Barry J Everitt

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Reconsolidation and extinction of conditioned fear: inhibition and potentiation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:10051-6. 2006
  2. ncbi request reprint From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
    Barry J Everitt
    Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK Electronic address
    Neurosci Biobehav Rev 37:1946-54. 2013
  3. ncbi request reprint Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
    Barry J Everitt
    Department of Experimental Psychology and the MRC Wellcome Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Nat Neurosci 8:1481-9. 2005
  4. pmc Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
    Barry J Everitt
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3125-35. 2008
  5. ncbi request reprint The orbital prefrontal cortex and drug addiction in laboratory animals and humans
    Barry J Everitt
    Behavioural and Clinical Neuroscience and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1121:576-97. 2007
  6. pmc Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 38:1963-73. 2013
  7. pmc Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:6950-9. 2008
  8. pmc Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbens
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 37:2057-66. 2012
  9. ncbi request reprint The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Behav Neurosci 123:875-85. 2009
  10. pmc Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome
    Daniele Caprioli
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 38:1460-71. 2013

Detail Information

Publications86

  1. ncbi request reprint Reconsolidation and extinction of conditioned fear: inhibition and potentiation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:10051-6. 2006
    ..These results have important implications for the use of reconsolidation blockade and potentiation of extinction as treatment strategies for maladaptive memory disorders...
  2. ncbi request reprint From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
    Barry J Everitt
    Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK Electronic address
    Neurosci Biobehav Rev 37:1946-54. 2013
    ..We further discuss aspects of the vulnerability to compulsive drug use and in particular the impact of impulsivity. In writing this review we acknowledge the untimely death of an outstanding scientist and a dear personal friend. ..
  3. ncbi request reprint Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
    Barry J Everitt
    Department of Experimental Psychology and the MRC Wellcome Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Nat Neurosci 8:1481-9. 2005
    ..These neural transitions may themselves depend on the neuroplasticity in both cortical and striatal structures that is induced by chronic self-administration of drugs...
  4. pmc Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
    Barry J Everitt
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3125-35. 2008
    ....
  5. ncbi request reprint The orbital prefrontal cortex and drug addiction in laboratory animals and humans
    Barry J Everitt
    Behavioural and Clinical Neuroscience and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1121:576-97. 2007
    ....
  6. pmc Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 38:1963-73. 2013
    ..These findings implicate novel markers underlying the vulnerability of impulsive rats to cocaine addiction that localize to the OFC, infralimbic cortex, and striatum...
  7. pmc Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:6950-9. 2008
    ....
  8. pmc Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbens
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 37:2057-66. 2012
    ....
  9. ncbi request reprint The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Behav Neurosci 123:875-85. 2009
    ..However, inactivation of the prelimbic cortex increased responding, suggesting that the prelimbic cortex mediates a form of inhibitory response control...
  10. pmc Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome
    Daniele Caprioli
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 38:1460-71. 2013
    ..A similar baseline-dependent mechanism may account for the therapeutic effects of stimulant drugs in clinical disorders such as ADHD...
  11. ncbi request reprint Compulsive drug seeking by rats under punishment: effects of drug taking history
    Yann Pelloux
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 194:127-37. 2007
    ..Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences...
  12. pmc The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation
    Florence R M Theberge
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Learn Mem 17:444-53. 2010
    ..However reconsolidation of memory representations formed during Pavlovian conditioning are differentially localized in each site...
  13. doi request reprint Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
    ....
  14. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences...
  15. ncbi request reprint Conditioned activity and instrumental reinforcement following long-term oral consumption of cocaine by rats
    Felicity J Miles
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Behav Neurosci 118:1331-9. 2004
    ..By contrast, chronic cocaine preexposure enhanced instrumental responding for both cocaine-sucrose and pure sucrose solutions. These results support the idea that long-term cocaine exposure enhances subsequent reinforcement...
  16. ncbi request reprint Attentional and motivational deficits in rats withdrawn from intravenous self-administration of cocaine or heroin
    Jeffrey W Dalley
    MRC Centre for Behavioural and Clinical Neuroscience, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 182:579-87. 2005
    ..Identifying the long-term neurocognitive sequelae of drug addiction may have important implications for understanding the compulsive, chronically relapsing nature of this brain disorder...
