V C Emery

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts
    Vincent C Emery
    Royal Free and University College Medical School, Dept of Virology, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Infect Dis 185:1723-8. 2002
  2. pmc Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy
    V C Emery
    Department of Virology, Royal Free and University College Medical School of University College, Rowland Hill Street, Hampstead, London, NW3 2QG, United Kingdom
    Proc Natl Acad Sci U S A 97:8039-44. 2000
  3. ncbi request reprint Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation
    V C Emery
    Department of Virology, Royal Free and University College Medical School, London, UK
    Lancet 355:2032-6. 2000
  4. ncbi request reprint Prophylaxis for CMV should not now replace pre-emptive therapy in solid organ transplantation
    V C Emery
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead NW3 2QG, UK
    Rev Med Virol 11:83-6. 2001
  5. ncbi request reprint Human herpesviruses 6 and 7 in solid organ transplant recipients
    V C Emery
    Royal Free and University College Medical School, Hampstead, London, United Kingdom
    Clin Infect Dis 32:1357-60. 2001
  6. ncbi request reprint Cytomegalovirus and the aging population
    V C Emery
    Virology Department, Royal Free and University College Medical School, London, England
    Drugs Aging 18:927-33. 2001
  7. ncbi request reprint Focus on new drugs in development against human cytomegalovirus
    Vincent C Emery
    Department of Virology, Royal Free and University College Medical School, London, UK
    Drugs 62:1853-8. 2002
  8. pmc Investigation of CMV disease in immunocompromised patients
    V C Emery
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Clin Pathol 54:84-8. 2001
  9. ncbi request reprint Prospective study of human betaherpesviruses after renal transplantation: association of human herpesvirus 7 and cytomegalovirus co-infection with cytomegalovirus disease and increased rejection
    I M Kidd
    Department of Virology, Royal Free and University College Medical School of University College London, United Kingdom
    Transplantation 69:2400-4. 2000
  10. ncbi request reprint Quantity of cytomegalovirus DNA in different leukocyte populations during active infection in vivo and the presence of gB and UL18 transcripts
    A F Hassan-Walker
    Department of Virology, Royal Free and University College Medical School, University College London, Royal Free Campus, Hampstead, London, United Kingdom
    J Med Virol 64:283-9. 2001

Detail Information

Publications65

  1. ncbi request reprint Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts
    Vincent C Emery
    Royal Free and University College Medical School, Dept of Virology, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Infect Dis 185:1723-8. 2002
    ....
  2. pmc Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy
    V C Emery
    Department of Virology, Royal Free and University College Medical School of University College, Rowland Hill Street, Hampstead, London, NW3 2QG, United Kingdom
    Proc Natl Acad Sci U S A 97:8039-44. 2000
    ..The modeled and experimental data showed excellent agreement over extended time periods (up to 270 days of therapy) and provide a framework to predict the virologic course of patients at therapeutic initiation...
  3. ncbi request reprint Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation
    V C Emery
    Department of Virology, Royal Free and University College Medical School, London, UK
    Lancet 355:2032-6. 2000
    ..Peak CMV load in the blood correlates with CMV disease but frequently occurs too late to provide prognostic information...
  4. ncbi request reprint Prophylaxis for CMV should not now replace pre-emptive therapy in solid organ transplantation
    V C Emery
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, Hampstead NW3 2QG, UK
    Rev Med Virol 11:83-6. 2001
    ..In contrast, prophylaxis is a high-cost strategy which exposes all patients to potentially toxic drugs, does not facilitate immune priming and leads to the development of late HCMV infection and disease in high-risk patients...
  5. ncbi request reprint Human herpesviruses 6 and 7 in solid organ transplant recipients
    V C Emery
    Royal Free and University College Medical School, Hampstead, London, United Kingdom
    Clin Infect Dis 32:1357-60. 2001
    ..Also discussed is whether the data on the pathological consequences of infection warrant routine screening for these viruses in solid organ transplant recipients...
  6. ncbi request reprint Cytomegalovirus and the aging population
    V C Emery
    Virology Department, Royal Free and University College Medical School, London, England
    Drugs Aging 18:927-33. 2001
    ..We await further investigations to determine whether the immune control of HCMV in the elderly patient is as effective as in the younger adult, and whether this is linked to pathological consequences...
  7. ncbi request reprint Focus on new drugs in development against human cytomegalovirus
    Vincent C Emery
    Department of Virology, Royal Free and University College Medical School, London, UK
    Drugs 62:1853-8. 2002
    ..Many of these compounds have undergone successful phase I clinical trials. There are other compounds which have been identified through drug-screening but are at the earlier stages of development...
