J K Field

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. pmc Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives
    A Cassidy
    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK
    Br J Cancer 95:1288-90. 2006
  2. doi request reprint The UK Lung Screen (UKLS): demographic profile of first 88,897 approaches provides recommendations for population screening
    Fiona E McRonald
    Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Roy Castle Building, 200 London Road, Liverpool L3 9TA, United Kingdom
    Cancer Prev Res (Phila) 7:362-71. 2014
  3. ncbi request reprint CT screening for lung cancer: countdown to implementation
    John K Field
    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool, UK Electronic address
    Lancet Oncol 14:e591-600. 2013
  4. pmc DNA methylation epigenotypes in breast cancer molecular subtypes
    Naiara G Bediaga
    BIOMICs Research Group, Centro de Investigación y Estudios Avanzados Lucio Lascaray, University of the Basque Country UPV EHU, Vitoria Gazteiz, Spain
    Breast Cancer Res 12:R77. 2010
  5. doi request reprint Prospects for population screening and diagnosis of lung cancer
    John K Field
    Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool Cancer Research Centre, Liverpool, UK
    Lancet 382:732-41. 2013
  6. pmc SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates
    Bernd Schmidt
    Universitätsklinik und Poliklinik für Innere Medizin I, Universitätsklinikum Halle Saale, Halle, Germany
    BMC Cancer 10:600. 2010
  7. ncbi request reprint Consensus statements from the Second International Lung Cancer Molecular Biomarkers Workshop: a European strategy for developing lung cancer molecular diagnostics in high risk populations
    J K Field
    Roy Castle International Centre for Lung Cancer Research, The University of Liverpool, Liverpool L3 9TA, UK
    Int J Oncol 21:369-73. 2002
  8. ncbi request reprint Methylation discriminators in NSCLC identified by a microarray based approach
    J K Field
    Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, UK
    Int J Oncol 27:105-11. 2005
  9. ncbi request reprint CT screening for lung cancer in the UK: position statement by UKLS investigators following the NLST report
    John Kirkpatrick Field
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 200 London Road, Liverpool L3 9TA, UK
    Thorax 66:736-7. 2011
  10. ncbi request reprint Genetic alterations in bronchial lavage as a potential marker for individuals with a high risk of developing lung cancer
    J K Field
    Roy Castle International Centre for Lung Cancer Research, Liverpool, United Kingdom
    Cancer Res 59:2690-5. 1999

Collaborators

Detail Information

Publications52

  1. pmc Family history and risk of lung cancer: age-at-diagnosis in cases and first-degree relatives
    A Cassidy
    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK
    Br J Cancer 95:1288-90. 2006
    ..08; 95% CI: 1.20-3.59). This finding is strongly consistent with a genetic component in early-onset lung cancer risk...
  2. doi request reprint The UK Lung Screen (UKLS): demographic profile of first 88,897 approaches provides recommendations for population screening
    Fiona E McRonald
    Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Roy Castle Building, 200 London Road, Liverpool L3 9TA, United Kingdom
    Cancer Prev Res (Phila) 7:362-71. 2014
    ..Key findings: (i) better recruitment from ex- rather than current smokers, (ii) few clinic attendees ages early 50s, and (iii) representative number of socioeconomically deprived people recruited, despite lower response rates...
  3. ncbi request reprint CT screening for lung cancer: countdown to implementation
    John K Field
    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool, UK Electronic address
    Lancet Oncol 14:e591-600. 2013
    ..In this Review, we summarise the existing evidence and identify questions that remain to be answered before the implementation of international lung cancer screening programmes. ..
  4. pmc DNA methylation epigenotypes in breast cancer molecular subtypes
    Naiara G Bediaga
    BIOMICs Research Group, Centro de Investigación y Estudios Avanzados Lucio Lascaray, University of the Basque Country UPV EHU, Vitoria Gazteiz, Spain
    Breast Cancer Res 12:R77. 2010
    ..The present study was undertaken to dissect the breast cancer methylome and deliver specific epigenotypes associated with particular breast cancer subtypes...
  5. doi request reprint Prospects for population screening and diagnosis of lung cancer
    John K Field
    Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool Cancer Research Centre, Liverpool, UK
    Lancet 382:732-41. 2013
    ..We suggest that a demonstration project of biennial screening over a 4-year period should be undertaken. ..
