T Martin Embley

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc A congruent phylogenomic signal places eukaryotes within the Archaea
    Tom A Williams
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Proc Biol Sci 279:4870-9. 2012
  2. ncbi request reprint Eukaryotic evolution, changes and challenges
    T Martin Embley
    School of Biology, The Devonshire Building, University of Newcastle upon Tyne, Newcastle NE1 7RU, UK
    Nature 440:623-30. 2006
  3. pmc Multiple secondary origins of the anaerobic lifestyle in eukaryotes
    T Martin Embley
    The Devonshire Building, University of Newcastle upon Tyne, Division of Biology, NE1 7RU, UK
    Philos Trans R Soc Lond B Biol Sci 361:1055-67. 2006
  4. pmc Diversity and reductive evolution of mitochondria among microbial eukaryotes
    Karin Hjort
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Philos Trans R Soc Lond B Biol Sci 365:713-27. 2010
  5. doi request reprint An archaeal origin of eukaryotes supports only two primary domains of life
    Tom A Williams
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Nature 504:231-6. 2013
  6. doi request reprint A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi
    Anastasios D Tsaousis
    Institute for Cell and Molecular Biosciences, Catherine Cookson Building, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Nature 453:553-6. 2008
  7. doi request reprint Horizontal gene transfer in eukaryotic parasites: a case study of Entamoeba histolytica and Trichomonas vaginalis
    U Cecilia Alsmark
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Methods Mol Biol 532:489-500. 2009
  8. pmc Informational gene phylogenies do not support a fourth domain of life for nucleocytoplasmic large DNA viruses
    Tom A Williams
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS ONE 6:e21080. 2011
  9. doi request reprint Localization and functionality of microsporidian iron-sulphur cluster assembly proteins
    Alina V Goldberg
    Institute for Cell and Molecular Biosciences, The Catherine Cookson Building, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Nature 452:624-8. 2008
  10. ncbi request reprint An [Fe] hydrogenase from the anaerobic hydrogenosome-containing fungus Neocallimastix frontalis L2
    Elizabeth A Davidson
    Department of Biochemistry, University of Cambridge, Tennis Court Road, UK
    Gene 296:45-52. 2002

