Research Topics
| M EliaSummaryAffiliation: University of Southampton Country: UK Publications
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Publications
Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes: a systematic review and meta-analysisMarinos Elia
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, MP 113 F Level, Tremona Road, Southampton, SO16 6YD, UK
Diabetes Care 28:2267-79. 2005..The aim of this systematic review was to determine the benefits of nutritional support in patients with type 1 or type 2 diabetes...
Techniques for the study of energy balance in manMarinos Elia
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Proc Nutr Soc 62:529-37. 2003..Unreliability increases to an unknown extent in free-living subjects eating a mixed and varied diet; thus, improved methodology is needed for the study of energy balance...
Enteral (oral or tube administration) nutritional support and eicosapentaenoic acid in patients with cancer: a systematic reviewM Elia
Institute of Human Nutrition, University of Southampton, MP 113 F Level, Southampton General Hospital, Southampton SO16 6YD, UK
Int J Oncol 28:5-23. 2006..In those undergoing surgery, EPA-enriched ETF had no effect. Further research is required to elucidate the clinical efficacy of enteral nutrition support, including the potential benefits of EPA supplementation, in patients with cancer...
Systematic review and meta-analysis: the clinical and physiological effects of fibre-containing enteral formulaeM Elia
Institute of Human Nutrition, Southampton General Hospital, Southampton, UK
Aliment Pharmacol Ther 27:120-45. 2008..Enteral nutrition can be associated with gastrointestinal side effects and fibre supplementation has been proposed as a means to normalize bowel function...
Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older EnglishmenOsama A Kensara
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Am J Clin Nutr 82:980-7. 2005....
Systematic review and meta-analysis of the effects of high protein oral nutritional supplementsA L Cawood
Institute of Human Nutrition, University of Southampton, UK
Ageing Res Rev 11:278-96. 2012..The systematic review and meta-analysis provides evidence that high protein supplements produce clinical benefits, with economic implications...
The effect of total starvation and very low energy diet in lean men on kinetics of whole body protein and five hepatic secretory proteinsPaul R Afolabi
Institute of Human Nutrition, Univ of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD United Kingdom
Am J Physiol Endocrinol Metab 293:E1580-9. 2007..Changes in concentration of these secreted proteins can occur independently of changes in synthetic rates, and vice versa...
Substrate-energy metabolism and metabolic risk factors for cardiovascular disease in relation to fetal growth and adult body compositionOsama A Kensara
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Am J Physiol Endocrinol Metab 291:E365-71. 2006..BW was found to be a significant predictor of REE that was independent of adult weight plus height...
The economics of malnutritionM Elia
Institute of Human Nutrition, University of Southampton, and Southampton General Hospital, Southampton, UK
Nestle Nutr Workshop Ser Clin Perform Programme 12:29-40. 2009..A summary of nutritional intervention studies with cost analyses (including meta-analyses) and cost-effectiveness analyses are presented, and some of the clinical and ethical implications discussed...
Physiological aspects of energy metabolism and gastrointestinal effects of carbohydratesM Elia
Institute of Human Nutrition, University of Southampton, Southampton, UK
Eur J Clin Nutr 61:S40-74. 2007....
To screen or not to screen for adult malnutrition?M Elia
Institute of Human Nutrition, University of Southampton, Mailpoint 113, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Clin Nutr 24:867-84. 2005..There is some controversy about whether all adults receiving healthcare should be routinely screened for nutritional problems...
Obesity in the elderlyM Elia
University of Southampton, United Kingdom
Obes Res 9:244S-248S. 2001..Furthermore, increased physical activity in the elderly, which is an important component of weight management, can produce beneficial effects on muscle strength, endurance, and well-being...
Prevalence of risk of undernutrition is associated with poor health status in older people in the UKB M Margetts
Institute of Human Nutrition, University of Southampton, Southampton, UK
Eur J Clin Nutr 57:69-74. 2003....
