B J Everitt

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Ann N Y Acad Sci 877:412-38. 1999
  2. ncbi request reprint The neuropsychological basis of addictive behaviour
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Brain Res Brain Res Rev 36:129-38. 2001
  3. ncbi request reprint Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learning
    Barry J Everitt
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 985:233-50. 2003
  4. ncbi request reprint Psychomotor stimulant addiction: a neural systems perspective
    Barry J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:3312-20. 2002
  5. ncbi request reprint Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 153:17-30. 2000
  6. ncbi request reprint Basal forebrain cholinergic lesions enhance conditioned approach responses to stimuli predictive of food
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 112:611-29. 1998
  7. ncbi request reprint The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement
    D M Hutcheson
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 153:464-72. 2001
  8. ncbi request reprint Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior
    P Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Neuropsychopharmacology 25:341-60. 2001
  9. ncbi request reprint The role of the primate amygdala in conditioned reinforcement
    J A Parkinson
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 21:7770-80. 2001
  10. pmc Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:6950-9. 2008

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, United Kingdom
    Ann N Y Acad Sci 877:412-38. 1999
    ....
  2. ncbi request reprint The neuropsychological basis of addictive behaviour
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Brain Res Brain Res Rev 36:129-38. 2001
    ....
  3. ncbi request reprint Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learning
    Barry J Everitt
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 985:233-50. 2003
    ....
  4. ncbi request reprint Psychomotor stimulant addiction: a neural systems perspective
    Barry J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:3312-20. 2002
  5. ncbi request reprint Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour
    B J Everitt
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 153:17-30. 2000
    ....
  6. ncbi request reprint Basal forebrain cholinergic lesions enhance conditioned approach responses to stimuli predictive of food
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 112:611-29. 1998
    ..Results suggest that NBM lesions may disrupt the balance between cortical and subcortical dopamine levels, and/or produce a deficit in attentional mechanisms that is manifested as increased responding to specific stimuli...
  7. ncbi request reprint The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement
    D M Hutcheson
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 153:464-72. 2001
    ..CONCLUSIONS: These results indicate an important role for the core of the NAcc in the acquisition of heroin-seeking behaviour under the control of drug-associated stimuli...
  8. ncbi request reprint Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior
    P Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Neuropsychopharmacology 25:341-60. 2001
    ..These results indicate that NMDA and AMPA receptor-mediated glutamate transmission in the core and shell are dissociably involved in cocaine-seeking behavior controlled in part by drug-associated cues...
  9. ncbi request reprint The role of the primate amygdala in conditioned reinforcement
    J A Parkinson
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 21:7770-80. 2001
    ....
  10. pmc Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:6950-9. 2008
    ....
  11. ncbi request reprint Cellular imaging of zif268 expression in the hippocampus and amygdala during contextual and cued fear memory retrieval: selective activation of hippocampal CA1 neurons during the recall of contextual memories
    J Hall
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB United Kingdom
    J Neurosci 21:2186-93. 2001
    ....
  12. ncbi request reprint Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    Neuropharmacology 26:893-901. 1987
    ..Various problems of interpretation are discussed and the utility of a comparison of the different patterns of the effects of these lesions of catecholaminergic and cholinergic projections is made clear...
  13. ncbi request reprint Impulsive choice induced in rats by lesions of the nucleus accumbens core
    R N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 292:2499-501. 2001
    ..Thus, dysfunction of the nucleus accumbens core may be a key element in the neuropathology of impulsivity...
  14. ncbi request reprint Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function
    J A Parkinson
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Behav Brain Res 137:149-63. 2002
    ..This difference in lesion-induced impairment implies that mesoaccumbens dopamine may play differential roles in the learning and performance of preparatory Pavlovian conditioning...
  15. ncbi request reprint Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues
    N R Selden
    Department of Experimental Psychology, University of Cambridge, U K
    Neuroscience 42:335-50. 1991
    ..These results suggest a double dissociation of the effects of amygdala and hippocampal damage on fear conditioning to explicit and contextual cues...
  16. ncbi request reprint Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcer
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:1413-25. 2008
    ..These results are discussed with reference to the neural systems involved in different aspects of responding maintained by drug-paired conditioned reinforcers...
