Douglas Fearon

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
    D T Fearon
    Wellcome Trust Immunology Unit, Department of Medicine, School of Clinical Medicine, University of Cambridge, United Kingdom
    Annu Rev Immunol 18:393-422. 2000
  2. ncbi Arrested differentiation, the self-renewing memory lymphocyte, and vaccination
    D T Fearon
    Wellcome Trust Immunology Unit, School of Clinical Medicine, University of Cambridge, MRC Centre, Cambridge CB2 2SP, UK
    Science 293:248-50. 2001
  3. ncbi Pathways of memory CD8+ T-cell development
    Oliver Bannard
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Cambridge, UK
    Eur J Immunol 39:2083-7. 2009
  4. ncbi BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes
    Peter M Manders
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Cambridge CB2 2QH, UK
    Proc Natl Acad Sci U S A 102:7418-25. 2005
  5. ncbi The rationale for the IL-2-independent generation of the self-renewing central memory CD8+ T cells
    Douglas T Fearon
    Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK
    Immunol Rev 211:104-18. 2006
  6. ncbi The expansion and maintenance of antigen-selected CD8(+) T cell clones
    Douglas T Fearon
    Wellcome Trust Immunology Unit, University of Cambridge, Medical Research Council Centre, Cambridge CB2 2QH, United Kingdom
    Adv Immunol 96:103-39. 2007
  7. ncbi Biography of Douglas T. Fearon
    Regina Nuzzo
    Proc Natl Acad Sci U S A 102:7415-7. 2005
  8. ncbi CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation
    James M Carr
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 103:19454-9. 2006
  9. ncbi Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte
    Maike Heffner
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 104:13414-9. 2007

Research Grants

  1. ANTIGEN-INDUCED B LYMPHOCYTE DEVELOPMENT
    Douglas Fearon; Fiscal Year: 2006

Collaborators

  • M C Carroll
  • Susan Kaech
  • James M Carr
  • Oliver Bannard
  • Matthew Kraman
  • Maike Heffner
  • Peter M Manders
  • Regina Nuzzo
  • Aymen Al-Shamkhani
  • James E D Thaventhiran
  • Paul J Bambrough
  • Marlene J Carrasco
  • Alexander D Edwards
  • Aino I Telaranta
  • Michael J Palmowski
  • Jennifer L Marshall
  • Marlene Carrasco
  • Patricia J Hunter
  • Yusuke Murakami
  • Vincenzo Cerundolo
  • Rafi Ahmed

Detail Information

Publications9

  1. ncbi Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
    D T Fearon
    Wellcome Trust Immunology Unit, Department of Medicine, School of Clinical Medicine, University of Cambridge, United Kingdom
    Annu Rev Immunol 18:393-422. 2000
    ..The integration of innate and adaptive immune recognition at this molecular site on the B cell guides the appropriate selection of antigen by adaptive immunity and emphasizes the importance of this coreceptor complex...
  2. ncbi Arrested differentiation, the self-renewing memory lymphocyte, and vaccination
    D T Fearon
    Wellcome Trust Immunology Unit, School of Clinical Medicine, University of Cambridge, MRC Centre, Cambridge CB2 2SP, UK
    Science 293:248-50. 2001
    ..Understanding how to regulate the terminal differentiation of lymphocytes will improve immunotherapeutic approaches for chronic infectious diseases and cancer...
  3. ncbi Pathways of memory CD8+ T-cell development
    Oliver Bannard
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Cambridge, UK
    Eur J Immunol 39:2083-7. 2009
    ....
  4. ncbi BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes
    Peter M Manders
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Cambridge CB2 2QH, UK
    Proc Natl Acad Sci U S A 102:7418-25. 2005
    ..Therefore, BCL6b is required for the enhanced magnitude of the secondary response of memory CD8(+) T cells...
  5. ncbi The rationale for the IL-2-independent generation of the self-renewing central memory CD8+ T cells
    Douglas T Fearon
    Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK
    Immunol Rev 211:104-18. 2006
    ..The challenge is now to identify this unknown pathway of clonal expansion...
  6. ncbi The expansion and maintenance of antigen-selected CD8(+) T cell clones
    Douglas T Fearon
    Wellcome Trust Immunology Unit, University of Cambridge, Medical Research Council Centre, Cambridge CB2 2QH, United Kingdom
    Adv Immunol 96:103-39. 2007
    ..This developmental program ensures that despite the occurrence of cellular senescence antiviral CD8(+) T cell clones are maintained for the duration of persistent viral infections...
  7. ncbi Biography of Douglas T. Fearon
    Regina Nuzzo
    Proc Natl Acad Sci U S A 102:7415-7. 2005
  8. ncbi CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation
    James M Carr
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 103:19454-9. 2006
    ..Thus, the TCR/CD27 pathway enables the CD8+ T cell to replicate by a process of self-renewal, which may contribute to the continuous generation of new effector CD8+ T cells in persistent viral infections...
  9. ncbi Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte
    Maike Heffner
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 104:13414-9. 2007
    ....

Research Grants5

  1. ANTIGEN-INDUCED B LYMPHOCYTE DEVELOPMENT
    Douglas Fearon; Fiscal Year: 2006
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