Bertus Eksteen

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease
    Bertus Eksteen
    University of Birmingham and the NIHR Biomedical Research Unit for Liver Disease, Centre for Liver Research, MRC Centre for Immune Regulation, The College of Medical and Dental Sciences, Queen Elizabeth Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 2TT, UK
    IDrugs 13:472-781. 2010
  2. doi Infections and the liver
    Bertus Eksteen
    Centre for Liver Research, MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, UK
    Dig Dis 29:184-90. 2011
  3. pmc CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver
    Ye Htun Oo
    Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, University of Birmingham, Birmingham, United Kingdom
    J Hepatol 57:1044-51. 2012
  4. pmc Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis
    Bertus Eksteen
    Liver Research Laboratories, Institute for Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, England, UK
    J Exp Med 200:1511-7. 2004
  5. ncbi Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis
    Simon C Afford
    National Institute for Health Research Biomedical Research Unit and Center for Liver Research, Medical Research Council Center for Immune Regulation, University of Birmingham, Birmingham, UK
    Hepatology 59:1932-43. 2014
  6. doi Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver
    Ye H Oo
    Centre for Liver Research, Institute of Biomedical Research, The University of Birmingham Medical School, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Immunol 184:2886-98. 2010
  7. doi Lymphocyte homing and its role in the pathogenesis of IBD
    Bertus Eksteen
    Liver Research Laboratories, MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
    Inflamm Bowel Dis 14:1298-312. 2008
  8. pmc CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow
    Stuart M Curbishley
    Liver Research Group, Institute of Biomedical Research, MRC Centre for Immune Regulation, The University of Birmingham Medical School, Edgbaston, Birmingham, UK B15 2TT
    Am J Pathol 167:887-99. 2005
  9. ncbi Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
    David H Adams
    Liver Research Laboratories, MRC Centre for Immune Regulation, 5th Floor, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nat Rev Immunol 6:244-51. 2006
  10. pmc Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells
    Bertus Eksteen
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
    Gastroenterology 137:320-9. 2009

