Research Topics
Species | Barry J EverittSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Reconsolidation and extinction of conditioned fear: inhibition and potentiationJonathan L C Lee
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 26:10051-6. 2006..These results have important implications for the use of reconsolidation blockade and potentiation of extinction as treatment strategies for maladaptive memory disorders...- The orbital prefrontal cortex and drug addiction in laboratory animals and humansBarry J Everitt
Behavioural and Clinical Neuroscience and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
Ann N Y Acad Sci 1121:576-97. 2007.... 
Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addictionBarry J Everitt
Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, UK
Philos Trans R Soc Lond B Biol Sci 363:3125-35. 2008....- Neural systems of reinforcement for drug addiction: from actions to habits to compulsionBarry J Everitt
Department of Experimental Psychology and the MRC Wellcome Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Nat Neurosci 8:1481-9. 2005..These neural transitions may themselves depend on the neuroplasticity in both cortical and striatal structures that is induced by chronic self-administration of drugs... 
Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioningRutsuko Ito
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 28:6950-9. 2008....- Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbensDaina Economidou
Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 37:2057-66. 2012.... - The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learningSietse Jonkman
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
Behav Neurosci 123:875-85. 2009..However, inactivation of the prelimbic cortex increased responding, suggesting that the prelimbic cortex mediates a form of inhibitory response control... - Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcementJeffrey W Dalley
Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Science 315:1267-70. 2007..These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences... - Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatumDavid Belin
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
Neuron 57:432-41. 2008.... - Compulsive drug seeking by rats under punishment: effects of drug taking historyYann Pelloux
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Psychopharmacology (Berl) 194:127-37. 2007..Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences... - Conditioned activity and instrumental reinforcement following long-term oral consumption of cocaine by ratsFelicity J Miles
Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
Behav Neurosci 118:1331-9. 2004..By contrast, chronic cocaine preexposure enhanced instrumental responding for both cocaine-sucrose and pure sucrose solutions. These results support the idea that long-term cocaine exposure enhances subsequent reinforcement... - The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidationFlorence R M Theberge
Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
Learn Mem 17:444-53. 2010..However reconsolidation of memory representations formed during Pavlovian conditioning are differentially localized in each site... - Attentional and motivational deficits in rats withdrawn from intravenous self-administration of cocaine or heroinJeffrey W Dalley
MRC Centre for Behavioural and Clinical Neuroscience, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Psychopharmacology (Berl) 182:579-87. 2005..Identifying the long-term neurocognitive sequelae of drug addiction may have important implications for understanding the compulsive, chronically relapsing nature of this brain disorder... - Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcerPatricia Di Ciano
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 33:1413-25. 2008..These results are discussed with reference to the neural systems involved in different aspects of responding maintained by drug-paired conditioned reinforcers... - Reduced forebrain serotonin transmission is causally involved in the development of compulsive cocaine seeking in ratsYann Pelloux
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 37:2505-14. 2012..These results indicate the causal involvement of reduced serotoninergic transmission in the emergence of compulsive drug seeking after a long cocaine-taking history... - D-cycloserine potentiates the reconsolidation of cocaine-associated memoriesJonathan L C Lee
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom
Learn Mem 16:82-5. 2009..This elevation of cocaine seeking was correlated with an increase in the expression of the reconsolidation-associated gene zif268... - High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinenceDaina Economidou
Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge CB2 3EB, United Kingdom
Biol Psychiatry 65:851-6. 2009..Relapse is a hallmark feature of cocaine addiction and a main challenge for treatment strategies. Human studies indicate a link between impulsivity and increased susceptibility to relapse... - High impulsivity predicts the switch to compulsive cocaine-takingDavid Belin
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Science 320:1352-5. 2008..This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction... - Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbensMorgane Besson
Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 35:560-9. 2010..Such divergent roles may have relevance for the etiology and treatment of clinical disorders of behavioral control, including attention-deficit hyperactivity disorder and drug addiction... - Reactivation-dependent amnesia for appetitive memories is determined by the contingency of stimulus presentationJonathan L C Lee
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
Learn Mem 15:390-3. 2008..These results have important implications for the potential translational use of glutamatergic treatments in conjunction with targeted memory reactivation... - Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamineJeffrey W Dalley
