I O Ellis

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer
    Mohammed A Aleskandarany
    Department of Histopathology, School of Molecular Medical Sciences, Queens Medical Centre, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK
    Breast Cancer Res 14:R3. 2012
  2. pmc erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines
    Janice M Knowlden
    Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK
    Breast Cancer Res 13:R93. 2011
  3. pmc Adenosquamous carcinoma of breast in a 19 years old woman: a case report
    Amit Agrawal
    Professorial Unit of Surgery, City Hospital Campus, University of Nottingham, Nottingham University Hospitals, Nottingham, NG5 1PB, UK
    World J Surg Oncol 8:44. 2010
  4. pmc High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
    Suet F Chin
    Breast Cancer Functional Genomics, Cancer Research UK Cambridge Research Institute and Department of Oncology University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R215. 2007
  5. pmc An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer
    Andrew E Teschendorff
    Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R157. 2007
  6. pmc MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
    Cherie Blenkiron
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R214. 2007
  7. pmc A consensus prognostic gene expression classifier for ER positive breast cancer
    Andrew E Teschendorff
    Cancer Genomics Program, Department of Oncology, University of Cambridge, Hutchison MRC Research Center, Hills Road, Cambridge CB2 2XZ, UK
    Genome Biol 7:R101. 2006
  8. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
  9. pmc Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer
    R S Rampaul
    Department of Pathology, Nottingham City Hospital, Nottingham, UK
    Breast Cancer Res 3:113-6. 2001
  10. pmc Are triple-negative tumours and basal-like breast cancer synonymous?
    Emad A Rakha
    Breast Cancer Res 9:404; author reply 405. 2007

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. pmc Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer
    Mohammed A Aleskandarany
    Department of Histopathology, School of Molecular Medical Sciences, Queens Medical Centre, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK
    Breast Cancer Res 14:R3. 2012
    ..This study aimed to assess the prognostic value of a proliferation assay by using Ki-67 immunohistochemistry as compared with mitotic count scores...
  2. pmc erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines
    Janice M Knowlden
    Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, UK
    Breast Cancer Res 13:R93. 2011
    ..In this study, we examined whether IRS-1 also associates with another erbB receptor family member, erbB3, and what impact this might have on IGF-IR signalling in three ER+ breast cancer cell lines...
  3. pmc Adenosquamous carcinoma of breast in a 19 years old woman: a case report
    Amit Agrawal
    Professorial Unit of Surgery, City Hospital Campus, University of Nottingham, Nottingham University Hospitals, Nottingham, NG5 1PB, UK
    World J Surg Oncol 8:44. 2010
    ..Adenosquamous carcinoma of the breast is a rare form of metaplastic breast carcinoma. We report such a case in a 19 years old female...
  4. pmc High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
    Suet F Chin
    Breast Cancer Functional Genomics, Cancer Research UK Cambridge Research Institute and Department of Oncology University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R215. 2007
    ..To date, most genome-wide array comparative genomic hybridization studies have used tumor panels of relatively large tumor size and high Nottingham Prognostic Index (NPI) that are not as representative of breast cancer demographics...
  5. pmc An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer
    Andrew E Teschendorff
    Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R157. 2007
    ..Reliable identification of ER-negative tumors that have a good prognosis is not yet possible...
  6. pmc MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
    Cherie Blenkiron
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R214. 2007
    ..MicroRNAs (miRNAs), a class of short non-coding RNAs found in many plants and animals, often act post-transcriptionally to inhibit gene expression...
  7. pmc A consensus prognostic gene expression classifier for ER positive breast cancer
    Andrew E Teschendorff
    Cancer Genomics Program, Department of Oncology, University of Cambridge, Hutchison MRC Research Center, Hills Road, Cambridge CB2 2XZ, UK
    Genome Biol 7:R101. 2006
    ..A consensus prognostic gene expression classifier is still elusive in heterogeneous diseases such as breast cancer...
  8. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
    ....
  9. pmc Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer
    R S Rampaul
    Department of Pathology, Nottingham City Hospital, Nottingham, UK
    Breast Cancer Res 3:113-6. 2001
    ..In this review, we address the pathological validation and significance of micrometastasis in sentinel node biopsy in primary breast cancer...
  10. pmc Are triple-negative tumours and basal-like breast cancer synonymous?
    Emad A Rakha
    Breast Cancer Res 9:404; author reply 405. 2007
  11. pmc Serum epidermal growth factor receptor and HER2 expression in primary and metastatic breast cancer patients
    Kristjan S Asgeirsson
    Division of Breast Surgery, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Breast Cancer Res 9:R75. 2007
    ..The clinical relevance of this has not been fully established...
