E J Feil

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. pmc The impact of recombination on dN/dS within recently emerged bacterial clones
    Santiago Castillo-Ramírez
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    PLoS Pathog 7:e1002129. 2011
  2. doi request reprint The emergence and spread of dysentery
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, UK
    Nat Genet 44:964-5. 2012
  3. pmc Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates
    Bernice Meng Qi Sim
    Genome Institute of Singapore, 60 Biopolis Street, 138672 Singapore
    Genome Biol 11:R89. 2010
  4. pmc Burkholderia pseudomallei genome plasticity associated with genomic island variation
    Sarinna Tumapa
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Genomics 9:190. 2008
  5. pmc Rapid detection of the pandemic methicillin-resistant Staphylococcus aureus clone ST 239, a dominant strain in Asian hospitals
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Clin Microbiol 46:1520-2. 2008
  6. ncbi request reprint Recombination and the population structures of bacterial pathogens
    E J Feil
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Annu Rev Microbiol 55:561-90. 2001
  7. pmc eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1518-30. 2004
  8. pmc How clonal is Staphylococcus aureus?
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    J Bacteriol 185:3307-16. 2003
  9. ncbi request reprint Analyses of clonality and the evolution of bacterial pathogens
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Curr Opin Microbiol 7:308-13. 2004
  10. ncbi request reprint Small change: keeping pace with microevolution
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Nat Rev Microbiol 2:483-95. 2004

