Karen D Ersche

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi Aberrant disgust responses and immune reactivity in cocaine-dependent men
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Electronic address
    Biol Psychiatry 75:140-7. 2014
  2. pmc The skinny on cocaine: insights into eating behavior and body weight in cocaine-dependent men
    Karen D Ersche
    University of Cambridge, Department of Psychiatry, Cambridge CB2 0SZ, UK University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge CB2 0SZ, UK Electronic address
    Appetite 71:75-80. 2013
  3. doi Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, UK
    Curr Opin Neurobiol 23:615-24. 2013
  4. pmc Distinctive personality traits and neural correlates associated with stimulant drug use versus familial risk of stimulant dependence
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Departments of Experimental Psychology and Psychiatry, Cambridge, United Kingdom
    Biol Psychiatry 74:137-44. 2013
  5. pmc Amisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions?
    Karen D Ersche
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    J Psychopharmacol 26:887-90. 2012
  6. pmc Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence
    Karen D Ersche
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Am J Psychiatry 169:926-36. 2012
  7. doi Abnormal brain structure implicated in stimulant drug addiction
    Karen D Ersche
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Science 335:601-4. 2012
  8. pmc Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, Cambridge, England
    Arch Gen Psychiatry 67:632-44. 2010
  9. pmc Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 68:770-3. 2010
  10. doi Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 70:754-62. 2011