Collaborators

Detail Information

Publications18

  1. ncbi GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease
    Bertus Eksteen
    University of Birmingham and the NIHR Biomedical Research Unit for Liver Disease, Centre for Liver Research, MRC Centre for Immune Regulation, The College of Medical and Dental Sciences, Queen Elizabeth Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 2TT, UK
    IDrugs 13:472-781. 2010
    ..Data suggest that GSK-1605786 is efficacious in patients with Crohn's disease with the advantage of being orally bioavailable...
  2. doi Infections and the liver
    Bertus Eksteen
    Centre for Liver Research, MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, UK
    Dig Dis 29:184-90. 2011
    ..Key requirements to successful outcomes with modern antiviral drugs are favourable host factors...
  3. pmc CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver
    Ye Htun Oo
    Centre for Liver Research and NIHR Biomedical Research Unit in Liver Disease, University of Birmingham, Birmingham, United Kingdom
    J Hepatol 57:1044-51. 2012
    ..IL-17 secreting CD4 (Th17) and CD8 (Tc17) T cells have been implicated in immune-mediated liver diseases, but the molecular basis for their recruitment and positioning within the liver is unknown...
  4. pmc Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis
    Bertus Eksteen
    Liver Research Laboratories, Institute for Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TT, England, UK
    J Exp Med 200:1511-7. 2004
    ..This is the first demonstration in humans that T cells activated in the gut can be recruited to an extra-intestinal site of disease and provides a paradigm to explain the pathogenesis of extra-intestinal complications of IBD...
  5. ncbi Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis
    Simon C Afford
    National Institute for Health Research Biomedical Research Unit and Center for Liver Research, Medical Research Council Center for Immune Regulation, University of Birmingham, Birmingham, UK
    Hepatology 59:1932-43. 2014
    ..We confirmed our findings in a murine model of hepatobiliary inflammation where inhibition of VCAM-1 decreased liver inflammation by reducing lymphocyte recruitment and increasing CD8 and T helper 17 CD4 T-cell survival...
  6. doi Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver
    Ye H Oo
    Centre for Liver Research, Institute of Biomedical Research, The University of Birmingham Medical School, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    J Immunol 184:2886-98. 2010
    ..Thus, different chemokine receptors play distinct roles in the recruitment and positioning of T(regs) at sites of hepatitis in chronic liver disease...
  7. doi Lymphocyte homing and its role in the pathogenesis of IBD
    Bertus Eksteen
    Liver Research Laboratories, MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
    Inflamm Bowel Dis 14:1298-312. 2008
    ..In this article we review the current understanding of the molecules that determine leukocyte trafficking to the gut and highlight opportunities where their inhibition could be exploited to treat IBD.(Inflamm Bowel Dis 2008)...
  8. pmc CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow
    Stuart M Curbishley
    Liver Research Group, Institute of Biomedical Research, MRC Centre for Immune Regulation, The University of Birmingham Medical School, Edgbaston, Birmingham, UK B15 2TT
    Am J Pathol 167:887-99. 2005
    ....
  9. ncbi Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
    David H Adams
    Liver Research Laboratories, MRC Centre for Immune Regulation, 5th Floor, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nat Rev Immunol 6:244-51. 2006
    ..Similar mechanisms might explain why certain diseases are associated with site-specific tissue distributions and might point to new therapeutic strategies that are based on modulating tissue-specific lymphocyte homing...
  10. pmc Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells
    Bertus Eksteen
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
    Gastroenterology 137:320-9. 2009
    ....
  11. ncbi Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10
    Bertus Eksteen
    Liver Research Laboratories, Medical Research Council for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK
    J Immunol 177:593-603. 2006
    ..We propose that CXCR3 promotes the recruitment of Tregs to inflamed tissues and CCR10 allows them to respond to CCL28 secreted by epithelial cells resulting in the accumulation of CCR10+ Tregs at mucosal surfaces...
  12. doi CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow
    Alice Miles
    Liver Research Group, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Am J Physiol Gastrointest Liver Physiol 294:G1257-67. 2008
    ....
  13. pmc Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors
    Guillaume E Desanti
    Medical School, Institute for Biomedical Research, Medical Research Council Center for Immune Regulation, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Immunol 186:5227-35. 2011
    ....
  14. ncbi Lymphocyte homing in the pathogenesis of extra-intestinal manifestations of inflammatory bowel disease
    Bertus Eksteen
    Liver Research Laboratories, MRC Centre for Immune Regulation, University of Birmingham, Queen Elizabeth Hospital, Birmingham
    Clin Med 4:173-80. 2004
    ....
  15. pmc The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals
    David R Withers
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
    J Immunol 183:5079-84. 2009
    ..Collectively, these data demonstrate that signals through CD30 and OX40 are required for the survival of CD4(+) T cells within the small intestine lamina propria...
  16. pmc Understanding of chemoprophylaxis and concordance in inflammatory bowel disease
    Adam Low
    Department of Gastroenterology, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 6HT, UK
    World J Gastroenterol 16:578-82. 2010
    ..To assess patients' understanding for the reasons for taking 5-aminosalicylic acid or ursodeoxycholic acid as chemoprophylaxis against colorectal carcinoma associated with inflammatory bowel disease (IBD)...
  17. ncbi Immune-mediated liver injury
    Bertus Eksteen
    Liver Research Group, MRC Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    Semin Liver Dis 27:351-66. 2007
    ..Understanding these interactions will elucidate the pathogenesis of liver disease and suggest new therapies...
  18. doi Mechanisms of disease: the evolving understanding of liver allograft rejection
    Bertus Eksteen
    Liver Unit, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Nat Clin Pract Gastroenterol Hepatol 5:209-19. 2008
    ....