Mark Farrant

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs
    Dorota Studniarczyk
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 16:1266-74. 2013
  2. pmc A role of TARPs in the expression and plasticity of calcium-permeable AMPARs: evidence from cerebellar neurons and glia
    Cecile Bats
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuropharmacology 74:76-85. 2013
  3. ncbi request reprint Properties of GABA(A) receptor-mediated transmission at newly formed Golgi-granule cell synapses in the cerebellum
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuropharmacology 44:181-9. 2003
  4. ncbi request reprint The cellular, molecular and ionic basis of GABA(A) receptor signalling
    Mark Farrant
    Department of Pharmacology, UCL University College London, Gower Street, London WC1E 6BT, UK
    Prog Brain Res 160:59-87. 2007
  5. ncbi request reprint Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
  6. pmc Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells
    Marzieh Zonouzi
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 14:1430-8. 2011
  7. pmc Cornichons modify channel properties of recombinant and glial AMPA receptors
    Ian D Coombs
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 32:9796-804. 2012
  8. pmc Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors
    David Soto
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 10:1260-7. 2007
  9. pmc Channel properties reveal differential expression of TARPed and TARPless AMPARs in stargazer neurons
    Cecile Bats
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 15:853-61. 2012
  10. pmc Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5
    David Soto
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 12:277-85. 2009

Collaborators

Detail Information

Publications18

  1. pmc TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs
    Dorota Studniarczyk
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 16:1266-74. 2013
    ..Our results also establish that TARPed synaptic receptors in granule cells require both γ-2 and γ-7 and reveal an unexpected basis for the loss of AMPAR-mediated transmission in stargazer mice...
  2. pmc A role of TARPs in the expression and plasticity of calcium-permeable AMPARs: evidence from cerebellar neurons and glia
    Cecile Bats
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuropharmacology 74:76-85. 2013
    ..This article is part of the Special Issue entitled 'Glutamate Receptor-Dependent Synaptic Plasticity'. ..
  3. ncbi request reprint Properties of GABA(A) receptor-mediated transmission at newly formed Golgi-granule cell synapses in the cerebellum
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Neuropharmacology 44:181-9. 2003
    ..Moreover, paired Golgi-granule cell recordings suggest a high level of connectivity and a high release probability at these early synapses...
  4. ncbi request reprint The cellular, molecular and ionic basis of GABA(A) receptor signalling
    Mark Farrant
    Department of Pharmacology, UCL University College London, Gower Street, London WC1E 6BT, UK
    Prog Brain Res 160:59-87. 2007
    ..Untangling all these complexities allows us to appreciate the variety of GABA-mediated signalling, a diverse set of phenomena encompassing both synaptic and non-synaptic functions that can be overtly excitatory as well as inhibitory...
  5. ncbi request reprint Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
    ..In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability...
  6. pmc Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells
    Marzieh Zonouzi
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 14:1430-8. 2011
    ..Finally, we found that stargazin-related transmembrane AMPAR regulatory proteins, which are critical for AMPAR surface expression in neurons, regulate CP-AMPAR plasticity in OPCs...
  7. pmc Cornichons modify channel properties of recombinant and glial AMPA receptors
    Ian D Coombs
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 32:9796-804. 2012
    ..Additionally, overexpression of CNIH-3 in OPCs markedly slowed AMPAR desensitization. Together, our experiments support the view that CNIHs are capable of altering key properties of AMPARs and suggest that they may do so in glia...
  8. pmc Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors
    David Soto
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 10:1260-7. 2007
    ....
  9. pmc Channel properties reveal differential expression of TARPed and TARPless AMPARs in stargazer neurons
    Cecile Bats
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 15:853-61. 2012
    ....
  10. pmc Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5
    David Soto
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 12:277-85. 2009
    ..Our results suggest an important role for gamma-5 in regulating the functional contribution of CP-AMPARs...
  11. doi request reprint Synaptic mGluR activation drives plasticity of calcium-permeable AMPA receptors
    Leah Kelly
    Department of Neuroscience, Physiology and Pharmacology, University College London, UK
    Nat Neurosci 12:593-601. 2009
    ..Regulation by both excitatory and inhibitory inputs provides an unexpected mechanism that determines the potential of these synapses to show dynamic changes in AMPAR Ca(2+) permeability...
  12. pmc TARP-associated AMPA receptors display an increased maximum channel conductance and multiple kinetically distinct open states
    Chris Shelley
    Department of Neuroscience, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 590:5723-38. 2012
    ..We have explored how these data place novel constraints on possible kinetic models of TARP-associated AMPARs that may be used to define AMPAR-mediated synaptic transmission...
  13. ncbi request reprint Maturation of EPSCs and intrinsic membrane properties enhances precision at a cerebellar synapse
    Laurence Cathala
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:6074-85. 2003
    ..We suggest that these concurrent developmental changes, which increase the temporal precision of EPSP-spike coupling, will increase the fidelity with which sensory information is processed within the input layer of the cerebellar cortex...
  14. ncbi request reprint Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond
    Stuart Cull-Candy
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Curr Opin Neurobiol 16:288-97. 2006
    ..The dynamic regulation of these receptors is important for normal synaptic function and in disease states...
  15. pmc Climbing-fibre activation of NMDA receptors in Purkinje cells of adult mice
    Massimiliano Renzi
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 585:91-101. 2007
    ..Furthermore, we show that NMDA receptor-mediated EPSCs can be evoked by climbing fibre stimulation, and appear to be mediated mainly by NR2A-containing receptors...
  16. pmc Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor α subunit isoforms
    Mark D Eyre
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083 Budapest, Hungary
    J Neurosci 32:5853-67. 2012
    ....
  17. pmc Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors
    Brandon M Stell
    Department of Neurology, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:14439-44. 2003
    ..Recognition that delta subunit-containing GABAARs responsible for a tonic conductance are a preferential target for neuroactive steroids may lead to novel pharmacological approaches for the treatment of these common conditions...
  18. pmc From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors
    Peer Wulff
    Department of Clinical Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Nat Neurosci 10:923-9. 2007
    ..This combined molecular and pharmacological technique has demonstrable advantages over targeted cell ablation and will be invaluable for investigating many neuronal circuits...