A G Eliopoulos

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    J Virol 77:1316-28. 2003
  2. pmc TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells
    Clare C Davies
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    Mol Cell Biol 25:9806-19. 2005
  3. pmc The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2
    Aristides G Eliopoulos
    The Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, England
    J Virol 76:4567-79. 2002
  4. ncbi Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, UK
    Oncogene 22:7557-69. 2003
  5. pmc Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies and MRC Center for Immune Regulation, The University of Birmingham Medical School, Birmingham B15 2TA, UK
    EMBO J 22:3855-64. 2003
  6. pmc CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
    Mol Cell Biol 20:5503-15. 2000
  7. ncbi LMP1 structure and signal transduction
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham, B15 2TA, UK
    Semin Cancer Biol 11:435-44. 2001
  8. pmc Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, England
    J Virol 73:1023-35. 1999
  9. pmc CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion
    N J Gallagher
    CRC Institute for Cancer Studies, University of Birmingham Medical School, Birmingham B15 2TA, UK
    Mol Pathol 55:110-20. 2002
  10. pmc Anti-proliferative activity and mechanism of action of titanocene dichloride
    C V Christodoulou
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, UK
    Br J Cancer 77:2088-97. 1998

Collaborators

  • C W Dawson
  • L S Young
  • Philip N Tsichlis
  • D H Adams
  • P G Murray
  • Calin D Dumitru
  • C J Poole
  • Piotr Potemski
  • Tak Wah Mak
  • C J Gordon
  • F Berditchevski
  • Zuzana Krcova
  • S C Afford
  • A M Blom
  • Clare C Davies
  • Amanda J Baxendale
  • Pauline G Knox
  • Rafal Sadej
  • Aristides Moschonas
  • Seran C Hill
  • Santasabuj Das
  • N J Gallagher
  • A E Milner
  • S M Blake
  • D J Kerr
  • El Nasir Lalani
  • Renata Kusinska
  • Jiri Ehrmann
  • Radzislaw Kordek
  • Christopher D Buckley
  • Vera Novitskaya
  • Gouri Baldwin
  • Andrew D Filer
  • Katerina Gkirtzimanaki
  • Hanna Romanska
  • Dimitris Kardassis
  • Maria Kouraki
  • Efstathia Thymiakou
  • C V Christodoulou
  • Keyong Du
  • Jeonghee Cho
  • John Gordon
  • Alan B Rickinson
  • Andrew Hislop
  • Glyn R Teale
  • Danai Bem
  • Sarah J Youde
  • David M Luesley
  • Irina Lambertz
  • Stephen Man
  • Gary Reynolds
  • Suzanne E Stewart
  • Michelle A Kelliher
  • Vivek Mudaliar
  • Michael J O Wakelam
  • Joanne Mason
  • Nicky K Green
  • Anne E Milner
  • J Crocker
  • J Oates
  • A Agathangelo
  • P G Knox
  • D H Palmer
  • E A Hodgkin
  • L Hodgkins
  • D R Ferry