  6. pmc SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates
    Bernd Schmidt
    Universitätsklinik und Poliklinik für Innere Medizin I, Universitätsklinikum Halle Saale, Halle, Germany
    BMC Cancer 10:600. 2010
    ..A test with a low false positive rate can reduce the need for further invasive and costly procedures and ensure early treatment...
  7. ncbi request reprint Consensus statements from the Second International Lung Cancer Molecular Biomarkers Workshop: a European strategy for developing lung cancer molecular diagnostics in high risk populations
    J K Field
    Roy Castle International Centre for Lung Cancer Research, The University of Liverpool, Liverpool L3 9TA, UK
    Int J Oncol 21:369-73. 2002
    ..A distillation of the Workshop discussions is given in this article...
  8. ncbi request reprint Methylation discriminators in NSCLC identified by a microarray based approach
    J K Field
    Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, UK
    Int J Oncol 27:105-11. 2005
    ..Our results provide compelling evidence that different histological types of lung cancer may be distinguished from normal tissue based on methylation profiles of specific genes...
  9. ncbi request reprint CT screening for lung cancer in the UK: position statement by UKLS investigators following the NLST report
    John Kirkpatrick Field
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 200 London Road, Liverpool L3 9TA, UK
    Thorax 66:736-7. 2011
    ..However, there remain important questions about the applicability of the results to the UK and the clinical effectiveness of this intervention, including its feasibility and cost-effectiveness...
  10. ncbi request reprint Genetic alterations in bronchial lavage as a potential marker for individuals with a high risk of developing lung cancer
    J K Field
    Roy Castle International Centre for Lung Cancer Research, Liverpool, United Kingdom
    Cancer Res 59:2690-5. 1999
    ..Our results suggest that microsatellite PCR-based assays can be developed as tools for the earlier identification of genetic changes in cells exfoliating in the bronchus...
  11. ncbi request reprint The Liverpool Lung Project: a molecular epidemiological study of early lung cancer detection
    J K Field
    Roy Castle International Centre for Lung Cancer Research, Liverpool, UK
    Eur Respir J 20:464-79. 2002
    ....
  12. doi request reprint International Association for the Study of Lung Cancer Computed Tomography Screening Workshop 2011 report
    John K Field
    Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Liverpool, UK
    J Thorac Oncol 7:10-9. 2012
    ....
  13. pmc Lung cancer screening: the way forward
    J K Field
    Department of Surgery and Oncology, Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool L3 9TA, UK
    Br J Cancer 99:557-62. 2008
    ....
  14. ncbi request reprint The Liverpool Lung Project research protocol
    J K Field
    Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, The University of Liverpool, Liverpool L3 9TA, UK
    Int J Oncol 27:1633-45. 2005
    ....
  15. ncbi request reprint EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration
    J K Field
    Roy Castle Lung Cancer Research Programme, Cancer Research Centre, University of Liverpool, 200 London Road, Liverpool, L3 9TA, UK
    Eur Respir J 34:1477-86. 2009
    ....
  16. pmc p53 gene aberrations in non-small-cell lung carcinomas from a smoking population
    T Liloglou
    Department of Clinical Dental Sciences, The University of Liverpool, UK
    Br J Cancer 75:1119-24. 1997
    ....
  17. ncbi request reprint Outcomes of oral squamous cell carcinoma arising from oral epithelial dysplasia: rationale for monitoring premalignant oral lesions in a multidisciplinary clinic
    M W Ho
    Regional Maxillofacial Unit, Aintree University Hospital, Liverpool, UK Electronic address
    Br J Oral Maxillofac Surg 51:594-9. 2013
    ..The high incidence of second primary oral SCC in high-risk patients with oral epithelial dysplasia further supports intensive targeted surveillance in this group. ..
  18. ncbi request reprint Loss of heterozygosity on chromosomes 3, 9, 13, and 17, including the retinoblastoma locus, in uveal melanoma
    A G Scholes
    Unit of Ophthalmology, Department of Medicine, The University of Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 42:2472-7. 2001
    ..To identify tumor-suppressor loci that may contribute to the pathogenesis of uveal melanoma...
