Martin Feelisch

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. pmc The role of nitrogen oxides in human adaptation to hypoxia
    Denny Z Levett
    Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Sci Rep 1:109. 2011
  2. doi request reprint The chemical biology of nitric oxide--an outsider's reflections about its role in osteoarthritis
    Martin Feelisch
    Experimental Medicine and Integrative Biology, Clinical Sciences Research Institute, Warwick Medical School, The University of Warwick, Coventry, UK
    Osteoarthritis Cartilage 16:S3-S13. 2008
  3. pmc Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems
    Martin Feelisch
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:33927-34. 2008
  4. ncbi request reprint An integrated approach to assessing nitroso-redox balance in systemic inflammation
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK
    Free Radic Biol Med 51:1137-45. 2011
  5. pmc Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products
    Alexandra B Milsom
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Antioxid Redox Signal 17:422-32. 2012
  6. doi request reprint On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease
    Fumito Saijo
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Nitric Oxide 22:155-67. 2010
  7. ncbi request reprint Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach
    David H Perlman
    Cardiovascular Proteomics Center, Boston University School of Medicine, Boston, MA, USA
    Circ Res 104:796-804. 2009
  8. pmc Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency
    Maria Francisca Garcia-Saura
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA
    Antioxid Redox Signal 17:937-50. 2012
  9. ncbi request reprint Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
    Nathan S Bryan
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Chem Biol 1:290-7. 2005
  10. pmc Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress
    Elizabeth S Klings
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Pathol 175:2309-18. 2009

Collaborators

Detail Information

Publications17

  1. pmc The role of nitrogen oxides in human adaptation to hypoxia
    Denny Z Levett
    Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Sci Rep 1:109. 2011
    ....
  2. doi request reprint The chemical biology of nitric oxide--an outsider's reflections about its role in osteoarthritis
    Martin Feelisch
    Experimental Medicine and Integrative Biology, Clinical Sciences Research Institute, Warwick Medical School, The University of Warwick, Coventry, UK
    Osteoarthritis Cartilage 16:S3-S13. 2008
    ..This essay aims to provide a glimpse into research areas that may hold promise for future investigations into the underlying causes of osteoarthritis...
  3. pmc Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems
    Martin Feelisch
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:33927-34. 2008
    ..These observations hint at conserved roles for the NO(2)(-)-NO pool in cellular processes such as oxygen-sensing and oxygen-dependent modulation of intermediary metabolism...
  4. ncbi request reprint An integrated approach to assessing nitroso-redox balance in systemic inflammation
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK
    Free Radic Biol Med 51:1137-45. 2011
    ....
  5. pmc Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products
    Alexandra B Milsom
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
    Antioxid Redox Signal 17:422-32. 2012
    ....
  6. doi request reprint On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease
    Fumito Saijo
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Nitric Oxide 22:155-67. 2010
    ..Its possible link to tissue oxygen consumption and the hypoxia that tends to accompany the inflammatory process warrants further investigation...
  7. ncbi request reprint Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach
    David H Perlman
    Cardiovascular Proteomics Center, Boston University School of Medicine, Boston, MA, USA
    Circ Res 104:796-804. 2009
    ..These findings help elucidate possible mechanisms of nitrite-induced cardioprotection and have implications for nitrite dosing in therapeutic regimens...
  8. pmc Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency
    Maria Francisca Garcia-Saura
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts, USA
    Antioxid Redox Signal 17:937-50. 2012
    ..This new model may have merit for the future study of redox-sensitive events in marginal ascorbate deficiency...
  9. ncbi request reprint Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
    Nathan S Bryan
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Chem Biol 1:290-7. 2005
    ..Thus, nitrite homeostasis may be of great importance to NO biology...
  10. pmc Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress
    Elizabeth S Klings
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Pathol 175:2309-18. 2009
    ..Therefore, reduced denitrosylation of proteins, possibly resulting in impaired cellular repair, and excessive apoptotic cell death likely contribute to increased lung injury and mortality of GGT(enu1) mice in hyperoxia...
  11. pmc Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury
    Yasuko Nagasaka
    Anesthesia Center for Critical Care Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 109:675-82. 2008
    ..Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood...
  12. ncbi request reprint Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment
    Xunde Wang
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 281:26994-7002. 2006
    ....
  13. pmc Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo
    David R Janero
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 101:16958-63. 2004
    ..These findings provide insight into the global in vivo metabolism of GTN at pharmacologically relevant doses and offer an additional experimental paradigm for the NObonomic analysis of NO-donor metabolism and signaling...
  14. doi request reprint Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice
    Xuebin Qin
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Hematol 84:221-7. 2009
    ..These results indicate that the thrombotic diathesis of PNH patients could be due to a combination of increased complement-mediated platelet activation and reduced NO-bioavailability as a consequence of hemolysis...
  15. ncbi request reprint Bound NO in human red blood cells: fact or artifact?
    Nathan S Bryan
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Nitric Oxide 10:221-8. 2004
    ....
  16. doi request reprint Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK University College London, Division of Surgery and Interventional Science, 9th Floor, Royal Free Hospital, Pond Street, London NW3 2QG, UK Electronic address
    Contemp Clin Trials 36:450-9. 2013
    ..Improved understanding of hypoxaemia in critical illness may provide new therapeutic avenues for interventions that will improve survival in critically ill patients. ..
  17. pmc Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers
    Lorenzo Berra
    Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School at Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Anesthesiology 117:56-63. 2012
    ..We hypothesized that the nitric oxide mediated hyperemic response after ischemia would be reduced after transfusion of packed erythrocytes stored for 40 days...