Detail Information

Publications28

  1. pmc TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    J Virol 77:1316-28. 2003
    ..These data further dissect the signaling components used by LMP1 and identify a novel role for TRAF1 as a modulator of oncogenic signals...
  2. pmc TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells
    Clare C Davies
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    Mol Cell Biol 25:9806-19. 2005
    ..These observations provide novel insight into the mechanisms of CD40 signaling and the multiple roles played by TRAF6 in signal transduction...
  3. pmc The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2
    Aristides G Eliopoulos
    The Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, England
    J Virol 76:4567-79. 2002
    ..These data identify Tpl-2 as a component of LMP1 signaling downstream of TRAF2 and as a modulator of LMP1-mediated effects...
  4. ncbi Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, UK
    Oncogene 22:7557-69. 2003
    ..These data point to the existence of a novel signalling pathway that regulates NF-kappaB in LMP1-expressing cells, and may thereby play a role in both oncogenic transformation and the establishment of persistent EBV infection...
  5. pmc Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies and MRC Center for Immune Regulation, The University of Birmingham Medical School, Birmingham B15 2TA, UK
    EMBO J 22:3855-64. 2003
    ..The selective signaling defect resulting from the inactivation of Tpl2 allowed us to demonstrate that CD40-mediated ERK activation contributes to immunoglobulin production but is not essential for B-cell proliferation...
  6. pmc CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom
    Mol Cell Biol 20:5503-15. 2000
    ..These findings identify a novel proapoptotic mechanism which is induced by CD40 in carcinoma cells and depends on the endogenous production of cytotoxic cytokines and autocrine or paracrine induction of cell death...
  7. ncbi LMP1 structure and signal transduction
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham, B15 2TA, UK
    Semin Cancer Biol 11:435-44. 2001
    ..The constitutive engagement of these signals and the characteristic molecular interactions that regulate them provide the basis for the molecular explanation of the transforming properties of this key EBV protein...
  8. pmc Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2
    A G Eliopoulos
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, England
    J Virol 73:1023-35. 1999
    ..These data further define a role for TRADD and TRAF2 in JNK activation and confirm that LMP1 utilizes signalling mechanisms used by the TNF receptor/CD40 family to elicit its pleiotropic activities...
  9. pmc CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion
    N J Gallagher
    CRC Institute for Cancer Studies, University of Birmingham Medical School, Birmingham B15 2TA, UK
    Mol Pathol 55:110-20. 2002
    ..This study investigated the effects of CD40 ligation on ovarian carcinoma cell growth and apoptosis and on cytokine production, in addition to the role of the NF-kappa B and JNK signalling pathways...
  10. pmc Anti-proliferative activity and mechanism of action of titanocene dichloride
    C V Christodoulou
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, UK
    Br J Cancer 77:2088-97. 1998
    ..The potent in vivo anti-tumour activity of this compound, supported by the encouraging results from two phase I clinical trials, suggests that titanocene dichloride could be a promising novel chemotherapeutic agent...
  11. ncbi CD40 and epithelial cells: across the great divide
    L S Young
    CRC Institute for Cancer Studies, University of Birmingham Medical School, UK
    Immunol Today 19:502-6. 1998
    ..Here, Lawrence Young and colleagues discuss the effect of CD40 ligation on epithelial cells and consider the role of this pathway in the pathogenesis and treatment of carcinomas...
  12. ncbi Induction of apoptosis by chemotherapeutic drugs: the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells
    A E Milner
    CRC Institute for Cancer Studies, Clinical Research Block, University of Birmingham, Birmingham B15 2TA, UK
    Cell Death Differ 9:287-300. 2002
    ....
  13. ncbi The transmembrane domains of the EBV-encoded latent membrane protein 1 (LMP1) variant CAO regulate enhanced signalling activity
    S M Blake
    CRC Institute for Cancer Studies, The University of Birmingham Medical School, Vincent Drive, Birmingham, Edgbaston, B15 2TT, United Kingdom
    Virology 282:278-87. 2001
    ..The ability of CAO-LMP1 to activate higher levels of NF-kappaB and AP-1 may contribute to its potent transforming properties...
  14. pmc The expression and function of Epstein-Barr virus encoded latent genes
    L S Young
    CRC Institute for Cancer Studies, University of Birmingham Medical School, UK
    Mol Pathol 53:238-47. 2000