Department of Experimental Psychology and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 32:1195-206. 2007..The demonstration of residual deficits in rats chronically exposed to MDMA raises some concern about the potential harm caused by this drug in human ecstasy users... - Disrupting reconsolidation of drug memories reduces cocaine-seeking behaviorJonathan L C Lee
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
Neuron 47:795-801. 2005.... - Trait-like impulsivity does not predict escalation of heroin self-administration in the ratRuth McNamara
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Psychopharmacology (Berl) 212:453-64. 2010.... - Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addictionDavid Belin
Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB Cambridge, UK
Behav Brain Res 199:89-102. 2009.... - Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seekingJennifer E Murray
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 37:2456-66. 2012.... - High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in ratsRuth Dilleen
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Psychopharmacology (Berl) 222:89-97. 2012..Although high anxiety is commonly associated with drug addiction, its causal role in this disorder is unclear... - Differential roles of the dorsolateral and midlateral striatum in punished cocaine seekingSietse Jonkman
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 32:4645-50. 2012.... - Appetitive memory reconsolidation depends upon NMDA receptor-mediated neurotransmissionJonathan L C Lee
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Neurobiol Learn Mem 90:147-54. 2008..These results demonstrate that NMDA receptor-mediated signaling is required for appetitive pavlovian memory reconsolidation... - Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedureRutsuko Ito
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Eur J Neurosci 23:3071-80. 2006..Here we provide strong support for the notion that the HPC and BLA subserve complementary and competing roles in appetitive cue and contextual conditioning... - Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in ratsPatricia Di Ciano
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Eur J Neurosci 19:1661-7. 2004..Inactivation of the BLA had no effect on drug-seeking. These results are discussed with reference to critical and distinct contributions of the VTA, NAcc core and BLA to drug-seeking maintained by conditioned reinforcers.. - Post-learning infusion of anisomycin into the anterior cingulate cortex impairs instrumental acquisition through an effect on reinforcer valuationSietse Jonkman
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
Learn Mem 16:706-13. 2009.... - The effects of selective orbitofrontal cortex lesions on the acquisition and performance of cue-controlled cocaine seeking in ratsDaniel M Hutcheson
Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
Ann N Y Acad Sci 1003:410-1. 2003 - The hippocampus and appetitive Pavlovian conditioning: effects of excitotoxic hippocampal lesions on conditioned locomotor activity and autoshapingRutsuko Ito
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB UK
Hippocampus 15:713-21. 2005.... - Induction of the learning and plasticity-associated gene Zif268 following exposure to a discrete cocaine-associated stimulusKerrie L Thomas
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Eur J Neurosci 17:1964-72. 2003.... - Neural and psychological mechanisms underlying appetitive learning: links to drug addictionRudolf N Cardinal
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Curr Opin Neurobiol 14:156-62. 2004..This process may be one of several contributing to addiction, and it may be amenable to pharmacological intervention... - Drug seeking becomes compulsive after prolonged cocaine self-administrationLouk J M J Vanderschuren
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
Science 305:1017-9. 2004.... - Prefrontal cortical-ventral striatal interactions involved in affective modulation of attentional performance: implications for corticostriatal circuit functionAnastasia Christakou
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 24:773-80. 2004..This distinction provides an insight into the functional specialization of corticostriatal circuits in similar behavioral contexts... - Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performanceJeffrey W Dalley
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
Neuropsychopharmacology 30:525-37. 2005..Thus, contingent i.v. amphetamine administration has both short- and long-term consequences, which may be relevant to the complex disturbances that accompany drug addiction... - Differential control over cocaine-seeking behavior by nucleus accumbens core and shellRutsuko Ito
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB1 1BB, UK
Nat Neurosci 7:389-97. 2004..These results further our understanding of how the NAc controls drug-seeking and drug-taking behavior... - Reactivation-dependent amnesia in Pavlovian approach and instrumental transferJonathan L C Lee
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
Learn Mem 15:597-602. 2008.... - Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine-seeking behavior by ratsPatricia Di Ciano
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 24:7167-73. 2004..The results of this study demonstrate an amygdala-nucleus accumbens system that critically underlies stimulus-controlled cocaine seeking and indicate possible neurochemical targets for relapse-prevention medication... - Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drug-seeking behaviorsAmy L Milton
Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
