C H D Fall

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Fetal programming and the risk of noncommunicable disease
    Caroline H D Fall
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, Hampshire, SO16 6YD, UK
    Indian J Pediatr 80:S13-20. 2013
  2. pmc Infant nutrition and later health: a review of current evidence
    Sian Robinson
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Nutrients 4:859-74. 2012
  3. pmc Maternal and paternal height and BMI and patterns of fetal growth: the Pune Maternal Nutrition Study
    Andrew K Wills
    MRC Epidemiology Resource Centre, University of Southampton, UK
    Early Hum Dev 86:535-40. 2010
  4. pmc A principal components approach to parent-to-newborn body composition associations in South India
    Sargoor R Veena
    Epidemiology Research Unit, Holdsworth Memorial Hospital, Mysore, South India
    BMC Pediatr 9:16. 2009
  5. pmc Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans
    Giriraj R Chandak
    Genome Research Group, Centre for Cellular and Molecular Biology, Hyderabad, India
    BMC Med Genet 7:76. 2006
  6. pmc Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of BMI gain during infancy: Data from the New Delhi Birth Cohort
    Caroline H D Fall
    MRC Epidemiology Resource Centre, Southampton, UK
    Diabetes Care 31:2349-56. 2008
  7. ncbi request reprint Maternal nutrition: effects on health in the next generation
    Caroline Fall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Indian J Med Res 130:593-9. 2009
  8. pmc Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation
    Caroline H D Fall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Food Nutr Bull 30:S533-46. 2009
  9. pmc Evidence for the intra-uterine programming of adiposity in later life
    Caroline H D Fall
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Ann Hum Biol 38:410-28. 2011
  10. ncbi request reprint Urinary GH and IGF-I excretion in nine year-old children: relation to sex, current size and size at birth
    C H Fall
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Clin Endocrinol (Oxf) 53:69-76. 2000

