson Research Centre, Newcastle upon Tyne NE4 6BE, UK
    Neurobiol Aging 28:1664-9. 2007
  6. ncbi request reprint High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with Lewy bodies
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle, UK
    J Alzheimers Dis 21:1129-40. 2010
  7. doi request reprint Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 22:804-11. 2010
  8. ncbi request reprint Validation of a fully automated hippocampal segmentation method on patients with dementia
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
    Hum Brain Mapp 29:1442-9. 2008
  9. ncbi request reprint Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Neuroimage 36:1-7. 2007
  10. pmc Cerebral blood flow by arterial spin labeling in poststroke dementia
    M J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neurology 76:1478-84. 2011

Detail Information

Publications60

  1. pmc Validation of automated white matter hyperintensity segmentation
    Sean D Smart
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    J Aging Res 2011:391783. 2011
    ..Discussion. Using our previously reported software, we demonstrated good segmentation of WMHs in a fully automated fashion...
  2. pmc Neuroimaging predictors of death and dementia in a cohort of older stroke survivors
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 83:263-7. 2012
    ..Stroke is a risk factor for subsequent death and dementia. Being able to identify subjects at particular risk would be beneficial to inform treatment and patient management...
  3. ncbi request reprint Partial volume effects in MRI studies of multiple sclerosis
    M J Firbank
    University Department of Radiology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Magn Reson Imaging 17:593-601. 1999
    ..We would recommend the use of a 3D sequence with 1 mm cubic voxels for accurate measurements of MS lesions...
  4. pmc Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year
    M J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 76:1448-51. 2005
    ..Brain perfusion deficits have been reported previously in subjects with Parkinson's disease in comparison with healthy controls...
  5. ncbi request reprint Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle, Wolfson Research Centre, Newcastle upon Tyne NE4 6BE, UK
    Neurobiol Aging 28:1664-9. 2007
    ..The association of MTA but not WMH with subsequent cognitive decline and increasing brain atrophy suggests a greater role for Alzheimer type than vascular pathology in delayed cognitive impairment after stroke...
  6. ncbi request reprint High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with Lewy bodies
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle, UK
    J Alzheimers Dis 21:1129-40. 2010
    ..Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB...
  7. doi request reprint Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 22:804-11. 2010
    ..Plasma homocysteine has been associated with reduced brain volumes in cross-sectional studies. We aimed to investigate if homocysteine is associated with ongoing atrophy, and if so, if this is localized to gray or white matter...
  8. ncbi request reprint Validation of a fully automated hippocampal segmentation method on patients with dementia
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
    Hum Brain Mapp 29:1442-9. 2008
    ..Linear regression between manual and automated volume gave V(auto) = V(manual) x 0.83 + 401 ml. The method provides an acceptable automated alternative to manual segmentation which may be of value in large studies...
  9. ncbi request reprint Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Neuroimage 36:1-7. 2007
    ..Future studies are needed to determine whether the disruption precedes or is consequent on atrophy or hypometabolism...
  10. pmc Cerebral blood flow by arterial spin labeling in poststroke dementia
    M J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neurology 76:1478-84. 2011
    ..To investigate the relationship between cerebral blood flow and dementia in older stroke survivors and subjects with Alzheimer disease (AD)...
  11. doi request reprint Diffusion tensor imaging in Alzheimer's disease and dementia with Lewy bodies
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Psychiatry Res 194:176-83. 2011
    ....
  12. ncbi request reprint A volumetric study of MRI signal hyperintensities in late-life depression
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK NE4 6BE
    Am J Geriatr Psychiatry 12:606-12. 2004
    ..The authors investigated whether the regional location varied between depressed and normal subjects and determined the relationship of magnetic resonance (MR) signal hyperintensities to known clinical risk factors for vascular disease...
  13. ncbi request reprint Longitudinal study of cerebral blood flow SPECT in Parkinson's disease with dementia, and dementia with Lewy bodies
    Michael J Firbank
    The Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:776-82. 2005
    ..Whilst perfusion studies have shown parieto-occipital hypoperfusion in DLB and PDD relative to controls, there have not been any longitudinal studies of perfusion changes in PDD and DLB...
