Kenneth C Fearon

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint The scientific rationale for optimizing nutritional support in cancer
    Richard J E Skipworth
    Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Eur J Gastroenterol Hepatol 19:371-7. 2007
  2. ncbi request reprint Pathophysiology of cancer cachexia: much more than host-tumour interaction?
    Richard J E Skipworth
    Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    Clin Nutr 26:667-76. 2007
  3. doi request reprint Understanding the mechanisms and treatment options in cancer cachexia
    Kenneth Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Nat Rev Clin Oncol 10:90-9. 2013
  4. doi request reprint Cancer cachexia: mediators, signaling, and metabolic pathways
    Kenneth C H Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, UK
    Cell Metab 16:153-66. 2012
  5. doi request reprint The 2011 ESPEN Arvid Wretlind lecture: cancer cachexia: the potential impact of translational research on patient-focused outcomes
    K C H Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    Clin Nutr 31:577-82. 2012
  6. pmc Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
    Nathan A Stephens
    Department of Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, EH16 4SB, UK
    Genome Med 2:1. 2010
  7. doi request reprint Definition and classification of cancer cachexia: an international consensus
    Kenneth Fearon
    Clinical and Surgical Sciences, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Lancet Oncol 12:489-95. 2011
  8. ncbi request reprint The nutritional management of surgical patients: enhanced recovery after surgery
    Kenneth C H Fearon
    Department of Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, The University of Edinburgh, Room F3307, The Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 45A, UK
    Proc Nutr Soc 62:807-11. 2003
  9. ncbi request reprint Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis
    Kenneth C Fearon
    Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Am J Clin Nutr 83:1345-50. 2006
  10. ncbi request reprint Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia
    Kenneth C H Fearon
    Department of Clinical and Surgical Sciences Surgery, The Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Clin Oncol 24:3401-7. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint The scientific rationale for optimizing nutritional support in cancer
    Richard J E Skipworth
    Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Eur J Gastroenterol Hepatol 19:371-7. 2007
    ..Therefore, clinical trials using combination therapies or immunonutrition are required for future success...
  2. ncbi request reprint Pathophysiology of cancer cachexia: much more than host-tumour interaction?
    Richard J E Skipworth
    Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, The University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    Clin Nutr 26:667-76. 2007
    ..Clinicians should consider such concepts in the design of an effective multimodal therapy for cachexia...
  3. doi request reprint Understanding the mechanisms and treatment options in cancer cachexia
    Kenneth Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Nat Rev Clin Oncol 10:90-9. 2013
    ....
  4. doi request reprint Cancer cachexia: mediators, signaling, and metabolic pathways
    Kenneth C H Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, UK
    Cell Metab 16:153-66. 2012
    ....
  5. doi request reprint The 2011 ESPEN Arvid Wretlind lecture: cancer cachexia: the potential impact of translational research on patient-focused outcomes
    K C H Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    Clin Nutr 31:577-82. 2012
    ..The combination of approaches promises a new era for the management of cachexia in the context of supportive oncology...
  6. pmc Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
    Nathan A Stephens
    Department of Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, EH16 4SB, UK
    Genome Med 2:1. 2010
    ..Our genomics analysis also supports the view that the available preclinical models do not accurately reflect the molecular characteristics of human muscle from cancer cachexia patients...
  7. doi request reprint Definition and classification of cancer cachexia: an international consensus
    Kenneth Fearon
    Clinical and Surgical Sciences, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Lancet Oncol 12:489-95. 2011
    ..Consensus exists on a framework for the definition and classification of cancer cachexia. After validation, this should aid clinical trial design, development of practice guidelines, and, eventually, routine clinical management...
  8. ncbi request reprint The nutritional management of surgical patients: enhanced recovery after surgery
    Kenneth C H Fearon
    Department of Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, The University of Edinburgh, Room F3307, The Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 45A, UK
    Proc Nutr Soc 62:807-11. 2003
    ..enhanced recovery programme, n 33, median stay 7d; P<0.01) can be achieved. Such findings emphasise the potential role of multi-modal care programmes in the promotion of early recovery from major surgical trauma...