J Neurosci 28:8230-7. 2008..These data suggest that drugs modulating glutamatergic transmission at the NMDA receptor may be useful in the future treatment of relapse prevention in drug addiction through memory reconsolidation blockade... - Conditioned reinforcing properties of stimuli paired with self-administered cocaine, heroin or sucrose: implications for the persistence of addictive behaviourPatricia Di Ciano
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Neuropharmacology 47:202-13. 2004.... - Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memoryAmy L Milton
Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 33:1109-15. 2013..These data demonstrate that glutamatergic signaling mechanisms within the basolateral amygdala differentially and dissociably mediate the retrieval, destabilization, and restabilization of previously consolidated fear memories... - Inhibition of opioid transmission at the μ-opioid receptor prevents both food seeking and binge-like eatingChiara Giuliano
Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 37:2643-52. 2012.... - The role of contextual conditioning in the effect of reinforcer devaluation on instrumental performance by ratsSietse Jonkman
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, United Kingdom
Behav Processes 83:276-81. 2010.... - Modelling human drug abuse and addiction with dedicated small animal positron emission tomographyJeffrey W Dalley
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Neuropharmacology 56:9-17. 2009.... - Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on {beta}-adrenergic receptorsAmy L Milton
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
Learn Mem 15:88-92. 2008.... - Involvement of the dorsal striatum in cue-controlled cocaine seekingLouk J M J Vanderschuren
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 25:8665-70. 2005..In addition, given the importance of the dorsal striatum in stimulus-response habit learning, these data suggest that the habitual or compulsive quality of persistent drug seeking depends on dorsal striatal mechanisms... - Disrupting reconsolidation of conditioned withdrawal memories in the basolateral amygdala reduces suppression of heroin seeking in ratsKim G C Hellemans
Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
J Neurosci 26:12694-9. 2006..These results demonstrate that drug withdrawal memories undergo protein synthesis-dependent reconsolidation in the BLA and suggest a common mechanism for the reconsolidation of both appetitive and aversive drug memories... - Impulsivity, compulsivity, and top-down cognitive controlJeffrey W Dalley
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
Neuron 69:680-94. 2011..These results indicate that the vulnerability to stimulant addiction may depend on an impulsivity endophenotype. Implications of these findings for the etiology, development, and treatment of drug addiction are considered... - Prolonged neglect following unilateral disruption of a prefrontal cortical-dorsal striatal systemAnastasia Christakou
Department of Experimental Psychology, University of Cambridge, CB2 3EB, UK
Eur J Neurosci 21:782-92. 2005.... - Dorsal and ventral striatal protein synthesis inhibition affect reinforcer valuation but not the consolidation of instrumental learningSietse Jonkman
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
Learn Mem 18:617-24. 2011..The anisomycin infusions induced an aversive state, but did not affect instrumental acquisition... - Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learningBarry J Everitt
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
Ann N Y Acad Sci 985:233-50. 2003.... - Limbic corticostriatal systems and delayed reinforcementRudolf N Cardinal
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Ann N Y Acad Sci 1021:33-50. 2004.... - High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stressAnna C Molander
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Psychopharmacology (Berl) 215:721-31. 2011..However, inter-relationships between impulsivity, novelty seeking and anxiety traits are poorly understood... - Neuropsychopharmacology of drug seeking: Insights from studies with second-order schedules of drug reinforcementPatricia Di Ciano
Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, UK
Eur J Pharmacol 526:186-98. 2005.... - Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in ratsRudolf N Cardinal
Department of Experimental Psychology, University of Cambridge, United Kingdom
Behav Neurosci 116:553-67. 2002..CeA lesions had no effect on performance. Thus, the CeA is required for learning, but not expression, of a conditioned approach response, implying that it makes a specific contribution to the learning of stimulus-reward associations... - Selective norepinephrine reuptake inhibition by atomoxetine prevents cue-induced heroin and cocaine seekingDaina Economidou
Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Addenbrooke s Hospital, United Kingdom
Biol Psychiatry 69:266-74. 2011..Here, we investigated further the effects of ATO on cue-maintained heroin and cocaine seeking and relapse and compared these effects with those of the anti-impulsivity stimulant drug methylphenidate (MPH)... - Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidationJonathan L C Lee
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 26:5881-7. 2006..Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction... - Drug intake is sufficient, but conditioning is not necessary for the emergence of compulsive cocaine seeking after extended self-administrationSietse Jonkman
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 37:1612-9. 2012..The results show that extended drug intake alone is sufficient, but extended conditioning in the test context is not necessary for the emergence of compulsive cocaine seeking, resolving a fundamental question in addiction research... - The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatmentsAmy L Milton
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
Neurosci Biobehav Rev 36:1119-39. 2012..Understanding the psychological, neurobiological and molecular basis of these drug memories may produce new methods of pro-abstinence, anti-relapse treatments for addiction... - Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in ratsRudolf N Cardinal