  12. pmc Heregulin beta1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells
    Iain R Hutcheson
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK
    Breast Cancer Res 9:R50. 2007
    ..In the present study we have examined whether HRG signalling can circumvent EGFR blockade in an EGFR-positive tamoxifen-resistant MCF-7 (Tam-R) breast cancer cell line...
  13. pmc Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer
    Mark R Pickard
    Institute for Science and Technology in Medicine and School of Life Sciences, Keele University, Huxley Building, Keele ST5 5BG, UK
    Breast Cancer Res 11:R60. 2009
    ..Fau modifies apoptosis-controller Bcl-G, which is also a key target for candidate oncoprotein maternal embryonic leucine zipper kinase (MELK)...
  14. pmc High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas
    Zahra Madjd
    Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, UK
    Breast Cancer Res 7:R780-7. 2005
    ..The SC101 mAb is a unique Lewisy/b binding antibody that binds to native and extended Lewisy and Lewisb haptens, displaying no cross reactivity with H type 1, H type 2, Lewisx or normal blood group antigens...
  15. pmc Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification
    Desmond G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham NG7 2UH, UK
    Breast Cancer Res 11:R90. 2009
    ....
  16. pmc IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines
    XingWu Zhu
    Academic Unit of Clinical Oncology, University of Nottingham City Hospital Campus, Nottingham NG5 1PB, UK
    Breast Cancer Res 10:R95. 2008
    ..We therefore examined IL-17 protein expression in human breast cancer and modelled its potential biological significance in vitro...
  17. pmc FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis
    Somaia Elbauomy Elsheikh
    Department of Histopathology, School of Molecular Medical Sciences, Queen s Medical Centre, Nottingham University Hospitals Trust and University of Nottingham, Nottingham, UK
    Breast Cancer Res 9:R23. 2007
    ..Recent studies have demonstrated that specific FGFR1 amplification correlates with gene expression and that FGFR1 activity is required for the survival of a FGFR1 amplified breast cancer cell line...
  18. pmc High-resolution array CGH clarifies events occurring on 8p in carcinogenesis
    Susanna L Cooke
    Department of Pathology and Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK
    BMC Cancer 8:288. 2008
    ..Rearrangements in 8p11-12 have been investigated using high-resolution array CGH, but the first 30 Mb of 8p are less well characterised, although this region contains several proposed tumour suppressor genes...
  19. doi request reprint Intraductal proliferative lesions of the breast: morphology, associated risk and molecular biology
    Ian O Ellis
    Department of Histopathology, University of Nottingham, Molecular Medical Sciences, Nottingham City Hospital, Nottingham, UK
    Mod Pathol 23:S1-7. 2010
    ....
  20. pmc Best Practice No 179. Guidelines for breast needle core biopsy handling and reporting in breast screening assessment
    I O Ellis
    Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 57:897-902. 2004
    ..This guidance has been produced by the UK National Coordinating Committee for Breast Screening Pathology and is endorsed by the European Commission working group on breast screening pathology...
  21. pmc Best Practice No 176: Updated recommendations for HER2 testing in the UK
    I O Ellis
    Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 57:233-7. 2004
    ..To ensure maintenance of expertise, an annual caseload volume of at least 250 cases is recommended for laboratories providing a testing service...
  22. pmc Recommendations for HER2 testing in the UK
    I O Ellis
    Department of Histopathology, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 53:890-2. 2000
    ..A group of three reference laboratories has been established to provide advice, quality assurance, and materials, where needed...
  23. pmc Impact of a national external quality assessment scheme for breast pathology in the UK
    I O Ellis
    Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 59:138-45. 2006
    ..This article presents the results and observed effects of the UK National Health Service Breast Screening Programme (NHSBSP) external quality assurance scheme in breast histopathology...
  24. pmc Expression of ras p21, p53 and c-erbB-2 in advanced breast cancer and response to first line hormonal therapy
    S G Archer
    Professional Unit of Surgery, Nottingham City Hospital, UK
    Br J Cancer 72:1259-66. 1995
    ....
  25. pmc Oestrogen receptor expression in ductal carcinoma in situ of the breast: relationship to flow cytometric analysis of DNA and expression of the c-erbB-2 oncoprotein
    D N Poller
    Department of Histopathology, City Hospital, Nottingham, UK
    Br J Cancer 68:156-61. 1993
    ....