    ..Understanding the function of these EBV latent proteins will not only provide insight into the mechanisms governing fundamental cell processes but will also identify targets for novel treatment...
  15. ncbi Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells
    Clare C Davies
    Cancer Research United Kingdom Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, United Kingdom
    J Biol Chem 279:1010-9. 2004
    ..Pharmacological agents that target this machinery or its upstream kinases could, therefore, be exploited for CD40-based tumor therapy...
  16. ncbi NF-kappaB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells
    Clare C Davies
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, United Kingdom
    Cell Signal 17:729-38. 2005
    ..These data provide new evidence for the role of NF-kappaB and PI3 kinase/Akt in phenotypic effects mediated by CD40 ligation and highlight differences in the mechanisms by which TNF family members regulate apoptosis in carcinoma cells...
  17. pmc CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection
    S C Afford
    Liver Research Laboratories, The University of Birmingham, Institute of Clinical Science, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
    J Exp Med 189:441-6. 1999
    ..Thus, CD40 engagement triggers apoptosis of human hepatocytes and might amplify Fas-dependent hepatocyte apoptosis in chronic rejection and other inflammatory liver diseases in which Fas-mediated apoptosis is involved...
  18. ncbi Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling
    Christopher W Dawson
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    J Biol Chem 278:3694-704. 2003
    ....
  19. ncbi Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth
    Amanda J Baxendale
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TA, UK
    Oncogene 24:7913-23. 2005
    ..Strategies that neutralize this pathway may therefore be useful in cancer treatment and prevention...
  20. ncbi The role of the CD40 pathway in the pathogenesis and treatment of cancer
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Curr Opin Pharmacol 4:360-7. 2004
    ..Thus, the CD40 pathway provides an opportunity to muster different anti-cancer approaches in one therapy, and offers an attractive option for future clinical trials...
  21. doi CD151 regulates tumorigenesis by modulating the communication between tumor cells and endothelium
    Rafal Sadej
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, United Kingdom
    Mol Cancer Res 7:787-98. 2009
    ..These results also identify CD151 as a potentially novel prognostic marker and target for therapy in breast cancer...
  22. ncbi Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner
    Santasabuj Das
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 280:23748-57. 2005
    ..These data confirm that defects caused by a single mutation may be cell-type and signal-specific and delineate the role of Tpl2 in the transduction of TNF-alpha signals that activate JNK and NF-kappaB in MEFs...
  23. pmc Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals
    Aristides G Eliopoulos
    Kimmel Cancer Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    EMBO J 21:4831-40. 2002
    ..These data identify physiological targets of Tpl2 signaling downstream of ERK and further implicate Tpl2 in the pathophysiology of inflammation...
  24. ncbi The tyrosine kinase Syk regulates TPL2 activation signals
    Aristides G Eliopoulos
    Laboratory of Molecular and Cellular Biology, Division of Basic Sciences, the University of Crete Medical School, Heraklion 71003, Crete, Greece
    J Biol Chem 281:1371-80. 2006
    ..These data therefore dissect the TNF receptor 1 proximal events that regulate Tpl2 and ERK and highlight a role for RIP1, TRAF2, and Syk in this pathway...
  25. doi Cell signaling. "Make and brake" in signaling
    Aristides G Eliopoulos
    University of Crete Medical School and Institute for Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas, Heraklion, Greece
    Science 321:648-9. 2008
  26. pmc CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1
    Aristides Moschonas
    Division of Basic Sciences, University of Crete Medical School, Heraklion, Crete, Greece
    Mol Cell Biol 28:6208-22. 2008
    ....
  27. ncbi Activation of CD40 in cervical carcinoma cells facilitates CTL responses and augments chemotherapy-induced apoptosis
    Seran C Hill
    Cancer Research UK Institute for Cancer Studies and Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birhimgham B15 2TA, UK
    J Immunol 174:41-50. 2005
    ....
  28. ncbi Inhibition of metalloproteinase cleavage enhances the cytotoxicity of Fas ligand
    Pauline G Knox
    Cancer Research United Kingdom Institute for Cancer Studies, University of Birmingham Medical School, Edgbaston, United Kingdom
    J Immunol 170:677-85. 2003
    ..Moreover, these findings have general implications for the therapeutic exploitation of TNF family ligands and for the possible impact of MP-based therapies on the normal physiology of Fas/TNF pathways...