  8. pmc Investigation of CMV disease in immunocompromised patients
    V C Emery
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Clin Pathol 54:84-8. 2001
    ..These studies focus attention on understanding the virological and immunological determinants of enhanced viral replication and its pathological consequences...
  9. ncbi request reprint Prospective study of human betaherpesviruses after renal transplantation: association of human herpesvirus 7 and cytomegalovirus co-infection with cytomegalovirus disease and increased rejection
    I M Kidd
    Department of Virology, Royal Free and University College Medical School of University College London, United Kingdom
    Transplantation 69:2400-4. 2000
    ..We have conducted a prospective investigation to compare the natural history of HHV-6 and HHV-7 infection with that of CMV after renal transplantation...
  10. ncbi request reprint Quantity of cytomegalovirus DNA in different leukocyte populations during active infection in vivo and the presence of gB and UL18 transcripts
    A F Hassan-Walker
    Department of Virology, Royal Free and University College Medical School, University College London, Royal Free Campus, Hampstead, London, United Kingdom
    J Med Virol 64:283-9. 2001
    ..The transient nature of UL18 gene expression, and the low abundance of the transcript relative to gB were confirmed...
  11. doi request reprint Polyfunctional cytomegalovirus-specific CD4+ and pp65 CD8+ T cells protect against high-level replication after liver transplantation
    G Nebbia
    Department of Infection, Royal Free and University College Medical School, London, UK
    Am J Transplant 8:2590-9. 2008
    ..Measuring polyfunctional CD4+ T cells against HCMV early posttransplant may allow targeted intervention to minimize the occurrence and acute and long-term consequences of HCMV replication...
  12. ncbi request reprint CD8+ cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: correlation with time from transplant to receipt of tacrolimus
    A F Hassan-Walker
    Department of Virology, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 183:835-43. 2001
    ..31; P=.005), which is consistent with the presence of a large proportion (70%) of activated (CD38(+)) ppUL83 CD8(+) CTL within the population of HLA class I tetramer-positive cells...
  13. ncbi request reprint Relationship between IgM antibody to human cytomegalovirus, virus load, donor and recipient serostatus, and administration of methylprednisolone as risk factors for cytomegalovirus disease after liver transplantation
    V C Emery
    Dept of Virology, Royal Free and University College Medical School, Royal Free Campus, London NW3 2PF, UK, USA
    J Infect Dis 182:1610-5. 2000
    ..However, in multivariate analyses, elevated virus load continued to be the predominant risk factor for progression to HCMV disease...
  14. pmc The dynamics of human cytomegalovirus replication in vivo
    V C Emery
    Department of Virology, Royal Free and University College Medical School of University College London, London NW3 2QG, United Kingdom
    J Exp Med 190:177-82. 1999
    ..These findings have implications for the potency, dose, and duration of antiviral chemotherapy needed for the effective treatment of this important human pathogen...
  15. ncbi request reprint Cytomegalovirus seropositivity and human immunodeficiency virus type 1 RNA levels in individuals with hemophilia
    C A Sabin
    Dept of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom NW3 2PF
    J Infect Dis 181:1800-3. 2000
    ..Thus, the effect of CMV seropositivity on clinical progression remains significant in this cohort but does not appear to be mediated through an increase in HIV RNA levels...
  16. ncbi request reprint The effect of valaciclovir on cytomegalovirus viremia and viruria detected by polymerase chain reaction in patients with advanced human immunodeficiency virus disease. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophy
    P D Griffiths
    Virology Department, Royal Free Hospital School of Medicine, London, United Kingdom
    J Infect Dis 177:57-64. 1998
    ..02). Thus, PCR viremia provides prognostic information about CMV disease in AIDS patients, and valaciclovir showed activity as both a preemptive and prophylactic agent...
  17. ncbi request reprint Betaherpesviruses in transplant recipients
    P D Griffiths
    Department of Virology, Royal Free and University College Medical School, UK
    J Antimicrob Chemother 45:29-34. 2000
    ..The full clinicopathological significance of the betaherpesviruses may, thus, be greater than is currently appreciated...
  18. pmc Histopathological detection of owl's eye inclusions is still specific for cytomegalovirus in the era of human herpesviruses 6 and 7
    F M Mattes
    Department of Virology, Royal Free and University College Medical School, London, UK
    J Clin Pathol 53:612-4. 2000
    ..Human herpesvirus 6 (HHV-6) and HHV-7 are newer members of the beta-herpesvirinae that can cause febrile illness in young children and are also possible pathogens in the immunocompromised patient...