  26. ncbi request reprint C-erbB2 expression predicts response to preoperative chemotherapy for locally advanced breast cancer
    P C Willsher
    Professorial Department of Surgery, City Hospital, Nottingham, U K
    Anticancer Res 18:3695-8. 1998
    ..Previous work suggests that the presence of c-erbB2 oncoprotein immunostaining and the proliferation rate of tumours, may be relevant to chemo-sensitivity in breast cancer...
  27. doi request reprint The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer
    H Zhang
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Breast Cancer Res Treat 121:41-51. 2010
    ..We have identified a novel subgroup of basal tumours showing FABP7 expression that have significantly better clinical outcome. Further studies analysing the role of FABP7 are therefore warranted...
  28. doi request reprint Incidence of intramammary nodes in completion mastectomy specimens after axillary node sampling: implications for breast conserving surgery
    R S Rampaul
    Nottingham Breast Institute, Nottingham University Hospital, City Hospital Campus, Hucknall Road, Nottingham NG5 1PB, UK
    Breast 17:195-8. 2008
    ..This study aims to assess the incidence of such nodes in completion mastectomy specimens in women who have had previous breast conserving surgery and ANS...
  29. pmc C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators
    A Travis
    Department of Histopathology, City Hospital, Nottingham, UK
    Br J Cancer 74:229-33. 1996
    ..It seems, however, unlikely that c-erbB-3 protein expression will emerge as a powerful enough prognostic factor to be of value in clinical practice...
  30. doi request reprint A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up
    S J Johnston
    Division of Breast Surgery, University of Nottingham, Nottingham, Nottingham, UK
    Ann Oncol 23:2296-300. 2012
    ..It was suggested that for patients with ER-rich tumours, local control and survival may be comparable. We now present long-term follow-up of a randomised trial designed to address this clinical scenario...
  31. ncbi request reprint Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation
    E A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust and University of Nottingham, UK
    J Pathol 208:495-506. 2006
    ..The basal rather than the myoepithelial phenotype has the strongest relationship with patient outcome...
  32. pmc Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival
    S E Pinder
    Department of Histopathology, City Hospital, Nottingham, UK
    Br J Cancer 71:146-9. 1995
    ..The results suggest that the tumour growth fraction, as assessed by the MIB1 labelling index, is an important predictor of survival...
  33. ncbi request reprint Prognostic and predictive factors in primary breast cancer and their role in patient management: The Nottingham Breast Team
    R S Rampaul
    Department of Surgery, City Hospital, Nottingham NHS Trust, Hucknall Road, Nottingham, UK
    Eur J Surg Oncol 27:229-38. 2001
    ..In this review we will discuss current prognostic and predictive factors with particular emphasis on those of relevance in routine histopathology, especially with respect to their clinical applications...
  34. pmc p53 protein expression in human breast carcinoma: relationship to expression of epidermal growth factor receptor, c-erbB-2 protein overexpression, and oestrogen receptor
    D N Poller
    Department of Histopathology, City Hospital, Nottingham, UK
    Br J Cancer 66:583-8. 1992
    ..Abnormal expression of p53 protein is a feature of both in situ and invasive breast carcinoma, implying that the abnormal p53 protein expression may be implicated in the early stages of mammary carcinoma progression...
  35. doi request reprint Long-term (37 years) clinical outcome of older women with early operable primary breast cancer managed in a dedicated clinic
    B M Syed
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    Ann Oncol 23:1465-71. 2012
    ..A dedicated clinic for older women with early primary breast cancer, established in 1973, has recently evolved into a combined surgical/oncology facility. This study aimed to compare the clinical outcome across these periods...
  36. doi request reprint The prognostic significance of B lymphocytes in invasive carcinoma of the breast
    S M A Mahmoud
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Breast Cancer Res Treat 132:545-53. 2012
    ..This suggests that humoral immunity, in addition to the cell mediated immunity, may be important in breast cancer. This should be considered in breast cancer immunotherapy and vaccine strategies...
  37. pmc The NHS breast screening programme (pathology) EQA: experience in recent years relating to issues involved in individual performance appraisal
    D M Parham
    Department of Pathology, Royal Bournemouth Hospital, Bournemouth, Dorset BH7 7DW, UK
    J Clin Pathol 59:130-7. 2006
    ....
  38. pmc Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma
    D M Abd El-Rehim
    Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 91:1532-42. 2004
    ..These data imply that the combined profile expression patterns of the four receptor family members together provide more accurate information on the tumour behaviour than studying the expression of each receptor individually...
  39. pmc c-erbB-2 oncoprotein expression in primary and advanced breast cancer
    C Lovekin
    Department of Pathology, City Hospital, Nottingham, UK
    Br J Cancer 63:439-43. 1991
    ..In conclusion, this study demonstrates, in a large series of patients presenting to one centre, that c-erbB-2 protein expression is a prognostic indicator in patients with primary operable and advanced breast disease...
