Affiliation: University of Bristol
Location: Bristol, UK
I have a great interest in genome-scale data mining: I developed the database of domain-centric ontologies to aid in functional genomics and phenotype prediction; applied network techniques to identify the possible connections among drugs, diseases and phenotypes; used the tree of life to study network evolution. I have also published several papers about transcriptome data mining which is unique in topology-preserving selection and clustering.
Bachelors Degree in Biotechnology Engineering (1999 - 2003) from Jiangnan University
M.S. - Ph.D. Degree in Genetics/Bioinformatics (2003 - 2009) from Institute of Health Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences
Research post-Doc on Network Biology (2009 - 2010) from Sino-French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Post-Doctoral Research Associate (2010 - Now) in Intelligent Systems Laboratory, Department of Computer Science, University of Bristol
Du Y, Wang K, Fang H, Li J, Xiao D, Zheng P, et al
. Coordination of intrinsic, extrinsic, and endoplasmic reticulum-mediated apoptosis by imatinib mesylate combined with arsenic trioxide in chronic myeloid leukemia. Blood. 2006;107:1582-90 pubmed
..This finding appears to be supported also by data derived from bone marrow cells of 2 patients with CML, one in chronic phase and the other in blast-crisis phase of the disease. ..
Fang H, Wang K, Zhang J. Transcriptome and proteome analyses of drug interactions with natural products. Curr Drug Metab. 2008;9:1038-48 pubmed
..Here, these recent advancements will be discussed in detail, along with perspectives in the field of drug synergism. ..
Bi Y, Liu R, Ye L, Fang H, Li X, Wang W, et al
. Gene expression profiles of thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome reveal novel molecular mechanism. Endocr Relat Cancer. 2009;16:1273-82 pubmed publisher
..Hence, this study has provided not only a detailed comprehension of the molecular pathogenesis of thymic carcinoids with ectopic ACTH syndrome, but also a road map to approach thymic NETs at the system level. ..
Wang K, Fang H, Xiao D, Zhu X, He M, Pan X, et al
. Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells. PLoS ONE. 2009;4:e7538 pubmed publisher
Wang K, Wang P, Shi J, Zhu X, He M, Jia X, et al
. PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell. 2010;17:186-97 pubmed publisher
..Thus, selective targeting of PU.1-regulated genes by PML/RARalpha is a critical mechanism for the pathogenesis of APL. ..
Liu R, Wang W, Ye L, Bi Y, Fang H, Cui B, et al
. p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration. Endocrine. 2010;38:38-47 pubmed publisher
..Activation of JNK pathway was also detected in thymic carcinoid with high level of PAK3 expression. Our findings suggested a potential role of PAK3 in the progression of ACTH-producing thymic carcinoid. ..
de Lima Morais D, Fang H, Rackham O, Wilson D, Pethica R, Chothia C, et al
. SUPERFAMILY 1.75 including a domain-centric gene ontology method. Nucleic Acids Res. 2011;39:D427-34 pubmed publisher
..A new methodology was developed to ensure a high quality GO annotation. The new methodology is general purpose and has been used to produce domain-based phenotypic ontologies in addition to GO. ..
Fang H, Du Y, Xia L, Li J, Zhang J, Wang K. A topology-preserving selection and clustering approach to multidimensional biological data. OMICS. 2011;15:483-94 pubmed publisher
..A Web server ( http://www.cs.bris.ac.uk/?hfang/TPSC ) hosting a MATLAB package that implements the methodology is freely available to both academic and nonacademic users. These advances will expand the scope of omics applications. ..
Fang H, Gough J. DcGO: database of domain-centric ontologies on functions, phenotypes, diseases and more. Nucleic Acids Res. 2013;41:D536-44 pubmed publisher
..The dcGO database is updated fortnightly, and its website provides downloads, search, browse, phylogenetic context and other data-mining facilities. ..