Collaborators

Detail Information

Publications34

  1. pmc A congruent phylogenomic signal places eukaryotes within the Archaea
    Tom A Williams
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Proc Biol Sci 279:4870-9. 2012
    ....
  2. ncbi request reprint Eukaryotic evolution, changes and challenges
    T Martin Embley
    School of Biology, The Devonshire Building, University of Newcastle upon Tyne, Newcastle NE1 7RU, UK
    Nature 440:623-30. 2006
    ..But the evolutionary gap between prokaryotes and eukaryotes is now deeper, and the nature of the host that acquired the mitochondrion more obscure, than ever before...
  3. pmc Multiple secondary origins of the anaerobic lifestyle in eukaryotes
    T Martin Embley
    The Devonshire Building, University of Newcastle upon Tyne, Division of Biology, NE1 7RU, UK
    Philos Trans R Soc Lond B Biol Sci 361:1055-67. 2006
    ..Comparative study of different mitochondrial homologues is needed to determine their fundamental importance for contemporary eukaryotic cells...
  4. pmc Diversity and reductive evolution of mitochondria among microbial eukaryotes
    Karin Hjort
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Philos Trans R Soc Lond B Biol Sci 365:713-27. 2010
    ..These investigations are contributing to understanding the essential functions of mitochondria, defined in the broadest sense, and the limits to which reductive evolution can proceed while maintaining a viable organelle...
  5. doi request reprint An archaeal origin of eukaryotes supports only two primary domains of life
    Tom A Williams
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Nature 504:231-6. 2013
    ..These results provide support for only two primary domains of life--Archaea and Bacteria--because eukaryotes arose through partnership between them...
  6. doi request reprint A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi
    Anastasios D Tsaousis
    Institute for Cell and Molecular Biosciences, Catherine Cookson Building, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Nature 453:553-6. 2008
    ..cuniculi, by reductive evolution and analogous gene replacement. Instead of the mitosome providing the parasite cytosol with ATP, the parasite cytosol now seems to provide ATP for the organelle...
  7. doi request reprint Horizontal gene transfer in eukaryotic parasites: a case study of Entamoeba histolytica and Trichomonas vaginalis
    U Cecilia Alsmark
    Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Methods Mol Biol 532:489-500. 2009
    ..We found a broad range of prokaryotic lineages represented among the donors, but organisms that share similar environmental niches with E. histolytica and T. vaginalis, such as the gut and the vaginal mucosa, dominate...
  8. pmc Informational gene phylogenies do not support a fourth domain of life for nucleocytoplasmic large DNA viruses
    Tom A Williams
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS ONE 6:e21080. 2011
    ..Our results suggest that a fourth domain is not required to explain the available sequence data...
  9. doi request reprint Localization and functionality of microsporidian iron-sulphur cluster assembly proteins
    Alina V Goldberg
    Institute for Cell and Molecular Biosciences, The Catherine Cookson Building, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Nature 452:624-8. 2008
    ..Together, our studies identify the essential biosynthetic process of Fe-S protein assembly as a key function of microsporidian mitosomes...
  10. ncbi request reprint An [Fe] hydrogenase from the anaerobic hydrogenosome-containing fungus Neocallimastix frontalis L2
    Elizabeth A Davidson
    Department of Biochemistry, University of Cambridge, Tennis Court Road, UK
    Gene 296:45-52. 2002
    ....
  11. pmc Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles
    Mark van der Giezen
    Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
    EMBO J 21:572-9. 2002
    ..These experiments provide some of the strongest evidence yet that yeast mitochondria and Neocallimastix hydrogenosomes are but two manifestations of the same fundamental organelle...
  12. ncbi request reprint Iron hydrogenases--ancient enzymes in modern eukaryotes
    David S Horner
    Dipartimento di Fisiologia e Biochimica Generali, University of Milan, Via Celoria 26, 20133, Milan, Italy
    Trends Biochem Sci 27:148-53. 2002
    ..These unique enzymes have thus moved from the margins of eukaryotic biology to become the focus of intense speculation and interest. This article summarizes current knowledge of their distribution, evolution and biochemistry...
  13. ncbi request reprint Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I
    Ivan Hrdy
    Department of Parasitology, Charles University, Vinicna 7, 128 44 Prague 2, Czech Republic
    Nature 432:618-22. 2004
    ..Recruitment of complex I subunits into a H2-producing pathway provides evidence that mitochondria and hydrogenosomes are aerobic and anaerobic homologues of the same endosymbiotically derived organelle...
  14. ncbi request reprint Evolutionary biology: Early evolution comes full circle
    William Martin
    Nature 431:134-7. 2004
  15. ncbi request reprint Anaerobic eukaryotes and their archaebacterial endosymbionts
    T Martin Embley
    The Natural History Museum, London
    Environ Microbiol 4:15-6. 2002
  16. ncbi request reprint Hydrogenosomes, mitochondria and early eukaryotic evolution
    T Martin Embley
    Department of Zoology, The Natural History Museum, London, SW7 5BD, UK
    IUBMB Life 55:387-95. 2003
    ..It remains to be seen if members of this family of organelles share a common function essential to the eukaryotic cell, that provides the underlying selection pressure for organelle retention under different living conditions...
  17. ncbi request reprint A mitochondrial remnant in the microsporidian Trachipleistophora hominis
    Bryony A P Williams
    Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Nature 418:865-9. 2002