  40. doi request reprint Lack of expression of the proteins GMPR2 and PPARĪ± are associated with the basal phenotype and patient outcome in breast cancer
    B G Baker
    School of Molecular Medical Sciences and Cellular Pathology, Nottingham University Hospitals and University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 137:127-37. 2013
    ..Further studies into their relevance in further classification of BP are warranted...
  41. ncbi request reprint Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma
    A H S Lee
    Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Eur J Cancer 42:357-62. 2006
    ..In conclusion, lymphovascular invasion is an independent prognostic factor in node-negative breast cancer and should be considered in decisions about adjuvant treatment in this group of women...
  42. pmc P-glycoprotein expression in locally advanced breast cancer treated by neoadjuvant chemotherapy
    A R Dixon
    City Hospital, Nottingham, UK
    Br J Cancer 66:537-41. 1992
    ..We have failed to demonstrate a clear clinical utility for C219 in breast cancer, particularly regarding the identification of patients in whom MDR chemotherapy be avoided once metastases develop...
  43. doi request reprint Sonographic correlations with the new molecular classification of invasive breast cancer
    I T H Au-Yong
    Nottingham Breast Institute, City Hospital, Hucknall Road, Nottingham, UK, NG5 1PB
    Eur Radiol 19:2342-8. 2009
    ..The biological reasons for these findings and their implications regarding imaging protocols require further study and may enable improved detection of these lesions...
  44. doi request reprint Biological profile of oestrogen receptor positive primary breast cancers in the elderly and response to primary endocrine therapy
    G Okunade
    Division of Breast Surgery, Nottingham University Hospitals, City Hospital Campus, Nottingham, NG5 1PB, UK
    Crit Rev Oncol Hematol 72:76-82. 2009
    ..In this population, ERalpha+ breast cancer also appears to have a less aggressive biological profile favouring better hormone sensitivity...
  45. doi request reprint The mammographic correlations of a new immunohistochemical classification of invasive breast cancer
    S Taneja
    Nottingham Breast Institute, City Hospital, Nottingham, UK
    Clin Radiol 63:1228-35. 2008
    ..The aim of this study was to identify the mammographic correlates of these novel molecular classes of invasive breast cancer...
  46. doi request reprint Three-dimensional reconstruction of sentinel lymph nodes with metastatic breast cancer indicates three distinct patterns of tumour growth
    E C Paish
    Breast Cancer Pathology Research Group, Department of Histopathology, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK
    J Clin Pathol 62:617-23. 2009
    ..Three-dimensional (3D) serial section alignment and reconstruction techniques can be used for visualisation of nodal metastasis and could provide better understanding of disease growth patterns...
  47. ncbi request reprint Survival of invasive breast cancer according to the Nottingham Prognostic Index in cases diagnosed in 1990-1999
    R W Blamey
    The Breast Institute, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Eur J Cancer 43:1548-55. 2007
    ..The Nottingham Prognostic Index (NPI) is a well established and widely used method of predicting survival of operable primary breast cancer...
  48. pmc c-erbB-4 protein expression in human breast cancer
    T Y Kew
    The Breast Unit, Nottingham City Hospital, Nottingham, UK
    Br J Cancer 82:1163-70. 2000
    ..Larger series with extended follow-up will be required to ascertain definitively the prognostic value of c-erbB-4 expression in breast carcinoma...
  49. pmc Early-onset breast cancer--histopathological and prognostic considerations
    J Kollias
    Nottingham City Hospital, UK
    Br J Cancer 75:1318-23. 1997
    ..The association of young age at diagnosis with a worse prognosis in this series is explained by a higher proportion of poorly differentiated cancers; age itself had no influence on the prognosis of the individual...
  50. ncbi request reprint Value of contralateral surveillance mammography for primary breast cancer follow-up
    J Kollias
    Professorial Unit of Surgery, City Hospital Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    World J Surg 24:983-7; discussion 988-9. 2000
    ..The results of this study suggest that surveillance mammography of the contralateral breast is of value in women whose first cancer predicted a favorable prognosis...
  51. pmc Identification of key clinical phenotypes of breast cancer using a reduced panel of protein biomarkers
    A R Green
    Breast Cancer Pathology Research Group, Division of Oncology, School of Medicine, Academic Unit of Clinical Oncology, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 109:1886-94. 2013
    ..As an alternative, immunohistochemical analysis applied to routinely processed tissue samples could be used to identify distinct biological classes of breast cancer...
