Susan J Fairweather-Tait

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. doi request reprint Methods of assessment of selenium status in humans: a systematic review
    Kate Ashton
    School of Medicine, Health Policy and Practice, The University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:2025S-2039S. 2009
  2. doi request reprint Risk-benefit analysis of mineral intakes: case studies on copper and iron
    Susan J Fairweather-Tait
    School of Medicine, University of East Anglia, Norwich NR4 7TJ, UK
    Proc Nutr Soc 70:1-9. 2011
  3. ncbi request reprint Iron status in the elderly
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK Electronic address
    Mech Ageing Dev 136:22-8. 2014
  4. pmc The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis
    Martin Falkingham
    Diet and Health Group, School of Medicine, Health Policy and Practice, University of East Anglia, UK
    Nutr J 9:4. 2010
  5. ncbi request reprint Does ageing affect zinc homeostasis and dietary requirements?
    Susan J Fairweather-Tait
    School of Medicine Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Exp Gerontol 43:382-8. 2008
  6. ncbi request reprint The use of solubility, dialyzability, and Caco-2 cell methods to predict iron bioavailability
    Susan Fairweather-Tait
    University of East Anglia, Norwich NR4 7TJ, UK
    Int J Vitam Nutr Res 77:158-65. 2007
  7. doi request reprint Estimating the bioavailability factors needed for setting dietary reference values
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich, UK
    Int J Vitam Nutr Res 80:249-56. 2010
  8. pmc Contribution made by biomarkers of status to an FP6 Network of Excellence, EURopean micronutrient RECommendations Aligned (EURRECA)
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich, UK
    Am J Clin Nutr 94:651S-4S. 2011
  9. doi request reprint Diet and bone mineral density study in postmenopausal women from the TwinsUK registry shows a negative association with a traditional English dietary pattern and a positive association with wine
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 94:1371-5. 2011
  10. doi request reprint Selenium in human health and disease
    Susan J Fairweather-Tait
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk, United Kingdom
    Antioxid Redox Signal 14:1337-83. 2011

Collaborators

Detail Information

Publications43

  1. doi request reprint Methods of assessment of selenium status in humans: a systematic review
    Kate Ashton
    School of Medicine, Health Policy and Practice, The University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:2025S-2039S. 2009
    ..To understand the effect of selenium intake on health, it is important to identify sensitive and population-specific biomarkers of selenium status...
  2. doi request reprint Risk-benefit analysis of mineral intakes: case studies on copper and iron
    Susan J Fairweather-Tait
    School of Medicine, University of East Anglia, Norwich NR4 7TJ, UK
    Proc Nutr Soc 70:1-9. 2011
    ....
  3. ncbi request reprint Iron status in the elderly
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK Electronic address
    Mech Ageing Dev 136:22-8. 2014
    ..In order to maintain body iron within the normal range a personalised approach is required, taking into account all of the factors that may affect iron metabolism and the available strategies for preventing iron deficiency or overload. ..
  4. pmc The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis
    Martin Falkingham
    Diet and Health Group, School of Medicine, Health Policy and Practice, University of East Anglia, UK
    Nutr J 9:4. 2010
    ..However, due to the potential for confounding by socio-economic status in observational studies, this needs to be verified in data from randomised controlled trials (RCTs)...
  5. ncbi request reprint Does ageing affect zinc homeostasis and dietary requirements?
    Susan J Fairweather-Tait
    School of Medicine Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Exp Gerontol 43:382-8. 2008
    ....
  6. ncbi request reprint The use of solubility, dialyzability, and Caco-2 cell methods to predict iron bioavailability
    Susan Fairweather-Tait
    University of East Anglia, Norwich NR4 7TJ, UK
    Int J Vitam Nutr Res 77:158-65. 2007
    ..Further developments are required to refine Caco-2 model systems, including optimization and standardization of methods...
