Michael R Ehrenstein

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine
    Michael R Ehrenstein
    Department of Medicine, University College London, London W1T 4JF, UK
    J Exp Med 204:2249-52. 2007
  2. pmc Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
    M R Ehrenstein
    Department of Medicine, University College London, London W1T 4NJ, United Kingdom
    Proc Natl Acad Sci U S A 98:14553-8. 2001
  3. doi request reprint Antibodies and other biomarkers - pathological consequences (2)
    M R Ehrenstein
    Centre for Rheumatology Research, Windeyer Institute of Medical Science, University College London, London, UK
    Lupus 17:256-8. 2008
  4. doi request reprint The importance of natural IgM: scavenger, protector and regulator
    Michael R Ehrenstein
    Centre for Rheumatology, Division of Medicine, University College London, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1P 4JF, UK
    Nat Rev Immunol 10:778-86. 2010
  5. pmc Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    Michael R Ehrenstein
    Dept of Medicine, Centre for Rheumatology, Windeyer Institute, University College London, London W1T 4JF, England, UK
    J Exp Med 200:277-85. 2004
  6. doi request reprint Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice
    Paul A Blair
    Department of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom
    J Immunol 182:3492-502. 2009
  7. doi request reprint CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
    Paul A Blair
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T4 JF, UK
    Immunity 32:129-40. 2010
  8. doi request reprint Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
    Elizabeth C Jury
    Department of Medicine, Centre for Rheumatology, University College London, London, UK
    Eur J Immunol 40:569-78. 2010
  9. ncbi request reprint Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis
    Geraldine Cambridge
    Centre for Rheumatology, University College London, Arthur Stanley House, 40 50 Tottenham Street, London W1T 4NJ, UK
    Arthritis Rheum 48:2146-54. 2003
  10. ncbi request reprint Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis
    Maria J Leandro
    University College London, Center for Rheumatology, London, UK
    Arthritis Rheum 54:613-20. 2006

