Ian M Evans

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
    Ian M Evans
    Department of Medicine, Centre for Cardiovascular Biology and Medicine, The Rayne Institute, University College London, UK
    Biochem J 429:565-72. 2010
  2. ncbi request reprint Protein kinase D in vascular biology and angiogenesis
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London, UK
    IUBMB Life 63:spcone. 2011
  3. doi request reprint Protein kinase D in vascular biology and angiogenesis
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London, UK
    IUBMB Life 63:258-63. 2011
  4. doi request reprint Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Cell Signal 20:1375-84. 2008
  5. pmc Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
    Caroline Pellet-Many
    Centre for Cardiovascular Science and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem J 435:609-18. 2011
  6. doi request reprint p130Cas: a key signalling node in health and disease
    Angela Barrett
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London WC1E 6JJ, United Kingdom
    Cell Signal 25:766-77. 2013
  7. doi request reprint A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling
    Angela Barrett
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, Rayne Building, University College London, London WC1E 6JJ, UK
    J Cell Sci 127:2647-58. 2014
  8. pmc Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
    Ian M Evans
    UCL Division of Medicine, 5 University Street, London WC1E 6JJ, United Kingdom
    Mol Cell Biol 31:1174-85. 2011
  9. pmc Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice
    Maiko Yamaji
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, The Rayne Building, University College London, London, WC1E 6JJ, United Kingdom
    PLoS ONE 10:e0115563. 2015
  10. doi request reprint The role of neuropilins in cell signalling
    Ian C Zachary
    Centre for Cardiovascular Science and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem Soc Trans 37:1171-8. 2009

Collaborators

Detail Information

Publications12

  1. pmc Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
    Ian M Evans
    Department of Medicine, Centre for Cardiovascular Biology and Medicine, The Rayne Institute, University College London, UK
    Biochem J 429:565-72. 2010
    ..CRT5, a novel specific PKD inhibitor, will greatly facilitate the study of the role of PKD signalling mechanisms in angiogenesis...
  2. ncbi request reprint Protein kinase D in vascular biology and angiogenesis
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London, UK
    IUBMB Life 63:spcone. 2011
    ..Protein kinase D1/2 signaling in endothelial cells by Ian M. Evans and Ian C. Zachary, pp. 258-263...
  3. doi request reprint Protein kinase D in vascular biology and angiogenesis
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London, UK
    IUBMB Life 63:258-63. 2011
    ..PKD is also emerging as a potentially important mediator of tumor growth and tumor angiogenesis and there is growing interest in PKD as a novel therapeutic target in cancer...
  4. doi request reprint Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
    Ian M Evans
    Centre for Cardiovascular Biology and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Cell Signal 20:1375-84. 2008
    ....
  5. pmc Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
    Caroline Pellet-Many
    Centre for Cardiovascular Science and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem J 435:609-18. 2011
    ..These results indicate a role for NRP1 and NRP1 glycosylation in mediating PDGF-induced VSMC migration, possibly by acting as a co-receptor for PDGFRα and via selective mobilization of a novel p130Cas tyrosine phosphorylation pathway...
  6. doi request reprint p130Cas: a key signalling node in health and disease
    Angela Barrett
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, London WC1E 6JJ, United Kingdom
    Cell Signal 25:766-77. 2013
    ....
  7. doi request reprint A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling
    Angela Barrett
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, Rayne Building, University College London, London WC1E 6JJ, UK
    J Cell Sci 127:2647-58. 2014
    ..These data show a crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway. [Corrected]..
  8. pmc Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
    Ian M Evans
    UCL Division of Medicine, 5 University Street, London WC1E 6JJ, United Kingdom
    Mol Cell Biol 31:1174-85. 2011
    ....
  9. pmc Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice
    Maiko Yamaji
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, The Rayne Building, University College London, London, WC1E 6JJ, United Kingdom
    PLoS ONE 10:e0115563. 2015
    ..We therefore investigated the biological relevance of NRP1 in SMC in vivo by generating mice with SMC-specific Nrp1 deficiency...
  10. doi request reprint The role of neuropilins in cell signalling
    Ian C Zachary
    Centre for Cardiovascular Science and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem Soc Trans 37:1171-8. 2009
    ..Growing evidence indicates, however, that NRP1 plays a selective role in signalling at least in part via its C-terminal domain and interaction with intracellular binding partners...
  11. doi request reprint N-terminal modification of VEGF-A C terminus-derived peptides delineates structural features involved in neuropilin-1 binding and functional activity
    Haiyan Jia
    Centre for Cardiovascular Biology and Medicine, Division of Medicine, University College London, 5 University Street, London WC1E 6JJ UK
    Chembiochem 15:1161-70. 2014
    ..EG00086 is a potent blocker of VEGF-promoted cellular adhesion to extracellular matrices, and phosphorylation of p130Cas contributes to this effect. ..
  12. ncbi request reprint Vascular endothelial growth factor synergistically enhances induction of E-selectin by tumor necrosis factor-alpha
    Anita K Stannard
    BHF Laboratories, Department of Medicine, The Rayne Building, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    Arterioscler Thromb Vasc Biol 27:494-502. 2007
    ..The regulation of endothelial cell adhesion molecules (CAMs) by vascular endothelial growth factor (VEGF) was investigated in cell cultures and in a rabbit model of atherogenic neointima formation...