  7. doi request reprint Estimating the bioavailability factors needed for setting dietary reference values
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich, UK
    Int J Vitam Nutr Res 80:249-56. 2010
    ..e. multiplying the requirement by a bioavailability factor. The latter can be determined using algorithms, or estimates from absorption studies, some of which are described in this short review paper...
  8. pmc Contribution made by biomarkers of status to an FP6 Network of Excellence, EURopean micronutrient RECommendations Aligned (EURRECA)
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich, UK
    Am J Clin Nutr 94:651S-4S. 2011
    ....
  9. doi request reprint Diet and bone mineral density study in postmenopausal women from the TwinsUK registry shows a negative association with a traditional English dietary pattern and a positive association with wine
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 94:1371-5. 2011
    ..The effect of diet on bone mineral density (BMD) remains controversial, mainly because of difficulties in isolating dietary factors from the confounding influences of age, lifestyle, and genetic factors...
  10. doi request reprint Selenium in human health and disease
    Susan J Fairweather-Tait
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk, United Kingdom
    Antioxid Redox Signal 14:1337-83. 2011
    ..The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies...
  11. doi request reprint Selenium bioavailability: current knowledge and future research requirements
    Susan J Fairweather-Tait
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    Am J Clin Nutr 91:1484S-1491S. 2010
    ..The effect of genotype adds a potential further dimension to the process of deriving bioavailability estimates and underlines the need for further research to facilitate the process of deriving dietary recommendations in the future...
  12. pmc Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial
    Rachel Hurst
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    Am J Clin Nutr 91:923-31. 2010
    ..Dietary recommendations for selenium differ between countries, mainly because of uncertainties over the definition of optimal selenium status...
  13. ncbi request reprint Iron absorption in male C282Y heterozygotes
    Mark A Roe
    Institute of Food Research, Norwich Research Park, Norwich, United Kingdom
    Am J Clin Nutr 81:814-21. 2005
    ..The suggestion that carriers of the HFE C282Y mutation absorb nonheme iron more efficiently than do carriers of the wild type has public health implications for countries where the C282Y mutation is common and foods are fortified with iron...
  14. doi request reprint EURRECA-Estimating selenium requirements for deriving dietary reference values
    Rachel Hurst
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK
    Crit Rev Food Sci Nutr 53:1077-96. 2013
    ..The main research outputs for selenium and future research priorities are discussed further in this review...
  15. ncbi request reprint Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women
    Linda J Harvey
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Am J Clin Nutr 85:131-6. 2007
    ..Iron supplements are commonly advocated as a prophylactic treatment and are generally taken with meals to reduce side effects, but iron can interfere with the absorption of zinc...
  16. doi request reprint EURRECA-Estimating iron requirements for deriving dietary reference values
    Linda J Harvey
    Norwich Medical School, Norwich Research Park, University of East Anglia, Norwich, United Kingdom
    Crit Rev Food Sci Nutr 53:1064-76. 2013
    ..It will also be essential to include information on polymorphisms that potentially influence iron absorption and status in the derivation process...
  17. pmc Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial
    Andrew J Goldson
    Institute of Food Research, Norwich Research Park, Norwich, United Kingdom
    PLoS ONE 6:e14771. 2011
    ....
  18. doi request reprint Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men
    Mark A Roe
    Institute of Food Research, Norwich, UK
    Am J Clin Nutr 89:1088-91. 2009
    ..Iron absorption is proposed to be regulated by circulating hepcidin, but, to date, little data are available to evaluate this relation in humans...
  19. ncbi request reprint Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women
    Mark A Roe
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Br J Nutr 97:544-9. 2007
    ..Serum prohepcidin is not a useful biomarker for clinical or research purposes...
  20. doi request reprint Methods of assessment of copper status in humans: a systematic review
    Linda J Harvey
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:2009S-2024S. 2009
    ..The assessment of dietary adequacy of copper is constrained by the absence of recognized copper status biomarkers...