Detail Information

Publications28

  1. doi Aberrant disgust responses and immune reactivity in cocaine-dependent men
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Electronic address
    Biol Psychiatry 75:140-7. 2014
    ....
  2. pmc The skinny on cocaine: insights into eating behavior and body weight in cocaine-dependent men
    Karen D Ersche
    University of Cambridge, Department of Psychiatry, Cambridge CB2 0SZ, UK University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge CB2 0SZ, UK Electronic address
    Appetite 71:75-80. 2013
    ..Weight changes in cocaine users reflect fundamental perturbations in fat regulation. These are likely to be overlooked in clinical practice but may produce significant health problems when cocaine use is discontinued during recovery. ..
  3. doi Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, UK
    Curr Opin Neurobiol 23:615-24. 2013
    ..Although the question of causality has not yet been answered completely, there has been significant progress made to date. ..
  4. pmc Distinctive personality traits and neural correlates associated with stimulant drug use versus familial risk of stimulant dependence
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Departments of Experimental Psychology and Psychiatry, Cambridge, United Kingdom
    Biol Psychiatry 74:137-44. 2013
    ....
  5. pmc Amisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions?
    Karen D Ersche
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    J Psychopharmacol 26:887-90. 2012
    ..We further speculate about the neuropathology possibly underlying this clinical observation and outline a testable hypothesis for future molecular imaging studies...
  6. pmc Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence
    Karen D Ersche
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Am J Psychiatry 169:926-36. 2012
    ....
  7. doi Abnormal brain structure implicated in stimulant drug addiction
    Karen D Ersche
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Science 335:601-4. 2012
    ....
  8. pmc Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, Cambridge, England
    Arch Gen Psychiatry 67:632-44. 2010
    ..We hypothesized that dopamine-related targets are relevant for treatment of stimulant dependence, and there will likely be individual differences in response to dopaminergic challenges...
  9. pmc Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 68:770-3. 2010
    ..However, it has not been clear whether these personality traits are a cause or an effect of stimulant drug dependence...
  10. doi Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 70:754-62. 2011
    ..The aim of this study was to measure behavioral and neural markers of compulsivity in stimulant-dependent individuals and to test whether these markers could be modulated by treatment with drugs targeting the dopamine system...
  11. pmc Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans
    Karen D Ersche
    Department of Psychiatry, Brain Mapping Unit, School of Clinical Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 197:421-31. 2008
    ..We investigated the ability to adapt behaviour according to changes in reward contingencies, using a probabilistic reversal-learning task, in chronic drug users and controls...
  12. pmc The neuropsychology of amphetamine and opiate dependence: implications for treatment
    Karen D Ersche
    School of Clinical Medicine, Department of Psychiatry, University of Cambridge, Brain Mapping Unit, Box 255, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychol Rev 17:317-36. 2007
    ....
  13. pmc Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Brain Mapping Unit, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 188:364-73. 2006
    ..One possible explanation for this behaviour is that methadone users were less sensitive to punishment on immediately preceding unsuccessful trials...
  14. pmc Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
    K D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:612-23. 2005
    ..We sought to investigate this possibility using functional neuroimaging...
  15. pmc Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence
    Karen D Ersche
    University of Cambridge, Department of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, Cambridge Biomedical Campus, Cambridge CB20SZ, UK
    Brain 134:2013-24. 2011
    ....
  16. pmc Peripheral biomarkers of cognitive response to dopamine receptor agonist treatment
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK
    Psychopharmacology (Berl) 214:779-89. 2011
    ..We investigated the use of dopamine receptor mRNA levels in circulating blood cells as predictors of cognitive response following dopamine agonist treatment, and as biomarkers of the severity of stimulant drug dependence...
  17. doi Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation
    Sharon Morein-Zamir
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Box 189, CB2 2QQ, Cambridge, UK
    Psychopharmacology (Berl) 212:357-67. 2010
    ..Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well...
  18. pmc Profile of executive and memory function associated with amphetamine and opiate dependence
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychopharmacology 31:1036-47. 2006
    ..Impairment persists after several years of drug abstinence and may reflect neuropathology in frontal and temporal cortices...
  19. pmc Punishment induces risky decision-making in methadone-maintained opiate users but not in heroin users or healthy volunteers
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:2115-24. 2005
    ..These findings are discussed with respect to the different mechanisms of action of heroin and methadone. Neuropsychopharmacology (2005) 30, 2115-2124. doi:10.1038/sj.npp.1300812; published online 6 July 2005...
  20. doi Brain functional connectivity in stimulant drug dependence and obsessive-compulsive disorder
    David Meunier
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuroimage 59:1461-8. 2012
    ..Orbitofrontal connectivity may serve as a human brain systems biomarker for compulsivity across diagnostic categories...
  21. pmc Prefrontal hypoactivity associated with impaired inhibition in stimulant-dependent individuals but evidence for hyperactivation in their unaffected siblings
    Sharon Morein-Zamir
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 38:1945-53. 2013
    ....
  22. ncbi Reflection impulsivity in current and former substance users
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 60:515-22. 2006
    ..We investigated impulsive responding in the context of decision making, using a novel behavioral measure of reflection impulsivity: the tendency to gather and evaluate information before making a decision...
  23. pmc Differences in self-reported decision-making styles in stimulant-dependent and opiate-dependent individuals
    Hadas Gorodetzky
    University of Cambridge, Department of Psychiatry, Cambridge, UK
    Psychiatry Res 186:437-40. 2011
    ..Consistent with the literature on laboratory tests of decision-making, we found that stimulant users reported less competent and more maladaptive decision-making styles compared with controls...
  24. doi Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry
    Trevor W Robbins
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
    Trends Cogn Sci 16:81-91. 2012
    ..We argue that this approach has important implications for the future classification of psychiatric disorders, genetics and therapeutics...
  25. pmc The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorder
    Elise E DeVito
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Biol Psychiatry 64:636-9. 2008
    ..The objectives of the study were to assess the effects of stimulant medication on decision making in ADHD and compare performance on the Cambridge Gamble Task between boys with and without ADHD...
  26. doi Enhanced orbitofrontal cortex function and lack of attentional bias to cocaine cues in recreational stimulant users
    Dana G Smith
    Department of Psychology and Department of Psychiatry, University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, United Kingdom Electronic address
    Biol Psychiatry 75:124-31. 2014
    ..Additionally, previous investigations into cognitive abilities in these individuals have been conflicting, and no research has been conducted on the neurobiological processes underlying cognitive functioning in this group...
  27. ncbi The orbital prefrontal cortex and drug addiction in laboratory animals and humans
    Barry J Everitt
    Behavioural and Clinical Neuroscience and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1121:576-97. 2007
    ....
  28. pmc Hierarchical modularity in human brain functional networks
    David Meunier
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge Cambridge, UK
    Front Neuroinform 3:37. 2009
    ..This could enable future investigations of Simon's original hypothesis that hierarchy or near-decomposability of physical symbol systems is a critical design feature for their fast adaptivity to changing environmental conditions...