Mark W J Ferguson

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels
    Ardeshir Bayat
    Centre for Integrated Genomic Medical Research and Division of Cells, Immunology, and Development, School of Biological Sciences, University of Manchester, England
    Plast Reconstr Surg 111:535-43; discussion 544-6. 2003
  2. pmc Scar-free healing: from embryonic mechanisms to adult therapeutic intervention
    Mark W J Ferguson
    UK Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 359:839-50. 2004
  3. ncbi request reprint Skin tension or skin compression? Small circular wounds are likely to shrink, not gape
    James A Bush
    Renovo Group plc, The Manchester Incubator Building, 48 Grafton Street, Manchester M13 9XX, UK
    J Plast Reconstr Aesthet Surg 61:529-34. 2008
  4. doi request reprint Prevention and reduction of scarring in the skin by Transforming Growth Factor beta 3 (TGFbeta3): from laboratory discovery to clinical pharmaceutical
    Nick L Occleston
    Renovo Group plc, Manchester Incubator Building, 48 Grafton Street, Manchester, UK
    J Biomater Sci Polym Ed 19:1047-63. 2008
  5. ncbi request reprint Bioengineering skin using mechanisms of regeneration and repair
    Anthony D Metcalfe
    UK Centre for Tissue Engineering UKCTE, Faculty of Life Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Biomaterials 28:5100-13. 2007
  6. pmc Location of injury influences the mechanisms of both regeneration and repair within the MRL/MpJ mouse
    Alice H M Beare
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Anat 209:547-59. 2006
  7. ncbi request reprint The microcirculation in acute murine cutaneous incisional wounds shows a spatial and temporal variation in the functionality of vessels
    Joanne E Bluff
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Manchester, UK
    Wound Repair Regen 14:434-42. 2006
  8. ncbi request reprint Bone marrow-derived endothelial progenitor cells do not contribute significantly to new vessels during incisional wound healing
    Joanne E Bluff
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Manchester, UK
    Exp Hematol 35:500-6. 2007
  9. doi request reprint Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies
    Mark W J Ferguson
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Lancet 373:1264-74. 2009
  10. pmc Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration
    Anthony D Metcalfe
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, UK
    J R Soc Interface 4:413-37. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Genetic susceptibility to keloid disease and hypertrophic scarring: transforming growth factor beta1 common polymorphisms and plasma levels
    Ardeshir Bayat
    Centre for Integrated Genomic Medical Research and Division of Cells, Immunology, and Development, School of Biological Sciences, University of Manchester, England
    Plast Reconstr Surg 111:535-43; discussion 544-6. 2003
    ..To the authors' knowledge, this is the first report of a case-control association study in keloid disease and hypertrophic scars using any single nucleotide polymorphisms...
  2. pmc Scar-free healing: from embryonic mechanisms to adult therapeutic intervention
    Mark W J Ferguson
    UK Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 359:839-50. 2004
    ....
  3. ncbi request reprint Skin tension or skin compression? Small circular wounds are likely to shrink, not gape
    James A Bush
    Renovo Group plc, The Manchester Incubator Building, 48 Grafton Street, Manchester M13 9XX, UK
    J Plast Reconstr Aesthet Surg 61:529-34. 2008
    ..Larger wounds, disrupting more of the lattice structure, will gape...
  4. doi request reprint Prevention and reduction of scarring in the skin by Transforming Growth Factor beta 3 (TGFbeta3): from laboratory discovery to clinical pharmaceutical
    Nick L Occleston
    Renovo Group plc, Manchester Incubator Building, 48 Grafton Street, Manchester, UK
    J Biomater Sci Polym Ed 19:1047-63. 2008
    ..Acute, local administration of TGFbeta3 (Juvista) significantly reduces dermal scarring in a dose responsive manner resulting in the regeneration of a skin structure that is permanently improved...
  5. ncbi request reprint Bioengineering skin using mechanisms of regeneration and repair
    Anthony D Metcalfe
    UK Centre for Tissue Engineering UKCTE, Faculty of Life Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Biomaterials 28:5100-13. 2007
    ..Central to the discussion is the development of the next generation of skin replacement therapy, the success of which is likely to be underpinned with our knowledge of wound repair and regeneration...
