Emad M El-Omar

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi request reprint Helicobacter pylori infection and gastric cancer
    Paul Lochhead
    Aberdeen Royal Infirmary, Aberdeen, Scotland, UK
    Best Pract Res Clin Gastroenterol 21:281-97. 2007
  2. doi request reprint Gastric cancer
    Paul Lochhead
    Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Br Med Bull 85:87-100. 2008
  3. ncbi request reprint Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Gastroenterology 123:92-105. 2002
  4. ncbi request reprint Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
  5. pmc The inflammatory microenvironment in colorectal neoplasia
    Mairi H McLean
    Gastrointestinal Research Group, School of Medicine and Dentistry, Aberdeen University, Aberdeen, United Kingdom
    PLoS ONE 6:e15366. 2011
  6. pmc Topical tacrolimus 0.1% ointment for treatment of cutaneous Crohn's Disease
    Shantini A Rice
    Department of Dermatology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB, UK
    BMC Res Notes 6:19. 2013
  7. pmc Iron deficiency and Helicobacter pylori-induced gastric cancer: too little, too bad
    Emad M El-Omar
    Division of Applied Medicine, Institute of Medical Sciences, School of Medicine and Dentistry, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Clin Invest 123:113-4. 2013
  8. pmc Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis
    Daisuke Ishikawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Gastroenterol 11:29. 2011
  9. doi request reprint Polymorphisms in Toll-like receptor genes and risk of cancer
    E M El-Omar
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK
    Oncogene 27:244-52. 2008
  10. ncbi request reprint Role of host genes in sporadic gastric cancer
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
    Best Pract Res Clin Gastroenterol 20:675-86. 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Helicobacter pylori infection and gastric cancer
    Paul Lochhead
    Aberdeen Royal Infirmary, Aberdeen, Scotland, UK
    Best Pract Res Clin Gastroenterol 21:281-97. 2007
    ..Defining the optimal timing of intervention is going to be the challenge facing us over the next two decades...
  2. doi request reprint Gastric cancer
    Paul Lochhead
    Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Br Med Bull 85:87-100. 2008
    ..The pathogenesis of gastric cancer represents a paradigm for microbially induced and inflammation-driven malignancies, and understanding this will be the best means of defeating this cancer...
  3. ncbi request reprint Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Gastroenterology 123:92-105. 2002
    ..This study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in Japan...
  4. ncbi request reprint Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
    ..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite...
  5. pmc The inflammatory microenvironment in colorectal neoplasia
    Mairi H McLean
    Gastrointestinal Research Group, School of Medicine and Dentistry, Aberdeen University, Aberdeen, United Kingdom
    PLoS ONE 6:e15366. 2011
    ..This study has provided evidence of increased inflammation within pre-malignant colonic adenomas. This may allow potential mechanistic pathways in the initiation and promotion of early colorectal carcinogenesis to be identified...
  6. pmc Topical tacrolimus 0.1% ointment for treatment of cutaneous Crohn's Disease
    Shantini A Rice
    Department of Dermatology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB, UK
    BMC Res Notes 6:19. 2013
    ..This is the first study in adults examining the effect of topical tacrolimus on the different cutaneous manifestations of Crohn's Disease...
  7. pmc Iron deficiency and Helicobacter pylori-induced gastric cancer: too little, too bad
    Emad M El-Omar
    Division of Applied Medicine, Institute of Medical Sciences, School of Medicine and Dentistry, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Clin Invest 123:113-4. 2013
    ..His symptoms improve, but his infection persists and he remains mildly anemic. He asks you whether the infection must be eradicated, as he read on the Internet that it can cause stomach cancer. He is also concerned about the anemia...
  8. pmc Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis
    Daisuke Ishikawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Gastroenterol 11:29. 2011
    ..We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity...
  9. doi request reprint Polymorphisms in Toll-like receptor genes and risk of cancer
    E M El-Omar
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK
    Oncogene 27:244-52. 2008
    ..In this review, we discuss polymorphisms in Toll-like receptors and give an insight into how they may influence risk of cancer...
  10. ncbi request reprint Role of host genes in sporadic gastric cancer
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
    Best Pract Res Clin Gastroenterol 20:675-86. 2006
    ..The ultimate value of host genetics should be in understanding the pathogenesis of the disease, which would offer a true opportunity to defeat this global killer...
  11. pmc Mechanisms of increased acid secretion after eradication of Helicobacter pylori infection
    E M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Gut 55:144-6. 2006
    ..In the short term, there is an impressive increase in expression of H+/K+-ATPase pumps without an increase in the number of parietal cells. Longer follow up studies are needed to see if the parietal cell mass eventually recovers...
  12. ncbi request reprint A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors
    Georgina L Hold
    Department of Medicine and Therapeutics, Aberdeen University, Aberdeen, Scotland
    Gastroenterology 132:905-12. 2007
    ..The TLR4+896A>G polymorphism linked with impaired reactivity to bacterial lipopolysaccharide may play a role in gastric carcinogenesis...