Enteral nutritional support in prevention and treatment of pressure ulcers: a systematic review and meta-analysisRebecca J Stratton
Institute of Human Nutrition, University of Southampton, MP 113 F Level, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Ageing Res Rev 4:422-50. 2005..Therefore, this systematic review and meta-analysis was undertaken to address the impact of enteral nutritional support on pressure ulcer incidence and healing and a range of other clinically relevant outcome measures in this group...
Insights into energy requirements in diseaseMarinos Elia
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, UK
Public Health Nutr 8:1037-52. 2005....
Geographical inequalities in nutrient status and risk of malnutrition among English people aged 65 y and olderMarinos Elia
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, UK
Nutrition 21:1100-6. 2005....
'Malnutrition Universal Screening Tool' predicts mortality and length of hospital stay in acutely ill elderlyRebecca J Stratton
Institute of Human Nutrition, School of Medicine, University of Southampton, Level F MP 113, Southampton General Hospital, Southampton SO16 6YD, UK
Br J Nutr 95:325-30. 2006..In those who cannot be weighed, a higher prevalence of malnutrition and associated poorer clinical outcome supports the importance of routine screening with a tool, like 'MUST', that can be used to screen all patients...
Who benefits from nutritional support: what is the evidence?Rebecca J Stratton
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
Eur J Gastroenterol Hepatol 19:353-8. 2007..This article discusses the evidence from systematic reviews and meta-analyses of the effectiveness of nutritional support...
How can we improve functional outcomes?Marinos Elia
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Mallpoint 113 Tremona Road, Southampton SO16 6YD, UK
Nestle Nutr Workshop Ser Clin Perform Programme 10:233-44; discussion 244-7. 2005
Multinutrient oral supplements and tube feeding in maintenance dialysis: a systematic review and meta-analysisRebecca J Stratton
Institute of Human Nutrition, University of Southampton, UK
Am J Kidney Dis 46:387-405. 2005..This systematic review aims to determine the potential benefits of enteral multinutrient support (oral or tube) in patients with chronic kidney disease (CKD) receiving maintenance dialysis...
Nutrition in acute careMarinos Elia
Institute of Human Nutrition, Southampton General Hospital, Southampton
Clin Med 4:405-7. 2004
Fetal programming of body dimensions and percentage body fat measured in prepubertal children with a 4-component model of body composition, dual-energy X-ray absorptiometry, deuterium dilution, densitometry, and skinfold thicknessesMarinos Elia
Institute of Human Nutrition, University of Southampton, Southampton, United Kingdom
Am J Clin Nutr 86:618-24. 2007..The effects on and consequences of body build (dimensions, mass, and length of body segments) are unclear...
Encouraging appropriate, evidence-based use of oral nutritional supplementsRebecca J Stratton
Institute of Human Nutrition, School of Medicine, University of Southampton, F Level, MP 113, Southampton General Hospital, Southampton SO16 6YD, UK
Proc Nutr Soc 69:477-87. 2010..As recently suggested by the National Institute for Health and Clinical Excellence, substantial cost savings could be made if screening and treatment of malnourished patients was undertaken...
Tight glucose control in intensive care units: an update with an emphasis on nutritional issuesMarinos Elia
aInstitute of Human Nutrition, University of Southampton, Southampton, UK
Curr Opin Clin Nutr Metab Care 11:465-70. 2008..Tight glucose control in ICU patients is now regarded as a goal of successful care. Some challenge this on the basis that it produces no benefit and may cause harm. We review the recent literature with an emphasis on nutritional aspects...
Short-term continuous enteral tube feeding schedules did not suppress appetite and food intake in healthy men in a placebo-controlled trialRebecca J Stratton
Institute of Human Nutrition, University of Southampton, Southampton, UK
J Nutr 133:2570-6. 2003..This could not be explained by changes in a variety of metabolic and hormonal signals within the time frame studied...
Deprivation linked to malnutrition risk and mortality in hospitalRebecca J Stratton
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
Br J Nutr 96:870-6. 2006..Effective strategies are required to tackle these common health inequalities in both clinical and public health settings...