Collaborators

Detail Information

Publications35

  1. pmc Fetal programming and the risk of noncommunicable disease
    Caroline H D Fall
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, Hampshire, SO16 6YD, UK
    Indian J Pediatr 80:S13-20. 2013
    ..Work in experimental animals suggests that epigenetic phenomena, whereby gene expression is modified by DNA methylation, and which are sensitive to the nutritional environment in early life, may be one mechanism underlying programming...
  2. pmc Infant nutrition and later health: a review of current evidence
    Sian Robinson
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Nutrients 4:859-74. 2012
    ..Future progress will depend on new studies that provide detailed prospective data on duration and exclusivity of breastfeeding together with appropriate characterisation of the weaning diet...
  3. pmc Maternal and paternal height and BMI and patterns of fetal growth: the Pune Maternal Nutrition Study
    Andrew K Wills
    MRC Epidemiology Resource Centre, University of Southampton, UK
    Early Hum Dev 86:535-40. 2010
    ..This study has highlighted how the pattern of parental-fetal associations varies over gestation. Further follow-up will determine whether and how these variations in fetal/placental development relate to health in later life...
  4. pmc A principal components approach to parent-to-newborn body composition associations in South India
    Sargoor R Veena
    Epidemiology Research Unit, Holdsworth Memorial Hospital, Mysore, South India
    BMC Pediatr 9:16. 2009
    ..We also compared maternal and paternal measurements (body mass index (BMI) and height) as predictors of newborn body composition...
  5. pmc Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans
    Giriraj R Chandak
    Genome Research Group, Centre for Cellular and Molecular Biology, Hyderabad, India
    BMC Med Genet 7:76. 2006
    ..There are few studies of these variants in South Asians. We investigated whether the two APOA5 variants also show similar association with various lipid parameters in Indian population as in the UK white subjects...
  6. pmc Adult metabolic syndrome and impaired glucose tolerance are associated with different patterns of BMI gain during infancy: Data from the New Delhi Birth Cohort
    Caroline H D Fall
    MRC Epidemiology Resource Centre, Southampton, UK
    Diabetes Care 31:2349-56. 2008
    ..The purpose of this study was to describe patterns of infant, childhood, and adolescent BMI and weight associated with adult metabolic risk factors for cardiovascular disease...
  7. ncbi request reprint Maternal nutrition: effects on health in the next generation
    Caroline Fall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Indian J Med Res 130:593-9. 2009
    ..Ongoing studies in India and elsewhere seek to understand the long-term effects of nutrition in early life, and how best to translate this knowledge into policies to improve health in future generations...
  8. pmc Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation
    Caroline H D Fall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Food Nutr Bull 30:S533-46. 2009
    ..Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes...
  9. pmc Evidence for the intra-uterine programming of adiposity in later life
    Caroline H D Fall
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Ann Hum Biol 38:410-28. 2011
    ..Other foetal exposures associated with increased adiposity in animals include glucocorticoids and endocrine disruptors...
  10. ncbi request reprint Urinary GH and IGF-I excretion in nine year-old children: relation to sex, current size and size at birth
    C H Fall
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Clin Endocrinol (Oxf) 53:69-76. 2000
    ..To test the hypothesis that small size at birth followed by postnatal catch-up growth is associated with elevated IGF-I production...
  11. ncbi request reprint The fetal and early life origins of adult disease
    Caroline H D Fall
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, Hampshire, S0166YD, UK
    Indian Pediatr 40:480-502. 2003
  12. ncbi request reprint Micronutrients and fetal growth
    Caroline H D Fall
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, Hampshire SO16 6YD, United Kingdom
    J Nutr 133:1747S-1756S. 2003
    ....
  13. ncbi request reprint Does birth weight predict adult serum cortisol concentrations? Twenty-four-hour profiles in the United kingdom 1920-1930 Hertfordshire Birth Cohort
    C H D Fall
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom SO16 6YD
    J Clin Endocrinol Metab 87:2001-7. 2002
    ..Programmed effects on the hypothalamic-pituitary-adrenal axis may influence reactivity rather than resting secretion...
  14. pmc Mother's lifetime nutrition and the size, shape and efficiency of the placenta
    N R Winder
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Placenta 32:806-10. 2011
    ..Studies have shown that the shape and size of the placenta at birth predict blood pressure in later life. The influences that determine placental morphology are largely unknown. We have examined the role of mother's body size...
  15. ncbi request reprint Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts
    R I G Holt
    Fetal Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Acta Physiol Scand 180:359-66. 2004
    ..Fetal programming of the growth hormone-insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings...
  16. pmc Prediction of body-fat percentage from skinfold and bio-impedance measurements in Indian school children
    S H Kehoe
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Eur J Clin Nutr 65:1263-70. 2011
    ..The objective of this study was to assess agreement between BF% derived from primary reference methods and that from skinfold equations and bio-impedance analysis (BIA) in Indian children...
  17. ncbi request reprint Is birth weight related to later glucose and insulin metabolism?--A systematic review
    C A Newsome
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Diabet Med 20:339-48. 2003
    ..To determine the relationship of birth weight to later glucose and insulin metabolism...
  18. ncbi request reprint Growth hormone predicts bone density in elderly women
    E M Dennison
    MRC Environmental Epidemiology Unit, University of Southampton, UK
    Bone 32:434-40. 2003
    ..08) with rising birth weight, while IGF-1 concentration fell (P = 0.05) with rising birth weight, suggesting a role for the GH/IGF-1 axis in the programming of adult bone mass among women...