  13. pmc Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals
    Paul Lochhead
    Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland
    Gastroenterology 140:435-41. 2011
    ..We set out to determine whether such an association exists in white individuals...
  14. pmc Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease
    Mike Tsz Hin Ng
    Division of Applied Medicine, Aberdeen University, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Infect Immun 78:1345-52. 2010
    ..Collectively, these findings confirm that the TLR9 -1237T/C polymorphism is a risk factor for the development of H. pylori-induced premalignant gastric changes and provide a plausible mechanistic explanation...
  15. pmc CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations
    Georgina L Hold
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Aberdeen, UK
    Eur J Cancer Prev 18:117-9. 2009
    ..This discrepancy merits further examination...
  16. ncbi request reprint Cellular and molecular aspects of gastric cancer
    Malcolm G Smith
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
    World J Gastroenterol 12:2979-90. 2006
    ..In this review, we examine the molecular and cellular events that underlie H pylori-induced gastric cancer...
  17. pmc Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations
    Andrew J Palmer
    GI Reseach Group, University of Aberdeen, Aberdeen, Scotland
    Eur J Cancer Prev 21:541-4. 2012
    ..To the best of our knowledge, this is the first study to report an association between rs2274223 and rs4072037 and the risk of oesophageal squamous cell carcinoma in a Caucasian population...
  18. pmc A comprehensive evaluation of colonic mucosal isolates of Sutterella wadsworthensis from inflammatory bowel disease
    Indrani Mukhopadhya
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    PLoS ONE 6:e27076. 2011
    ..Our studies indicate that S. wadsworthensis is unlikely to play a role in the pathogenesis of IBD. Strains from cases of IBD could not be distinguished from those identified from controls...
  19. pmc Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer
    Paul Lochhead
    Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Scotland
    Eur J Cancer Prev 20:54-7. 2011
    ..Our data represent novel findings on heritable susceptibility to gastric and oesophageal cancer and warrant validation in additional populations...
  20. pmc The microaerophilic microbiota of de-novo paediatric inflammatory bowel disease: the BISCUIT study
    Richard Hansen
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    PLoS ONE 8:e58825. 2013
    ..We set out to study these and other microaerophilic bacteria in de-novo paediatric IBD...
  21. ncbi request reprint The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
  22. ncbi request reprint The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk
    Esther Troost
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Can J Gastroenterol 17:8B-12B. 2003
    ..The roles of IL-1b and other host genetic factors in the pathogenesis of H pylori related cancer are discussed in this article...
  23. pmc Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study
    Christopher Smith
    Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland
    BMC Res Notes 5:371. 2012
    ..In addition, we performed immunohistochemical staining for PSCA in colonic tissue representing all stages of the adenoma-carcinoma sequence...
  24. doi request reprint Helicobacter pylori infection, host genetics and gastric cancer
    Anne Marie Shanks
    Division of Applied Medicine, Institute of Medical Sciences, School of Medicine and Dentistry, Aberdeen University, Aberdeen, UK
    J Dig Dis 10:157-64. 2009
    ..This will aid in targeting the testing and treatment of Helicobacter pylori, which offers a true opportunity to prevent and defeat this global killer...
  25. doi request reprint Genetic aspects of inflammation
    Mairi H McLean
    Division of Applied Medicine, Institute of Medical Sciences, Aberdeen University, United Kingdom
    Curr Opin Pharmacol 9:370-4. 2009
    ..Both approaches are necessary to make advances in reducing disease burden in society...
  26. doi request reprint Helicobacter pylori: host genetics and disease outcomes
    Ailsa Snaith
    Department Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK
    Expert Rev Gastroenterol Hepatol 2:577-85. 2008
    ..pylori-induced gastric neoplasia. This will help to target the population most at risk by directing eradication therapy and closer follow-up to the affected individuals...
  27. doi request reprint Genetics of inflammation in the gastrointestinal tract and how it can cause cancer
    Mairi H McLean
    Gastrointestinal Research Group, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
    Recent Results Cancer Res 185:173-83. 2011
    ..Increasing our understanding of host genetics in cancer development may allow particularly susceptible individuals to be targeted for screening or treatment to reduce risk of future malignant transformation...
  28. doi request reprint The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers
    Natalie Jeffery
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    Histopathology 54:820-8. 2009
    ..Roles in pathways involved in early tumour development are also being identified for this system, and the aim of this study was to define the expression profile of the major MMPs and TIMPs in colorectal polyp cancers...
  29. doi request reprint Microbiota of de-novo pediatric IBD: increased Faecalibacterium prausnitzii and reduced bacterial diversity in Crohn's but not in ulcerative colitis
    Richard Hansen
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK
    Am J Gastroenterol 107:1913-22. 2012
    ..The majority of studies to date are however potentially confounded by the effect of treatment and a reliance on established rather than de-novo disease...