Collaborators

Detail Information

Publications35

  1. pmc The impact of recombination on dN/dS within recently emerged bacterial clones
    Santiago Castillo-Ramírez
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    PLoS Pathog 7:e1002129. 2011
    ..We also consider the role of increased drift acting on recently emerged, highly specialised clones, and the impact of recombination on selection at linked sites. This work has implications for a wide range of genomic analyses...
  2. doi request reprint The emergence and spread of dysentery
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, UK
    Nat Genet 44:964-5. 2012
    ..Phylogenetic analysis based on whole-genome sequencing of a global sample has detailed the recent evolutionary history of this pathogen and shed light on the genetic changes associated with this epidemiological shift...
  3. pmc Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates
    Bernice Meng Qi Sim
    Genome Institute of Singapore, 60 Biopolis Street, 138672 Singapore
    Genome Biol 11:R89. 2010
    ..To study B. thailandensis genomic variation, we profiled 50 isolates using a pan-genome microarray comprising genomic elements from 28 Burkholderia strains and species...
  4. pmc Burkholderia pseudomallei genome plasticity associated with genomic island variation
    Sarinna Tumapa
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Genomics 9:190. 2008
    ..pseudomallei isolates, little is known about the extent of variation between related strains or their association with disease or environmental survival...
  5. pmc Rapid detection of the pandemic methicillin-resistant Staphylococcus aureus clone ST 239, a dominant strain in Asian hospitals
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Clin Microbiol 46:1520-2. 2008
    ..Results based on previously uncharacterized isolates from a hospital in northeast Thailand support the view that at least 90% of HA-MRSA isolates in mainland Asia correspond to ST 239 or close relatives...
  6. ncbi request reprint Recombination and the population structures of bacterial pathogens
    E J Feil
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Annu Rev Microbiol 55:561-90. 2001
    ....
  7. pmc eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1518-30. 2004
    ..pneumoniae and Staphylococcus aureus MLST databases, and the more complicated clonal complexes observed for Campylobacter jejuni and Neisseria meningitidis...
  8. pmc How clonal is Staphylococcus aureus?
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    J Bacteriol 185:3307-16. 2003
    ....
  9. ncbi request reprint Analyses of clonality and the evolution of bacterial pathogens
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Curr Opin Microbiol 7:308-13. 2004
    ....
  10. ncbi request reprint Small change: keeping pace with microevolution
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Nat Rev Microbiol 2:483-95. 2004
  11. pmc The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
    Mark C Enright
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 99:7687-92. 2002
    ..aureus genotypes...
  12. ncbi request reprint Protein evolution: causes of trends in amino-acid gain and loss
    Laurence D Hurst
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Nature 442:E11-2; discussion E12. 2006
    ..This reinforces the need for caution in the interpretation of results derived from closely related taxa...
  13. ncbi request reprint The phylogeny of Staphylococcus aureus - which genes make the best intra-species markers?
    Jessica E Cooper
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Microbiology 152:1297-305. 2006
    ..In the case of S. aureus this threshold is >1 % mean pairwise diversity...
  14. pmc MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi
    Gabriele Margos
    Departments of Biology and Biochemistry and Mathematical Sciences, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 105:8730-5. 2008
    ..burgdorferi correspond to genetically distinct populations. Importantly, the MLST data suggest that B. burgdorferi originated in Europe rather than in North America as proposed previously...
  15. pmc The persistence of parasitic plasmids
    Loukia N Lili
    Department of Mathematical Sciences, University of Bath, BA2 7AY, Bath, United Kingdom
    Genetics 177:399-405. 2007
    ....
  16. ncbi request reprint Multilocus sequence typing--what is resolved?
    Jessica E Cooper
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
    Trends Microbiol 12:373-7. 2004
    ....
  17. doi request reprint The temporal dynamics of slightly deleterious mutations in Escherichia coli and Shigella spp
    Kevin J Balbi
    Department of Biology and Biochemistry, University of Bath, Claverton Down, United Kingdom
    Mol Biol Evol 26:345-55. 2009
    ..This argument sheds light on the enrichment of adenine and thymine in the genomes of bacterial endosymbionts where purifying selection is very weak...
  18. ncbi request reprint S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formation
    Karen L Atkins
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Mol Immunol 45:1600-11. 2008
    ..The formation of insoluble immune complexes with Sbi occurs only via Fc binding and free Fc regions are unlikely to be available for Fc gamma R recognition and complement fixation...
  19. ncbi request reprint The rise and fall of deleterious mutation
    Kevin J Balbi
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Res Microbiol 158:779-86. 2007
    ..Here we review the impact of this effect by considering the gradual selective purging of deleterious mutation over time. We outline an approach to explore the dynamics of this process, and highlight its profound implications...
  20. pmc The carriage population of Staphylococcus aureus from Mali is composed of a combination of pandemic clones and the divergent Panton-Valentine leukocidin-positive genotype ST152
    Raymond Ruimy
    Hopital Bichat Claude Bernard, AP HP, EA 3964, Université Denis Diderot Paris 7 Medical School, 75870 Paris Cedex, France
    J Bacteriol 190:3962-8. 2008
    ..aureus clone noted mostly in Central Europe. We show that 100% of the ST152 isolates recovered from nasal carriage samples in Mali are PVL positive and discuss implications relating to the emergence and spread of this virulent genotype...
