A D Filer
Affiliation: University of Birmingham
- Infliximab leads to a rapid but transient improvement in endothelial function in patients with primary systemic vasculitisK Raza
Rheumatology Research Group, Division of Immunity and Infection, The Medical School, The University of Birmingham, and Department of Rheumatology, City Hospital, UK
Ann Rheum Dis 65:946-8. 2006..To assess the immediate effects of tumour necrosis factor alpha (TNFalpha) blockade on endothelial function in systemic vasculitis...
- Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritisRowan Hardy
Arthritis Res Ther 14:R226. 2012..Consequently, the links between synovial inflammation, altered Wnt signalling and bone remodelling are not direct but are dependent on local activation of endogenous glucocorticoids...
- The fibroblast as a therapeutic target in rheumatoid arthritisAndrew Filer
MRC Centre for Immune Regulation, School of Immunity and Infection, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Curr Opin Pharmacol 13:413-9. 2013....
- Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse eventsParesh Jobanputra
Department of Rheumatology, Selly Oak Hospital, University Hospital Birmingham NHS Foundation Trust, Raddlebarn Road, Birmingham, B29 6JD, UK
BMC Musculoskelet Disord 9:48. 2008..We report an investigation from a local surveillance for serious adverse drug reactions associated with disease modifying anti-rheumatic drugs that was triggered by the occurrence of liver failure in two of our patients...
- The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritisMohammed Z Cader
MRC Centre for Immune Regulation, School of Immunity and Infection, The University of Birmingham, Birmingham, UK
BMC Musculoskelet Disord 11:187. 2010..The aim of this study was to establish whether the clinical phenotypes of anti-CCP positive and negative disease are distinct at the earliest clinically apparent phase of disease...
- Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiationCaroline Schmutz
Leopold Muller Arthritis Research Centre, Keele University, Oswestry, Shropshire, SY10 7AG, UK
Arthritis Res Ther 12:R161. 2010..This study investigated the expression and function of chemokine receptor CCR9 in the peripheral blood (PB) and synovium of RA, non-RA patients and healthy volunteers...
- Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammationRowan S Hardy
Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham Medical School, Birmingham, UK
Arthritis Res Ther 8:R108. 2006....
- Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalphaGreg Parsonage
Rheumatology Research Group, MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
Arthritis Res Ther 10:R47. 2008..We therefore tested the hypothesis that synovial fibroblasts bridge the biological responses that connect TH17 cells to neutrophils by producing neutrophil survival factors following their activation with IL-17...
- Takayasu arteritis and atherosclerosis: illustrating the consequences of endothelial damageA Filer
Department of Rheumatology, University of Birmingham, UK
J Rheumatol 28:2752-3. 2001..Postmortem findings presented a picture of chronic atherosclerotic disease but in a distribution consistent with lesions of Takayasu arteritis...
- Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitisAndrew Filer
Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, Institute for Biomedical Research, The University of Birmingham, Birmingham B15 2TT, UK
Ann Rheum Dis 70:500-7. 2011..This study evaluated musculoskeletal ultrasound, a sensitive tool for the detection of synovitis and erosions, as a predictor of outcome in very early synovitis...
- Diffuse endothelial dysfunction is common to ANCA associated systemic vasculitis and polyarteritis nodosaA D Filer
Department of Rheumatology, University of Birmingham, UK
Ann Rheum Dis 62:162-7. 2003..It has previously been shown that such endothelial cell dysfunction (ECD) occurring in the brachial artery can complicate primary systemic necrotising vasculitis (SNV)...
- Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathwaysAndrew Filer
University of Birmingham, Division of Immunity and Infection, Birmingham, UK
Arthritis Rheum 60:1604-14. 2009..This study was undertaken to investigate the hypothesis that galectin 3 induces proinflammatory effects in RA by modulating the pattern of cytokine and chemokine production in synovial fibroblasts...
- Defining a role for fibroblasts in the persistence of chronic inflammatory joint diseaseC D Buckley
Department of Rheumatology, Division of Immunity and Infection, University of Birmingham, Birmingham, B15 2TT, UK
Ann Rheum Dis 63:ii92-ii95. 2004....
- Suppression of inflammation in primary systemic vasculitis restores vascular endothelial function: lessons for atherosclerotic disease?K Raza
Department of Rheumatology, University of Birmingham, Birmingham, UK
Circulation 102:1470-2. 2000..Our hypothesis that vasculitis results in arteriosclerosis by causing vascular endothelial dysfunction was tested in patients with primary systemic necrotizing vasculitis (SNV)...
- Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitmentH M McGettrick
Department of Physiology, The Medical School, The University of Birmingham, Birmingham B15 2TT, U K
Biochem Soc Trans 35:1161-2. 2007..Here, we describe a novel co-culture filter-based flow assay and highlight the ability of synovial fibroblasts obtained from chronically inflamed tissue to promote leucocyte recruitment to otherwise 'resting' endothelial cells...
- Fibroblasts as novel therapeutic targets in chronic inflammationS J Flavell
Rheumatology Research Group, Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
Br J Pharmacol 153:S241-6. 2008..Therapeutic manipulation of fibroblasts and their biologically active products is an emerging concept in treating cancer and is likely to provide a novel method to achieve improved control of chronic inflammatory disease...
- Local and systemic glucocorticoid metabolism in inflammatory arthritisR Hardy
Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
Ann Rheum Dis 67:1204-10. 2008..Isolated, primary synovial fibroblasts generate active glucocorticoids through expression of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). This enzyme produces cortisol from inactive cortisone (and prednisolone from prednisone)...