  19. pmc S100A2 is strongly expressed in airway basal cells, preneoplastic bronchial lesions and primary non-small cell lung carcinomas
    S L Smith
    Gene Function Group, Roy Castle Lung Cancer Programme Clinical Dental Sciences, University of Liverpool Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK
    Br J Cancer 91:1515-24. 2004
    ..Furthermore, an examination of multiple tumour-free epithelial sites from 20 patients showed that strong expression was often associated with increasing levels of disorder in preinvasive bronchial lesions (P<0.0001)...
  20. pmc Fractional allele loss data indicate distinct genetic populations in the development of non-small-cell lung cancer
    J K Field
    Molecular Genetics and Oncology Group, University of Liverpool, UK
    Br J Cancer 74:1968-74. 1996
    ..e. LOH on 5p, 5q, 8p, 13q, 16q and 19q. These results indicate that LFAL patients form a new subset of NSCLC tumours with distinct molecular-initating events, and may represent a discrete genetic population...
  21. ncbi request reprint Cancer-specific genomic instability in bronchial lavage: a molecular tool for lung cancer detection
    T Liloglou
    Roy Castle International Centre for Lung Cancer Research, Molecular Oncology Unit, Liverpool, United Kingdom
    Cancer Res 61:1624-8. 2001
    ..This paper has shown that these first four markers may be considered to form an individual set of cancer-specific genomic instability markers...
  22. pmc Allelotype of squamous cell carcinoma of the head and neck: fractional allele loss correlates with survival
    J K Field
    Department of Clinical Dental Sciences, University of Liverpool, UK
    Br J Cancer 72:1180-8. 1995
    ..019). These results indicate that assessment of the accumulation of genetic damage, as provided by allelotype data, provides a useful molecular indicator of the tumour behaviour and clinical outcome...
  23. pmc Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing
    R J Shaw
    Molecular Genetics and Oncology Group, School of Dental Sciences, University of Liverpool, Liverpool L69 3GN, UK
    Br J Cancer 94:561-8. 2006
    ..Significant tumour specific methylation of cyclin A1 promoter was also seen. Cytoglobin is a novel candidate tumour suppressor gene highly methylated in upper aero-digestive tract squamous cancer...
  24. pmc Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at multiple sites
    K Dolan
    Molecular Genetics and Oncology Group, Clinical Dental Sciences, Department of Surgery, University of Liverpool, UK
    Br J Cancer 78:950-7. 1998
    ..Six of nine carcinomas displaying microsatellite alterations also demonstrated LOH at CDKN2, which may be associated with widespread genomic instability. Overall, there are nine sites of LOH associated with oesophageal adenocarcinoma...
  25. pmc Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer
    R J Shaw
    Molecular Genetics and Oncology Group, School of Dental Sciences, University of Liverpool, Liverpool, UK
    Br J Cancer 101:139-44. 2009
    ..Cytoglobin (Cygb) was first described in 2002 as an intracellular globin of unknown function. We have previously shown the downregulation of cytoglobin as a key event in a familial cancer syndrome of the upper aerodigestive tract...
  26. ncbi request reprint Loss of heterozygosity studies on chromosome 17 in head and neck cancer using microsatellite markers
    R Adamson
    Department of Clinical Dental Sciences, School of Dentistry, University of Liverpool, UK
    Oncogene 9:2077-82. 1994
    ..We propose from our data that the 17p12-p11 region contains a novel predisposing gene for hypopharyngeal SCCHN that may function as a tumour suppressor gene...
  27. pmc METH-2 silencing and promoter hypermethylation in NSCLC
    J R Dunn
    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK
    Br J Cancer 91:1149-54. 2004
    ..In conclusion, the downregulation of METH-2 expression in primary NSCLC, often associated with promoter hypermethylation, is a frequent event, which may be related to the development of the disease...
  28. ncbi request reprint Allelic imbalance at the DNA mismatch repair loci, hMSH2, hMLH1, hPMS1, hPMS2 and hMSH3, in squamous cell carcinoma of the head and neck
    J Nunn
    Molecular Genetics and Oncology Group, Department of Clinical Dental Science, The University of Liverpool, Liverpool L69 3BX, UK
    Oral Oncol 39:115-29. 2003
    ..In a variety of microsatellite instability (MSI) positive cancers where mutations in the mismatch repair (MMR) genes were not observed, allelic imbalance at the loci of the MMR genes was prevalent...