Collaborators

Detail Information

Publications50

  1. pmc If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine
    Michael R Ehrenstein
    Department of Medicine, University College London, London W1T 4JF, UK
    J Exp Med 204:2249-52. 2007
    ..Studies aimed at understanding the mechanism of action of biologic agents will yield significant benefits for experimental medicine...
  2. pmc Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
    M R Ehrenstein
    Department of Medicine, University College London, London W1T 4NJ, United Kingdom
    Proc Natl Acad Sci U S A 98:14553-8. 2001
    ....
  3. doi request reprint Antibodies and other biomarkers - pathological consequences (2)
    M R Ehrenstein
    Centre for Rheumatology Research, Windeyer Institute of Medical Science, University College London, London, UK
    Lupus 17:256-8. 2008
  4. doi request reprint The importance of natural IgM: scavenger, protector and regulator
    Michael R Ehrenstein
    Centre for Rheumatology, Division of Medicine, University College London, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1P 4JF, UK
    Nat Rev Immunol 10:778-86. 2010
    ....
  5. pmc Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    Michael R Ehrenstein
    Dept of Medicine, Centre for Rheumatology, Windeyer Institute, University College London, London W1T 4JF, England, UK
    J Exp Med 200:277-85. 2004
    ....
  6. doi request reprint Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice
    Paul A Blair
    Department of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom
    J Immunol 182:3492-502. 2009
    ..Taken together, our results suggest a novel cellular approach for the amelioration of experimental lupus...
  7. doi request reprint CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
    Paul A Blair
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T4 JF, UK
    Immunity 32:129-40. 2010
    ..Altered cellular function within this compartment may impact effector immune responses in SLE and other autoimmune disorders...
  8. doi request reprint Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
    Elizabeth C Jury
    Department of Medicine, Centre for Rheumatology, University College London, London, UK
    Eur J Immunol 40:569-78. 2010
    ..Collectively our data identify CTLA-4 dysfunction as a potential cause for abnormal T-cell activation in patients with SLE, which could be targeted for therapy...
  9. ncbi request reprint Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis
    Geraldine Cambridge
    Centre for Rheumatology, University College London, Arthur Stanley House, 40 50 Tottenham Street, London W1T 4NJ, UK
    Arthritis Rheum 48:2146-54. 2003
    ..To explore the changes in serologic variables and clinical disease activity following B lymphocyte depletion in 22 patients with rheumatoid arthritis (RA)...
  10. ncbi request reprint Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis
    Maria J Leandro
    University College London, Center for Rheumatology, London, UK
    Arthritis Rheum 54:613-20. 2006
    ..To study the quantitative and phenotypic reconstitution of peripheral blood B cells and its relationship to the dynamics of clinical response in patients with rheumatoid arthritis (RA) following B cell depletion with rituximab...
  11. doi request reprint Secreted IgM enhances B cell receptor signaling and promotes splenic but impairs peritoneal B cell survival
    Clare A Notley
    Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom
    J Immunol 184:3386-93. 2010
    ..This work provides new insight into the regulation of B cell signaling and homeostasis in different peripheral compartments by secreted IgM...
  12. ncbi request reprint Novel suppressive function of transitional 2 B cells in experimental arthritis
    Jamie G Evans
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London, United Kingdom
    J Immunol 178:7868-78. 2007
    ..The ability to regulate an established immune response by T2-MZP B cells endows this subset of B cells with a striking and previously unrecognized immunoregulatory potential...
  13. doi request reprint Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells
    Clare A Notley
    Center for Rheumatology, University College London, London W1P 4JF, United Kingdom
    J Immunol 186:4967-72. 2011
    ..Our results demonstrate that natural IgM is a critical factor in a chain of events triggered by the administration of apoptotic cells that promote IL-10-secreting B and T cells and restrain the development of inflammation...
  14. ncbi request reprint Natural serum IgM maintains immunological homeostasis and prevents autoimmunity
    Jessica J Manson
    Department of Rheumatology, University College London, London, UK
    Springer Semin Immunopathol 26:425-32. 2005
    ..This review focuses on these new areas of research, which also show that many pathologies not normally recognised as having an immunological basis are modulated by serum IgM...
  15. ncbi request reprint Atorvastatin inhibits autoreactive B cell activation and delays lupus development in New Zealand black/white F1 mice
    Sarah Lawman
    Department of Medicine, University College London, London, United Kingdom
    J Immunol 173:7641-6. 2004
    ..This is the first demonstration that atorvastatin can delay the progression of a spontaneous autoimmune disease and may specifically benefit patients with systemic lupus erythematosus...
  16. doi request reprint The 'short' history of regulatory B cells
    Claudia Mauri
    Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Immunol 29:34-40. 2008
    ..The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies...
  17. pmc Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    Fabian Flores-Borja
    Centre for Rheumatology, Division of Medicine, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 105:19396-401. 2008
    ..Our results suggest that defects in CTLA-4 could contribute to abnormal Treg function in RA and may represent a target for therapy for inducing long-lasting remission...
  18. doi request reprint Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells
    Natalie A Carter
    Division of Medicine, Centre for Rheumatology Research, University College London, London W1T 4JF, United Kingdom
    J Immunol 186:5569-79. 2011
    ..Thus, IL-10-producing B cells restrain inflammation by promoting differentiation of immunoregulatory over proinflammatory T cells...
  19. pmc Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
    Suchita Nadkarni
    Centre for Rheumatology, Department of Medicine, Windeyer Institute, University College London, London W1T 4JF, England, UK
    J Exp Med 204:33-9. 2007
    ..Therefore, manipulation of a proinflammatory environment could represent a therapeutic strategy for the induction of T reg cells and the restoration of tolerance...