  21. ncbi request reprint Iron nutrition in the UK: getting the balance right
    Susan J Fairweather-Tait
    Institute of Food Research, Norwich, UK
    Proc Nutr Soc 63:519-28. 2004
    ..Current information suggests that in the UK Fe deficiency is a greater problem than Fe overload...
  22. ncbi request reprint Effect of iron intake on iron status: a systematic review and meta-analysis of randomized controlled trials
    Amélie Casgrain
    Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 96:768-80. 2012
    ..The response of status biomarkers to an increase in iron supply depends on several physiologic and environmental factors, which make it difficult to predict the outcome of an intervention...
  23. doi request reprint Micronutrient bioavailability research priorities
    Amélie Casgrain
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 91:1423S-1429S. 2010
    ..The involvement of all participants in the structured discussions ensured a broad overview of current knowledge, state-of-the-art research, and consideration of priorities for future research...
  24. doi request reprint The absorption of iron from whole diets: a systematic review
    Rachel Collings
    Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom
    Am J Clin Nutr 98:65-81. 2013
    ..Absorption factors are required to convert physiologic requirements for iron into Dietary Reference Values, but the absorption from single meals cannot be used to estimate dietary iron absorption...
  25. ncbi request reprint Dietary patterns and heritability of food choice in a UK female twin cohort
    Birgit Teucher
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Twin Res Hum Genet 10:734-48. 2007
    ..The relatively high heritability of specific dietary components implicates taste perception as a possible target for future genetic studies...
  26. doi request reprint Selenium and prostate cancer: systematic review and meta-analysis
    Rachel Hurst
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom
    Am J Clin Nutr 96:111-22. 2012
    ..Prostate cancer is a growing public health problem. Several human studies have shown a potentially protective effect of selenium, but the conclusions from published reports are inconsistent...
  27. ncbi request reprint Calcium bioavailability in relation to bone health
    Susan J Fairweather-Tait
    Institute of Food Research, Norwich Research Park, Colney, Norwich, Norfolk, NR4 7UA, UK
    Int J Vitam Nutr Res 72:13-8. 2002
    ..Further research is required to quantify the effects of major dietary modulators of calcium balance on bone health and to understand their relationship with genetic and physiological variables...
  28. doi request reprint Evidence for an enhancing effect of alginate on iron availability in Caco-2 cells
    Anna A Wawer
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Agric Food Chem 60:11318-22. 2012
    ..5% alginate. Alginate beads delivered available iron to Caco-2 cells, indicating that they are a promising vehicle for soluble iron with potential use in food fortification programs...
  29. ncbi request reprint Inhibitory effect of calcium on non-heme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes
    Ben A V Thompson
    School of Medicine, University of East Anglia, Norwich NR4 7TJ, UK
    J Agric Food Chem 58:8414-7. 2010
    ..No change was seen in ferroportin expression. Our data suggest that calcium reduces iron bioavailability by decreasing DMT-1 expression at the apical cell membrane, thereby downregulating iron transport into the cell...
  30. pmc The contribution of diet and genotype to iron status in women: a classical twin study
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    PLoS ONE 8:e83047. 2013
    ..Measured single nucleotide polymorphisms explained 5% and selected dietary factors 6% of the variance in iron status; there was a negative association between calcium intake and body iron (p = 0.02) and SF (p = 0.04). ..
  31. doi request reprint Assessing potential biomarkers of micronutrient status by using a systematic review methodology: methods
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:1953S-1959S. 2009
    ..To explore the relation between micronutrient status and health, it is important to understand which markers of micronutrient status can be relied on and under what circumstances...
  32. ncbi request reprint Relative bioavailability of micronized, dispersible ferric pyrophosphate added to an apple juice drink
    Mark A Roe
    Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    Eur J Nutr 48:115-9. 2009
    ..A micronized dispersible ferric pyrophosphate, trademarked as SunActive Fe, has recently been developed. SunActive Fe has a small particle size, is water soluble and may be suitable for fortifying liquid products...
  33. pmc Soil-type influences human selenium status and underlies widespread selenium deficiency risks in Malawi
    Rachel Hurst
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK
    Sci Rep 3:1425. 2013
    ....