    ..The finding of relictual mitochondria in microsporidia provides further evidence of the reluctance of eukaryotes to lose the mitochondrial organelle, even when its canonical function of aerobic respiration has been apparently lost...
  18. ncbi request reprint Fungal hydrogenosomes contain mitochondrial heat-shock proteins
    Mark van der Giezen
    Department of Zoology, The Natural History Museum, London, United Kingdom
    Mol Biol Evol 20:1051-61. 2003
    ..The extraordinary capacity of eukaryotes to repeatedly evolve hydrogen-producing organelles apparently reflects a general ability to modify the biochemistry of the mitochondrial compartment...
  19. pmc Mitochondria and hydrogenosomes are two forms of the same fundamental organelle
    T Martin Embley
    Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Philos Trans R Soc Lond B Biol Sci 358:191-201; discussion 201-2. 2003
    ....
  20. ncbi request reprint Of clades and clans: terms for phylogenetic relationships in unrooted trees
    Mark Wilkinson
    Trends Ecol Evol 22:114-5. 2007
  21. pmc Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
    ..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria...
  22. ncbi request reprint Hydrogenosomal succinyl-CoA synthetase from the rumen-dwelling fungus Neocallimastix patriciarum; an energy-producing enzyme of mitochondrial origin
    Joel B Dacks
    Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Gene 373:75-82. 2006
    ..Our analyses further confirm the mitochondrial ancestry of the Neocallimastix hydrogenosome and sheds light upon the stepwise process by which mitochondria evolve into alternate forms of the organelle...
  23. ncbi request reprint Inference of the phylogenetic position of oxymonads based on nine genes: support for metamonada and excavata
    Vladimir Hampl
    Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic
    Mol Biol Evol 22:2508-18. 2005
    ....
  24. ncbi request reprint The ribulose-1,5-bisphosphate carboxylase/oxygenase gene cluster of Methylococcus capsulatus (Bath)
    Nardia J Baxter
    Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
    Arch Microbiol 177:279-89. 2002
    ....
  25. ncbi request reprint The diversity and evolution of thioredoxin reductase: new perspectives
    Robert P Hirt
    Dept of Zoology, Natural History Museum, Cromwell Rd, London, UK SW7 5BD
    Trends Parasitol 18:302-8. 2002
    ..This article reviews these fundamental differences between the thioredoxin reductases of some parasites and their hosts, discusses their phylogenetic relationships and considers the potential of the enzymes as therapeutic targets...
  26. ncbi request reprint Phylogenetic analyses of diplomonad genes reveal frequent lateral gene transfers affecting eukaryotes
    Jan O Andersson
    The Canadian Institute for Advanced Research, Program in Evolutionary Biology, Department of Biochemistry, Dalhousie University, B3H 4H7, Halifax, Nova Scotia, Canada
    Curr Biol 13:94-104. 2003
    ..Here, we perform a systematic analysis to investigate the impact of LGT on the evolution of diplomonads, a group of anaerobic protists...
  27. ncbi request reprint Horizontal gene transfer and the evolution of parasitic protozoa
    Thomas A Richards
    Protist 154:17-32. 2003
  28. ncbi request reprint The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system
    Graham H Coombs
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Bldg, Glasgow G12 8QQ, United Kingdom
    J Biol Chem 279:5249-56. 2004
    ..The data are thus consistent with the complexity hypothesis that predicts that the evolution of simple pathways such as the thioredoxin cascade are likely to be affected by horizontal gene transfer between species...
  29. ncbi request reprint Primary succession of soil Crenarchaeota across a receding glacier foreland
    Graeme W Nicol
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Environ Microbiol 7:337-47. 2005
    ..These results indicate the potential role of soil crenarchaea in the development of soil substrates, as well as ecological diversity within and between major Group 1 lineages...
  30. ncbi request reprint The genome of the protist parasite Entamoeba histolytica
    Brendan Loftus
    TIGR, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 433:865-8. 2005
    ..Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen...
  31. ncbi request reprint Links between ammonia oxidizer species composition, functional diversity and nitrification kinetics in grassland soils
    Gordon Webster
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Environ Microbiol 7:676-84. 2005
    ..The data therefore demonstrate a direct link between bacterial community structure, physiological diversity and ecosystem function...
  32. ncbi request reprint A novel ADP/ATP transporter in the mitosome of the microaerophilic human parasite Entamoeba histolytica
    Ka Wai Chan
    Dunn Human Nutrition Unit, Medical Research Council, Cambridge, UK
    Curr Biol 15:737-42. 2005
    ..Because many functions of yeast and human mitochondria rely on solutes transported by specialized members of this family, the Entamoeba mitosome must contain only a small subset of these processes requiring adenine nucleotide exchange...
  33. ncbi request reprint Comparative genomics of trypanosomatid parasitic protozoa
    Najib M El-Sayed
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:404-9. 2005
    ..Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont...
  34. pmc Grassland management regimens reduce small-scale heterogeneity and species diversity of beta-proteobacterial ammonia pxidizer populations
    Gordon Webster
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom
    Appl Environ Microbiol 68:20-30. 2002
    ..The results therefore demonstrate significant effects of soil management on diversity and heterogeneity of ammonia oxidizer populations that are related to similar changes in relevant soil characteristics...