  17. ncbi request reprint Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 22:6247-53. 2002
    ..These data indicate a possible involvement of the dopaminergic innervation of the dorsal striatum in well established, or habitual, cocaine-seeking behavior...
  18. ncbi request reprint Conditioned activity and instrumental reinforcement following long-term oral consumption of cocaine by rats
    Felicity J Miles
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Behav Neurosci 118:1331-9. 2004
    ..By contrast, chronic cocaine preexposure enhanced instrumental responding for both cocaine-sucrose and pure sucrose solutions. These results support the idea that long-term cocaine exposure enhances subsequent reinforcement...
  19. ncbi request reprint Drug seeking becomes compulsive after prolonged cocaine self-administration
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 305:1017-9. 2004
    ....
  20. ncbi request reprint Prefrontal cortical-ventral striatal interactions involved in affective modulation of attentional performance: implications for corticostriatal circuit function
    Anastasia Christakou
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:773-80. 2004
    ..This distinction provides an insight into the functional specialization of corticostriatal circuits in similar behavioral contexts...
  21. pmc The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation
    Florence R M Theberge
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Learn Mem 17:444-53. 2010
    ..However reconsolidation of memory representations formed during Pavlovian conditioning are differentially localized in each site...
  22. ncbi request reprint Effects of excitotoxic lesions of the rat prefrontal cortex on CREB regulation and presynaptic markers of dopamine and amino acid function in the nucleus accumbens
    J W Dalley
    Department of Experimental Psychology, University of Cambridge, UK
    Eur J Neurosci 11:1265-74. 1999
    ....
  23. ncbi request reprint The role of withdrawal in heroin addiction: enhances reward or promotes avoidance?
    D M Hutcheson
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Nat Neurosci 4:943-7. 2001
    ..In support of this hypothesis, we show here that previous experience with heroin in withdrawal is necessary for subsequent heroin-seeking behavior to be enhanced when dependent rats once again experience withdrawal...
  24. ncbi request reprint Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior
    P Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 21:9471-7. 2001
    ....
  25. ncbi request reprint Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat
    L S Wilkinson
    The Babraham Institute, Department of Neurobiology, Cambridge, UK
    Eur J Neurosci 10:1019-26. 1998
    ....
  26. doi request reprint Drug addiction and the memory systems of the brain
    T W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Ann N Y Acad Sci 1141:1-21. 2008
    ..Finally, we consider the ancillary point that chronic abuse of many drugs may impact directly on neural memory systems via neuroadaptive and neurotoxic effects that lead to cognitive impairments in which memory dysfunction is prominent...
  27. ncbi request reprint Neurobehavioural mechanisms of reward and motivation
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Curr Opin Neurobiol 6:228-36. 1996
    ..This progress has enabled the dissection of motivational processes into components that can begin to be related to the functioning of specific limbic cortical structures that project to different compartments of the ventral striatum...
  28. pmc Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 35:560-9. 2010
    ..Such divergent roles may have relevance for the etiology and treatment of clinical disorders of behavioral control, including attention-deficit hyperactivity disorder and drug addiction...
  29. pmc D-cycloserine potentiates the reconsolidation of cocaine-associated memories
    Jonathan L C Lee
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom
    Learn Mem 16:82-5. 2009
    ..This elevation of cocaine seeking was correlated with an increase in the expression of the reconsolidation-associated gene zif268...
  30. ncbi request reprint A role for mesencephalic dopamine in activation: commentary on Berridge (2006)
    T W Robbins
    University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 191:433-7. 2007
  31. ncbi request reprint Lesions of the pedunculopontine tegmental nucleus increase sucrose consumption but do not affect discrimination or contrast effects
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 113:732-43. 1999
    ..Somewhat surprisingly, lesions increased sucrose intake when rats were food-restricted. These results suggest that PPTg lesions do not disrupt primary motivation or the ability to evaluate and respond to changes in reward strength...
  32. ncbi request reprint Lesions of the medial and lateral striatum in the rat produce differential deficits in attentional performance
    R D Rogers
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 115:799-811. 2001
    ..These data suggest that the medial and lateral striatum have contrasting roles in the control of instrumental responding related to the primary sources of their cortical innervation...