  21. pmc Determining the genetic structure of the natural population of Staphylococcus aureus: a comparison of multilocus sequence typing with pulsed-field gel electrophoresis, randomly amplified polymorphic DNA analysis, and phage typing
    Hajo Grundmann
    Division of Microbiology and Infectious Diseases, University Hospital Nottingham, Nottingham NG7 2UH, United Kingdom
    J Clin Microbiol 40:4544-6. 2002
    ..Only MLST was able to define clonal complexes unambiguously. All DNA-based typing approaches achieved a high degree of agreement, implying phylogenetic concordance, but predicted epidemiological associations with variable accuracy...
  22. pmc Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing
    Emma Meats
    Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Hospital, London W2 1PG, United Kingdom
    J Clin Microbiol 41:1623-36. 2003
    ..The H. influenzae MLST scheme is available at www.mlst.net, it allows any isolate to be compared with those in the MLST database, and (for encapsulated isolates) it assigns isolates to their phylogenetic lineage, via the Internet...
  23. pmc Searching for species in haloarchaea
    R Thane Papke
    Department of Molecular and Cell Biology, University of Connecticut, 91 North Eagleville Road, Storrs, CT 06269 3125, USA
    Proc Natl Acad Sci U S A 104:14092-7. 2007
    ..Arbitrary criteria might have limited practical use, but still must be agreed upon by the community...
  24. pmc Emergence of a virulent clade of Vibrio vulnificus and correlation with the presence of a 33-kilobase genomic island
    Ana Luisa V Cohen
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Appl Environ Microbiol 73:5553-65. 2007
    ..Our data suggest that lineage I may have a higher pathogenic potential and that region XII, along with other regions, may give isolates a selective advantage either in the human host or in the aquatic environment or both...
  25. pmc Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 101:9786-91. 2004
    ....
  26. ncbi request reprint Displaying the relatedness among isolates of bacterial species -- the eBURST approach
    Brian G Spratt
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Hospital, Old Medical School Building, London W2 1PG, UK
    FEMS Microbiol Lett 241:129-34. 2004
    ..We discuss the advantages of this approach and describe its use to explore patterns of descent within clonal complexes identified using multilocus sequence typing...
  27. ncbi request reprint Opinion: Re-evaluating prokaryotic species
    Dirk Gevers
    Laboratory of Microbiology and the Bioinformatics and Evolutionary Genomics Research Group, Ghent University VIB, Ghent, Belgium
    Nat Rev Microbiol 3:733-9. 2005
    ..We also consider the potential, and difficulties, of assigning species status to biologically or ecologically meaningful sequence clusters...
  28. ncbi request reprint Comparisons of dN/dS are time dependent for closely related bacterial genomes
    Eduardo P C Rocha
    Atelier de BioInformatique, Universite Paris VI, 75005 Paris, France
    J Theor Biol 239:226-35. 2006
    ..We conclude that, because of the critical effect of time since divergence, inter-taxa comparisons are only possible by comparing trajectories of dN/dS over time and it is not valid to compare taxa on the basis of single time points...
  29. pmc Evolutionary genetics of the accessory gene regulator (agr) locus in Staphylococcus aureus
    D Ashley Robinson
    New York Medical College, Department of Microbiology and Immunology, Valhalla, NY 10595, USA
    J Bacteriol 187:8312-21. 2005
    ..aureus that horizontally transferred agr groups between two subspecies groups near the time that these subspecies groups diverged...
  30. pmc High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae
    Alison J Cody
    Molecular Infectious Diseases Group, Department of Paediatrics, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    Infect Genet Evol 3:57-66. 2003
    ..These findings provide a population based foundation for a better understanding of the role of NTHi LPS as a virulence factor and its potential as a candidate vaccine...
  31. ncbi request reprint The secret life of the multilocus sequence type
    Katherine M E Turner
    Department of Infectious Disease Epidemiology, Imperial College, St Mary s Hospital, Norfolk Place, London W2 1PG, UK
    Int J Antimicrob Agents 29:129-35. 2007
    ..aureus (MRSA) clones using MLST. We conclude with a speculative rationale for promoting the 'clonal complexes' of S. aureus to species status...
  32. pmc Nonrandom distribution of Burkholderia pseudomallei clones in relation to geographical location and virulence
    Mongkol Vesaratchavest
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand, and Churchill Hospital, Oxford, UK
    J Clin Microbiol 44:2553-7. 2006
    ..This analysis reveals strong genetic differentiation on the basis of geographical isolation and a significant differentiation on the basis of virulence potential...
  33. pmc Multi-locus sequence typing of Bartonella henselae isolates from three continents reveals hypervirulent and feline-associated clones
    Mardjan Arvand
    Institut fur Medizinische Mikrobiologie, Virologie und Hygiene, Universitat Rostock, Rostock, Germany
    PLoS ONE 2:e1346. 2007
    ..These data indicate that B. henselae lineages differ in their virulence properties for humans and contribute to a better understanding of the population structure of B. henselae...
  34. ncbi request reprint Databases and software for the comparison of prokaryotic genomes
    Dawn Field
    Oxford Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
    Microbiology 151:2125-32. 2005
    ..This article reviews progress towards the development of computational tools and databases for organizing and extracting biological meaning from the comparison of large collections of genomes...
  35. pmc Similar compositional biases are caused by very different mutational effects
    Eduardo P C Rocha
    Unité Génétique des Génomes Bactériens, URA 2171, Institut Pasteur, 75015 Paris, France
    Genome Res 16:1537-47. 2006
    ....