  17. ncbi request reprint Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcer
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:1413-25. 2008
    ..These results are discussed with reference to the neural systems involved in different aspects of responding maintained by drug-paired conditioned reinforcers...
  18. pmc Reduced forebrain serotonin transmission is causally involved in the development of compulsive cocaine seeking in rats
    Yann Pelloux
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 37:2505-14. 2012
    ..These results indicate the causal involvement of reduced serotoninergic transmission in the emergence of compulsive drug seeking after a long cocaine-taking history...
  19. pmc Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 35:560-9. 2010
    ..Such divergent roles may have relevance for the etiology and treatment of clinical disorders of behavioral control, including attention-deficit hyperactivity disorder and drug addiction...
  20. doi request reprint High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge CB2 3EB, United Kingdom
    Biol Psychiatry 65:851-6. 2009
    ..Relapse is a hallmark feature of cocaine addiction and a main challenge for treatment strategies. Human studies indicate a link between impulsivity and increased susceptibility to relapse...
  21. pmc D-cycloserine potentiates the reconsolidation of cocaine-associated memories
    Jonathan L C Lee
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom
    Learn Mem 16:82-5. 2009
    ..This elevation of cocaine seeking was correlated with an increase in the expression of the reconsolidation-associated gene zif268...
  22. ncbi request reprint Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine
    Jeffrey W Dalley
    Department of Experimental Psychology and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:1195-206. 2007
    ..The demonstration of residual deficits in rats chronically exposed to MDMA raises some concern about the potential harm caused by this drug in human ecstasy users...
  23. doi request reprint Reactivation-dependent amnesia for appetitive memories is determined by the contingency of stimulus presentation
    Jonathan L C Lee
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:390-3. 2008
    ..These results have important implications for the potential translational use of glutamatergic treatments in conjunction with targeted memory reactivation...
  24. pmc High impulsivity predicts the switch to compulsive cocaine-taking
    David Belin
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 320:1352-5. 2008
    ..This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction...
  25. ncbi request reprint Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction
    David Belin
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB Cambridge, UK
    Behav Brain Res 199:89-102. 2009
    ....
  26. ncbi request reprint Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Neuron 47:795-801. 2005
    ....
  27. ncbi request reprint Trait-like impulsivity does not predict escalation of heroin self-administration in the rat
    Ruth McNamara
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 212:453-64. 2010
    ....
  28. pmc Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking
    Jennifer E Murray
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 37:2456-66. 2012
    ....
  29. ncbi request reprint High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats
    Ruth Dilleen
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 222:89-97. 2012
    ..Although high anxiety is commonly associated with drug addiction, its causal role in this disorder is unclear...
  30. doi request reprint Differential roles of the dorsolateral and midlateral striatum in punished cocaine seeking
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 32:4645-50. 2012
    ....
  31. pmc Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedure
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Eur J Neurosci 23:3071-80. 2006
    ..Here we provide strong support for the notion that the HPC and BLA subserve complementary and competing roles in appetitive cue and contextual conditioning...
  32. ncbi request reprint Appetitive memory reconsolidation depends upon NMDA receptor-mediated neurotransmission
    Jonathan L C Lee
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurobiol Learn Mem 90:147-54. 2008
    ..These results demonstrate that NMDA receptor-mediated signaling is required for appetitive pavlovian memory reconsolidation...
  33. ncbi request reprint Induction of the learning and plasticity-associated gene Zif268 following exposure to a discrete cocaine-associated stimulus
    Kerrie L Thomas
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Eur J Neurosci 17:1964-72. 2003
    ....
  34. ncbi request reprint The effects of selective orbitofrontal cortex lesions on the acquisition and performance of cue-controlled cocaine seeking in rats
    Daniel M Hutcheson
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Ann N Y Acad Sci 1003:410-1. 2003
  35. ncbi request reprint The hippocampus and appetitive Pavlovian conditioning: effects of excitotoxic hippocampal lesions on conditioned locomotor activity and autoshaping
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB UK
    Hippocampus 15:713-21. 2005
    ....