  19. pmc Why are rural Indian women so thin? Findings from a village in Maharashtra
    G P Chorghade
    MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton SO16 6YD, UK
    Public Health Nutr 9:9-18. 2006
    ..To identify social, behavioural and cultural factors that explain the thinness of young women relative to their men in rural Maharashtra, India...
  20. pmc Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size
    H J W Farrant
    MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK
    Eur J Clin Nutr 63:646-52. 2009
    ..We have related maternal vitamin D status in pregnancy to maternal and newborn glucose and insulin concentrations, and newborn size, in a South Indian population...
  21. pmc Cortisol and the metabolic syndrome in South Asians
    Alexandra M V Ward
    MRC Environmental Epidemiology Unit and Regional Endocrine Laboratory, Southampton General Hospital, UK
    Clin Endocrinol (Oxf) 58:500-5. 2003
    ..South Asians have high rates of cardiovascular disease and its risk factors. We have investigated the relationships between HPAA activity, adiposity and the metabolic syndrome in a South Asian population...
  22. ncbi request reprint Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males
    Sandra D O'Dell
    Division of Human Genetics, University of Southampton School of Medicine, Duthie Building MP 808, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Eur J Hum Genet 10:749-52. 2002
    ..03, 2 df) and 3 kg/m(2) greater BMI (P=0.02, 2 df). There was no effect in women. The CNTF G>A null mutation therefore confers a moderate effect on obesity in males of A/A genotype, who represent 1% of the general population...
  23. ncbi request reprint Left ventricular mass and arterial compliance: relation to coronary heart disease and its risk factors in South Indian adults
    K Kumaran
    South and West Devon Health Authority, The Lescaze Offices, Shinner s Bridge, Dartington, Devon TQ9 6JE, UK
    Int J Cardiol 83:1-9. 2002
    ..We have measured LV mass and arterial compliance, and examined their relation to CHD and other known risk factors, in men and women living in Mysore, South India...
  24. ncbi request reprint Higher offspring birth weight predicts the metabolic syndrome in mothers but not fathers 8 years after delivery: the Pune Children's Study
    Chittaranjan S Yajnik
    Diabetes Unit, King Edward Memorial Hospital and Research Centre, Pune, India
    Diabetes 52:2090-6. 2003
    ..Our findings highlight the need for a better understanding of the relation between fetal growth and future health before contemplating public health interventions to improve fetal growth...
  25. pmc Consequences of poor maternal micronutrition before and during early pregnancy
    Stephen Owens
    MRC Keneba, Medical Research Council Laboratories, P O Box 273, Banjul, The Gambia
    Trans R Soc Trop Med Hyg 102:103-4. 2008
    ..The effects of targeted interventions during this period have been little studied in humans...
  26. pmc Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood
    Santosh K Bhargava
    Department of Pediatrics, Sunder Lal Jain Hospital, Delhi, India
    N Engl J Med 350:865-75. 2004
    ..Understanding the origin of obesity may be especially important in developing countries, where type 2 diabetes is rapidly increasing yet public health messages still focus on reducing childhood "undernutrition."..
  27. ncbi request reprint Glucose tolerance in pregnancy in South India: relationships to neonatal anthropometry
    Jacqueline C Hill
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, England, UK
    Acta Obstet Gynecol Scand 84:159-65. 2005
    ..This paper reports neonatal outcomes...
  28. ncbi request reprint Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort
    Harshpal S Sachdev
    Department of Pediatrics, Sunder Lal Jain Hospital, Delhi, India
    Am J Clin Nutr 82:456-66. 2005
    ..South Asians have a muscle-thin but adipose body phenotype and high rates of obesity-related disease. Adult body composition may be predictable in early life...
  29. ncbi request reprint Anthropometry, glucose tolerance, and insulin concentrations in Indian children: relationships to maternal glucose and insulin concentrations during pregnancy
    Ghattu V Krishnaveni
    Post Box 38, Holdsworth Memorial Hospital, Mandi Mohalla, Mysore 570021, Karnataka, India
    Diabetes Care 28:2919-25. 2005
    ....
  30. pmc High prevalence of glucose intolerance even among young adults in south India
    Palany Raghupathy
    Department of Child Health, Christian Medical College, Vellore 632004, India
    Diabetes Res Clin Pract 77:269-79. 2007
    ..Our data suggest high levels of glucose intolerance in young rural and urban adults highlighting an urgent need for preventive action to avert a public health catastrophe in India...
  31. pmc Determinants of incident hyperglycemia 6 years after delivery in young rural Indian mothers: the Pune Maternal Nutrition Study (PMNS)
    Smita R Kulkarni
    Kamalnayan Bajaj Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India
    Diabetes Care 30:2542-7. 2007
    ..To study determinants of incident hyperglycemia in rural Indian mothers 6 years after delivery...
  32. pmc Gestational diabetes and the incidence of diabetes in the 5 years following the index pregnancy in South Indian women
    Ghattu V Krishnaveni
    CSI Holdsworth Memorial Hospital, Mysore, Karnataka, India
    Diabetes Res Clin Pract 78:398-404. 2007
    ..001). Our findings suggest high diabetes and cardiovascular risks in women with previous GDM. Follow-up of these women after delivery would provide opportunities to modify adverse lifestyle factors...
  33. ncbi request reprint Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:1059-65. 2003
    ..Prospective studies should address whether this group is susceptible to type 2 diabetes, coronary heart disease, and osteoporosis...
  34. ncbi request reprint Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Clin Endocrinol (Oxf) 62:692-7. 2005
    ..We have therefore attempted to measure the impact of 11beta-HSD1 activity on bone in vivo by examining the association of circulating cortisone with bone markers, bone mineral density (BMD) and bone loss in a cohort of women and men...
  35. ncbi request reprint Increasing maternal parity predicts neonatal adiposity: Pune Maternal Nutrition Study
    Niranjan P Joshi
    Diabetes Unit, KEM Hospital and Research Centre, Pune, Maharashtra, India
    Am J Obstet Gynecol 193:783-9. 2005
    ..This study was undertaken to study the effect of parity on maternal and neonatal characteristics...