  33. ncbi request reprint Cocaine-seeking by rats: regulation, reinforcement and activation
    M C Olmstead
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 152:123-31. 2000
    ..In animal models of drug self-administration, response rates often decrease with dose suggesting that a regulative process may mask the reinforcing effects of the drug...
  34. ncbi request reprint Lesions of the orbitofrontal but not medial prefrontal cortex disrupt conditioned reinforcement in primates
    Andrew Pears
    Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, United Kingdom
    J Neurosci 23:11189-201. 2003
    ..Together, these findings demonstrate the critical and specific involvement of the orbitofrontal cortex but not the medial PFC in conditioned reinforcement...
  35. ncbi request reprint Involvement of the central nucleus of the amygdala and nucleus accumbens core in mediating Pavlovian influences on instrumental behaviour
    J Hall
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB. UK
    Eur J Neurosci 13:1984-92. 2001
    ..We suggest that this effect may depend upon the regulation of the dopaminergic innervation of the NAcc core by projections from the CeN to the ventral tegmental area...
  36. ncbi request reprint The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins
    J McGaughy
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, Cambridge, UK
    Behav Brain Res 115:251-63. 2000
    ..Additionally, the conceptual and methodological cost and benefits of the methods of infusion used to produce lesions with these immunotoxins is assessed...
  37. ncbi request reprint Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: locomotion, cocaine self-administration, and prepulse inhibition of startle
    S B Caine
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 115:880-94. 2001
    ....
  38. ncbi request reprint Neural systems underlying arousal and attention. Implications for drug abuse
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Ann N Y Acad Sci 846:222-37. 1998
    ....
  39. ncbi request reprint The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats
    H L Alderson
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 153:455-63. 2001
    ..v. heroin, may mediate processes that are of special importance during the acquisition of instrumental behaviour...
  40. ncbi request reprint Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set
    H S Crofts
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3DY, UK
    Cereb Cortex 11:1015-26. 2001
    ..Frontal catecholamine depletion caused an increase in distractibility while caudate dopamine loss induced greater focusing of responding...
  41. pmc Reactivation-dependent amnesia in Pavlovian approach and instrumental transfer
    Jonathan L C Lee
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:597-602. 2008
    ....
  42. pmc Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedure
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Eur J Neurosci 23:3071-80. 2006
    ..Here we provide strong support for the notion that the HPC and BLA subserve complementary and competing roles in appetitive cue and contextual conditioning...
  43. ncbi request reprint Cognitive enhancers in theory and practice: studies of the cholinergic hypothesis of cognitive deficits in Alzheimer's disease
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, UK
    Behav Brain Res 83:15-23. 1997
    ..The cognitive costs, as well as benefits, of cognitive enhancers are discussed, as well as the need to broaden our therapeutic approach to other neurotransmitter systems and other neurodegenerative disorders...
  44. ncbi request reprint Limbic-cortical-ventral striatal activation during retrieval of a discrete cocaine-associated stimulus: a cellular imaging study with gamma protein kinase C expression
    K L Thomas
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 21:2526-35. 2001
    ....
  45. ncbi request reprint Involvement of the dorsal striatum in cue-controlled cocaine seeking
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:8665-70. 2005
    ..In addition, given the importance of the dorsal striatum in stimulus-response habit learning, these data suggest that the habitual or compulsive quality of persistent drug seeking depends on dorsal striatal mechanisms...
  46. ncbi request reprint Independent cellular processes for hippocampal memory consolidation and reconsolidation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 304:839-43. 2004
    ..These findings confirm a requirement for BDNF specifically in memory consolidation and also resolve the role of Zif268 in brain plasticity, learning, and memory...
  47. ncbi request reprint Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB1 1BB, UK
    Nat Neurosci 7:389-97. 2004
    ..These results further our understanding of how the NAc controls drug-seeking and drug-taking behavior...
  48. ncbi request reprint Acquisition of instrumental conditioned reinforcement is resistant to the devaluation of the unconditioned stimulus
    J A Parkinson
    University of Cambridge, Cambridge, UK
    Q J Exp Psychol B 58:19-30. 2005
    ....
  49. pmc Introduction. The neurobiology of drug addiction: new vistas
    T W Robbins
    Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3109-11. 2008
  50. ncbi request reprint Limbic-striatal memory systems and drug addiction
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Neurobiol Learn Mem 78:625-36. 2002
    ..These systems include separate and overlapping influences from the amygdala, hippocampus, and cingulate and medial prefrontal cortex on drug-seeking as well as drug-taking behavior, including the propensity to relapse...
