E Elkord

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells
    Eyad Elkord
    Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Cardiff, UK
    Immunology 114:204-12. 2005
  2. ncbi request reprint CD4+ T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25+ T cells
    Eyad Elkord
    Department of Immunology, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Cancer Immunol Immunother 57:833-47. 2008
  3. ncbi request reprint Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer
    Eyad Elkord
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK
    Int Immunol 17:1315-25. 2005
  4. ncbi request reprint Correlation between CD8+ T cells specific for prostate-specific antigen and level of disease in patients with prostate cancer
    Eyad Elkord
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK
    Clin Immunol 120:91-8. 2006
  5. doi request reprint Frequency of human T regulatory cells in peripheral blood is significantly reduced by cryopreservation
    Eyad Elkord
    Clinical Immunotherapy Laboratory, Department of Medical Oncology, University of Manchester, Wilmslow Road, Manchester M204BX, UK
    J Immunol Methods 347:87-90. 2009
  6. doi request reprint Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4)
    Eyad Elkord
    CR UK Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK
    Cancer Immunol Immunother 58:1657-67. 2009
  7. ncbi request reprint Role of regulatory T cells in allergy: implications for therapeutic strategy
    Eyad Elkord
    CRUK Immunology Department, Paterson Institute for Cancer Research, University of Manchester, UK
    Inflamm Allergy Drug Targets 5:211-7. 2006
  8. ncbi request reprint Immunology and immunotherapy approaches for prostate cancer
    E Elkord
    CRUK Immunology Department, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Prostate Cancer Prostatic Dis 10:224-36. 2007
  9. doi request reprint Novel therapeutic strategies by regulatory T cells in allergy
    Eyad Elkord
    Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Chem Immunol Allergy 94:150-7. 2008
  10. ncbi request reprint Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy
    Eyad Elkord
    University of Manchester, Paterson Institute for Cancer Research, Department of Medical Oncology, Wilmslow Road, Manchester M20 4BX, UK
    Expert Opin Biol Ther 8:385-95. 2008