  52. ncbi request reprint Prognostic significance of BRCA1 expression in sporadic breast carcinomas
    H Lambie
    Department of Histopathology, Nottingham City Hospital, Nottingham, UK
    J Pathol 200:207-13. 2003
    ..Loss of BRCA1 expression associated with high-grade breast tumours suggests that BRCA1 may play an important role in the pathogenesis of sporadic breast cancer...
  53. pmc Diagnosis of axillary nodal metastases by ultrasound-guided core biopsy in primary operable breast cancer
    A Damera
    Department of Radiology, Helen Garrod Breast Screening Unit, Nottingham International Breast Education Centre, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 89:1310-3. 2003
    ..In conclusion, US can identify abnormal nodes in patients presenting with primary operable breast cancer. In all, 65% of these nodes are malignant and this can often be confirmed with US-guided core biopsy...
  54. ncbi request reprint Excision biopsy findings of patients with breast needle core biopsies reported as suspicious of malignancy (B4) or lesion of uncertain malignant potential (B3)
    A H S Lee
    Department of Histopathology, City Hospital, Nottingham, UK
    Histopathology 42:331-6. 2003
    ..The majority of cores are reported as benign (B1), normal (B2) or malignant (B5). The predictive value of the two borderline categories suspicious of malignancy (B4) and lesion of uncertain malignant potential (B3) was studied...
  55. ncbi request reprint Change in expression of ER, bcl-2 and MIB1 on primary tamoxifen and relation to response in ER positive breast cancer
    F S Kenny
    Professorial Unit of Surgery, Nottingham City Hospital, UK
    Breast Cancer Res Treat 65:135-44. 2001
    ....
  56. ncbi request reprint Sentinel node biopsy for breast cancer may have little to offer four-node-samplers. results of a prospective comparison study
    R D Macmillan
    The Breast Unit, Nottingham City Hospital, Hucknall Road, NG5 1PB, Nottingham, UK
    Eur J Cancer 37:1076-80. 2001
    ..For 1 patient, the SN was positive and the 4NAS negative. SNB performed using radiolabelled colloid has no advantage over 4NAS when nodes are assessed by standard histological technique...
  57. ncbi request reprint Clinical value of epidermal growth factor receptor expression in primary breast cancer
    R S Rampaul
    Nottingham Breast Institute, University of Nottingham, Nottingham City Hospital, NHS Trust, Nottingham, UK
    Adv Anat Pathol 12:271-3. 2005
    ..The impetus to standardize such studies is much needed as there are now several tyrosine kinase inhibitors directed against the EGF receptor and phase II trials are showing significant promise...
  58. ncbi request reprint Basal phenotype: a powerful prognostic factor in small screen-detected invasive breast cancer with long-term follow-up
    A J Evans
    Radiology, Breast Institute, Nottingham City Hospital, Nottingham, UK
    J Med Screen 14:210-4. 2007
    ..To assess the frequency and prognostic significance of a basal phenotype in a group of women with screen-detected invasive breast cancers with long-term follow-up and to focus particularly on women with small ( < 15 mm) breast cancers...
  59. doi request reprint Vacuum-assisted excision of breast lesions of uncertain malignant potential (B3) - an alternative to surgery in selected cases
    S L Tennant
    Nottingham Breast Institute, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Breast 17:546-9. 2008
    ..Follow-up mammography after VAE of radial scars often showed residual distortion. VAE can be a safe alternative to surgery in the treatment of B3 lesions without atypia, providing thorough multidisciplinary discussion has taken place...
  60. pmc The significance of lobular neoplasia on needle core biopsy of the breast
    S Menon
    Department of Histopathology, Nottingham University Hospital, City Hospital Campus, Hucknall Road, Nottingham NG5 1PB, UK
    Virchows Arch 452:473-9. 2008
    ..Some carcinomas were found after apparently adequate core biopsy, raising the question of whether excision biopsy should be considered after all core biopsy diagnoses of lobular neoplasia...
  61. ncbi request reprint Extent of ductal carcinoma in situ within and surrounding invasive primary breast carcinoma
    N Crombie
    Department of Histopathology, City Hospital NHS Trust, Nottingham, UK
    Br J Surg 88:1324-9. 2001
    ..This effect is restricted to the volume of DCIS in the tissue surrounding the invasive lesion rather than the intratumoral component...
  62. ncbi request reprint Prognostic significance of synchronous and metachronous bilateral breast cancer
    J Kollias
    Professorial Unit of Surgery, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    World J Surg 25:1117-24. 2001
    ..However, the time duration to metachronous contralateral breast cancer did not have prognostic significance in a multivariate model compared with the prognostic features of the original primary...