  19. ncbi request reprint Kinetics of cytomegalovirus load decrease in solid-organ transplant recipients after preemptive therapy with valganciclovir
    F M Mattes
    Centre for Virology, Division of Infection and Immunity, Royal Free and University College Medical School, London NW32QG, UK
    J Infect Dis 191:89-92. 2005
    ..73 days; P=.63). Preemptive therapy with VGCV provides control of HCMV replication that is comparable to that achieved with preemptive intravenous therapy with GCV...
  20. doi request reprint Functional impairment of cytomegalovirus specific CD8 T cells predicts high-level replication after renal transplantation
    F M Mattes
    Department of Infection, Royal Free and University College Medical School Hampstead campus and Royal Free Hampstead NHS Trust, London, UK
    Am J Transplant 8:990-9. 2008
    ....
  21. ncbi request reprint Diagnostic approaches to cytomegalovirus infection in bone marrow and organ transplantation
    P D Griffiths
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, London, UK
    Transpl Infect Dis 1:179-86. 1999
    ..Note..
  22. ncbi request reprint Changes in the natural history of cytomegalovirus retinitis following the introduction of highly active antiretroviral therapy
    J R Deayton
    Department of Virology, Royal Free Hampstead National Health Service Trust and Royal Free and University College School of Medicine, London, UK
    AIDS 14:1163-70. 2000
    ..To determine the effect of highly active antiretroviral therapy (HAART) on the natural history of cytomegalovirus (CMV) retinitis...
  23. ncbi request reprint Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy
    Jane R Deayton
    Department of Virology, Royal Free and University College Medical School of University College London, Royal Free Campus, London, UK
    Lancet 363:2116-21. 2004
    ..We have investigated whether cytomegalovirus viraemia remains a significant risk factor for progression of HIV disease and death in the era of HAART...
  24. ncbi request reprint Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapy
    Jane R Deayton
    Department of Virology, Royal Free Hampstead NHS Trust and Royal Free and University College School of Medicine, London, UK
    AIDS 16:2129-35. 2002
    ....
  25. pmc Cytomegalovirus replication kinetics in solid organ transplant recipients managed by preemptive therapy
    S F Atabani
    Division of Infection and Immunity, Centre for Virology, Royal Free NHS Trust and UCL Medical School, London, UK
    Am J Transplant 12:2457-64. 2012
    ..Overall, our findings provide quantitative biomarkers which can be used in pharmacodynamic assessments of the ability of novel CMV vaccines or antiviral drugs to reduce or even interrupt such transmission...
  26. ncbi request reprint Cytomegalovirus drug resistance
    V C Emery
    Royal Free Hospital School of Medicine, London, UK
    Antivir Ther 3:239-42. 1998
    ..Finally, the changing face of CMV disease in the era of highly active antiviral chemotherapy is considered with respect to its impact on the frequency of CMV resistance in the clinic...
  27. doi request reprint The risk of early and late CMV DNAemia associated with Campath use in stem cell transplant recipients
    H C Buyck
    Department of Infection, Centre for Virology, UCL, London, UK
    Bone Marrow Transplant 45:1212-9. 2010
    ..Multivariable analysis of risk factors for HCMV DNAemia occurring beyond 100 days after transplant were older age, acute GVHD>grade II and a lower CD34 stem cell dose, whereas Campath-1H use was not associated with late HCMV DNAemia...
  28. ncbi request reprint Viral dynamics during active cytomegalovirus infection and pathology
    V C Emery
    Department of Virology, Royal Free and University College Medical School, London, UK
    Intervirology 42:405-11. 1999
    ..The data show that both these parameters have prognostic value in multivariate models and should allow the development of novel patient management strategies...
  29. ncbi request reprint Prevalence of anti-vif antibodies in HIV-1 infected individuals assessed using recombinant baculovirus expressed vif protein
    D Lee
    Department of Virology, Royal Free Hospital and School of Medicine, London, United Kingdom
    J Med Virol 51:139-44. 1997
    ..0003). However, there was no significant difference in the prevalence of anti-vif antibodies in patients stratified according to p24 antigen status. The implications of these findings in the context of HIV replication are discussed...
