William R English

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. doi request reprint LPS activates ADAM9 dependent shedding of ACE from endothelial cells
    William R English
    Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, The Li Ka Shing Centre, Robinson Way CB2 0RE, UK
    Biochem Biophys Res Commun 421:70-5. 2012
  2. doi request reprint Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness
    David M Winder
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    J Pathol 225:448-62. 2011
  3. doi request reprint MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src
    Patricia A Eisenach
    University of Cambridge, Department of Oncology, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    J Cell Sci 123:4182-93. 2010
  4. doi request reprint Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
    Christian Roghi
    Cancer Research UK Cambridge Research Institute, The Li Ka Shing Centre, UK
    FEBS J 277:3158-75. 2010
  5. pmc A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis
    Pedro Correa de Sampaio
    University of Cambridge, Department of Oncology, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
    PLoS ONE 7:e30753. 2012
  6. ncbi request reprint Granulocyte-macrophage colony stimulating factor induces endothelial capillary formation through induction of membrane-type 1 matrix metalloproteinase expression in vitro
    Davia Krubasik
    Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom
    Int J Cancer 122:1261-72. 2008
  7. doi request reprint Modulation of integrin α4β1 by ADAM28 promotes lymphocyte adhesion and transendothelial migration
    Owen J McGinn
    Department of Oncology, Cambridge University, Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, U K
    Cell Biol Int 35:1043-53. 2011

Collaborators

Detail Information

Publications7

  1. doi request reprint LPS activates ADAM9 dependent shedding of ACE from endothelial cells
    William R English
    Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, The Li Ka Shing Centre, Robinson Way CB2 0RE, UK
    Biochem Biophys Res Commun 421:70-5. 2012
    ..Transient transfection of ADAM9 and ACE cDNAs into HEK293 cells demonstrated that ADAM9 requires both membrane anchorage and its catalytic domain to shed ACE...
  2. doi request reprint Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness
    David M Winder
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    J Pathol 225:448-62. 2011
    ..OSMR is a potential prognostic and therapeutic target in cervical SCC. The genes that mediate OSM:OSMR effects will be valuable indicators of the effectiveness of antibody blockade in pre-clinical systems...
  3. doi request reprint MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src
    Patricia A Eisenach
    University of Cambridge, Department of Oncology, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    J Cell Sci 123:4182-93. 2010
    ..The signalling cascade dependent on the MT1-MMP-VEGFR-2-Src complex activated Akt and mTOR, ultimately leading to increased VEGF-A transcription...
  4. doi request reprint Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
    Christian Roghi
    Cancer Research UK Cambridge Research Institute, The Li Ka Shing Centre, UK
    FEBS J 277:3158-75. 2010
    ..Taken together, these data suggest that GRASP55 may function as an adaptor protein coupling MT1-MMP with furin, thus leading to the activation of the zymogen...
  5. pmc A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis
    Pedro Correa de Sampaio
    University of Cambridge, Department of Oncology, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
    PLoS ONE 7:e30753. 2012
    ..Finally, using this technique, we were able to show the requirement of the metalloproteinase MT1-MMP in endothelial cells and fibroblasts, but not cancer cells, for sprouting angiogenesis...
  6. ncbi request reprint Granulocyte-macrophage colony stimulating factor induces endothelial capillary formation through induction of membrane-type 1 matrix metalloproteinase expression in vitro
    Davia Krubasik
    Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom
    Int J Cancer 122:1261-72. 2008
    ....
  7. doi request reprint Modulation of integrin α4β1 by ADAM28 promotes lymphocyte adhesion and transendothelial migration
    Owen J McGinn
    Department of Oncology, Cambridge University, Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, U K
    Cell Biol Int 35:1043-53. 2011
    ....