  9. ncbi request reprint Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis
    Kenneth C Fearon
    Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Am J Clin Nutr 83:1345-50. 2006
    ..Cancer cachexia is a multifactorial syndrome that is poorly defined...
  10. ncbi request reprint Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia
    Kenneth C H Fearon
    Department of Clinical and Surgical Sciences Surgery, The Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Clin Oncol 24:3401-7. 2006
    ..Eicosapentaenoic acid (EPA) has been proposed to have specific anticachectic effects. This trial compared EPA diethyl ester with placebo in cachectic cancer patients for effects on weight and lean body mass...
  11. doi request reprint Cancer cachexia: developing multimodal therapy for a multidimensional problem
    K C H Fearon
    Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh, United Kingdom
    Eur J Cancer 44:1124-32. 2008
    ..The current evidence-base justifies new enthusiasm for the design of complex intervention studies in the management of cancer cachexia...
  12. doi request reprint Magnetic resonance imaging with k-means clustering objectively measures whole muscle volume compartments in sarcopenia/cancer cachexia
    Calum Gray
    Wellcome Trust Clinical Research Facility, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Clin Nutr 30:106-11. 2011
    ....
  13. ncbi request reprint Is there a human homologue to the murine proteolysis-inducing factor?
    Barbara M Wieland
    Departments of Oncology and Chemistry, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 13:4984-92. 2007
    ..We aimed to establish the clinical significance of PIF in cancer patients and to elucidate its structural features...
  14. doi request reprint Cachexia: prevalence and impact in medicine
    Benjamin H L Tan
    Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Curr Opin Clin Nutr Metab Care 11:400-7. 2008
    ..g., cancer, chronic obstructive pulmonary disease, chronic heart failure, and chronic kidney disease). The aim of this article is to describe the prevalence and impact of cachexia (and precachexia) in such patients...
  15. ncbi request reprint Eicosanoid-dependent cancer cachexia and wasting
    James A Ross
    Lister Research Laboratories, University Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh, Edinburgh, UK
    Curr Opin Clin Nutr Metab Care 5:241-8. 2002
    ..This review examines the biology of the eicosanoids and the evidence of a role for the eicosanoids in cancer cachexia and wasting...
  16. ncbi request reprint Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia
    Cornelis H C Dejong
    Department of Surgery, University Hospital Maastricht, PO Box 5800, Maastricht NL 6202 AZ, The Netherlands
    Oncol Rep 14:257-63. 2005
    ..The pro-inflammatory network and ubiquitin proteasome pathway may be targets for intervention in pancreatic cancer cachexia...
  17. ncbi request reprint Cancer cachexia and fatigue
    Grant D Stewart
    Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary Edinburgh
    Clin Med 6:140-3. 2006
  18. ncbi request reprint Cancer cachexia
    Kenneth C H Fearon
    Department of Clinical and Surgical Sciences Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK
    Int J Cardiol 85:73-81. 2002
    ..Combination treatments such as nutritional support plus metabolic/inflammation modulation promise improved functional capacity and quality of life...
  19. ncbi request reprint Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells
    James A Ross
    Tissue Injury and Repair Group, Centre for Inflammation Research, University of Edinburgh Department of Clinical and Surgical Sciences, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Int J Oncol 23:1733-8. 2003
    ..These results suggest that the omega-3 fatty acid EPA perturbs the NFkappaB pathway by a novel mechanism. This mechanism may be important in delineating alternative pathways to NFkappaB activation...
  20. ncbi request reprint Modulation of the liver export protein synthetic response to feeding by an n-3 fatty-acid-enriched nutritional supplement is associated with anabolism in cachectic cancer patients
    Matthew D Barber
    Department of Clinical and Surgical Sciences Surgery, The University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, Scotland, U K
    Clin Sci (Lond) 106:359-64. 2004
    ..7 compared with 14.6 g/day; P = 0.01). Modulation of hepatic export protein synthesis with feeding may have contributed to the net whole-body anabolism observed with administration of the n -3 fatty-acid-enriched oral supplement...