  6. pmc Location of injury influences the mechanisms of both regeneration and repair within the MRL/MpJ mouse
    Alice H M Beare
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Anat 209:547-59. 2006
    ....
  7. ncbi request reprint The microcirculation in acute murine cutaneous incisional wounds shows a spatial and temporal variation in the functionality of vessels
    Joanne E Bluff
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Manchester, UK
    Wound Repair Regen 14:434-42. 2006
    ..This study has important implications for assays of wound-healing angiogenesis based on histology and immunohistochemical markers for vessels, because vessel functionality differs both spatially and temporally during wound healing...
  8. ncbi request reprint Bone marrow-derived endothelial progenitor cells do not contribute significantly to new vessels during incisional wound healing
    Joanne E Bluff
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Manchester, UK
    Exp Hematol 35:500-6. 2007
    ..To assess the contribution of bone marrow (BM)-derived endothelial progenitor cells (EPCs) to the neovascularisation of cutaneous incisional wounds...
  9. doi request reprint Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies
    Mark W J Ferguson
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Lancet 373:1264-74. 2009
    ..Research into mechanisms of skin scarring identified transforming growth factor beta3 (TGFbeta3) as a potential antiscarring therapy. We assessed scar improvement with avotermin (recombinant, active, human TGFbeta3)...
  10. pmc Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration
    Anthony D Metcalfe
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, UK
    J R Soc Interface 4:413-37. 2007
    ....
  11. ncbi request reprint Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene
    Ardeshir Bayat
    Center for Integrated Genomic Research and Division of Cell Immunology and Development, School of Biological Sciences, University of Manchester, United Kingdom
    Plast Reconstr Surg 111:2133-9. 2003
    ..9; 95 percent confidence interval, 1.2 to 2.9). The authors believe this to be the first report of a positive genetic association study in Dupuytren disease using single nucleotide polymorphisms...
  12. pmc Characterizing regeneration in the vertebrate ear
    Anthony D Metcalfe
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, UK
    J Anat 209:439-46. 2006
    ..Identification of such signals could lead to their manipulation and use in a novel tissue-engineered skin substitute with scar-free integration...
  13. pmc Denervation affects regenerative responses in MRL/MpJ and repair in C57BL/6 ear wounds
    Gemma Buckley
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Anat 220:3-12. 2012
    ..These data suggest that innervation may be important not only for regeneration but also for normal wound repair processes...
  14. doi request reprint Maturation of the human scar: an observational study
    Jeremy S Bond
    University of Manchester, UK
    Plast Reconstr Surg 121:1650-8. 2008
    ..The natural history of scar maturation in humans has never been formally described from either a clinical or a histologic standpoint...
  15. ncbi request reprint Variable impairment of wound healing in the heterozygous collagenase-resistant mouse
    Alice H M Beare
    United Kingdom Center for Tissue Engineering and Division of Immunology, Microbiology, Development and Repair, School of Biological Sciences, University of Manchester, Manchester, United Kingdom
    Wound Repair Regen 13:27-40. 2005
    ....
  16. ncbi request reprint Animal models for adult dermal wound healing
    Mary Birch
    School of Biological Sciences, University of Manchester, Manchester, UK
    Methods Mol Med 117:223-35. 2005
    ....
  17. pmc Peripheral nerve regeneration in the MRL/MpJ ear wound model
    Gemma Buckley
    Faculty of Life Sciences, UK Centre for Tissue Engineering, University of Manchester, Manchester, UK
    J Anat 218:163-72. 2011
    ..Immunohistochemical data suggest that factors within the blastemal mesenchyme, such as aggrecan, may direct nerve regrowth in the regenerating ear tissue...
  18. doi request reprint Scar-improving efficacy of avotermin administered into the wound margins of skin incisions as evaluated by a randomized, double-blind, placebo-controlled, phase II clinical trial
    James Bush
    Department of Plastic and Reconstructive Surgery, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Plast Reconstr Surg 126:1604-15. 2010
    ..The authors report on a prospective, randomized, placebo-controlled phase II trial to investigate avotermin (transforming growth factor beta-3) for reducing scarring resulting from acute incised skin wounds...
