Francis M Finucane

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285 Hills Road, Cambridge CB20QQ, UK Galway Diabetes Research Centre, School of Medicine, Clinical Science Institute, NUI Galway, Galway, Ireland
    Int J Endocrinol 2013:870487. 2013
  2. doi request reprint Adverse metabolic profiles in a cohort of obese Irish children
    F M Finucane
    Metabolic Research Unit, Hospital 5, St James s Hospital, Dublin 8, Ireland
    Ann Clin Biochem 45:206-9. 2008
  3. doi request reprint The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 53:624-31. 2010
  4. doi request reprint Obesity in Irish youth: epidemiology and implications
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB20QQ, UK
    Ir J Med Sci 178:249-55. 2009
  5. pmc Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Endocr Disord 9:15. 2009
  6. doi request reprint Glucose metabolism after normalization of markers of iron overload by venesection in subjects with hereditary hemochromatosis
    Mensud Hatunic
    Metabolic Research Unit, St James s Hospital, Trinity College, Dublin, Ireland
    Metabolism 59:1811-5. 2010
  7. doi request reprint Ultrasound measurements of visceral and subcutaneous abdominal thickness to predict abdominal adiposity among older men and women
    Ema De Lucia Rolfe
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Obesity (Silver Spring) 18:625-31. 2010
  8. ncbi request reprint Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training
    N Burns
    Metabolic Research Unit, Department of Endocrinology, Hospital 5, St James Hospital, Trinity College Dublin, Dublin 8, Ireland
    Diabetologia 50:1500-8. 2007
  9. doi request reprint Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis
    Mensud Hatunic
    Metabolic Research Unit, St James s Hospital, Trinity College, Dublin, Ireland
    Metabolism 59:380-4. 2010
  10. ncbi request reprint Obesity is associated with altered lung function independently of physical activity and fitness
    Rebekah M Steele
    Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Obesity (Silver Spring) 17:578-84. 2009