  36. ncbi request reprint Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Eur J Neurosci 19:1661-7. 2004
    ..Inactivation of the BLA had no effect on drug-seeking. These results are discussed with reference to critical and distinct contributions of the VTA, NAcc core and BLA to drug-seeking maintained by conditioned reinforcers..
  37. pmc Post-learning infusion of anisomycin into the anterior cingulate cortex impairs instrumental acquisition through an effect on reinforcer valuation
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Learn Mem 16:706-13. 2009
    ....
  38. ncbi request reprint Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
    ....
  39. ncbi request reprint Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine-seeking behavior by rats
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:7167-73. 2004
    ..The results of this study demonstrate an amygdala-nucleus accumbens system that critically underlies stimulus-controlled cocaine seeking and indicate possible neurochemical targets for relapse-prevention medication...
  40. ncbi request reprint Neural and psychological mechanisms underlying appetitive learning: links to drug addiction
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Curr Opin Neurobiol 14:156-62. 2004
    ..This process may be one of several contributing to addiction, and it may be amenable to pharmacological intervention...
  41. ncbi request reprint Prefrontal cortical-ventral striatal interactions involved in affective modulation of attentional performance: implications for corticostriatal circuit function
    Anastasia Christakou
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:773-80. 2004
    ..This distinction provides an insight into the functional specialization of corticostriatal circuits in similar behavioral contexts...
  42. ncbi request reprint Conditioned reinforcing properties of stimuli paired with self-administered cocaine, heroin or sucrose: implications for the persistence of addictive behaviour
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neuropharmacology 47:202-13. 2004
    ....
  43. ncbi request reprint Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB1 1BB, UK
    Nat Neurosci 7:389-97. 2004
    ..These results further our understanding of how the NAc controls drug-seeking and drug-taking behavior...
  44. ncbi request reprint Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performance
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Neuropsychopharmacology 30:525-37. 2005
    ..Thus, contingent i.v. amphetamine administration has both short- and long-term consequences, which may be relevant to the complex disturbances that accompany drug addiction...
  45. pmc Reactivation-dependent amnesia in Pavlovian approach and instrumental transfer
    Jonathan L C Lee
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:597-602. 2008
    ....
  46. ncbi request reprint Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drug-seeking behaviors
    Amy L Milton
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:8230-7. 2008
    ..These data suggest that drugs modulating glutamatergic transmission at the NMDA receptor may be useful in the future treatment of relapse prevention in drug addiction through memory reconsolidation blockade...
  47. pmc Attenuation of cocaine and heroin seeking by μ-opioid receptor antagonism
    Chiara Giuliano
    Behavioral and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 227:137-47. 2013
    ..The μ-opioid receptor antagonist naltrexone (NTX) has been reported to be effective in preventing relapse to alcoholism and in reducing alcohol and cocaine craving during abstinence...
  48. doi request reprint Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 33:1109-15. 2013
    ..These data demonstrate that glutamatergic signaling mechanisms within the basolateral amygdala differentially and dissociably mediate the retrieval, destabilization, and restabilization of previously consolidated fear memories...
  49. pmc Inhibition of opioid transmission at the μ-opioid receptor prevents both food seeking and binge-like eating
    Chiara Giuliano
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 37:2643-52. 2012
    ....
  50. doi request reprint Impulsivity, compulsivity, and top-down cognitive control
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Neuron 69:680-94. 2011
    ..These results indicate that the vulnerability to stimulant addiction may depend on an impulsivity endophenotype. Implications of these findings for the etiology, development, and treatment of drug addiction are considered...
  51. doi request reprint The role of contextual conditioning in the effect of reinforcer devaluation on instrumental performance by rats
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, United Kingdom
    Behav Processes 83:276-81. 2010
    ....
  52. doi request reprint Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on {beta}-adrenergic receptors
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:88-92. 2008
    ....
  53. ncbi request reprint Involvement of the dorsal striatum in cue-controlled cocaine seeking
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:8665-70. 2005
    ..In addition, given the importance of the dorsal striatum in stimulus-response habit learning, these data suggest that the habitual or compulsive quality of persistent drug seeking depends on dorsal striatal mechanisms...