  14. ncbi request reprint Regional cerebral blood flow in Parkinson's disease with and without dementia
    M J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Neuroimage 20:1309-19. 2003
    ..The perfusion deficits in PDD are similar those in DLB, and in a location associated with visual processing, and may be associated with the visuospatial perception deficits which are present in persons with DLB and PDD...
  15. ncbi request reprint Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects
    M J Firbank
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 61:950-4. 2003
    ..To assess normal-appearing white matter (NAWM) characteristics by magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) in elderly subjects...
  16. ncbi request reprint A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease
    M J Firbank
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 14:64-76. 2002
    ..This may aid in the diagnosis of PSP. Further research is needed to determine spectroscopic changes in other dementias, to monitor how markers change with disease progression and to establish clinical utility...
  17. ncbi request reprint Measuring extraocular muscle volume using dynamic contours
    M J Firbank
    University Department of Radiology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, England, UK
    Magn Reson Imaging 19:257-65. 2001
    ..The manual technique took an experienced operator approximately 20 min to perform, compared to 7 min for the automated technique. The automated method is therefore rapid, reproducible and at least as accurate as other available methods...
  18. ncbi request reprint Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Westgate Road, Newcastle upon Tyne, UK
    Psychiatry Res 155:135-45. 2007
    ..We conclude that there are subtle changes visible with diffusion imaging in DLB and AD which may reflect disrupted connectivity and underlie observed perfusion changes in these disorders...
  19. doi request reprint Plasma homocysteine and cognitive decline in older hypertensive subjects
    Sunil K Narayan
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 23:1607-15. 2011
    ..We examined the relationship between plasma homocysteine and cognitive decline in an older hypertensive population...
  20. doi request reprint Longitudinal testing of visual perception in dementia with Lewy bodies and Alzheimer's disease
    Joshua S Wood
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Campus for Ageing and Vitality, Newcastle University, Newcastle, UK
    Int J Geriatr Psychiatry 28:567-72. 2013
    ..We studied the progression of visuo-perceptual abnormalities over a 12-month period in DLB and AD by using a novel computerised test battery...
  21. ncbi request reprint Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging
    Emma J Burton
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:842-9. 2006
    ..The objective of this study was to investigate cross-sectional and longitudinal white matter hyperintensity (WMH) changes in older subjects with clinically diagnosed dementia...
  22. ncbi request reprint A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 20:1124-40. 2008
    ....
  23. doi request reprint Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 199:404-10. 2011
    ..There is strong evidence linking vascular disease to WMH, but limited evidence on its association with subcortical volumes...
  24. doi request reprint Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?
    James O'Donovan
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Int Psychogeriatr 25:111-9. 2013
    ..Therefore, we assessed whether visual rating scales for assessing posterior atrophy (PA), medial temporal lobe atrophy (MTA), and ventricular enlargement (VEn) aid in the discrimination between AD, DLB, and normal aging...
  25. doi request reprint Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Br J Psychiatry 201:40-5. 2012
    ..Brain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear...
  26. doi request reprint Covariance 99mTc-exametazime SPECT patterns in Alzheimer's disease and dementia with Lewy bodies: utility in differential diagnosis
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    J Geriatr Psychiatry Neurol 23:54-62. 2010
    ..Principal component analysis captures additional sources of variance and if perfusion SPECT is the only scan available, this procedure may offer extra information...
  27. ncbi request reprint White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:834-41. 2006
    ..This study investigates the relationship between location and burden of WMH and lacunes on depressive features in older people...
  28. ncbi request reprint Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT
    Sanjeet Pakrasi
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol 254:907-13. 2007
    ..One of the most characteristic changes in Alzheimer's disease (AD) is a deficit in cortical cholinergic neurotransmission and associated receptor changes...
  29. ncbi request reprint Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure. Brain atrophy, WMH change and blood pressure
    Michael J Firbank
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol 254:713-21. 2007
    ..These changes are independent. Successful hypertension treatment was associated with reduced risk of WMH progression and possibly brain atrophy...