Detail Information

Publications19

  1. pmc Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285 Hills Road, Cambridge CB20QQ, UK Galway Diabetes Research Centre, School of Medicine, Clinical Science Institute, NUI Galway, Galway, Ireland
    Int J Endocrinol 2013:870487. 2013
    ..24 after adjustment). Conclusions. Impaired postprandial NEFA suppression, but not fasting NEFA, contributes to the strong and well-established association between whole body insulin resistance and liver fat accumulation...
  2. doi request reprint Adverse metabolic profiles in a cohort of obese Irish children
    F M Finucane
    Metabolic Research Unit, Hospital 5, St James s Hospital, Dublin 8, Ireland
    Ann Clin Biochem 45:206-9. 2008
    ..We prospectively examined the relationship between the degree of obesity and glucose metabolism, insulin sensitivity and suspected non-alcoholic steatohepatosis (NASH) in a pilot study of obese Irish children...
  3. doi request reprint The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 53:624-31. 2010
    ..We sought to determine the effect of an aerobic exercise intervention on clustered metabolic risk and related outcomes in healthy older adults in a single-centre, explanatory randomised controlled trial...
  4. doi request reprint Obesity in Irish youth: epidemiology and implications
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB20QQ, UK
    Ir J Med Sci 178:249-55. 2009
    ..Recent studies have described the clinical and metabolic characteristics of these children. A solution to the obesity crisis will need to be co-ordinated, multi-faceted and well resource...
  5. pmc Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
    Francis M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Endocr Disord 9:15. 2009
    ..TRIAL REGISTRATION: Current Controlled Trials: ISRCTN60986572...
  6. doi request reprint Glucose metabolism after normalization of markers of iron overload by venesection in subjects with hereditary hemochromatosis
    Mensud Hatunic
    Metabolic Research Unit, St James s Hospital, Trinity College, Dublin, Ireland
    Metabolism 59:1811-5. 2010
    ..Most patients with AGM had an improvement in glucose tolerance status, probably due to the augmented action of insulin in peripheral tissues...
  7. doi request reprint Ultrasound measurements of visceral and subcutaneous abdominal thickness to predict abdominal adiposity among older men and women
    Ema De Lucia Rolfe
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Obesity (Silver Spring) 18:625-31. 2010
    ..In conclusion, ultrasound is a valid method to estimate visceral fat in epidemiological studies of older men and women when MRI and computed tomography are not feasible...
  8. ncbi request reprint Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training
    N Burns
    Metabolic Research Unit, Department of Endocrinology, Hospital 5, St James Hospital, Trinity College Dublin, Dublin 8, Ireland
    Diabetologia 50:1500-8. 2007
    ..We hypothesised that exercise alone, with stable diet, should improve insulin sensitivity...
  9. doi request reprint Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis
    Mensud Hatunic
    Metabolic Research Unit, St James s Hospital, Trinity College, Dublin, Ireland
    Metabolism 59:380-4. 2010
    ..Our cohort of patients with hemochromatosis and AGT had features similar to typical type 2 DM patients. These findings challenge the traditional view that DM in hemochromatosis is due primarily to iron-induced beta-cell failure...
  10. ncbi request reprint Obesity is associated with altered lung function independently of physical activity and fitness
    Rebekah M Steele
    Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Obesity (Silver Spring) 17:578-84. 2009
    ..These associations were independent of the degree of physical activity and aerobic fitness in this cohort...
  11. doi request reprint Elevated blood pressure in overweight and obese Irish children
    F M Finucane
    Metabolic Research Unit, Hospital 5, St James s Hospital, Dublin 8, Ireland
    Ir J Med Sci 177:379-81. 2008
    ..The Irish childhood obesity epidemic, one of the highest ranking internationally, represents a major threat to public health. We sought to perform a retrospective observational study of a clinic based cohort of obese Irish children...
  12. pmc Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes
    Isabel Huang-Doran
    Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge Metabolic Research Laboratories, Cambridge, UK
    Diabetes 60:925-35. 2011
    ..We thus set out to determine the prevalence of diabetes and insulin resistance among patients with PCNT defects and examined the effects of pericentrin depletion on insulin action using 3T3-L1 adipocytes as a model system...
  13. pmc Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    Tuomas O Kilpeläinen
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Nat Genet 43:753-60. 2011
    ..Our findings provide new insights into adiposity and insulin resistance...
  14. pmc Validation of the historical adulthood physical activity questionnaire (HAPAQ) against objective measurements of physical activity
    Herve Besson
    Medical Research Council Epidemiology Unit, IMS, Cambridge, UK
    Int J Behav Nutr Phys Act 7:54. 2010
    ..abstract:..
  15. pmc Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals
    F M Finucane
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:2345-9. 2009
    ..We sought to assess the usefulness of the LAR as a measure of insulin resistance in non-diabetic white adults...
  16. doi request reprint Differences in the structure of outpatient diabetes care between endocrinologist-led and general physician-led services
    Máire O'Donnell
    Clinical Science Institute, Galway Diabetes Research Centre and HRB Clinical Research Facility, School of Medicine, National University Ireland, University Road, Galway, Ireland
    BMC Health Serv Res 13:493. 2013
    ..The aim of this study was to ascertain the structure of outpatient diabetes care in public hospitals in the Republic of Ireland and whether differences existed in services provided across hospitals...
  17. doi request reprint Altered respiratory function is associated with increased metabolic risk, independently of adiposity, fitness and physical activity
    R M Steele
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabet Med 26:362-9. 2009
    ....
  18. doi request reprint Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites
    P W Franks
    Genetic Epidemiology and Clinical Research Group, Dept of Public Health and Clinical Medicine, Division of Medicine, Umea University Hospital, Umeå 90 187, Sweden
    FASEB J 22:3135-45. 2008
    ..We demonstrate that PINK1 polymorphisms are associated with PINK1 transcript levels and measures of fatty acid metabolism in a concordant manner, whereas our RNAi data imply that PINK1 may indirectly influence lipid metabolism...