  34. ncbi request reprint Calcium absorption is not increased by caseinophosphopeptides
    Birgit Teucher
    Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 84:162-6. 2006
    ..This possibility is based on the assumption that they resist proteolysis in the upper gastrointestinal tract and maintain calcium in a soluble form at alkaline pH in the distal ileum...
  35. doi request reprint Development of a modified Caco-2 cell model system for studying iron availability in eggs
    Ben Thompson
    School of Medicine, University of East Anglia, Norwich, United Kingdom
    J Agric Food Chem 58:3833-9. 2010
    ..0012 and p = 9.2 x 10(-10), respectively); the enhancing effect of salad was greater than orange juice (p = 0.028). These results suggest that the iron in eggs will be more readily absorbed when consumed with foods high in ascorbic acid...
  36. ncbi request reprint Use of mathematical modeling to study copper metabolism in humans
    Linda J Harvey
    Institute of Food Research, Norwich Research Park, Norwich, United Kingdom
    Am J Clin Nutr 81:807-13. 2005
    ..An improved understanding of copper metabolism is needed to derive more precise estimates of dietary requirements...
  37. ncbi request reprint Clinical implications of changes in the modern diet: iron intake, absorption and status
    Anne Louise M Heath
    Nutrition and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
    Best Pract Res Clin Haematol 15:225-41. 2002
    ....
  38. ncbi request reprint Water-loss dehydration and aging
    Lee Hooper
    Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, Norfolk, UK Electronic address
    Mech Ageing Dev 136:50-8. 2014
    ..Research needs are discussed, some of which will be addressed by the FP7-funded NU-AGE (New dietary strategies addressing the specific needs of elderly population for a healthy ageing in Europe) trial. ..
  39. doi request reprint Se-methylselenocysteine alters collagen gene and protein expression in human prostate cells
    Rachel Hurst
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk NR4 7TJ, UK
    Cancer Lett 269:117-26. 2008
    ..This study reveals for the first time that MSC can alter the expression of several types of collagen and thus potentially modulate the extracellular matrix and stroma, which may at least partially explain the anti-cancer activity of MSC...
  40. ncbi request reprint Iron solubility compared with in vitro digestion-Caco-2 cell culture method for the assessment of iron bioavailability in a processed and unprocessed complementary food for Tanzanian infants (6-12 months)
    Ilse Pynaert
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Br J Nutr 95:721-6. 2006
    ..These data clearly demonstrate that the Fe solubility test was not a good indicator of Fe bioavailability in these particular food matrices. In contrast, the results of an in vitro Caco-2 model supported the effects observed in vivo...
  41. ncbi request reprint The usefulness of elemental iron for cereal flour fortification: a SUSTAIN Task Force report. Sharing United States Technology to Aid in the Improvement of Nutrition
    Richard Hurrell
    Swiss Federal Institute of Technology, Zurich, Switzerland
    Nutr Rev 60:391-406. 2002
    ..Because it is only approximately half as well absorbed as ferrous sulfate, it should be added to provide double the amount of iron...
  42. ncbi request reprint Absorption of calcium from milks enriched with fructo-oligosaccharides, caseinophosphopeptides, tricalcium phosphate, and milk solids
    Eduardo Lopez-Huertas
    Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 83:310-6. 2006
    ..Adequate intakes of calcium are required for optimal bone health and protection against chronic disease. Dairy products are an excellent source of calcium...
  43. ncbi request reprint Risk of iron overload in carriers of genetic mutations associated with hereditary haemochromatosis: UK Food Standards Agency workshop
    Mamta Singh
    Food Standards Agency, Aviation House, London WC2B 6NH, UK
    Br J Nutr 96:770-3. 2006
    ..The workshop concluded that individuals who are heterozygous for the C282Y mutation of the HFE gene do not appear to respond abnormally to dietary Fe and therefore do not need to change their diet to prevent accumulation of body Fe...