  29. ncbi request reprint Expression of p53, pRB, and p16 in lung tumours: a validation study on tissue microarrays
    M A Leversha
    Molecular Oncology, Roy Castle International Centre for Lung Cancer Research, 200 London Road, Liverpool L3 9TA, UK
    J Pathol 200:610-9. 2003
    ..The strong inverse correlation between p16 and pRB seen in SCC was essentially absent in AD. This study represents the largest single immunohistochemical survey of protein expression for p53, p16, and RB in NSCLCs...
  30. pmc The LLP risk model: an individual risk prediction model for lung cancer
    A Cassidy
    Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre, Liverpool, L3 9TA, UK
    Br J Cancer 98:270-6. 2008
    ..70, indicating good discrimination.If independent validation studies confirm these results, the LLP risk models' application as the first stage in an early detection strategy is a logical evolution in patient care...
  31. ncbi request reprint An investigation of the tylosis with oesophageal cancer (TOC) locus in Iranian patients with oesophageal squamous cell carcinoma
    M Shahabi
    Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, The University of Liverpool, Liverpool, L69 3GN, UK
    Int J Oncol 25:389-95. 2004
    ....
  32. pmc Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck
    J K Field
    Department of Clinical Dental Sciences, University of Liverpool, UK
    Br J Cancer 64:573-7. 1991
    ..Epidemiological studies have shown a correlation between heavy smoking and head and neck cancer. The present study indicate a genetic link for this correlation...
  33. pmc Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck
    H Kiaris
    Department of Clinical Dental Sciences, University of Liverpool, School of Dentistry, UK
    Br J Cancer 72:123-8. 1995
    ..We therefore conclude that ras mutations are an infrequent event in the progression of the SCCHN in the Western world, whereas overexpression of the H-ras proto-oncogene is a common event...
  34. ncbi request reprint Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas
    S Miyakis
    Roy Castle International Centre for Lung Cancer Research, Liverpool, L3 9TA, UK
    Lung Cancer 39:273-7. 2003
    ..746) than adenocarcinomas (0.493) (Wilcoxon P=0.002). This is the first investigation of the VHL gene mutational status in primary lung tumours. Our results indicate that mutation is not a common means of VHL inactivation in NSCLC...
  35. pmc Microsatellite instability in squamous cell carcinoma of the head and neck
    J K Field
    Department of Clinical Dental Sciences, University of Liverpool, UK
    Br J Cancer 71:1065-9. 1995
    ..02). Two or more markers of MI were found in three of four non-smokers compared with one of 13 in the smoking group of patients, which suggests a novel mechanism of carcinogenesis in non-smokers...
  36. pmc A microRNA-based prediction algorithm for diagnosis of non-small lung cell carcinoma in minimal biopsy material
    N G Bediaga
    1 Roy Castle Lung Cancer Research programme, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK 2 BIOMICs Research Group, University of the Basque Country, Vitoria, Spain
    Br J Cancer 109:2404-11. 2013
    ..Here we developed and validated a prediction algorithm based on microRNA (miRNA) expression that can assist clinical diagnosis of lung cancer in minimal biopsy material to improve clinical management...
  37. ncbi request reprint The clinical determinants of malignant transformation in oral epithelial dysplasia
    M W Ho
    Regional Maxillofacial Unit, Aintree University Hospital, Liverpool, UK
    Oral Oncol 48:969-76. 2012
    ..We aim to report the clinical determinants of malignant progression in a series of patients with histopathologically graded oral epithelial dysplasia (OED)...
  38. pmc Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma
    A Swift
    Department of Clinical Dental Sciences, University of Liverpool, UK
    Br J Cancer 71:995-8. 1995
    ..We propose from these data that the 17q11.2-q12 region contains a novel predisposing gene in Barrett's adenocarcinomas and may represent the site of a tumour-suppressor gene...