  19. pmc "Aggressive keloid": a severe variant of familial keloid scarring
    Ardeshir Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Manchester, UK
    J R Soc Med 96:554-5. 2003
  20. doi request reprint Repigmentation of cutaneous scars depends on original wound type
    Sarah L Chadwick
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Anat 223:74-82. 2013
    ..Pigmentation of scars is dependent on the width and depth of wounds. This study has provided important information on which we can base future studies to investigate factors controlling the repigmentation of scars...
  21. ncbi request reprint Wound healing: a model of dermal wound repair
    Annette Tomlinson
    University of Manchester, UK
    Methods Mol Biol 225:249-60. 2003
  22. ncbi request reprint Quantification of total and perfused blood vessels in murine skin autografts using a fluorescent double-labeling technique
    Siobhan O'Ceallaigh
    UK Centre for Tissue Engineering, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Plast Reconstr Surg 117:140-51. 2006
    ..This study characterizes revascularization, spatially and chronologically, in a murine skin autograft model using a double-labeling technique...
  23. ncbi request reprint Regeneration of the ear after wounding in different mouse strains is dependent on the severity of wound trauma
    Charissa Rajnoch
    UK Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, Manchester, United Kingdom
    Dev Dyn 226:388-97. 2003
    ..However, all regenerative features were more pronounced and accelerated in MRL/MpJ mice when compared with C57BL/6 and Balb/c biopsy-punched mouse ears...
  24. ncbi request reprint Temporal and spatial expression of Pax9 and Sonic hedgehog during development of normal mouse palates and cleft palates in TGF-beta3 null embryos
    Yasunori Sasaki
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Arch Oral Biol 52:260-7. 2007
    ..These results indicate that Pax9 and Shh expression are altered when the TGF-beta3 gene is deleted and suggest that Pax9 and Shh may be involved in the TGF-beta3 regulation of normal palatal fusion...
  25. ncbi request reprint Severely impaired wound healing in the collagenase-resistant mouse
    Alice H M Beare
    Division of Immunology, Microbiology and Development, and UK Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, UK
    J Invest Dermatol 120:153-63. 2003
    ..There was no significant difference in scarring between Col1a1(r/r) and Col1a1+/+ wounds after 70 d...
  26. pmc Microscopic and histological examination of the mouse hindpaw digit and flexor tendon arrangement with 3D reconstruction
    Jason Wong
    Faculty of Life Sciences, University of Manchester, UK
    J Anat 209:533-45. 2006
    ..In conclusion, although the dimensions of the mouse digit pose technical challenges for surgical intervention, we have identified a model for the study of flexor tendon injury that will permit future genetic manipulation studies...
  27. ncbi request reprint The effect of antibodies to TGF-beta1 and TGF-beta2 at a site of sciatic nerve repair
    Simon Atkins
    Department of Oral and Maxillofacial Surgery, University of Sheffield and Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Peripher Nerv Syst 11:286-93. 2006
    ..We conclude that administration of antibodies to TGF-beta1 and TGF-beta2 reduced scar formation at the repair site but did not enhance regeneration of the nerve or reduce the development of multiple axonal sprouts...
  28. doi request reprint Scar redness in humans: how long does it persist after incisional and excisional wounding?
    Jeremy S Bond
    University of Manchester, United Kingdom
    Plast Reconstr Surg 121:487-96. 2008
    ..The natural history of scar redness in humans has never been formally described, and the point at which normal scar redness fades is unknown...
  29. ncbi request reprint Studies of transforming growth factors beta 1-3 and their receptors I and II in fibroblast of keloids and hypertrophic scars
    Oliver Bock
    Primary Health Care Center, Fabriksgatan 17, SE 552 85 Jönköping, Sweden
    Acta Derm Venereol 85:216-20. 2005
    ..Therefore our data support a possible role of TGFssRI and TGFssRII in combination with a certain TGFss expression pattern as fibrosis-inducing factors in keloids...