  54. ncbi request reprint Prolonged neglect following unilateral disruption of a prefrontal cortical-dorsal striatal system
    Anastasia Christakou
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, UK
    Eur J Neurosci 21:782-92. 2005
    ....
  55. ncbi request reprint Disrupting reconsolidation of conditioned withdrawal memories in the basolateral amygdala reduces suppression of heroin seeking in rats
    Kim G C Hellemans
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 26:12694-9. 2006
    ..These results demonstrate that drug withdrawal memories undergo protein synthesis-dependent reconsolidation in the BLA and suggest a common mechanism for the reconsolidation of both appetitive and aversive drug memories...
  56. doi request reprint Modelling human drug abuse and addiction with dedicated small animal positron emission tomography
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Neuropharmacology 56:9-17. 2009
    ....
  57. doi request reprint Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex
    Bianca Jupp
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Eur J Neurosci 37:1519-28. 2013
    ..Alterations in binding for D1 receptors in the NAcbC and GABA(A) receptors in the anterior cingulate cortex demonstrate additional markers and putative mechanisms underlying the expression of behavioural impulsivity...
  58. ncbi request reprint Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Behav Neurosci 116:553-67. 2002
    ..CeA lesions had no effect on performance. Thus, the CeA is required for learning, but not expression, of a conditioned approach response, implying that it makes a specific contribution to the learning of stimulus-reward associations...
  59. ncbi request reprint Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learning
    Barry J Everitt
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 985:233-50. 2003
    ....
  60. ncbi request reprint High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress
    Anna C Molander
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 215:721-31. 2011
    ..However, inter-relationships between impulsivity, novelty seeking and anxiety traits are poorly understood...
  61. ncbi request reprint Selective norepinephrine reuptake inhibition by atomoxetine prevents cue-induced heroin and cocaine seeking
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Biol Psychiatry 69:266-74. 2011
    ..Here, we investigated further the effects of ATO on cue-maintained heroin and cocaine seeking and relapse and compared these effects with those of the anti-impulsivity stimulant drug methylphenidate (MPH)...
  62. ncbi request reprint Limbic corticostriatal systems and delayed reinforcement
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1021:33-50. 2004
    ....
  63. pmc Dorsal and ventral striatal protein synthesis inhibition affect reinforcer valuation but not the consolidation of instrumental learning
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    Learn Mem 18:617-24. 2011
    ..The anisomycin infusions induced an aversive state, but did not affect instrumental acquisition...
  64. ncbi request reprint Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:5881-7. 2006
    ..Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction...
  65. ncbi request reprint Neuropsychopharmacology of drug seeking: Insights from studies with second-order schedules of drug reinforcement
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, UK
    Eur J Pharmacol 526:186-98. 2005
    ....
  66. pmc Drug intake is sufficient, but conditioning is not necessary for the emergence of compulsive cocaine seeking after extended self-administration
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 37:1612-9. 2012
    ..The results show that extended drug intake alone is sufficient, but extended conditioning in the test context is not necessary for the emergence of compulsive cocaine seeking, resolving a fundamental question in addiction research...
  67. doi request reprint The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatments
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 36:1119-39. 2012
    ..Understanding the psychological, neurobiological and molecular basis of these drug memories may produce new methods of pro-abstinence, anti-relapse treatments for addiction...
  68. ncbi request reprint Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in rats
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Behav Neurosci 117:566-87. 2003
    ..It is suggested that the ACC is not critical for stimulus-reward learning per se, but is required to discriminate multiple stimuli on the basis of their association with reward...
  69. ncbi request reprint Conditioned suppression and freezing as measures of aversive Pavlovian conditioning: effects of discrete amygdala lesions and overtraining
    Jonathan L C Lee
    Department of Experimental Psychology, MRC Centre for Behavioural and Clinical Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Behav Brain Res 159:221-33. 2005
    ....
  70. ncbi request reprint Differential control over drug-seeking behavior by drug-associated conditioned reinforcers and discriminative stimuli predictive of drug availability
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, England, UK
    Behav Neurosci 117:952-60. 2003
    ..These results suggest that drug-seeking behavior can be influenced differentially by CSs and that conditioned reinforcers are especially important for maintaining prolonged sequences of drug-seeking behavior...
