P G Fallon

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom and Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Immunol 164:2585-91. 2000
  2. pmc Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Infect Immun 68:6005-11. 2000
  3. ncbi request reprint IL-13 overexpression predisposes to anaphylaxis following antigen sensitization
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 166:2712-6. 2001
  4. ncbi request reprint Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection
    P G Fallon
    Department of Pathology, University of Cambridge, GB
    Eur J Immunol 28:1408-16. 1998
  5. ncbi request reprint Defective in vivo induction of functional type 2 cytokine responses in aged mice
    P Smith
    Department of Pathology, University of Cambridge, GB
    Eur J Immunol 31:1495-502. 2001
  6. ncbi request reprint Schistosoma mansoni: maturation rate and drug susceptibility of different geographic isolates
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    Exp Parasitol 86:29-36. 1997
  7. ncbi request reprint Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    J Immunol 162:4122-32. 1999
  8. ncbi request reprint Effect of praziquantel and oxamniquine treatment on human isotype responses to Schistosoma mansoni: elevated IgE to adult worm
    M Webster
    Department of Pathology, University of Cambridge, UK
    Parasite Immunol 19:333-5. 1997
  9. pmc Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    Clin Diagn Lab Immunol 5:251-3. 1998
  10. pmc Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses
    G J McKenzie
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Exp Med 189:1565-72. 1999

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom and Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Immunol 164:2585-91. 2000
    ..Therefore, we demonstrate that during a dynamic type 2 cytokine disease process IL-13 is detrimental to survival following infection, whereas IL-4 is beneficial...
  2. pmc Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Infect Immun 68:6005-11. 2000
    ..This study highlights the pleiotropic in vivo activity of IL-9 and demonstrates that an elevated Th2 cytokine phenotype leads to death during murine schistosome infection...
  3. ncbi request reprint IL-13 overexpression predisposes to anaphylaxis following antigen sensitization
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 166:2712-6. 2001
    ..The systemic regulation of this response makes these mice an important resource for studying atopic responses...
  4. ncbi request reprint Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection
    P G Fallon
    Department of Pathology, University of Cambridge, GB
    Eur J Immunol 28:1408-16. 1998
    ..Schistosome regulation of Tc1 during egg laying may be required to prevent type 1 inflammatory responses from exacerbating egg-induced pathology...
  5. ncbi request reprint Defective in vivo induction of functional type 2 cytokine responses in aged mice
    P Smith
    Department of Pathology, University of Cambridge, GB
    Eur J Immunol 31:1495-502. 2001
    ....
  6. ncbi request reprint Schistosoma mansoni: maturation rate and drug susceptibility of different geographic isolates
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    Exp Parasitol 86:29-36. 1997
    ..The praziquantel tolerance of the Senegal parasite is not solely attributed to the state of maturation of the parasite at the time of drug administration...
  7. ncbi request reprint Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    J Immunol 162:4122-32. 1999
    ..This study demonstrates that mice tolerized to schistosome eggs have elevated type 1 cytokine responses with diminished type 2 responses and reduced anti-egg Ab during schistosome infection, and these effects are detrimental to the host...
  8. ncbi request reprint Effect of praziquantel and oxamniquine treatment on human isotype responses to Schistosoma mansoni: elevated IgE to adult worm
    M Webster
    Department of Pathology, University of Cambridge, UK
    Parasite Immunol 19:333-5. 1997
    ..No significant difference was observed between pre- and post-treatment isotype responses to egg antigens following either praziquantel or oxamniquine therapy...
  9. pmc Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    Clin Diagn Lab Immunol 5:251-3. 1998
    ..621 and r = -0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone...
  10. pmc Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses
    G J McKenzie
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Exp Med 189:1565-72. 1999
    ..We conclude that IL-4 and IL-13 cooperate to initiate rapid Th2 cell-driven responses, and that although their functions overlap, they perform additive roles...
  11. pmc T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses
    M J Townsend
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Exp Med 191:1069-76. 2000
    ..These data clearly demonstrate that T1/ST2 expression plays a role in the development of Th2-like cytokine responses and indicate that effector functions are inhibited in its absence...
  12. ncbi request reprint Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice
    C M Walsh
    Institute of Molecular Medicine, Trinity College Dublin, St James s Hospital, Dublin 8, Ireland
    Parasite Immunol 29:293-308. 2007
    ..This study illustrates the complexity of regulation of T cells in schistosome infection and highlights a specific role for CTLA-4+, but not CD25+ cells, in the regulation of Th2 responses in helminth infection...