David W Ellison

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint APC and CTNNB1 mutations are rare in sporadic ependymomas
    Olabisi E Onilude
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Cancer Genet Cytogenet 168:158-61. 2006
  2. pmc Genetic abnormalities detected in ependymomas by comparative genomic hybridisation
    M Carter
    Department of Neurosurgery, Southampton General Hospital, Southampton, UK
    Br J Cancer 86:929-39. 2002
  3. ncbi request reprint beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee
    David W Ellison
    Northern Institute for Cancer Research, University of Newcastle, UK
    J Clin Oncol 23:7951-7. 2005
  4. ncbi request reprint What's new in neuro-oncology? Recent advances in medulloblastoma
    David W Ellison
    The Northern Institute for Cancer Research, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
    Eur J Paediatr Neurol 7:53-66. 2003
  5. ncbi request reprint Classifying the medulloblastoma: insights from morphology and molecular genetics
    D Ellison
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 28:257-82. 2002
  6. pmc Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2
    Jennifer A Anderton
    Northern Institute for Cancer Research, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
    Neuro Oncol 10:981-94. 2008
  7. ncbi request reprint Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Int J Cancer 118:346-52. 2006
  8. doi request reprint MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma
    Sarra L Ryan
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Acta Neuropathol 123:501-13. 2012
  9. ncbi request reprint DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies
    Edward C Schwalbe
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Acta Neuropathol 125:359-71. 2013
  10. ncbi request reprint Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Carcinogenesis 25:661-8. 2004