  71. ncbi request reprint Dopamine receptors in the learning, memory and drug reward circuitry
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Semin Cell Dev Biol 20:403-10. 2009
    ....
  72. ncbi request reprint Lesions of the orbitofrontal but not medial prefrontal cortex disrupt conditioned reinforcement in primates
    Andrew Pears
    Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, United Kingdom
    J Neurosci 23:11189-201. 2003
    ..Together, these findings demonstrate the critical and specific involvement of the orbitofrontal cortex but not the medial PFC in conditioned reinforcement...
  73. ncbi request reprint Independent cellular processes for hippocampal memory consolidation and reconsolidation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 304:839-43. 2004
    ..These findings confirm a requirement for BDNF specifically in memory consolidation and also resolve the role of Zif268 in brain plasticity, learning, and memory...
  74. ncbi request reprint Oral cocaine seeking by rats: action or habit?
    Felicity J Miles
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, England, UK
    Behav Neurosci 117:927-38. 2003
    ..By contrast, performance of the cocaine-sucrose response was unaffected by whether the cocaine-sucrose or the lemon-sucrose solution had been devalued...
  75. ncbi request reprint Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 22:6247-53. 2002
    ..These data indicate a possible involvement of the dopaminergic innervation of the dorsal striatum in well established, or habitual, cocaine-seeking behavior...
  76. ncbi request reprint Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): an anterograde and retrograde tract-tracing study
    Angela C Roberts
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    J Comp Neurol 502:86-112. 2007
    ..In addition it had extensive connections with limbic regions including the amygdala, parahippocampal cortex, cingulate, and retrosplenial cortex...
  77. ncbi request reprint Cellular imaging with zif268 expression in the rat nucleus accumbens and frontal cortex further dissociates the neural pathways activated following the retrieval of contextual and cued fear memory
    Kerrie L Thomas
    Department of Experimental Psychology, University of Cambridge, Downing Site, Tennis Court Road, Cambridge, CB2 3EB, UK
    Eur J Neurosci 16:1789-96. 2002
    ..Moreover, the expression of zif268 may contribute to plasticity and reconsolidation of fear memory in these dissociable pathways...
  78. ncbi request reprint Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 26:321-52. 2002
    ....
  79. ncbi request reprint Psychomotor stimulant addiction: a neural systems perspective
    Barry J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:3312-20. 2002
  80. doi request reprint The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction
    Amy L Milton
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Eur J Neurosci 31:2308-19. 2010
    ..We also discuss here the subsequent translation to the clinic of this preclinical work...
  81. ncbi request reprint The GABA(B) receptor agonist baclofen attenuates cocaine- and heroin-seeking behavior by rats
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neuropsychopharmacology 28:510-8. 2003
    ..These results therefore support preliminary clinical findings and suggest that drugs with GABA(B) receptor agonist properties may aid abstinence in human drug addicts by decreasing the propensity to cue-induced drug-seeking and relapse...
  82. ncbi request reprint Motivational control of heroin seeking by conditioned stimuli associated with withdrawal and heroin taking by rats
    Kim G C Hellemans
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Behav Neurosci 120:103-14. 2006
    ..The authors conclude that the conditioned motivation of drug seeking in withdrawal depends on previous association of the CS with drug taking...
  83. ncbi request reprint Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats
    Boyer D Winters
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Eur J Neurosci 19:490-6. 2004
    ....
  84. ncbi request reprint Behavioral and neural mechanisms of compulsive drug seeking
    Louk J M J Vanderschuren
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, The Netherlands
    Eur J Pharmacol 526:77-88. 2005
    ..Furthermore, we will try to put these studies in a theoretical perspective, and discuss the hypothesized underlying neural and behavioral mechanisms...
  85. ncbi request reprint Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 28:329-38. 2003
    ....
  86. ncbi request reprint Local analysis of behaviour in the adjusting-delay task for assessing choice of delayed reinforcement
    Rudolf N Cardinal
    Department of Experimental Psychology University of Cambridge, UK
    Neural Netw 15:617-34. 2002
    ..Consequently, the use of explicit analysis of delay sensitivity is advocated in future research on delayed reinforcement...