Collaborators

Detail Information

Publications19

  1. pmc Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells
    Eyad Elkord
    Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Cardiff, UK
    Immunology 114:204-12. 2005
    ....
  2. ncbi request reprint CD4+ T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25+ T cells
    Eyad Elkord
    Department of Immunology, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Cancer Immunol Immunother 57:833-47. 2008
    ..We have recently shown that CD8(+) T cells recognizing h5T4 can be generated in the absence of CD4(+) T cells from peripheral blood lymphocytes of human healthy individuals...
  3. ncbi request reprint Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer
    Eyad Elkord
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK
    Int Immunol 17:1315-25. 2005
    ....
  4. ncbi request reprint Correlation between CD8+ T cells specific for prostate-specific antigen and level of disease in patients with prostate cancer
    Eyad Elkord
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, UK
    Clin Immunol 120:91-8. 2006
    ..Our data suggest that frequency of PSA-specific CD8+ T cells is correlated to CPECs, but not to serum PSA level...
  5. doi request reprint Frequency of human T regulatory cells in peripheral blood is significantly reduced by cryopreservation
    Eyad Elkord
    Clinical Immunotherapy Laboratory, Department of Medical Oncology, University of Manchester, Wilmslow Road, Manchester M204BX, UK
    J Immunol Methods 347:87-90. 2009
    ..Herein, we report a significant reduction in Treg frequency in all samples following cryopreservation...
  6. doi request reprint Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4)
    Eyad Elkord
    CR UK Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK
    Cancer Immunol Immunother 58:1657-67. 2009
    ..More than half of the patients showed phenotypes consistent with relative immune suppression and/or escape highlighting the complexity of positive and negative factors challenging any simple correlation with clinical outcome...
  7. ncbi request reprint Role of regulatory T cells in allergy: implications for therapeutic strategy
    Eyad Elkord
    CRUK Immunology Department, Paterson Institute for Cancer Research, University of Manchester, UK
    Inflamm Allergy Drug Targets 5:211-7. 2006
    ..In this review, I summarize the role of Tregs in allergic diseases and discuss the possibility of manipulating these cells for treating allergic diseases...
  8. ncbi request reprint Immunology and immunotherapy approaches for prostate cancer
    E Elkord
    CRUK Immunology Department, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Prostate Cancer Prostatic Dis 10:224-36. 2007
    ..More importantly, clinical trials in advanced PC patients have shown that immunotherapy may generate significant clinical responses. Immunology and immunotherapy aspects of PC with focus on prostate-specific antigen will be presented...
  9. doi request reprint Novel therapeutic strategies by regulatory T cells in allergy
    Eyad Elkord
    Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Chem Immunol Allergy 94:150-7. 2008
    ..Herein, I review the potential of Treg as exciting targets for developing new immunotherapeutic strategies for treating allergic diseases...
  10. ncbi request reprint Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy
    Eyad Elkord
    University of Manchester, Paterson Institute for Cancer Research, Department of Medical Oncology, Wilmslow Road, Manchester M20 4BX, UK
    Expert Opin Biol Ther 8:385-95. 2008
    ..Despite improvement in conventional strategies for treating gastrointestinal (GI) carcinoma, large numbers of patients still suffer from incurable or progressive disease...
  11. doi request reprint T cell-based immunotherapy of metastatic renal cell carcinoma: modest success and future perspective
    Alaaeldin Shablak
    Department of Medical Oncology, School of Cancer, Enabling Sciences and Technology, The University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Manchester, United Kingdom
    Clin Cancer Res 15:6503-10. 2009
    ....
  12. ncbi request reprint Adoptive transfer of T(reg) depleted autologous T cells in advanced renal cell carcinoma
    Fiona C Thistlethwaite
    Cancer Research UK Department of Medical Oncology, University of Manchester and Christie Hospital NHS Foundation Trust, Manchester, UK
    Cancer Immunol Immunother 57:623-34. 2008
    ..The aim of this study was to assess the feasibility and safety of adoptive transfer of CD25(+) depleted autologous T cells in patients with advanced renal cell carcinoma and to examine resulting changes in lymphocyte subsets...
  13. ncbi request reprint Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival
    Richard W Griffiths
    Department of Medical Oncology, Christie Research Centre, Paterson Institute for Cancer Research, Manchester, UK
    Cancer Immunol Immunother 56:1743-53. 2007
    ..We have investigated the presence of T(Reg) cells systemically and in situ in previously untreated patients with renal cell carcinoma (RCC)...
  14. doi request reprint An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases
    Eyad Elkord
    CRUK Immunology, Medical Oncology Groups, Paterson Institute for Cancer Research, University of Manchester, Christie Hospital NHS Trust, Manchester, UK
    J Immunother 31:820-9. 2008
    ..These observations warrant more studies to identify the precise underlying mechanisms...
  15. ncbi request reprint CD8 T-cell recognition of human 5T4 oncofetal antigen
    Lucy J C Smyth
    Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Int J Cancer 119:1638-47. 2006
    ..In conclusion, there is a repertoire of CD8 T cell recognition of 5T4 in normal human donors and some candidate HLA-A*0201 epitopes have been identified...
  16. pmc 5T4 oncofetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype
    F V Castro
    Cancer Research UK Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Leukemia 26:1487-98. 2012
    ..We also show that 5T4-positive Sup-B15 cells are susceptible to 5T4-specific superantigen antibody-dependent cellular toxicity providing support for targeted immunotherapy in high-risk pre-B-ALL...
  17. doi request reprint Clinical and immunologic results of a phase II trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia
    Ursula Winters
    School of Cancer and Imaging, University of Manchester, St Mary s Hospital, Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 14:5292-9. 2008
    ..Indeed, there is evidence that immunosuppressed individuals have higher rates of VIN, suggesting immune control is relevant...
  18. doi request reprint Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma
    Christy Ralph
    Department of Medical Oncology, School of Cancer, Enabling Sciences and Technology, University of Manchester, Manchester, United Kingdom
    Clin Cancer Res 16:1662-72. 2010
    ..Cytotoxic T lymphocyte antigen 4 (CTLA4), a key negative regulator of T-cell activation, is targeted by the antibody tremelimumab to release potentially useful antitumor activity...
  19. ncbi request reprint Bead-isolated human CD4+CD25+ T regulatory cells are anergic and significantly suppress proliferation of CD4+CD25- T responder cells
    Eyad Elkord
    Clin Immunol 120:232-3. 2006