  63. ncbi request reprint Loss of heterozygosity in bilateral breast cancer
    J Kollias
    Nottingham City Hospital, UK
    Breast Cancer Res Treat 64:241-51. 2000
    ..No concordant allelic loss was demonstrated for D17S786 suggesting that germline mutations in p53 are unlikely in such cases of bilateral breast cancer...
  64. doi request reprint Predictive value of needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening
    M E el-Sayed
    Department of Histopathology, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK
    Histopathology 53:650-7. 2008
    ..The aim was to study a large series of B3 cases from population-based screening subjects in order to evaluate positive predictive values (PPVs) for malignancy...
  65. doi request reprint The prognostic significance of inflammation and medullary histological type in invasive carcinoma of the breast
    E A Rakha
    Departments of Histopathology and Surgery, Nottingham University Hospitals, Nottingham, UK
    Eur J Cancer 45:1780-7. 2009
    ..Further studies are needed to investigate the difference in survival between medullary carcinoma and other forms of basal carcinomas and the role of inflammation in any such differences in behaviour...
  66. ncbi request reprint The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome
    A R Panigrahi
    Department of Histopathology, Nottingham Breast Unit, Nottingham City Hospital, Nottingham, UK
    J Pathol 204:93-100. 2004
    ..It also suggests that, in this group of breast cancers, the most common upstream regulator of AKT may be ER rather than PTEN, EGFR or Her2...
  67. ncbi request reprint Breast carcinoma with basal differentiation: a proposal for pathology definition based on basal cytokeratin expression
    E A Rakha
    Molecular Medical Sciences, University of Nottingham and Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham, UK
    Histopathology 50:434-8. 2007
    ....
  68. ncbi request reprint The influence of basal phenotype on the metastatic pattern of breast cancer
    A A Luck
    Breast Institute, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Clin Oncol (R Coll Radiol) 20:40-5. 2008
    ..To assess whether basal phenotype influences the metastatic pattern and survival in patients with metastatic breast cancer...
  69. ncbi request reprint Detecting which invasive cancers at mammographic screening saves lives?
    A J Evans
    Helen Garrod Breast Screening Unit, Nottingham City Hospital, Nottingham, UK
    J Med Screen 8:86-90. 2001
    ..These data were applied to a separate series of screen detected cancers...
  70. ncbi request reprint Interval breast cancers: prognostic features and survival by subtype and time since screening
    Gareth J R Porter
    Nottingham Breast Institute, Nottingham City NHS Trust, Nottingham, UK
    J Med Screen 13:115-22. 2006
    ....
  71. pmc The detection of ductal carcinoma in situ at mammographic screening enables the diagnosis of small, grade 3 invasive tumours
    A J Evans
    Department of Radiology, Nottingham City Hospital, UK
    Br J Cancer 75:542-4. 1997
    ..Detection of calcification suggestive of DCIS should remain an important part of mammographic screening...
  72. ncbi request reprint Expression of p27kip1 in breast cancer and its prognostic significance
    A Barnes
    Department of Histopathology, Nottingham City Hospital Breast Unit, Nottingham, UK
    J Pathol 201:451-9. 2003
    ..It is concluded that the inverse relationship between p27kip1 levels and histological grade and individual grade components suggests a role for p27kip1 in both cell proliferation and differentiation, but is not clinically useful...
  73. doi request reprint Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial
    R W Blamey
    Nottingham City Hospital, Hucknall Rd, Nottingham NG5 1PB, United Kingdom
    Eur J Cancer 49:2294-302. 2013
    ..The aim of this study was to examine the effect of adjuvant therapies in tumours with excellent prognostic features...
  74. doi request reprint Molecular characteristics and prognostic features of breast cancer in Nigerian compared with UK women
    A J Agboola
    Division of Pathology, School of Molecular Medical Sciences, University Hospitals and University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 135:555-69. 2012
    ....
  75. doi request reprint Tumour-infiltrating macrophages and clinical outcome in breast cancer
    S M A Mahmoud
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    J Clin Pathol 65:159-63. 2012
    ..In breast cancer, the presence of macrophages has been correlated with increased angiogenesis and poor prognosis but little information is available about the independent prognostic role of macrophages infiltrating breast carcinomas...
  76. doi request reprint Frequency and patterns of metastatic disease in locally advanced inflammatory and non-inflammatory breast cancer
    M Z Mvere
    Nottingham Breast Institute, City Hospital, Hucknall Road, Nottingham, UK
    Clin Oncol (R Coll Radiol) 23:608-12. 2011
    ..To determine the frequency and pattern of metastatic disease as detected by staging computed tomography in patients presenting with locally advanced primary breast cancer, comparing non-inflammatory and inflammatory subtypes...
