Research Topics
Genomes and Genes | Emad M El-OmarSummaryAffiliation: University of Aberdeen Country: UK Publications
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Publications
Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in JapanTakahisa Furuta
First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
Gastroenterology 123:92-105. 2002..This study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in Japan...- Helicobacter pylori infection and gastric cancerPaul Lochhead
Aberdeen Royal Infirmary, Aberdeen, Scotland, UK
Best Pract Res Clin Gastroenterol 21:281-97. 2007..Defining the optimal timing of intervention is going to be the challenge facing us over the next two decades... 
Gastric cancerPaul Lochhead
Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
Br Med Bull 85:87-100. 2008..The pathogenesis of gastric cancer represents a paradigm for microbially induced and inflammation-driven malignancies, and understanding this will be the best means of defeating this cancer...
Iron deficiency and Helicobacter pylori-induced gastric cancer: too little, too badEmad M El-Omar
Division of Applied Medicine, Institute of Medical Sciences, School of Medicine and Dentistry, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
J Clin Invest 123:113-4. 2013..His symptoms improve, but his infection persists and he remains mildly anemic. He asks you whether the infection must be eradicated, as he read on the Internet that it can cause stomach cancer. He is also concerned about the anemia...- Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitisDaisuke Ishikawa
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
BMC Gastroenterol 11:29. 2011..We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity... - Role of host genes in sporadic gastric cancerEmad M El-Omar
Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
Best Pract Res Clin Gastroenterol 20:675-86. 2006..The ultimate value of host genetics should be in understanding the pathogenesis of the disease, which would offer a true opportunity to defeat this global killer... - Mechanisms of increased acid secretion after eradication of Helicobacter pylori infectionE M El-Omar
Department of Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
Gut 55:144-6. 2006..In the short term, there is an impressive increase in expression of H+/K+-ATPase pumps without an increase in the number of parietal cells. Longer follow up studies are needed to see if the parietal cell mass eventually recovers... - Polymorphisms in Toll-like receptor genes and risk of cancerE M El-Omar
Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK
Oncogene 27:244-52. 2008..In this review, we discuss polymorphisms in Toll-like receptors and give an insight into how they may influence risk of cancer... - Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphismsEmad M El-Omar
Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
Gastroenterology 124:1193-201. 2003..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite... - A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursorsGeorgina L Hold
Department of Medicine and Therapeutics, Aberdeen University, Aberdeen, Scotland
Gastroenterology 132:905-12. 2007..The TLR4+896A>G polymorphism linked with impaired reactivity to bacterial lipopolysaccharide may play a role in gastric carcinogenesis... - Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individualsPaul Lochhead
Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland
Gastroenterology 140:435-41. 2011..We set out to determine whether such an association exists in white individuals... - Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populationsAndrew J Palmer
GI Reseach Group, University of Aberdeen, Aberdeen, Scotland
Eur J Cancer Prev 21:541-4. 2012..To the best of our knowledge, this is the first study to report an association between rs2274223 and rs4072037 and the risk of oesophageal squamous cell carcinoma in a Caucasian population... - A comprehensive evaluation of colonic mucosal isolates of Sutterella wadsworthensis from inflammatory bowel diseaseIndrani Mukhopadhya
Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
PLoS ONE 6:e27076. 2011..Our studies indicate that S. wadsworthensis is unlikely to play a role in the pathogenesis of IBD. Strains from cases of IBD could not be distinguished from those identified from controls... - Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric diseaseMike Tsz Hin Ng
Division of Applied Medicine, Aberdeen University, Aberdeen AB25 2ZD, Scotland, United Kingdom
Infect Immun 78:1345-52. 2010..Collectively, these findings confirm that the TLR9 -1237T/C polymorphism is a risk factor for the development of H. pylori-induced premalignant gastric changes and provide a plausible mechanistic explanation... - Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancerPaul Lochhead
Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Scotland
Eur J Cancer Prev 20:54-7. 2011..Our data represent novel findings on heritable susceptibility to gastric and oesophageal cancer and warrant validation in additional populations... - CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populationsGeorgina L Hold
Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Aberdeen, UK
Eur J Cancer Prev 18:117-9. 2009..This discrepancy merits further examination... - The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of ScotlandMairi Macarthur
Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required... - The inflammatory microenvironment in colorectal neoplasiaMairi H McLean
Gastrointestinal Research Group, School of Medicine and Dentistry, Aberdeen University, Aberdeen, United Kingdom
PLoS ONE 6:e15366. 2011..This study has provided evidence of increased inflammation within pre-malignant colonic adenomas. This may allow potential mechanistic pathways in the initiation and promotion of early colorectal carcinogenesis to be identified... - Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical studyChristopher Smith
Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland
BMC Res Notes 5:371. 2012..In addition, we performed immunohistochemical staining for PSCA in colonic tissue representing all stages of the adenoma-carcinoma sequence... - The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer riskEsther Troost
Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
Can J Gastroenterol 17:8B-12B. 2003..The roles of IL-1b and other host genetic factors in the pathogenesis of H pylori related cancer are discussed in this article... - Helicobacter pylori infection, host genetics and gastric cancerAnne Marie Shanks
Division of Applied Medicine, Institute of Medical Sciences, School of Medicine and Dentistry, Aberdeen University, Aberdeen, UK
J Dig Dis 10:157-64. 2009..This will aid in targeting the testing and treatment of Helicobacter pylori, which offers a true opportunity to prevent and defeat this global killer... - Helicobacter pylori: host genetics and disease outcomesAilsa Snaith
Department Medicine and Therapeutics, Aberdeen University, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK
Expert Rev Gastroenterol Hepatol 2:577-85. 2008..pylori-induced gastric neoplasia. This will help to target the population most at risk by directing eradication therapy and closer follow-up to the affected individuals... - The Microaerophilic Microbiota of De-Novo Paediatric Inflammatory Bowel Disease: The BISCUIT StudyRichard Hansen
Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom Child Health, University of Aberdeen, Royal Aberdeen Children s Hospital, Foresterhill, Aberdeen, United Kingdom
PLoS ONE 8:e58825. 2013..We set out to study these and other microaerophilic bacteria in de-novo paediatric IBD... - Genetics of inflammation in the gastrointestinal tract and how it can cause cancerMairi H McLean
Gastrointestinal Research Group, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
Recent Results Cancer Res 185:173-83. 2011..Increasing our understanding of host genetics in cancer development may allow particularly susceptible individuals to be targeted for screening or treatment to reduce risk of future malignant transformation... - Microbiota of de-novo pediatric IBD: increased Faecalibacterium prausnitzii and reduced bacterial diversity in Crohn's but not in ulcerative colitisRichard Hansen
Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK
Am J Gastroenterol 107:1913-22. 2012..The majority of studies to date are however potentially confounded by the effect of treatment and a reliance on established rather than de-novo disease... - Could Helicobacter organisms cause inflammatory bowel disease?Richard Hansen
Gastrointestinal Research Group, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
FEMS Immunol Med Microbiol 61:1-14. 2011..The possibility that novel Helicobacter organisms have a role in the initiation of human IBD warrants further consideration and targeted investigations... - Detection of Campylobacter concisus and other Campylobacter species in colonic biopsies from adults with ulcerative colitisIndrani Mukhopadhya
Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
PLoS ONE 6:e21490. 2011..This study investigated the prevalence of Campylobacter species in colonic biopsy samples from adults with UC and healthy controls... - Genetic aspects of inflammation and cancerGeorgina L Hold
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, U K