  30. doi request reprint Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease
    Eva R Kenny
    Newcastle Magnetic Resonance Centre and Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 203:209-14. 2013
    ....
  31. ncbi request reprint Cortical thickness and VBM-DARTEL in late-life depression
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Affect Disord 133:158-64. 2011
    ..The objective was to investigate GM changes in older depressed and similar aged healthy subjects using two different methods, cortical thickness in frontal lobe structures and voxel-based morphometry (VBM)...
  32. ncbi request reprint Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study
    Mani S Krishnan
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 21:983-9. 2006
    ..However, it remains controversial as to whether PVL, DWML, or both are most strongly associated with depression and this was the aim of the current study...
  33. doi request reprint Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertension
    Sunil K Narayan
    Institute for Ageing and Health, Newcastle University, UK
    Dement Geriatr Cogn Disord 31:341-8. 2011
    ..01, p = 0.29). New SBIs were uncommon. In older hypertensive individuals, plasma homocysteine levels are associated with increased rates of whole-brain atrophy but not WML progression...
  34. ncbi request reprint Post-stroke dementia: the contribution of thalamus and basal ganglia changes
    Marcos Antônio Lopes
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 24:568-76. 2012
    ..This study aimed to investigate the contribution of changes in subcortical gray matter structures to post-stroke dementia (PSD)...
  35. doi request reprint Intensive blood pressure lowering increases cerebral blood flow in older subjects with hypertension
    Dinesh Tryambake
    Institute for Ageing and Health, Newcastle University, Stroke Research Group, Level 6, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Hypertension 61:1309-15. 2013
    ..These findings suggest hypertension in older people shifts the autoregulatory CBF curve rightward and downward and is reversible with BP lowering...
  36. pmc Multivariate spatial covariance analysis of 99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer's disease: utility in differential diagnosis
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    J Cereb Blood Flow Metab 33:612-8. 2013
    ..86, sensitivity 80%, specificity 80%). Multivariate analysis of blood flow SPECT data appears to be robust and shows good diagnostic accuracy in two independent cohorts for distinguishing DLB from AD...
  37. doi request reprint Relationship between cognition, magnetic resonance white matter hyperintensities, and cardiovascular autonomic changes in late-life depression
    Akshya Vasudev
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 20:691-9. 2012
    ..To explore the relationship between specific aspects of cognition, white matter hyperintensities (WMHs), and cardiovascular autonomic parameters in late-life depression (LLD)...
  38. pmc Visual cortex in dementia with Lewy bodies: magnetic resonance imaging study
    John Paul Taylor
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, UK
    Br J Psychiatry 200:491-8. 2012
    ..Visual hallucinations and visuoperceptual deficits are common in dementia with Lewy bodies, suggesting that cortical visual function may be abnormal...
  39. doi request reprint Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study
    Sean J Colloby
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Br J Psychiatry 200:150-5. 2012
    ..A limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies...
  40. doi request reprint White matter changes in late-life depression: a diffusion tensor imaging study
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Affect Disord 135:216-20. 2011
    ..The objective was to investigate the integrity of white matter tracts in subjects with LLD compared to similar aged healthy individuals using diffusion tensor imaging (DTI)...
  41. ncbi request reprint The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 23:956-66. 2004
    ....
  42. ncbi request reprint In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 33:423-9. 2006
    ..123I-QNB binding was also compared to the corresponding cerebral perfusion changes in the same subjects...
  43. ncbi request reprint Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Psychiatry Res 139:79-88. 2005
    ..We have identified important neural correlates of key clinical features in Lewy body dementia and postulate that the associations can be understood through the influence of the cholinergic system on attention...
  44. pmc Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer's disease
    Eva R Kenny
    Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Brain 135:569-81. 2012
    ..This implicates areas beyond visual sensory input level in the visual symptoms and visual-perceptual dysfunction seen in dementia with Lewy bodies...
  45. pmc Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors
    Louise M Allan
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    Brain 134:3716-27. 2011
    ..Careful monitoring and treatment of modifiable vascular risk factors may be of benefit in preventing post-stroke dementia in the general population...