  39. ncbi request reprint TP53 mutations in malignant and premalignant Barrett's esophagus
    K Dolan
    Molecular Genetics and Oncology Group, University of Liverpool, Liverpool L69 3BX, UK
    Dis Esophagus 16:83-9. 2003
    ..TP53 mutation can be detected before the development of high-grade dysplasia or carcinoma, and may be useful in stratifying the risk of adenocarcinoma in patients with Barrett's esophagus...
  40. ncbi request reprint Peptide amidating activity in human bronchoalveolar lavage fluid: relationship to lung cancer, inflammation and infection
    F M Scott
    Roy Castle International Centre for Lung Cancer Research, Liverpool L3 9TA, UK
    Int J Oncol 16:327-32. 2000
    ..The presence of elevated levels of amidating enzymes in specimens with non-cancerous conditions may reflect events of promotional phase cancer biology occurring simultaneously with inflammatory and infectious processes...
  41. ncbi request reprint Sequencing of difficult templates containing poly(A/T) tracts: closure of sequence gaps
    J E Langan
    The University of Liverpool, UK
    Biotechniques 33:276, 278, 280. 2002
  42. ncbi request reprint The Liverpool Statement 2005: priorities for the European Union/United States spiral computed tomography collaborative group
    J K Field
    Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, The University of Liverpool, Liverpool, UK
    J Thorac Oncol 1:497-8. 2006
    ..The EU-US researchers have agreed to a number of long-term objectives and to explore strategic areas for harmonization of complementary investigations...
  43. ncbi request reprint A comparative guide to gene prediction tools for the bioinformatics amateur
    J Jones
    Molecular Genetics and Oncology Group, Clinical Dental Sciences, University of Liverpool, Liverpool, L69 3GN, UK
    Int J Oncol 20:697-705. 2002
    ..Overall, NIX was found to be the most user-friendly package, in terms of easy access to databases and the interactive graphical display of results...
  44. ncbi request reprint Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25
    J M Risk
    Department of Clinical Dental Sciences, The University of Liverpool, Liverpool, L69 3BX, United Kingdom
    Genomics 59:234-42. 1999
    ....
  45. pmc Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival
    S L Smith
    Gene Function Group, Roy Castle International Centre for Lung Cancer Research, 200 London Road, Liverpool L3 9TA, UK
    Br J Cancer 87:1308-13. 2002
    ..Our findings suggest a role for endothelin receptor type B in the metastasis of uveal melanoma and, potentially, in the metastasis of other neural crest tumours...
  46. ncbi request reprint Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs)
    G A Garinis
    Department of Histology and Embryology, Medical School, University of Athens, Greece
    J Pathol 193:55-65. 2001
    ..8), although this was not significant. Further studies are needed in order to elucidate the role of FHIT and its relationships with other cell-cycle regulatory molecules involved in NSCL carcinogenesis...
  47. ncbi request reprint IV international conference on prevention and early detection of lung cancer, Reykjavik, Iceland, August 9-12, 2001
    Fred R Hirsch
    Department of Medical Oncology Pathology, University of Colorado Cancer Center, 4200 E Ninth Avenue, B 188, Denver, CO 80262, USA
    Lung Cancer 37:325-44. 2002
  48. ncbi request reprint Additional characterization of a hexanucleotide polymorphic site in the first intron of human H-ras gene: comparative study of its alterations in non-small cell lung carcinomas and sporadic invasive breast carcinomas
    A Kotsinas
    Department of Histology and Embryology, Medical School, University of Athens, Athens, Greece
    Cancer Genet Cytogenet 126:147-54. 2001
    ....
  49. ncbi request reprint Von Hippel-Lindau tumour suppressor gene is not involved in sporadic human breast cancer
    G Sourvinos
    Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece
    Tumour Biol 22:131-6. 2001
    ..CONCLUSION: These results strongly indicate against a critical involvement of the tumour suppressor vhl in breast carcinogenesis...
  50. ncbi request reprint A new rare allele at the CGG repeat polymorphism in the first intron of human c-H-ras gene
    A Kotsinas
    Department of Histology-Embryology, Medical School, University of Athens, Athens, Greece
    In Vivo 15:105-8. 2001
    ..This polymorphism coincides in position with an element that was previously shown to possess regulatory activity...
  51. ncbi request reprint Major conceptual change required to improve lung cancer: see a respiratory physician
    J K Field
    Eur Respir J 21:565-6. 2003