Mark C Field
Affiliation: University of Cambridge
Field M, Dacks J. First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexes. Curr Opin Cell Biol. 2009;21:4-13 pubmed publisher
..These studies, plus the realization of a role for the ESCRT complex as an alternate, but equally ancient, system for membrane deformation are providing insight into the earliest stages of endomembrane evolution. ..
Field M, O Reilly A. How complex is GTPase signaling in trypanosomes?. Trends Parasitol. 2008;24:253-7 pubmed publisher
..Here, we ask how complex are these small GTPase signaling pathways in trypanosomes? We seek to address this issue by comparisons with the representation of both the GTPase molecules and their accessory factors in several genomes. ..
Field M. Drug screening by crossing membranes: a novel approach to identification of trypanocides. Biochem J. 2009;419:e1-3 pubmed publisher
..These observations may present interesting new leads in the fight against trypanosomiasis, and potentially identify a new target that can be explored for therapeutic potential. ..
Field M, Sergeenko T, Wang Y, BÃ¶hm S, Carrington M. Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein. PLoS ONE. 2010;5:e8468 pubmed publisher
..Finally as much of the core ERQC system is functionally conserved in trypanosomes, the pathway has an ancient evolutionary origin, and was present in the last common eukaryotic ancestor. ..
Natesan S, Peacock L, Leung K, Gibson W, Field M. Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomes. BMC Res Notes. 2010;3:63 pubmed publisher
..Hence an important aspect of endocytic modulation in the nutrient-poor tsetse midgut is likely energetic conservation. ..
Lumb J, Field M. Rab23 is a flagellar protein in Trypanosoma brucei. BMC Res Notes. 2011;4:190 pubmed publisher
..The location of Rab23 at the flagellum is conserved between mammals and trypanosomes and the Rab23 gene is restricted to flagellated organisms. These data may suggest the presence of a Rab23-mediated signaling mechanism in trypanosomes. ..
Field M, Carrington M. The trypanosome flagellar pocket. Nat Rev Microbiol. 2009;7:775-86 pubmed publisher
..In this Review we discuss the contribution of the flagellar pocket to protein trafficking, immune evasion and other processes. ..
Koumandou V, Dacks J, Coulson R, Field M. Control systems for membrane fusion in the ancestral eukaryote; evolution of tethering complexes and SM proteins. BMC Evol Biol. 2007;7:29 pubmed
..However, the independent origin of the tethering complexes suggests a novel pattern for increasing complexity in the membrane trafficking system, in addition to the pattern of paralogous machinery elaboration seen thus far. ..
Field M, Natesan S, Gabernet Castello C, Koumandou V. Intracellular trafficking in the trypanosomatids. Traffic. 2007;8:629-39 pubmed