  30. ncbi request reprint The effect of highly active antiretroviral therapy for HIV on the anti-HCV specific humoral immune response
    Esteban Herrero-Martinez
    Department of Virology, Royal Free and University College Medical School, London, United Kingdom
    J Med Virol 72:187-93. 2004
    ..The relationship disappeared or was obscured after therapy (R = 0.24, P = 0.30 and R = 0.16, P = 0.50, respectively). Thus, we show that HAART affects the HCV specific humoral immune responses without affecting the HCV RNA level...
  31. ncbi request reprint Exploring the bidirectional interactions between human cytomegalovirus and hepatitis C virus replication after liver transplantation
    Gaia Nebbia
    Department of Infection, Royal Free and University College Medical School, London, UK
    Liver Transpl 13:130-5. 2007
    ..In conclusion, short term CMV viremia does not enhance the replication of HCV after LT, while HCV replication does not alter the replication dynamics of CMV...
  32. pmc Cytomegalovirus: recent progress in understanding pathogenesis and control
    V C Emery
    Department of Infection Royal Free Campus, University College London, Rowland Hill Street, Hampstead, London, NW3 2QG, UK
    QJM 105:401-5. 2012
    ..This review will focus on advances in understanding the virus-host interaction and options for the new therapeutic control measures...
  33. ncbi request reprint Progress in understanding cytomegalovirus drug resistance
    V C Emery
    Royal Free and University College Medical School, Rowland Hill Street, NW3 2PF, London, UK
    J Clin Virol 21:223-8. 2001
    ..Using such models, a good agreement between experimentally determined viral load and resistance patterns is observed...
  34. pmc Quantitation of porcine cytomegalovirus in pig tissues by PCR
    J F Fryer
    Department of Virology, Royal Free and University College Medical School of UCL, Rowland Hill Street, London NW3 2PF, United Kingdom
    J Clin Microbiol 39:1155-6. 2001
    ..This assay will have significant utility for studying the activation and replication of PCMV and in swine models for allo- and xenotransplantation...
  35. ncbi request reprint A randomized, controlled trial comparing ganciclovir to ganciclovir plus foscarnet (each at half dose) for preemptive therapy of cytomegalovirus infection in transplant recipients
    Frank M Mattes
    Department of Virology, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 189:1355-61. 2004
    ..This study did not support a synergistic effect of ganciclovir plus foscarnet in vivo...
  36. ncbi request reprint Cytomegalovirus-specific cellular immune responses and viremia in recipients of allogeneic stem cell transplants
    G Aubert
    Anthony Nolan Research Institute, Royal Free and University College Medical School, Royal Free Campus, Hampstead, London, United Kingdom
    J Infect Dis 184:955-63. 2001
    ..Together with polymerase chain reaction testing, this technique provides measurable parameters that can be a guide to therapeutic decision making and can form the basis of CMV immunotherapy...
  37. ncbi request reprint Encouraging prospects for immunisation against primary cytomegalovirus infection
    P D Griffiths
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, NW32PF, London
    Vaccine 19:1356-62. 2001
    ..In conclusion, CMV is a prime candidate for eradication from the human population through vaccination...
  38. ncbi request reprint Replicative fitness in vivo of HIV-1 variants with multiple drug resistance-associated mutations
    H L Devereux
    Department of Retrovirology, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Med Virol 65:218-24. 2001
    ..The rapid re-population of wild-type viruses may allow the recycling of antiretroviral drugs prescribed previously...
  39. pmc Kinetics of acute hepatitis B virus infection in humans
    S A Whalley
    Centre for Hepatology, Department of Medicine, Royal Free Campus, United Kingdom
    J Exp Med 193:847-54. 2001
    ..At this peak rate of virion production we estimate that every possible single and most double mutations would be created each day...
  40. ncbi request reprint Sequence variability of the alpha-chemokine UL146 from clinical strains of human cytomegalovirus
    Aycan F Hassan-Walker
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Med Virol 74:573-9. 2004
    ..Mixed populations of HCMV strains occur in vivo so cloning of these strains is essential if an authentic genotype is to be defined...
  41. ncbi request reprint The prognostic value of a single hepatitis C virus RNA load measurement taken early after human immunodeficiency virus seroconversion
    Esteban Herrero-Martinez
    Department of Virology, Royal Free and University College Medical School, Royal Free Hospital, London, United Kingdom
    J Infect Dis 186:470-6. 2002
    ..25; P=.01). Adjusting for HIV RNA levels, CD4 cell counts, and the age effect, HCV RNA load >5.90 log(10) copies/mL was predictive of progression to AIDS and all-cause mortality over a period of at least 15 years...