  51. ncbi request reprint Reinstatement and spontaneous recovery of cocaine-seeking following extinction and different durations of withdrawal
    P Di Ciano
    Department of Experimental Psychology, University of Cambridge, UK
    Behav Pharmacol 13:397-405. 2002
    ....
  52. ncbi request reprint Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function
    A Christakou
    Department of Experimental Psychology, University of Cambridge, England
    Behav Neurosci 115:812-25. 2001
    ....
  53. ncbi request reprint Prolonged neglect following unilateral disruption of a prefrontal cortical-dorsal striatal system
    Anastasia Christakou
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, UK
    Eur J Neurosci 21:782-92. 2005
    ....
  54. ncbi request reprint Limbic corticostriatal systems and delayed reinforcement
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1021:33-50. 2004
    ....
  55. ncbi request reprint Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in rats
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Behav Neurosci 117:566-87. 2003
    ..It is suggested that the ACC is not critical for stimulus-reward learning per se, but is required to discriminate multiple stimuli on the basis of their association with reward...
  56. ncbi request reprint Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 26:321-52. 2002
    ....
  57. ncbi request reprint Disrupting reconsolidation of conditioned withdrawal memories in the basolateral amygdala reduces suppression of heroin seeking in rats
    Kim G C Hellemans
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 26:12694-9. 2006
    ..These results demonstrate that drug withdrawal memories undergo protein synthesis-dependent reconsolidation in the BLA and suggest a common mechanism for the reconsolidation of both appetitive and aversive drug memories...
  58. ncbi request reprint Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala
    S Killcross
    Department of Experimental Psychology, University of Cambridge, UK
    Nature 388:377-80. 1997
    ..We suggest that theories of amygdala function should take into account the roles of discrete amygdala subsystems in controlling different components of integrated emotional responses...
  59. ncbi request reprint Excitotoxic lesions of the mediodorsal thalamic nucleus attenuate intravenous cocaine self-administration
    R Weissenborn
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 140:225-32. 1998
    ....
  60. ncbi request reprint The expression of Huntingtin-associated protein (HAP1) mRNA in developing, adult and ageing rat CNS: implications for Huntington's disease neuropathology
    K J Page
    The MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, UK
    Eur J Neurosci 10:1835-45. 1998
    ..These observations support the suggestion that HAP1 plays an important role in the neuropathology of HD...
  61. ncbi request reprint Perseveration and strategy in a novel spatial self-ordered sequencing task for nonhuman primates: effects of excitotoxic lesions and dopamine depletions of the prefrontal cortex
    P Collins
    University of Cambridge Department of Experimental Psychology Cambridge UK Downing Street CB2 3EB
    J Cogn Neurosci 10:332-54. 1998
    ....
  62. ncbi request reprint Compulsive drug seeking by rats under punishment: effects of drug taking history
    Yann Pelloux
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 194:127-37. 2007
    ..Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences...
  63. doi request reprint Reactivation-dependent amnesia for appetitive memories is determined by the contingency of stimulus presentation
    Jonathan L C Lee
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:390-3. 2008
    ..These results have important implications for the potential translational use of glutamatergic treatments in conjunction with targeted memory reactivation...
  64. ncbi request reprint Appetitive memory reconsolidation depends upon NMDA receptor-mediated neurotransmission
    Jonathan L C Lee
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurobiol Learn Mem 90:147-54. 2008
    ..These results demonstrate that NMDA receptor-mediated signaling is required for appetitive pavlovian memory reconsolidation...
  65. doi request reprint Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
    ....
  66. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences...
  67. doi request reprint Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on {beta}-adrenergic receptors
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:88-92. 2008
    ....
  68. pmc High impulsivity predicts the switch to compulsive cocaine-taking
    David Belin
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 320:1352-5. 2008
    ..This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction...
  69. doi request reprint Modelling human drug abuse and addiction with dedicated small animal positron emission tomography
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Neuropharmacology 56:9-17. 2009
    ....
  70. pmc Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
    Barry J Everitt
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 363:3125-35. 2008
    ....