  21. ncbi request reprint Patterns and clinical outcomes associated with routine intravenous sodium and fluid administration after colorectal resection
    Andrew L Tambyraja
    University Department of Clinical and Surgical Sciences Surgery, Royal Infirmary of Edinburgh, 51 Little France Crescent, EH16 4SA, Edinburgh, UK
    World J Surg 28:1046-51; discussion 1051-2. 2004
    ..Because colonic resection poses less of a physiologic insult than rectal resection, the overall outcome in the former group may be more sensitive to the interplay between fluid and sodium overload and patient co-morbidity...
  22. ncbi request reprint Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia
    Swarnali Acharyya
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Cell 8:421-32. 2005
    ..Based on these results, we propose that, similar to muscular dystrophy, DGC dysfunction plays a critical role in cancer-induced wasting...
  23. ncbi request reprint Plasma arginine concentrations are reduced in cancer patients: evidence for arginine deficiency?
    Yvonne L J Vissers
    Department of Surgery, Research Institute Maastricht, Maastricht University, and University Hospital Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 81:1142-6. 2005
    ..The disturbances leading to cancer cachexia remain to be unraveled. Preliminary evidence suggests that arginine availability in cancer is reduced. However, no valid data are available on plasma arginine concentrations in cancer patients...
  24. ncbi request reprint Serum parathyroid hormone-related peptide is associated with systemic inflammation and adverse prognosis in gastroesophageal carcinoma
    Chris Deans
    Tissue Injury and Repair Group, Medical Research Council Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Medical School, Edinburgh University, Edinburgh, United Kingdom
    Cancer 103:1810-8. 2005
    ....
  25. ncbi request reprint De-repression of heat shock transcription factor-1 in interleukin-6- treated hepatocytes is mediated by downregulation of glycogen synthase kinase 3beta and MAPK/ERK-1
    Stephen J Wigmore
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research, Medical School 6th Floor, Edinburgh EH8 9AG, UK
    Int J Mol Med 19:413-20. 2007
    ....
  26. ncbi request reprint Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Clin Nutr 26:614-8. 2007
    ..Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients...
  27. ncbi request reprint Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia
    Grant D Stewart
    Tissue Injury and Repair Group, University of Edinburgh, UK
    Prostate 67:1308-17. 2007
    ..The aim of this work was to: (i) establish if the DCD gene confers resistance of prostate cancer cells to hypoxia and oxidative stress; (ii) identify the component of the gene transcript responsible for this effect...
  28. ncbi request reprint Effect of high-fat enteral nutrition on hepatocyte injury in response to hemorrhagic shock in the rat
    Mary M Chu
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research Medical School, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK
    World J Surg 31:1693-701. 2007
    ..High-fat enteral nutrition reduces the inflammatory response following hemorrhagic shock in the rat...
  29. ncbi request reprint Febrile-range temperature but not heat shock augments the acute phase response to interleukin-6 in human hepatoma cells
    Stephen J Wigmore
    Liver Research Group, University of Birmingham, Institute of Biomedical Research 5th Floor, Wolfson Drive, Birmingham B15 2TT, UK
    Am J Physiol Gastrointest Liver Physiol 290:G903-11. 2006
    ..The mechanism of this action appears to be transcriptionally regulated in the case of ACT, but in the case of transferrin, it may be mediated by another process such as posttranslational modification...
  30. ncbi request reprint Objective physical activity and self-reported quality of life in patients receiving palliative chemotherapy
    Max Dahele
    Department of Radiation Oncology, Toronto Sunnybrook Regional Cancer Center, Toronto, Ontario, Canada
    J Pain Symptom Manage 33:676-85. 2007
    ..59, P=0.009 and r=0.59, P=0.008). It is concluded that patients receiving palliative chemotherapy were less active than healthy controls; however, the relationship between physical activity and QoL requires further characterization...