  46. doi request reprint Magnetic resonance imaging: a biomarker for cognitive impairment in Parkinson's disease?
    Gordon W Duncan
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    Mov Disord 28:425-38. 2013
    ..Future work should adopt agreed scan protocols, should be adequately powered, and should use carefully phenotyped patients to fully maximize the contribution of MRI as a biomarker for PDD...
  47. doi request reprint Testing visual perception in dementia with Lewy bodies and Alzheimer disease
    Joshua S Wood
    Institute for Cellular Medicine, Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle, United Kingdom Electronic address
    Am J Geriatr Psychiatry 21:501-8. 2013
    ..We aimed to test its utility to identify visuoperceptual deficits in people with dementia...
  48. ncbi request reprint High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with lewy bodies
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle, UK
    J Alzheimers Dis 21:1129-40. 2010
    ..Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB...
  49. doi request reprint Development of a novel FMRI compatible visual perception prototype battery to test older people with and without dementia
    Joshua S Wood
    Institute for Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    J Geriatr Psychiatry Neurol 24:73-83. 2011
    ..We aimed to develop, pilot, and test a novel visuocognitive prototype test battery which addressed these issues, suitable for both clinical and functional imaging use...
  50. ncbi request reprint Functional connectivity in late-life depression using resting-state functional magnetic resonance imaging
    Eva R Kenny
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 18:643-51. 2010
    ..To investigate whether there are differences in brain connectivity in late-life depression (LLD) and nondepressed subjects using the left and right heads of caudate nuclei (hCN) as the seed regions...
  51. pmc The assessment of cognition in visually impaired older adults
    Alison Killen
    Newcastle University Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom
    Age Ageing 42:98-102. 2013
    ..visual and cognitive impairments are common in later life. Yet there are very few cognitive screening tests for the visually impaired...
  52. doi request reprint Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study
    A Teodorczuk
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Psychol Med 40:603-10. 2010
    ..We investigated whether baseline severity of cerebral white-matter changes predict longer-term future depressive outcomes in a community sample of non-disabled older adults...
  53. ncbi request reprint White matter changes and late-life depressive symptoms: longitudinal study
    A Teodorczuk
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Br J Psychiatry 191:212-7. 2007
    ..Evidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear...
  54. doi request reprint Alterations in nicotinic α4β2 receptor binding in vascular dementia using ¹²³I-5IA-85380 SPECT: comparison with regional cerebral blood flow
    S J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Neurobiol Aging 32:293-301. 2011
    ..I-5IA-85380 binding was compared to corresponding regional cerebral blood flow (rCBF) changes in the same subjects...
  55. pmc Extraocular muscle atrophy and central nervous system involvement in chronic progressive external ophthalmoplegia
    Cynthia Yu-Wai-Man
    Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e75048. 2013
    ..The aim of this magnetic resonance imaging (MRI) study was to investigate whether the ophthalmoplegia in CPEO is primarily myopathic in origin or whether there is evidence of contributory supranuclear pathway dysfunction...
  56. ncbi request reprint Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks
    Eva R Lowther
    Institute for Ageing and Health and Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom
    Psychiatry Res 223:192-201. 2014
    ....
  57. ncbi request reprint White matter hyperintensities and depression--preliminary results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:674-9. 2005
    ..White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood...
  58. pmc Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study
    Louise Hayes
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Public Health 10:723. 2010
    ..The aim of this study was to determine to what extent differences in metabolic health in very obese women are explained by differences in body fat distribution, insulin resistance and level of physical activity...
  59. pmc Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content
    Balasubramanian Ravikumar
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U K
    Diabetes 57:2288-95. 2008
    ..We studied the effect of pioglitazone on hepatic triglyceride content and the consequent effect on postprandial endogenous glucose production (EGP) in type 2 diabetes...
  60. ncbi request reprint Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production
    Peter E Carey
    Dept of Medicine, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Am J Physiol Endocrinol Metab 289:E941-7. 2005
    ..Acute pharmacological sequestration of fatty acids in triglyceride stores improves postprandial glucose homeostasis without effect on the immediate postprandial suppression of EGP...