  71. ncbi request reprint Selective norepinephrine reuptake inhibition by atomoxetine prevents cue-induced heroin and cocaine seeking
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Biol Psychiatry 69:266-74. 2011
    ..Here, we investigated further the effects of ATO on cue-maintained heroin and cocaine seeking and relapse and compared these effects with those of the anti-impulsivity stimulant drug methylphenidate (MPH)...
  72. doi request reprint The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction
    Amy L Milton
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Eur J Neurosci 31:2308-19. 2010
    ..We also discuss here the subsequent translation to the clinic of this preclinical work...
  73. doi request reprint The role of contextual conditioning in the effect of reinforcer devaluation on instrumental performance by rats
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, United Kingdom
    Behav Processes 83:276-81. 2010
    ....
  74. pmc Post-learning infusion of anisomycin into the anterior cingulate cortex impairs instrumental acquisition through an effect on reinforcer valuation
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Learn Mem 16:706-13. 2009
    ....
  75. ncbi request reprint The rat prelimbic cortex mediates inhibitory response control but not the consolidation of instrumental learning
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Behav Neurosci 123:875-85. 2009
    ..However, inactivation of the prelimbic cortex increased responding, suggesting that the prelimbic cortex mediates a form of inhibitory response control...
  76. doi request reprint High impulsivity predicts relapse to cocaine-seeking after punishment-induced abstinence
    Daina Economidou
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing St, Cambridge CB2 3EB, United Kingdom
    Biol Psychiatry 65:851-6. 2009
    ..Relapse is a hallmark feature of cocaine addiction and a main challenge for treatment strategies. Human studies indicate a link between impulsivity and increased susceptibility to relapse...
  77. ncbi request reprint Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction
    David Belin
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB Cambridge, UK
    Behav Brain Res 199:89-102. 2009
    ....
  78. ncbi request reprint Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drug-seeking behaviors
    Amy L Milton
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:8230-7. 2008
    ..These data suggest that drugs modulating glutamatergic transmission at the NMDA receptor may be useful in the future treatment of relapse prevention in drug addiction through memory reconsolidation blockade...
  79. ncbi request reprint Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): an anterograde and retrograde tract-tracing study
    Angela C Roberts
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    J Comp Neurol 502:86-112. 2007
    ..In addition it had extensive connections with limbic regions including the amygdala, parahippocampal cortex, cingulate, and retrosplenial cortex...
  80. ncbi request reprint Enduring deficits in sustained visual attention during withdrawal of intravenous methylenedioxymethamphetamine self-administration in rats: results from a comparative study with d-amphetamine and methamphetamine
    Jeffrey W Dalley
    Department of Experimental Psychology and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:1195-206. 2007
    ..The demonstration of residual deficits in rats chronically exposed to MDMA raises some concern about the potential harm caused by this drug in human ecstasy users...
  81. ncbi request reprint Dopamine receptors in the learning, memory and drug reward circuitry
    Jeffrey W Dalley
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Semin Cell Dev Biol 20:403-10. 2009
    ....
  82. ncbi request reprint Oral cocaine seeking by rats: action or habit?
    Felicity J Miles
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, England, UK
    Behav Neurosci 117:927-38. 2003
    ..By contrast, performance of the cocaine-sucrose response was unaffected by whether the cocaine-sucrose or the lemon-sucrose solution had been devalued...
  83. ncbi request reprint The effects of selective orbitofrontal cortex lesions on the acquisition and performance of cue-controlled cocaine seeking in rats
    Daniel M Hutcheson
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Ann N Y Acad Sci 1003:410-1. 2003
  84. ncbi request reprint Cellular imaging with zif268 expression in the rat nucleus accumbens and frontal cortex further dissociates the neural pathways activated following the retrieval of contextual and cued fear memory
    Kerrie L Thomas
    Department of Experimental Psychology, University of Cambridge, Downing Site, Tennis Court Road, Cambridge, CB2 3EB, UK
    Eur J Neurosci 16:1789-96. 2002
    ..Moreover, the expression of zif268 may contribute to plasticity and reconsolidation of fear memory in these dissociable pathways...