  42. pmc The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein
    Claire D Shannon-Lowe
    Department of Infection, Centre for Virology, UCL Royal Free Campus Campus, Rowland Hill Street, Hampstead, London NW3 2QG, UK
    Herpesviridae 1:4. 2010
    ..abstract:..
  43. ncbi request reprint Susceptibility of porcine cytomegalovirus to antiviral drugs
    Jacqueline F L Fryer
    Centre for Virology, Department of Infection, Royal Free and University College Medical School of UCL, Hampstead Site, Rowland Hill Street, London NW3 2PF, UK
    J Antimicrob Chemother 53:975-80. 2004
    ..We therefore investigated the effect of selected antiviral agents, currently licensed for the treatment of human herpesvirus infections, on PCMV replication...
  44. pmc Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial
    Paul D Griffiths
    Centre for Virology, UCL Medical School, London, UK
    Lancet 377:1256-63. 2011
    ..Values of viral load correlate with development of end-organ disease and are moderated by pre-existing natural immunity. Our aim was to determine whether vaccine-induced immunity could do likewise...
  45. ncbi request reprint Porcine cytomegalovirus in pigs being bred for xenograft organs: progress towards control
    Duncan A Clark
    Department of Virology, Royal Free and University College Medical School of UCL, Royal Free Campus, London, UK
    Xenotransplantation 10:142-8. 2003
    ..Our findings demonstrate that PCMV could be eradicated from pig herds being bred for xenotransplantation and argue that the spleen from donor animals should be examined as part of quality control procedures if clinical trials proceed...
  46. ncbi request reprint Markers of HIV-1 disease progression in individuals with haemophilia coinfected with hepatitis C virus: a longitudinal study
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    Lancet 360:1546-51. 2002
    ..We aimed to assess the relation between markers of liver function and progression to AIDS and death in individuals with haemophilia infected with HIV-1 and hepatitis C virus...
  47. doi request reprint Immunotherapy and vaccination after transplant: the present, the future
    Vincent C Emery
    Department of Infection, University College London, Rowland Hill Street, Hampstead, London NW3 2QG, UK
    Infect Dis Clin North Am 24:515-29. 2010
    ..At present, many of these approaches in transplant recipients have focused on infections such as human cytomegalovirus, but the opportunity to use these examples as proof of concept for other infections is discussed...
  48. pmc Use of semi-quantitative PCR for human papillomavirus DNA type 16 to identify women with high grade cervical disease in a population presenting with a mildly dyskaryotic smear report
    P J Bavin
    Division of Communicable Diseases, Royal Free Hospital School of Medicine, London, UK
    Br J Cancer 67:602-5. 1993
    ..The possibility of using such an approach for selecting women for more rapid or for routine colposcopy appointments in the two groups respectively is discussed...
  49. ncbi request reprint [Drugs against human cytomegalovirus]
    Zbigniew J Lesnikowski
    Department of Virology, Royal Free and University College Medical School, London
    Pol Merkur Lekarski 13:242-9. 2002
    ..In this outline we present anti-CMV drugs currently in clinical use and give examples of new molecules under laboratory and clinical development...
  50. ncbi request reprint Differential effects of prednisolone and azathioprine on the development of human cytomegalovirus replication post liver transplantation
    Gaia Nebbia
    Department of Infection, Royal Free and University College Medical School, London, UK
    Transplantation 84:605-10. 2007
    ..We sought to investigate the impact of different immunosuppressive regimens on human cytomegalovirus (HCMV) incidence and replication dynamics in a cohort of 256 patients after liver transplantation...
  51. ncbi request reprint Development of a novel single tube nested PCR for enhanced detection of cytomegalovirus DNA from dried blood spots
    C Atkinson
    Centre for Virology, UCL Medical School, Rowland Hill Street, London NW3 2PF, UK Electronic address
    J Virol Methods 196:40-4. 2014
    ..Owing to its increased sensitivity, it has the potential to be used as a screening assay and ultimately allow early identification and intervention for children with congenital CMV. ..
  52. ncbi request reprint Impact of HIV on host-virus interactions during early hepatitis C virus infection
    M Danta
    Centre for Hepatology, Royal Free and University College Medical School, London
    J Infect Dis 197:1558-66. 2008
    ..Human immunodeficiency virus (HIV) may influence the outcome and natural history of hepatitis C virus (HCV) infection through an impact on acute HCV-specific T cell responses...