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
Behav Neurosci 117:566-87. 2003..It is suggested that the ACC is not critical for stimulus-reward learning per se, but is required to discriminate multiple stimuli on the basis of their association with reward... - Differential control over drug-seeking behavior by drug-associated conditioned reinforcers and discriminative stimuli predictive of drug availabilityPatricia Di Ciano
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, England, UK
Behav Neurosci 117:952-60. 2003..These results suggest that drug-seeking behavior can be influenced differentially by CSs and that conditioned reinforcers are especially important for maintaining prolonged sequences of drug-seeking behavior... - Lesions of the orbitofrontal but not medial prefrontal cortex disrupt conditioned reinforcement in primatesAndrew Pears
Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, United Kingdom
J Neurosci 23:11189-201. 2003..Together, these findings demonstrate the critical and specific involvement of the orbitofrontal cortex but not the medial PFC in conditioned reinforcement... - Dopamine receptors in the learning, memory and drug reward circuitryJeffrey W Dalley
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Semin Cell Dev Biol 20:403-10. 2009.... - Conditioned suppression and freezing as measures of aversive Pavlovian conditioning: effects of discrete amygdala lesions and overtrainingJonathan L C Lee
Department of Experimental Psychology, MRC Centre for Behavioural and Clinical Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Behav Brain Res 159:221-33. 2005.... - Independent cellular processes for hippocampal memory consolidation and reconsolidationJonathan L C Lee
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Science 304:839-43. 2004..These findings confirm a requirement for BDNF specifically in memory consolidation and also resolve the role of Zif268 in brain plasticity, learning, and memory... - Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cueRutsuko Ito
Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
J Neurosci 22:6247-53. 2002..These data indicate a possible involvement of the dopaminergic innervation of the dorsal striatum in well established, or habitual, cocaine-seeking behavior... - Cellular imaging with zif268 expression in the rat nucleus accumbens and frontal cortex further dissociates the neural pathways activated following the retrieval of contextual and cued fear memoryKerrie L Thomas
Department of Experimental Psychology, University of Cambridge, Downing Site, Tennis Court Road, Cambridge, CB2 3EB, UK
Eur J Neurosci 16:1789-96. 2002..Moreover, the expression of zif268 may contribute to plasticity and reconsolidation of fear memory in these dissociable pathways... - Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): an anterograde and retrograde tract-tracing studyAngela C Roberts
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
J Comp Neurol 502:86-112. 2007..In addition it had extensive connections with limbic regions including the amygdala, parahippocampal cortex, cingulate, and retrosplenial cortex... - Oral cocaine seeking by rats: action or habit?Felicity J Miles
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, England, UK
Behav Neurosci 117:927-38. 2003..By contrast, performance of the cocaine-sucrose response was unaffected by whether the cocaine-sucrose or the lemon-sucrose solution had been devalued... - Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortexRudolf N Cardinal
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Neurosci Biobehav Rev 26:321-52. 2002.... - Motivational control of heroin seeking by conditioned stimuli associated with withdrawal and heroin taking by ratsKim G C Hellemans
Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
Behav Neurosci 120:103-14. 2006..The authors conclude that the conditioned motivation of drug seeking in withdrawal depends on previous association of the CS with drug taking... - Psychomotor stimulant addiction: a neural systems perspectiveBarry J Everitt
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
J Neurosci 22:3312-20. 2002 - Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in ratsBoyer D Winters
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Eur J Neurosci 19:490-6. 2004.... - The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addictionAmy L Milton
Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Eur J Neurosci 31:2308-19. 2010..We also discuss here the subsequent translation to the clinic of this preclinical work... - The GABA(B) receptor agonist baclofen attenuates cocaine- and heroin-seeking behavior by ratsPatricia Di Ciano
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Neuropsychopharmacology 28:510-8. 2003..These results therefore support preliminary clinical findings and suggest that drugs with GABA(B) receptor agonist properties may aid abstinence in human drug addicts by decreasing the propensity to cue-induced drug-seeking and relapse... - Behavioral and neural mechanisms of compulsive drug seekingLouk J M J Vanderschuren
Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, The Netherlands
Eur J Pharmacol 526:77-88. 2005..Furthermore, we will try to put these studies in a theoretical perspective, and discuss the hypothesized underlying neural and behavioral mechanisms... - Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-APatricia Di Ciano
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 28:329-38. 2003.... - Local analysis of behaviour in the adjusting-delay task for assessing choice of delayed reinforcementRudolf N Cardinal
Department of Experimental Psychology University of Cambridge, UK
Neural Netw 15:617-34. 2002..Consequently, the use of explicit analysis of delay sensitivity is advocated in future research on delayed reinforcement...