  30. doi request reprint Genetic aspects of inflammation and cancer
    Georgina L Hold
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, U K
    Biochem J 410:225-35. 2008
    ..The purpose of the present review is to evaluate the mechanistic pathways that underlie chronic inflammation and cancer with particular emphasis on the role of host genetic factors that increase the risk of carcinogenesis...
  31. pmc Detection of Campylobacter concisus and other Campylobacter species in colonic biopsies from adults with ulcerative colitis
    Indrani Mukhopadhya
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    PLoS ONE 6:e21490. 2011
    ..This study investigated the prevalence of Campylobacter species in colonic biopsy samples from adults with UC and healthy controls...
  32. doi request reprint Could Helicobacter organisms cause inflammatory bowel disease?
    Richard Hansen
    Gastrointestinal Research Group, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    FEMS Immunol Med Microbiol 61:1-14. 2011
    ..The possibility that novel Helicobacter organisms have a role in the initiation of human IBD warrants further consideration and targeted investigations...
  33. ncbi request reprint Sporadic colorectal cancer--role of the commensal microbiota
    Mairi E Hope
    GI Research Group, Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    FEMS Microbiol Lett 244:1-7. 2005
    ....
  34. ncbi request reprint Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy
    Mairi Macarthur
    Department of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Am J Physiol Gastrointest Liver Physiol 286:G515-20. 2004
    ..In this review, we discuss the role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy and outline some of the possible mechanisms involved...
  35. doi request reprint IBD-what role do Proteobacteria play?
    Indrani Mukhopadhya
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nat Rev Gastroenterol Hepatol 9:219-30. 2012
    ....
  36. doi request reprint The role of infection in the aetiology of inflammatory bowel disease
    Richard Hansen
    Gastrointestinal Research Group, Division of Applied Medicine, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, UK
    J Gastroenterol 45:266-76. 2010
    ..It may be that infectious organisms have an orchestrator role in the development of dysbiosis and subsequently IBD...
  37. doi request reprint Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?
    Georgina L Hold
    Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M El Omar, Indrani Mukhopadhya, Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom
    World J Gastroenterol 20:1192-210. 2014
    ..Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years...
  38. doi request reprint The mesenchyme in malignancy: a partner in the initiation, progression and dissemination of cancer
    Mark A Glaire
    Division of Applied Medicine, University of Aberdeen, Aberdeen, Scotland
    Pharmacol Ther 136:131-41. 2012
    ..Understanding the biological heterogeneity of specific mesenchymal cells in cancer will provide new opportunities for targeted cancer prevention and therapy...
  39. pmc Role of host genetics in fibrosis
    Georgina L Hold
    Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Fibrogenesis Tissue Repair 2:6. 2009
    ..This is particularly important when considering gastrointestinal and hepatic disease, where inappropriate Toll-like receptor signalling, in response to the local microbe-rich environment, is thought to play an important role...
  40. ncbi request reprint Polymorphism of interleukin-1beta affects the eradication rates of Helicobacter pylori by triple therapy
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1, Handa yama, Hamamatsu 431 3192, Japan
    Clin Gastroenterol Hepatol 2:22-30. 2004
    ..pylori in the stomach. The aim of this study was to investigate whether IL-1beta polymorphism is associated with eradication rates of H. pylori by triple therapy with a proton pump inhibitor (PPI), amoxicillin, and clarithromycin...
  41. ncbi request reprint Mannose-binding lectin-2 genetic variation and stomach cancer risk
    Andrea Baccarelli
    EPOCA Epidemiology Research Centre, Maggiore Hospital IRCCS Foundation, University of Milan, Milan, Italy
    Int J Cancer 119:1970-5. 2006
    ..6-7.6; p = 0.001). Our findings suggest that the codon 52 D MBL2 variant causing a cysteine > arginine replacement, but not B and C variants producing glycine substitutions, is specifically associated with gastric cancer risk...
  42. pmc Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population
    Rajeev Mahajan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Jpn J Clin Oncol 38:626-33. 2008
    ..7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology...
  43. doi request reprint Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families
    Richard H Argent
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University Park and Wolfson Digestive Diseases Centre, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
    Clin Cancer Res 14:2227-35. 2008
    ..We aimed to determine whether infection with virulent H. pylori preceded precancerous gastric hypochlorhydria and atrophy in gastric cancer relatives and quantify the extent of virulence factor evolution...
  44. doi request reprint Host-bacterial interactions in Helicobacter pylori infection
    Manuel R Amieva
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
    Gastroenterology 134:306-23. 2008
    ..This review offers an insight into H pylori host-bacterial interactions...
  45. ncbi request reprint GP management of dyspepsia
    Lindsay McLeman
    Aberdeen University, Aberdeen Royal Infirmary
    Practitioner 250:134, 136, 139 passim. 2006
  46. doi request reprint Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion
    Richard H Argent
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    J Med Microbiol 57:1062-7. 2008
    ....