  53. doi request reprint Extensive human cytomegalovirus (HCMV) genomic DNA in the renal tubular epithelium early after renal transplantation: Relationship with HCMV DNAemia and long-term graft function
    Ying Ting Li
    Department of Infection, University College Medical School Campus, Rowland Hill Street, Hampstead, London, UK
    J Med Virol 82:85-93. 2010
    ..HCMV DNA is frequently detected in renal tubular epithelial cells early after renal transplantation, precedes DNAemia and is associated with poor long-term graft function...
  54. ncbi request reprint Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides
    Nigel J Temperton
    Department of Virology, Royal Free and University College Medical School, London, United Kingdom
    J Med Virol 70:86-90. 2003
    ..The results provide a rationale for evaluating combinations of other HCMV proteins for incorporation into a multi-target DNA vaccine, and for the optimization of adjuvant usage, to elicit enhanced levels of neutralizing antibodies. 2003...
  55. ncbi request reprint Cytomegalovirus, human herpesvirus-6, and human herpesvirus-7 in hematological patients
    Duncan A Clark
    Department of Virology, Royal Free and University College Medical School of UCL, London, UK
    Semin Hematol 40:154-62. 2003
    ..Both of these newer herpesviruses are potentially susceptible to existing and licensed antiherpesvirus drugs...
  56. pmc Modelling cytomegalovirus replication patterns in the human host: factors important for pathogenesis
    Roland R Regoes
    Ecology and Evolution, Swiss Federal Institute of Technology Zurich, ETH Zentrum NW, Zurich, Switzerland
    Proc Biol Sci 273:1961-7. 2006
    ..The model accurately predicted the time of disease onset for fever, gastrointestinal disease and pneumonitis but not for hepatitis and retinitis, implying that other factors may be involved in the pathology of these diseases...
  57. pmc Genotypic analysis of two hypervariable human cytomegalovirus genes
    Amanda J Bradley
    MRC Virology Unit, Institute of Virology, University of Glasgow, Glasgow, United Kingdom
    J Med Virol 80:1615-23. 2008
    ..The emerging scenario is that the HCMV genotypes developed in early human populations (or even earlier), becoming established via founder or bottleneck effects, and have spread, recombined and mixed worldwide in more recent times...
  58. ncbi request reprint Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection: relationship to CMV disease
    Mostafa A Nokta
    Department of Internal Medicine, Division of Infectious Disease, University of Texas Medical Branch, Galveston, TX 77555 0835, USA
    J Infect Dis 185:1717-22. 2002
    ..42; 95% CI, 2.87-6.81). Change in cumulative PCR status was informative for the risk of subsequent CMV disease...
  59. ncbi request reprint Detection of cytomegalovirus in human placental cells by polymerase chain reaction
    Edyta Paradowska
    Center for Medical Biology, Polish Academy of Sciences, Laboratory of Molecular Virology and Biological Chemistry, Lodz, Poland
    APMIS 114:764-71. 2006
    ..Our results demonstrated that detection of HCMV DNA in placental tissues by DNA amplification provides a specific and sensitive method for diagnosis of intrauterine HCMV infection...
  60. ncbi request reprint Management of CMV infection and disease in transplant patients. 27-29 February 2004
    Raymund R Razonable
    Division of Infectious Diseases and Internal Medicine at the Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Herpes 11:77-86. 2004
    ..This article presents supporting evidence for these recommendations and statements...
  61. ncbi request reprint Genetic content of wild-type human cytomegalovirus
    Aidan Dolan
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 85:1301-12. 2004
    ..The case in support of a lack of protein-coding potential in the region between UL105 and UL111A was also strengthened...
  62. ncbi request reprint Clinical xenotransplantation
    Duncan A Clark
    Lancet 362:1421. 2003
  63. ncbi request reprint Two novel spliced genes in human cytomegalovirus
    Parvis Akter
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 84:1117-22. 2003
    ..Although the functions of these genes are unknown, sequence comparisons suggest that UL128 encodes a beta-chemokine...
  64. ncbi request reprint The ESCRT machinery is not required for human cytomegalovirus envelopment
    Alberto Fraile-Ramos
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Universidad Autonoma, Madrid 28049, Spain
    Cell Microbiol 9:2955-67. 2007
    ..Treatment of infected cells with protease inhibitors also increased viral production. These studies indicate that, in contrast to some enveloped RNA viruses, HCMV does not require the cellular ESCRT machinery to complete its envelopment...
  65. ncbi request reprint Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes
    Andrew J Davison
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, Scotland, UK
    J Gen Virol 84:657-63. 2003
    ..These features prompt speculation about the roles of these genes in the two virus families...