Mark C Enright

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. pmc The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
    Mark C Enright
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 99:7687-92. 2002
  2. ncbi request reprint Amoebae promote persistence of epidemic strains of MRSA
    Sharon A Huws
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Environ Microbiol 8:1130-3. 2006
  3. pmc Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 101:9786-91. 2004
  4. pmc Vancomycin susceptibility within methicillin-resistant Staphylococcus aureus lineages
    Robin A Howe
    Southmead Hospital, Bristol, United Kingdom
    Emerg Infect Dis 10:855-7. 2004
  5. ncbi request reprint The evolution of a resistant pathogen--the case of MRSA
    Mark C Enright
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Curr Opin Pharmacol 3:474-9. 2003
  6. pmc How clonal is Staphylococcus aureus?
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    J Bacteriol 185:3307-16. 2003
  7. ncbi request reprint Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone
    D Ashley Robinson
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    Lancet 365:1256-8. 2005
  8. ncbi request reprint Genetic analysis of Staphylococcus aureus from intravenous drug user lesions
    Alastair B Monk
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Med Microbiol 53:223-7. 2004
  9. ncbi request reprint Analyses of clonality and the evolution of bacterial pathogens
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Curr Opin Microbiol 7:308-13. 2004
  10. pmc Evolutionary models of the emergence of methicillin-resistant Staphylococcus aureus
    D Ashley Robinson
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Antimicrob Agents Chemother 47:3926-34. 2003