Collaborators

Detail Information

Publications29

  1. ncbi request reprint APC and CTNNB1 mutations are rare in sporadic ependymomas
    Olabisi E Onilude
    Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Cancer Genet Cytogenet 168:158-61. 2006
    ....
  2. pmc Genetic abnormalities detected in ependymomas by comparative genomic hybridisation
    M Carter
    Department of Neurosurgery, Southampton General Hospital, Southampton, UK
    Br J Cancer 86:929-39. 2002
    ..Our extensive data on ependymomas demonstrate significant associations between genetic aberrations and clinicopathological variables, and represent a starting point for further biological and clinical studies...
  3. ncbi request reprint beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee
    David W Ellison
    Northern Institute for Cancer Research, University of Newcastle, UK
    J Clin Oncol 23:7951-7. 2005
    ..We tested the hypothesis that nuclear immunoreactivity for beta-catenin is a prognostic marker in medulloblastoma, and assessed the relationship between nuclear beta-catenin immunoreactivity and mutations of CTNNB1 and APC...
  4. ncbi request reprint What's new in neuro-oncology? Recent advances in medulloblastoma
    David W Ellison
    The Northern Institute for Cancer Research, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
    Eur J Paediatr Neurol 7:53-66. 2003
  5. ncbi request reprint Classifying the medulloblastoma: insights from morphology and molecular genetics
    D Ellison
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 28:257-82. 2002
    ....
  6. pmc Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2
    Jennifer A Anderton
    Northern Institute for Cancer Research, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
    Neuro Oncol 10:981-94. 2008
    ....
  7. ncbi request reprint Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Int J Cancer 118:346-52. 2006
    ....
  8. doi request reprint MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma
    Sarra L Ryan
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Acta Neuropathol 123:501-13. 2012
    ....
  9. ncbi request reprint DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies
    Edward C Schwalbe
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level 5, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Acta Neuropathol 125:359-71. 2013
    ..These findings have important implications for future risk-adapted clinical disease management...
  10. ncbi request reprint Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling
    Janet C Lindsey
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Carcinogenesis 25:661-8. 2004
    ..Furthermore, methylation observed in the normal cerebellum emphasises the requirement for appropriate control tissues when assessing the tumour-specificity of TSG hypermethylation...
  11. pmc Rapid diagnosis of medulloblastoma molecular subgroups
    Ed C Schwalbe
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Clin Cancer Res 17:1883-94. 2011
    ..Microarray studies indicate medulloblastoma comprises distinct molecular disease subgroups, which offer potential for improved clinical management...
  12. ncbi request reprint Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients
    Jayne M Lamont
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Clin Cancer Res 10:5482-93. 2004
    ....
  13. ncbi request reprint Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis
    Steven C Clifford
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Cell Cycle 5:2666-70. 2006
    ....
  14. ncbi request reprint Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior
    Charles S McManamy
    Northern Institute for Cancer Research, University of Newcastle, and Department of Neuropathology, Newcastle upon Tyne Hospitals Trust, Newcastle upon Tyne, UK
    Brain Pathol 17:151-64. 2007
    ..In conclusion, the nodular/desmoplastic medulloblastoma appears to have clinical, genetic and biological characteristics that set it apart from other variants of this tumor...
  15. ncbi request reprint Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma
    Deborah K Scott
    Northern Institute for Cancer Research, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    Cell Cycle 5:2381-9. 2006
    ..MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma...
  16. ncbi request reprint Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma
    David W Hamilton
    Northern Institute for Cancer Research, Paul O Gorman Building, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Cancer Lett 227:75-81. 2005
    ..The remaining TSGs showed no evidence of methylation. RASSF1A hypermethylation represents the most common gene-specific defect identified in ependymoma highlighting the importance of its further investigation in this disease...
  17. pmc Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma
    Yuan Lu
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 4:e6159. 2009
    ..The identification of critical genes involved in its pathogenesis will be central to advances in our understanding of its molecular basis, and the development of improved therapeutic approaches...
  18. ncbi request reprint Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas
    Charles S McManamy
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
    J Neuropathol Exp Neurol 62:627-32. 2003
    ..Our study supports the concept of an anaplastic variant among MBs, demonstrating that it has clinical utility...
  19. ncbi request reprint Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma
    Jacqueline A Langdon
    Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
    Genes Chromosomes Cancer 45:47-60. 2006
    ....
  20. ncbi request reprint Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development
    Meryl E Lusher
    Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Cancer Res 62:5906-11. 2002
    ..Importantly, these data demonstrate that comprehensive analysis of the genome and epigenome will be required for identification of the key tumor suppressor genes involved in medulloblastoma development...
  21. ncbi request reprint Surgery for malignant gliomas: mechanistic reasoning and slippery statistics
    Patrick Mitchell
    Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Lancet Neurol 4:413-22. 2005
    ..In this review we examine the prevailing mechanistic model and observational data; we assess how these are applied and the priorities they indicate for future research...
  22. ncbi request reprint Clinical and molecular characteristics of malignant transformation of low-grade glioma in children
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:682-9. 2007
    ..To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children...
  23. ncbi request reprint ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA Richard
    Clin Cancer Res 8:3054-64. 2002
    ..Functional assessment of ERBB-dependent cell signaling and proliferation, in addition to novel therapeutic inhibition of these processes, was conducted using short-term cultures of human ependymoma cells...
  24. ncbi request reprint Genetic and expression profiles of cerebellar liponeurocytomas
    Sonja Horstmann
    International Agency for Research on Cancer, Lyon, France
    Brain Pathol 14:281-9. 2004
    ..Furthermore, the cDNA expression array data suggest a relationship to central neurocytomas, but the presence of TP53 mutations, which are absent in central neurocytomas, suggests that their genetic pathways are different...
  25. doi request reprint Young age may predict a better outcome for children with diffuse pontine glioma
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer 113:566-72. 2008
    ..Because diffuse pontine glioma (DPG) is rare among young children, the outcome of affected patients is unknown...
  26. ncbi request reprint The origins of medulloblastoma subtypes
    Richard J Gilbertson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Annu Rev Pathol 3:341-65. 2008
    ..Definitive characterization of each medulloblastoma subtype will undoubtedly improve treatment of this disease and provide important insights to the origins of cancer...
  27. ncbi request reprint Primary postoperative chemotherapy without radiotherapy for intracranial ependymoma in children: the UKCCSG/SIOP prospective study
    Richard G Grundy
    Children s Brain Tumour Research Centre, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Lancet Oncol 8:696-705. 2007
    ..We aimed to assess the role of a primary chemotherapy strategy in avoiding or delaying radiotherapy in children younger than 3 years with intracranial ependymoma...
  28. ncbi request reprint A 7-year-old boy with midline cerebellar mass
    Azzam Ismail
    Brain Pathol 15:261-2, 267. 2005
    ..On the basis of the histologic and genetic abnormalities, we propose a diagnosis of PNET with multilineal differentiation...
  29. ncbi request reprint Analysis of patients with supratentorial primitive neuro-ectodermal tumours entered into the SIOP/UKCCSG PNET 3 study
    Barry L Pizer
    Alder Hey s Children s Hospital Oncology Unit, Eaton Road, Liverpool L12 2AP, UK
    Eur J Cancer 42:1120-8. 2006
    ..Future treatment programs should be directed at the particular natural history of these tumours, to further define prognostic factors and to explore further biological characteristics...