  77. ncbi request reprint Loss of CD59 expression in breast tumours correlates with poor survival
    Z Madjd
    CRC Academic Unit of Clinical Oncology, University of Nottingham, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK
    J Pathol 200:633-9. 2003
    ..These findings indicate that loss of CD59 may offer a selective advantage for breast cancers, resulting in more aggressive tumours and conferring a poor prognosis for patients...
  78. ncbi request reprint Predicting invasion in mammographically detected microcalcification
    M J Bagnall
    International Breast Screening Education Centre, Nottingham City Hospital, UK
    Clin Radiol 56:828-32. 2001
    ..It would seem reasonable to consider staging the axilla at therapeutic surgery in these patients...
  79. doi request reprint Vascular invasion in breast cancer; an overview of recent prognostic developments and molecular pathophysiological mechanisms
    R A A Mohammed
    Clinical Oncology, University of Nottingham, University Hospitals, Nottingham, UK
    Histopathology 55:1-9. 2009
    ....
  80. ncbi request reprint Woman feels breast lump--surgeon cannot: the role of ultrasound in arbitration
    J A Cid
    The Breast Institute, City Hospital, Nottingham, UK
    Eur J Cancer 40:2053-5. 2004
    ..98). Ultrasound may be a suitable complimentary investigation, which will relieve symptoms in those with cysts and can detect small clinically--and sometimes mammographically--occult breast cancers...
  81. ncbi request reprint Mammographic size of ductal carcinoma in situ does not predict the presence of an invasive focus
    Y Wahedna
    Professorial Unit of Surgery, Nottingham City Hospital, Hucknall Road, NG5 1PB, Nottingham, UK
    Eur J Cancer 37:459-62. 2001
    ..In contrast to previous expressed opinions, neither mammography or grade were predictive. We have not identified any factor capable of predicting a higher likelihood of an invasive focus...
  82. pmc An overview of assessment of prognostic and predictive factors in breast cancer needle core biopsy specimens
    E A Rakha
    Molecular Medical Sciences, University of Nottingham, Department of Histopathology, Nottingham City Hospital NHS Trust Nottingham University, Nottingham, UK
    J Clin Pathol 60:1300-6. 2007
    ....
  83. ncbi request reprint Phenotypic similarities in bilateral breast cancer
    J Kollias
    Nottingham City Hospital, Nottingham, UK
    Breast Cancer Res Treat 85:255-61. 2004
    ..It is likely that this is related to similar tumourogenic pathways occurring at equivalent exposure times to various environmental and hormonal influences, although, in a proportion of cases, inherited genetic factors may play a role...
  84. ncbi request reprint Breast pathology practice: most common problems in a consultation service
    T C Putti
    Department of Pathology, National University of Singapore, Singapore, and Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust, UK
    Histopathology 47:445-57. 2005
    ..The use of common immunohistochemical stains such as various cytokeratin and myoepithelial markers, E-cadherin and hormone receptors is helpful in solving most of these diagnostic dilemmas...
  85. doi request reprint Early primary breast cancer in the elderly - pattern of presentation and treatment
    S W Tang
    Division of Breast Surgery, City Hospital, Hucknall Road, University of Nottingham, Nottingham NG5 1PB, UK
    Surg Oncol 20:7-12. 2011
    ..This study aimed to identify a profile of characteristics in elderly women with operable primary breast cancer and investigate the dynamics influencing the treatment decision-making process...
  86. ncbi request reprint Laboratory handling and histology reporting of breast specimens from patients who have received neoadjuvant chemotherapy
    S E Pinder
    Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Histopathology 50:409-17. 2007
    ..We also present a brief review of the literature and suggest a simple method for quantifying the degree of response to neoadjuvant chemotherapy in both the primary breast carcinoma and the lymph nodes...
  87. pmc c-myc oncogene product expression and prognosis in operable breast cancer
    A P Locker
    Nottingham City Hospital, UK
    Br J Cancer 60:669-72. 1989
    ..The other findings imply that measurement of c-myc oncoprotein levels does not yield useful prognostic information...
  88. pmc Three dimensional reconstruction of a human breast carcinoma using routine laboratory equipment and immunohistochemistry
    T Kurien
    Breast Cancer Pathology Research Group, Department of Histopathology, Nottingham City Hospital NHS Trust and University of Nottingham, Nottingham NG5 1PB, UK
    J Clin Pathol 58:968-72. 2005
    ..To establish a three dimensional reconstruction of an invasive breast carcinoma using basic laboratory equipment to evaluate and characterise the spatial arrangement of the parenchymal cells of the breast...