  30. ncbi request reprint Interleukin-10 reduces scarring and enhances regeneration at a site of sciatic nerve repair
    Simon Atkins
    Department of Oral and Maxillofacial Medicine and Surgery, University of Sheffield, Sheffield, UK
    J Peripher Nerv Syst 12:269-76. 2007
    ..We conclude that administration of a low-dose of IL-10 to a site of sciatic nerve repair reduces scar formation and permits better regeneration of the damaged axons...
  31. ncbi request reprint The dynamic rotation of Langer's lines on facial expression
    James Bush
    Renovo plc, The Manchester Incubator Building, 48 Grafton Street, Manchester M13 9XX, United Kingdom
    J Plast Reconstr Aesthet Surg 60:393-9. 2007
    ..0001). We conclude that Langer's lines are not a static feature but are dynamic with rotation of up to 90 degrees . It is possible that this rotation in the axis of mechanical tension will affect the appearance of the resulting scar...
  32. ncbi request reprint Visual analogue scale scoring and ranking: a suitable and sensitive method for assessing scar quality?
    Jonathan A L Duncan
    Renovo Ltd
    Plast Reconstr Surg 118:909-18. 2006
    ..The field of scar assessment lacks a standard methodology. Previous methods have focused on a wide range of scar types, resulting in poorer sensitivity and diminishing their discriminatory effectiveness...
  33. ncbi request reprint Scarring impedes regeneration at sites of peripheral nerve repair
    Simon Atkins
    Department of Oral and Maxillofacial Surgery, University of Sheffield, Sheffield, UK
    Neuroreport 17:1245-9. 2006
    ..We conclude that scarring impedes regeneration at sites of nerve repair and suggest that this could be amenable to therapeutic manipulation...
  34. ncbi request reprint Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring
    Haiyan Yu
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Plast Reconstr Aesthet Surg 59:221-9. 2006
    ..This could explain why TGFbeta signaling is not terminated in keloids leading to overexpression of extracellularmatrix in keloids. These data support a possible role of SMAD6 and 7 in the pathogenesis of keloids...
  35. ncbi request reprint The development of archosaurian first-generation teeth in a chicken mutant
    Matthew P Harris
    Department of Anatomy, University of Wisconsin, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Curr Biol 16:371-7. 2006
    ....
  36. pmc Experimental manipulation of transforming growth factor-beta isoforms significantly affects adhesion formation in a murine surgical model
    Dylan A Gorvy
    Faculty of Life Sciences, University of Manchester, Manchester, UK M13 9PT
    Am J Pathol 167:1005-19. 2005
    ..In conclusion, these results show that by blocking both TGF-beta1 and TGF-beta2 using neutralizing antibodies, it is possible to prevent abdominal adhesion formation...
  37. ncbi request reprint Identification of a novel mitochondrial mutation in Dupuytren's disease using multiplex DHPLC
    Ardeshir Bayat
    Center for Integrated Genomic Medical Research, University of Manchester, Manchester, United Kingdom
    Plast Reconstr Surg 115:134-41. 2005
    ..001; chi2 = 16.1). This mutation may be important in the pathogenesis of Dupuytren's disease...
  38. ncbi request reprint Latent TGF-beta1 activation by platelets
    Robert Blakytny
    Department of Cancer Research, Fachklinik Hornheide, University of Munster, Munster, Germany
    J Cell Physiol 199:67-76. 2004
    ..This novel mechanism of latent TGF-beta activation might represent an important mediator and therapeutic target of platelet TGF-beta1 functions, for example, in early wound repair, fibrosis, or arteriosclerosis...
  39. ncbi request reprint Transforming growth factor-beta levels during second- intention healing are related to the different course of wound contraction in horses and ponies
    Robin van den Boom
    Department of Equine Sciences, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
    Wound Repair Regen 10:188-94. 2002
    ..Further research on the temporal patterns of the different TGF-beta isoforms seems indicated, because manipulation of TGF-beta levels appears to be a promising option for intervention in problematic wound healing in horses...