Collaborators

Detail Information

Publications27

  1. pmc The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
    Mark C Enright
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Proc Natl Acad Sci U S A 99:7687-92. 2002
    ..aureus genotypes...
  2. ncbi request reprint Amoebae promote persistence of epidemic strains of MRSA
    Sharon A Huws
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Environ Microbiol 8:1130-3. 2006
    ..50% amoebae had viable MRSA within phago-lysosomes and 2% of amoebae were heavily infected with viable cocci throughout the cytoplasm. Infection control strategies should recognize the contribution of protozoa...
  3. pmc Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 101:9786-91. 2004
    ....
  4. pmc Vancomycin susceptibility within methicillin-resistant Staphylococcus aureus lineages
    Robin A Howe
    Southmead Hospital, Bristol, United Kingdom
    Emerg Infect Dis 10:855-7. 2004
    ..Increasing antimicrobial resistance in genetically distinct pandemic clones may lead to MRSA infections that will become increasingly difficult to treat...
  5. ncbi request reprint The evolution of a resistant pathogen--the case of MRSA
    Mark C Enright
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Curr Opin Pharmacol 3:474-9. 2003
    ..Only five major lineages of hospital methicillin-resistant Staphylococcus aureus exist, but these are globally distributed and evolving resistance to even the newest antibiotics...
  6. pmc How clonal is Staphylococcus aureus?
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    J Bacteriol 185:3307-16. 2003
    ....
  7. ncbi request reprint Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone
    D Ashley Robinson
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    Lancet 365:1256-8. 2005
    ....
  8. ncbi request reprint Genetic analysis of Staphylococcus aureus from intravenous drug user lesions
    Alastair B Monk
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Med Microbiol 53:223-7. 2004
    ..PCR detection of 22 toxin genes revealed a high prevalence of the gene for staphylococcal enterotoxin B compared with previous studies, indicating that this toxin may promote infections in this patient group...
  9. ncbi request reprint Analyses of clonality and the evolution of bacterial pathogens
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Curr Opin Microbiol 7:308-13. 2004
    ....
  10. pmc Evolutionary models of the emergence of methicillin-resistant Staphylococcus aureus
    D Ashley Robinson
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    Antimicrob Agents Chemother 47:3926-34. 2003
    ..Our findings suggest that most clones of MRSA arise by the acquisition of SCCmec type IV by methicillin-sensitive isolates...
  11. pmc Evolution of Staphylococcus aureus by large chromosomal replacements
    D Ashley Robinson
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom
    J Bacteriol 186:1060-4. 2004
    ..The replacements are unprecedented in natural populations of bacteria because of their large size and unique structure and may have a dramatic impact on bacterial evolution...
  12. pmc Evolutionary genetics of the accessory gene regulator (agr) locus in Staphylococcus aureus
    D Ashley Robinson
    New York Medical College, Department of Microbiology and Immunology, Valhalla, NY 10595, USA
    J Bacteriol 187:8312-21. 2005
    ..aureus that horizontally transferred agr groups between two subspecies groups near the time that these subspecies groups diverged...
  13. ncbi request reprint Genome of an epidemic community-acquired MRSA
    Mark C Enright
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London W2 1PG, UK
    Lancet 367:705-6. 2006
  14. pmc Improved multilocus sequence typing scheme for Staphylococcus epidermidis
    Jonathan C Thomas
    Department of Infectious Disease Epidemiology, St Mary s Hospital Campus, Imperial College London, London W2 1PG, United Kingdom
    J Clin Microbiol 45:616-9. 2007
    ..This improved scheme gave 31 sequence types (STs) and 5 clonal complexes (CCs), whereas the other schemes delineate 16 to 24 STs and 1 to 3 CCs...
  15. pmc Global distribution of Panton-Valentine leukocidin--positive methicillin-resistant Staphylococcus aureus, 2006
    Anne Tristan
    Centre National de Référence des Staphylocoques, INSERM, Lyon, France
    Emerg Infect Dis 13:594-600. 2007
    ..g., to gentamicin) in certain countries. The major trait shared by all these clones is a short staphylococcal chromosomal cassette mec element of type IV or V...
  16. pmc Evaluation of molecular typing methods in characterizing a European collection of epidemic methicillin-resistant Staphylococcus aureus strains: the HARMONY collection
    Barry D Cookson
    Laboratory of Hospital Infection, Centre for Infections, Health Protection Agency, London, United Kingdom
    J Clin Microbiol 45:1830-7. 2007
    ....
  17. pmc Detection of new methicillin-resistant Staphylococcus aureus clones containing the toxic shock syndrome toxin 1 gene responsible for hospital- and community-acquired infections in France
    Geraldine Durand
    Centre National de Référence des Staphylocoques, Faculte Laennec, INSERM E0230, IFR62, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    J Clin Microbiol 44:847-53. 2006
    ..aureus (MSSA) clones by a single band involving the SCCmec element. These findings suggest that the tst-positive MRSA clones may have emerged from their respective MSSA counterparts...
  18. pmc Seven novel variants of the staphylococcal chromosomal cassette mec in methicillin-resistant Staphylococcus aureus isolates from Ireland
    Anna Shore
    Microbiology Research Unit, Department of Oral Surgery, Oral Medicine and Pathology, Trinity College, University of Dublin, Dublin 2, Republic of Ireland
    Antimicrob Agents Chemother 49:2070-83. 2005
    ..This study has demonstrated a hitherto-undescribed degree of diversity within SCCmec...
  19. doi request reprint A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005
    Catherine Liu
    Div of Infectious Diseases, University of California, San Francisco, 513 Parnassus Ave, S 380, Box 0654, San Francisco, CA 94143, USA
    Clin Infect Dis 46:1637-46. 2008
    ..Our objective was to perform a population-based survey of the clinical and molecular epidemiology of MRSA disease in San Francisco, California...
  20. pmc Determining the genetic structure of the natural population of Staphylococcus aureus: a comparison of multilocus sequence typing with pulsed-field gel electrophoresis, randomly amplified polymorphic DNA analysis, and phage typing
    Hajo Grundmann
    Division of Microbiology and Infectious Diseases, University Hospital Nottingham, Nottingham NG7 2UH, United Kingdom
    J Clin Microbiol 40:4544-6. 2002
    ..Only MLST was able to define clonal complexes unambiguously. All DNA-based typing approaches achieved a high degree of agreement, implying phylogenetic concordance, but predicted epidemiological associations with variable accuracy...
  21. pmc Multilocus sequence typing of Staphylococcus aureus with DNA array technology
    Willem B van Leeuwen
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, 3015 GD Rotterdam, The Netherlands
    J Clin Microbiol 41:3323-6. 2003
    ..Analysis of strains from the second collection revealed that chip-defined MLST was concordant with conventional MLST. Array-mediated MLST data were reproducible, exchangeable, and epidemiologically concordant...
  22. pmc Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence
    Francois Vandenesch
    INSERM E0230, Lyon, France
    Emerg Infect Dis 9:978-84. 2003
    ..Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA...
  23. pmc Related clones containing SCCmec type IV predominate among clinically significant Staphylococcus epidermidis isolates
    Hilmar Wisplinghoff
    Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23292, USA
    Antimicrob Agents Chemother 47:3574-9. 2003
    ..These data support the hypothesis of intra- and interspecies transfer of type IV SCCmec and suggest that there are clonal associations in S. epidermidis that correlate with SCCmec type...
  24. pmc Influence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenes
    Awdhesh Kalia
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
    Infect Immun 70:1971-83. 2002
    ..Maintenance of a relationship between emm pattern and tissue tropism in the face of underlying recombination suggests that tissue tropism is associated with emm or a closely linked gene...
  25. pmc Stability of serotypes during nasopharyngeal carriage of Streptococcus pneumoniae
    Emma Meats
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Hospital Campus, London W2 1PG, United Kingdom
    J Clin Microbiol 41:386-92. 2003
    ..There was therefore no evidence in this study for any change of serotype due to recombinational replacements at the capsular locus among the pneumococci carried within the nasopharynges of the children...
  26. ncbi request reprint In vitro activity of a novel compound, the metal ion chelating agent AQ+, against clinical isolates of Staphylococcus aureus
    Benjamin R D Short
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Old Medical School Building, St Mary s Hospital, Norfolk Place, London W2 1PG, UK
    J Antimicrob Chemother 57:104-9. 2006
    ..AQ+ is an aqueous preparation containing 0.5% 8-hydroxyquinoline...
  27. pmc Genetic background affects stability of mecA in Staphylococcus aureus
    Yuki Katayama
    Department of Bacteriology, Fuculty of Medicine, Juntendo University, Tokyo Japan
    J Clin Microbiol 43:2380-3. 2005
    ..These data support the hypothesis that the presence of mecA within relatively few clonal complexes is partly due to genetic factors that are permissive of mecA and its gene product...