- Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomesLél Eöry
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
Mol Biol Evol 27:177-92. 2010..Including coding and noncoding sites, we estimate that the genomic deleterious mutation rate U = 4.2. The mutational load predicted under a multiplicative model is therefore about 99% in hominids...
- Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodentsDaniel L Halligan
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
PLoS Genet 9:e1003995. 2013..We conclude that although there appear to be many more adaptive noncoding changes, substitutions in proteins may dominate phenotypic evolution...
- Inference of mutation parameters and selective constraint in mammalian coding sequences by approximate Bayesian computationPeter D Keightley
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
Genetics 187:1153-61. 2011..Synonymous site selective constraint is weakest in murids, a surprising result, considering that murid effective population sizes are likely to be considerably higher than the other two taxa...