Bolus tube feeding suppresses food intake and circulating ghrelin concentrations in healthy subjects in a short-term placebo-controlled trialRebecca J Stratton
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
Am J Clin Nutr 88:77-83. 2008..Previous investigations suggest continuous tube feeding (TF) schedules do not suppress appetite and food intake, but bolus TF has been little studied...
A cost-utility analysis in patients receiving enteral tube feeding at home and in nursing homesMarinos Elia
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Mailpoint 113, Tremona Road, Southampton SO16 6YD, UK
Clin Nutr 27:416-23. 2008..The cost-effectiveness of ETF in nursing homes when the state pays all non-medical costs compares unfavourably with other treatments, raising economic, clinical, and ethical concerns...
Malnutrition in hospital outpatients and inpatients: prevalence, concurrent validity and ease of use of the 'malnutrition universal screening tool' ('MUST') for adultsRebecca J Stratton
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, UK
Br J Nutr 92:799-808. 2004..MUST' was quick and easy to use in these patient groups...
Artificial nutrition support in hospital: indications and complicationsTrevor Smith
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, Southampton
Clin Med 6:457-60. 2006
Malnutrition in the UK: policies to address the problemM Elia
Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Proc Nutr Soc 69:470-6. 2010..These generally aim to span across all care settings and various government departments in a co-ordinated manner, but their effectiveness remains to be properly evaluated...
A cost-utility analysis in patients receiving enteral tube feeding at home and in nursing homesR J Stratton
Institute of Human Nutrition, University of Southampton, Southampton SO16 6YD, UK
Proc Nutr Soc 67:E111. 2008
Quantitative biology and nutritional supportM Elia
Institute of Human Nutrition, Southampton General Hospital, Southampton, UK
Clin Nutr 22:S33-5. 2003
Editorial: 'Thousands starving in U.K. hospitals'; letter 1Marinos Elia
Clin Med 8:113; author reply 114. 2008
Two-component models are of limited value for the assessment of body composition in patients with cirrhosisMarsha Y Morgan
The UCL Institute of Hepatology, Hampstead Campus, Royal Free and University College Medical School, London, United Kingdom
Am J Clin Nutr 84:1151-62. 2006..Most techniques for measuring body composition are based on 2-component models (2-CMs) and depend on assumptions relating to the constancy of the density (D(FFM)) and hydration fraction (HF(FFM)) of fat-free mass (FFM)...
A double-blind, placebo-controlled, glutamine-supplementation trial in growth-faltering Gambian infantsElizabeth A Williams
Human Nutrition Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
Am J Clin Nutr 86:421-7. 2007..Previous studies have shown that small-intestine mucosal enteropathy, accompanied by endotoxemia and a persistent systemic inflammatory response, accounts for up to 64% of the growth faltering in Gambian infants...
Metabolic and hormonal changes during the refeeding period of prolonged fastingMarta Korbonits
Department of Endocrinology, Barts and the London Medical School, UK
Eur J Endocrinol 157:157-66. 2007....
Small organs with a high metabolic rate explain lower resting energy expenditure in African American than in white adultsDympna Gallagher
Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
Am J Clin Nutr 83:1062-7. 2006..Whether the composition of FFM at the organ-tissue level differs between African Americans and whites and, if so, whether that difference could account for differences by race in REE are unknown...
Age-related association of small intestinal mucosal enteropathy with nutritional status in rural Gambian childrenDavid I Campbell
Medical Research Council, Keneba, The Gambia
Br J Nutr 88:499-505. 2002..Although the lesion improves with age, the relationship between attained height and L:M permeability raises the possibility that enteropathy may continue to limit growth throughout childhood and puberty...
On the ESPEN guidelines for nutritional screening 2002Marinos Elia
Clin Nutr 23:131-2. 2004
The effect of rate of weight loss on erythrocyte glutathione concentration and synthesis in healthy obese menPeter Faber
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Clin Sci (Lond) 102:569-77. 2002..An acute reduction in GSH synthesis in response to a rapid weight loss may constitute a risk factor during periods of increased GSH demands...