  89. pmc Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast
    R E Hewitt
    Department of Histopathology, University of Nottingham Medical School, Queen s Medical Centre, UK
    Br J Cancer 75:221-9. 1997
    ..Within carcinomas, vascular BM staining for beta 2(lam) was clearly weaker than in normal tissues, which may reflect incomplete maturation of these vessels...
  90. pmc Preoperative assessment of prognostic factors in breast cancer
    H Denley
    Department of Histopathology, Nottingham City Hospital NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 54:20-4. 2001
    ..In the future, other molecular markers such as C-erbB-2 might also prove beneficial in predicting response to newly developed treatments...
  91. ncbi request reprint Screen detected ductal carcinoma in situ (DCIS): overdiagnosis or an obligate precursor of invasive disease?
    A J Evans
    Helen Garrod Breast Screening Unit, City Hospital, Nottingham, UK
    J Med Screen 8:149-51. 2001
    ..This study aims to clarify the value of detecting DCIS at mammographic screening by assessing its biological characteristics and by comparing screen detected DCIS with a series of symptomatic DCIS lesions...
  92. pmc Expression of the transcription factor CTCF in invasive breast cancer: a candidate gene located at 16q22.1
    E A Rakha
    The Breast Unit, Department of Histopathology, Nottingham City Hospital NHS Trust, Hucknall Road, University of Nottingham, Nottingham NG5 1PB, UK
    Br J Cancer 91:1591-6. 2004
    ..1 loss in breast cancer and thus another gene or genes at this region remain to be identified...
  93. doi request reprint Pathological features of primary breast cancer in the elderly based on needle core biopsies--a large series from a single centre
    K L Cheung
    Division of Breast Surgery, University of Nottingham, UK
    Crit Rev Oncol Hematol 67:263-7. 2008
    ..We have clearly confirmed the high frequency of ER-positive tumours in elderly patients. Further work is underway to assess long-term outcome and clinical relevance...
  94. doi request reprint MicroRNA involvement in the pathogenesis and management of breast cancer
    S M Khoshnaw
    Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals Trust, Nottingham, UK
    J Clin Pathol 62:422-8. 2009
    ....
  95. ncbi request reprint Accuracy of mammography in predicting histological extent of ductal carcinoma in situ (DCIS)
    J Chakrabarti
    Department of Breast Surgery, Nottingham Breast Institute, Nottingham City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    Eur J Surg Oncol 32:1089-92. 2006
    ..Accuracy of mammography in predicting pathological extent of ductal carcinoma in situ (DCIS)...
  96. doi request reprint Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study
    D G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals Trust and School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2UH, UK
    Breast Cancer Res Treat 130:457-63. 2011
    ..These findings suggest a possible role for targeted therapy using adrenoceptor antagonists...
  97. pmc Evaluation of immunoreactivity with monoclonal antibody NCRC 11 in breast carcinoma
    I O Ellis
    Department of Histopathology, Queens Medical Centre, University Hospital, Nottingham, UK
    Br J Cancer 56:295-9. 1987
    ..Simplification of staining assessment by modification to two staining groups still allows significant separation of patients into prognostic groups and incorporation into an existing prognostic index...
  98. ncbi request reprint Histological features useful in the distinction of phyllodes tumour and fibroadenoma on needle core biopsy of the breast
    A H S Lee
    Histopathology Department, Nottingham University Hospitals, Nottingham, UK
    Histopathology 51:336-44. 2007
    ..To identify features useful in distinguishing phyllodes tumours from fibroadenomas on core biopsy...
  99. pmc Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype
    S E Elsheikh
    Department of Histopathology, School of Molecular Medical Sciences, Nottingham, UK
    Br J Cancer 99:327-34. 2008
    ..Further studies are warranted to determine whether they play an oncogenic role in basal-like/triple-negative breast cancer development or are just surrogate markers for this subgroup...
  100. ncbi request reprint An audit of "equivocal" (C3) and "suspicious" (C4) categories in fine needle aspiration cytology of the breast
    R A Deb
    Department of Histopathology, Nottingham City Hospital NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK
    Cytopathology 12:219-26. 2001
    ....
  101. pmc Sections of the nipple and quadrants in mastectomy specimens for carcinoma are of limited value
    K Sikand
    Department of Histopathology, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 58:543-5. 2005
    ..To assess the value of nipple and quadrant sections in mastectomy specimens for carcinoma in detecting Paget's disease and multifocal carcinoma...