  85. ncbi request reprint Conditioned suppression and freezing as measures of aversive Pavlovian conditioning: effects of discrete amygdala lesions and overtraining
    Jonathan L C Lee
    Department of Experimental Psychology, MRC Centre for Behavioural and Clinical Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Behav Brain Res 159:221-33. 2005
    ....
  86. ncbi request reprint Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats
    Boyer D Winters
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Eur J Neurosci 19:490-6. 2004
    ....
  87. ncbi request reprint Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performance
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Neuropsychopharmacology 30:525-37. 2005
    ..Thus, contingent i.v. amphetamine administration has both short- and long-term consequences, which may be relevant to the complex disturbances that accompany drug addiction...
  88. ncbi request reprint The GABA(B) receptor agonist baclofen attenuates cocaine- and heroin-seeking behavior by rats
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neuropsychopharmacology 28:510-8. 2003
    ..These results therefore support preliminary clinical findings and suggest that drugs with GABA(B) receptor agonist properties may aid abstinence in human drug addicts by decreasing the propensity to cue-induced drug-seeking and relapse...
  89. ncbi request reprint Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine-seeking behavior by rats
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:7167-73. 2004
    ..The results of this study demonstrate an amygdala-nucleus accumbens system that critically underlies stimulus-controlled cocaine seeking and indicate possible neurochemical targets for relapse-prevention medication...
  90. ncbi request reprint Neural and psychological mechanisms underlying appetitive learning: links to drug addiction
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Curr Opin Neurobiol 14:156-62. 2004
    ..This process may be one of several contributing to addiction, and it may be amenable to pharmacological intervention...
  91. ncbi request reprint Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Eur J Neurosci 19:1661-7. 2004
    ..Inactivation of the BLA had no effect on drug-seeking. These results are discussed with reference to critical and distinct contributions of the VTA, NAcc core and BLA to drug-seeking maintained by conditioned reinforcers..
  92. ncbi request reprint The hippocampus and appetitive Pavlovian conditioning: effects of excitotoxic hippocampal lesions on conditioned locomotor activity and autoshaping
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB UK
    Hippocampus 15:713-21. 2005
    ....
  93. ncbi request reprint Attentional and motivational deficits in rats withdrawn from intravenous self-administration of cocaine or heroin
    Jeffrey W Dalley
    MRC Centre for Behavioural and Clinical Neuroscience, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 182:579-87. 2005
    ..Identifying the long-term neurocognitive sequelae of drug addiction may have important implications for understanding the compulsive, chronically relapsing nature of this brain disorder...
  94. ncbi request reprint Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:5881-7. 2006
    ..Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction...
  95. ncbi request reprint Motivational control of heroin seeking by conditioned stimuli associated with withdrawal and heroin taking by rats
    Kim G C Hellemans
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Behav Neurosci 120:103-14. 2006
    ..The authors conclude that the conditioned motivation of drug seeking in withdrawal depends on previous association of the CS with drug taking...
  96. ncbi request reprint Neuropsychopharmacology of drug seeking: Insights from studies with second-order schedules of drug reinforcement
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3EB, UK
    Eur J Pharmacol 526:186-98. 2005
    ....
  97. ncbi request reprint Conditioned reinforcing properties of stimuli paired with self-administered cocaine, heroin or sucrose: implications for the persistence of addictive behaviour
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neuropharmacology 47:202-13. 2004
    ....
  98. ncbi request reprint Differential control over drug-seeking behavior by drug-associated conditioned reinforcers and discriminative stimuli predictive of drug availability
    Patricia Di Ciano
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, England, UK
    Behav Neurosci 117:952-60. 2003
    ..These results suggest that drug-seeking behavior can be influenced differentially by CSs and that conditioned reinforcers are especially important for maintaining prolonged sequences of drug-seeking behavior...
  99. ncbi request reprint The orbital prefrontal cortex and drug addiction in laboratory animals and humans
    Barry J Everitt
    Behavioural and Clinical Neuroscience and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1121:576-97. 2007
    ....
  100. ncbi request reprint Induction of the learning and plasticity-associated gene Zif268 following exposure to a discrete cocaine-associated stimulus
    Kerrie L Thomas
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Eur J Neurosci 17:1964-72. 2003
    ....
  101. ncbi request reprint Disrupting reconsolidation of drug memories reduces cocaine-seeking behavior
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Neuron 47:795-801. 2005
    ....