Intestinal inflammation measured by fecal neopterin in Gambian children with enteropathy: association with growth failure, Giardia lamblia, and intestinal permeabilityDavid I Campbell
School of Clinical and Medical Sciences, Sir James Spence Institute of Child Health, University of Newcastle upon Tyne, United Kingdom
J Pediatr Gastroenterol Nutr 39:153-7. 2004..Secondary outcome measures tested the associations between Giardia lamblia infestation, fecal neopterin and lactulose mannitol absorption ratio(L:M), a measure of intestinal permeability...
The development, validation and reliability of a nutrition screening tool based on the recommendations of the British Association for Parenteral and Enteral Nutrition (BAPEN)C Elizabeth Weekes
Department of Nutrition and Dietetics, Guy s and St Thomas Hospital NHS Trust, Lambeth Palace Road, SE1 7EH London, UK
Clin Nutr 23:1104-12. 2004....
Bioelectrical impedance analysis--part I: review of principles and methodsUrsula G Kyle
Geneva University Hospital, Switzerland
Clin Nutr 23:1226-43. 2004..ESPEN guidelines for the clinical use of BIA measurements are described in a paper to appear soon in Clinical Nutrition...
Do interventions which reduce colonic bacterial fermentation improve symptoms of irritable bowel syndrome?Keith L E Dear
Department of Gastroenterology, Addenbrooke s Hospital NHS Trust, Cambridge, UK
Dig Dis Sci 50:758-66. 2005..35 vs 0.45 ml/min), with a significant improvement in abdominal symptoms. IBS may be associated with rapid excretion of gaseous products of fermentation, whose reduction may improve symptoms...
Nutrition and health economicsMarinos Elia
Nutrition 22:576-8. 2006
[Microgravity and weightlessness: experimental model accelerates nutritional pathology]Laurence Genton
, , Suisse
Rev Med Suisse Romande 122:339-43. 2002..It discusses potential countermeasures (nutrition, physical activity) to the negative effects of microgravity on human body. Future research possibilities in ground and space medicine are evoked...
Chronic T cell-mediated enteropathy in rural west African children: relationship with nutritional status and small bowel functionDavid I Campbell
Medical Research Council (UK, Keneba, The Gambia
Pediatr Res 54:306-11. 2003..Protein-energy malnutrition is associated with reduction of regulatory immune responses in the mucosal microenvironment, potentially impairing the mechanisms of oral tolerance...
Refeeding David Blaine--studies after a 44-day fastMarta Korbonits
N Engl J Med 353:2306-7. 2005
Influence of short-term dietary weight loss on cortisol secretion and metabolism in obese menAlexandra M Johnstone
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Eur J Endocrinol 150:185-94. 2004..We suggest that activation of cortisol secretion is not an irreversible intrinsic abnormality in obese patients, and speculate that dietary content has an important influence on the neuroendocrine response to weight loss...
The effect of rate and extent of weight loss on urea salvage in obese male subjectsPeter Faber
Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Br J Nutr 90:221-31. 2003..It was concluded that no adaptive changes in urea kinetics occurred in response to either the different rate or extent of weight loss...
Changes in circulating concentrations of vitamins and trace elements after cessation of nocturnal enteral tube feedingChristine Baldwin
Department of Medicine and Therapeutics, Imperial College, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
Clin Nutr 23:249-55. 2004..The timing for blood sampling should be standardised when the status of these nutrients is assessed in patients receiving cyclic tube feeding...
Bioelectrical impedance analysis-part II: utilization in clinical practiceUrsula G Kyle
Clinical Nutrition Unit, Geneva University Hospital, 1211 Geneva 14, Switzerland
Clin Nutr 23:1430-53. 2004..Further validation of BIA is necessary to understand the mechanisms for the changes observed in acute illness, altered fat/lean mass ratios, extreme heights and body shape abnormalities...
Plasma concentrations of alpha-MSH, AgRP and leptin in lean and obese men and their relationship to differing states of energy balance perturbationNigel Hoggard
Rowett Research Institute, Aberdeen, UK
Clin Endocrinol (Oxf) 61:31-9. 2004..We aimed to determine whether circulating alpha-MSH and AgRP are responsive to long-term perturbations in energy balance, in a manner consistent with their central putative functions...