Biochem J 410:225-35. 2008..The purpose of the present review is to evaluate the mechanistic pathways that underlie chronic inflammation and cancer with particular emphasis on the role of host genetic factors that increase the risk of carcinogenesis... - Genetic aspects of inflammationMairi H McLean
Division of Applied Medicine, Institute of Medical Sciences, Aberdeen University, United Kingdom
Curr Opin Pharmacol 9:370-4. 2009..Both approaches are necessary to make advances in reducing disease burden in society... - IBD-what role do Proteobacteria play?Indrani Mukhopadhya
Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Nat Rev Gastroenterol Hepatol 9:219-30. 2012.... - The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancersNatalie Jeffery
Department of Pathology, University of Aberdeen, Aberdeen, UK
Histopathology 54:820-8. 2009..Roles in pathways involved in early tumour development are also being identified for this system, and the aim of this study was to define the expression profile of the major MMPs and TIMPs in colorectal polyp cancers... - The role of infection in the aetiology of inflammatory bowel diseaseRichard Hansen
Gastrointestinal Research Group, Division of Applied Medicine, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, UK
J Gastroenterol 45:266-76. 2010..It may be that infectious organisms have an orchestrator role in the development of dysbiosis and subsequently IBD... - Sporadic colorectal cancer--role of the commensal microbiotaMairi E Hope
GI Research Group, Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
FEMS Microbiol Lett 244:1-7. 2005.... - The mesenchyme in malignancy: a partner in the initiation, progression and dissemination of cancerMark A Glaire
Division of Applied Medicine, University of Aberdeen, Aberdeen, Scotland
Pharmacol Ther 136:131-41. 2012..Understanding the biological heterogeneity of specific mesenchymal cells in cancer will provide new opportunities for targeted cancer prevention and therapy... - Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancyMairi Macarthur
Department of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
Am J Physiol Gastrointest Liver Physiol 286:G515-20. 2004..In this review, we discuss the role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy and outline some of the possible mechanisms involved... - Role of host genetics in fibrosisGeorgina L Hold
Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Fibrogenesis Tissue Repair 2:6. 2009..This is particularly important when considering gastrointestinal and hepatic disease, where inappropriate Toll-like receptor signalling, in response to the local microbe-rich environment, is thought to play an important role... - Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these familiesRichard H Argent
Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University Park and Wolfson Digestive Diseases Centre, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
Clin Cancer Res 14:2227-35. 2008..We aimed to determine whether infection with virulent H. pylori preceded precancerous gastric hypochlorhydria and atrophy in gastric cancer relatives and quantify the extent of virulence factor evolution... - Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish populationRajeev Mahajan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Jpn J Clin Oncol 38:626-33. 2008..7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology... - Polymorphism of interleukin-1beta affects the eradication rates of Helicobacter pylori by triple therapyTakahisa Furuta
First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1, Handa yama, Hamamatsu 431 3192, Japan
Clin Gastroenterol Hepatol 2:22-30. 2004..pylori in the stomach. The aim of this study was to investigate whether IL-1beta polymorphism is associated with eradication rates of H. pylori by triple therapy with a proton pump inhibitor (PPI), amoxicillin, and clarithromycin... - Mannose-binding lectin-2 genetic variation and stomach cancer riskAndrea Baccarelli
EPOCA Epidemiology Research Centre, Maggiore Hospital IRCCS Foundation, University of Milan, Milan, Italy
Int J Cancer 119:1970-5. 2006..5, 95% CI 1.6-7.6; p = 0.001). Our findings suggest that the codon 52 D MBL2 variant causing a cysteine > arginine replacement, but not B and C variants producing glycine substitutions, is specifically associated with gastric cancer risk... - Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretionRichard H Argent
Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
J Med Microbiol 57:1062-7. 2008.... - GP management of dyspepsiaLindsay McLeman
Aberdeen University, Aberdeen Royal Infirmary
Practitioner 250:134, 136, 139 passim. 2006 - Host-bacterial interactions in Helicobacter pylori infectionManuel R Amieva
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
Gastroenterology 134:306-23. 2008..This review offers an insight into H pylori host-bacterial interactions...