  20. ncbi request reprint Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus
    Elizabeth C Jury
    Department of Medicine, Centre for Rheumatology, University College London, United Kingdom
    J Immunol 177:7416-22. 2006
    ..These findings demonstrate the potential for atorvastatin to target lipid raft-associated signaling abnormalities in autoreactive T cells and provide a rationale for its use in therapy of autoimmune disease...
  21. pmc Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice
    Myles J Lewis
    BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College, Hammersmith Hospital, Du Cane Rd, London, W12 0NN, UK
    Circulation 120:417-26. 2009
    ..We have directly investigated the requirement for IgM by studying the effects of IgM deficiency in LDL receptor-deficient (Ldlr(-/-)) mice...
  22. pmc Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
    Graham P Wright
    Department of Immunology, University College London, Royal Free Hospital, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 106:19078-83. 2009
    ..This opens the possibility to target Tregs to tissue-specific antigens for the treatment of autoimmune tissue damage without the knowledge of the disease-causing autoantigens recognized by pathogenic T cells...
  23. pmc Repeated B cell depletion in treatment of refractory systemic lupus erythematosus
    K P Ng
    Centre for Rheumatology, University College London, Arthur Stanley House, 40 50 Tottenham Street, London W1T 4NJ, UK
    Ann Rheum Dis 65:942-5. 2006
    ..To report the clinical outcome and safety profile of repeated B cell depletion in seven patients with refractory systemic lupus erythematosus (SLE)...
  24. ncbi request reprint B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients
    M J Leandro
    Centre for Rheumatology, University College London, London, UK
    Rheumatology (Oxford) 44:1542-5. 2005
    ..To assess the clinical and basic serological consequences of B-cell depletion with rituximab in the treatment of patients with systemic lupus erythematosus (SLE) who have failed conventional immunosuppression...
  25. doi request reprint CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation
    Fabian Flores-Borja
    Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK
    Sci Transl Med 5:173ra23. 2013
    ..These results suggest that in patients with active RA, CD19(+)CD24(hi)CD38(hi) B cells with regulatory function may fail to prevent the development of autoreactive responses and inflammation, leading to autoimmunity...
  26. doi request reprint Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy
    Jenny L McGovern
    University College London, London, UK
    Arthritis Rheum 64:3129-38. 2012
    ..This study sought to address whether Th17 cells are inhibited by Treg cells in rheumatoid arthritis (RA) patients responding to anti-tumor necrosis factor (anti-TNF) therapy, and if so defining the underlying mechanisms of suppression...
  27. pmc B-cell numbers and phenotype at clinical relapse following rituximab therapy differ in SLE patients according to anti-dsDNA antibody levels
    Mark N Lazarus
    Centre for Rheumatology, University College London, 5 University Street, London WC1E 6JF, UK
    Rheumatology (Oxford) 51:1208-15. 2012
    ..To correlate the kinetics of B-cell repopulation with relapse after B-cell depletion therapy in SLE patients and address whether variation in relapse rate, B-cell numbers and phenotype are related to anti-dsDNA antibody levels...
  28. doi request reprint The efficacy of repeated treatment with B-cell depletion therapy in systemic lupus erythematosus: an evaluation
    Tabitha Turner-Stokes
    Centre for Rheumatology Research, University College Hospital, London, UK
    Rheumatology (Oxford) 50:1401-8. 2011
    ..The aims of the study were to: (i) assess the efficacy and safety of repeated cycles of BCDT in treating refractory SLE; and (ii) assess whether retreatment produced a more sustained clinical response...
  29. pmc Cells of the synovium in rheumatoid arthritis. B cells
    Claudia Mauri
    Centre for Rheumatology Research, Department of Medicine, University College London, Cleveland Street, London, W1T 4JF, UK
    Arthritis Res Ther 9:205. 2007
    ..In this review we analyze the multifaceted role that B cells play in the pathogenesis of rheumatoid arthritis and discuss how this information can be used to guide more specific targeting of B cells for the therapy of this disease...
  30. pmc Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen-specific regulatory T cells, and suppresses experimental inflammatory arthritis
    Frederick Arce
    University College London, London, UK
    Arthritis Rheum 63:84-95. 2011
    ..The aim of the present study was to define the ERK-dependent immunosuppressive mechanisms and to apply selective ERK activation for the treatment of experimental inflammatory arthritis...
  31. doi request reprint Therapeutic potential of Tregs to treat rheumatoid arthritis
    Graham P Wright
    Centre for Rheumatology Research, University College London, Rayne Building, 5 University Street, London WC1E 6JF, United Kingdom
    Semin Immunol 23:195-201. 2011
    ..Here we discuss these approaches, their refinement to restore tolerance in patients with rheumatoid arthritis, and strategies to prevent their conversion towards a Th17 phenotype...
  32. doi request reprint Restoring the balance: harnessing regulatory T cells for therapy in rheumatoid arthritis
    Fabian Flores-Borja
    Department of Medicine, University College London, London, UK
    Eur J Immunol 38:934-7. 2008
    ..Here we discuss strategies aimed at enhancing Treg function in patients with rheumatoid arthritis with the ultimate aim of restoring lasting tolerance but without increasing the risk of infections or cancer...
  33. ncbi request reprint International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease
    D A Isenberg
    Center for Rheumatology, Department of Medicine, The Middlesex Hospital, University College London, London, UK
    Rheumatology (Oxford) 43:49-54. 2004
    ..To devise new tools to assess activity and damage in patients with idiopathic myopathies (IIM)...
  34. ncbi request reprint Fifty years of anti-ds DNA antibodies: are we approaching journey's end?
    D A Isenberg
    Centre for Rheumatology Research, Division of Medicine, University College London, London W1T 4JF, UK
    Rheumatology (Oxford) 46:1052-6. 2007
    ....
  35. ncbi request reprint Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis
    C T Ravirajan
    Department of Medicine, University College London, GB
    Eur J Immunol 28:339-50. 1998
    ..In this study we have shown for the first time using electron microscopy that a human IgG anti-dsDNA mAb, RH-14, is nephritogenic and that deposition of such an antibody alone is sufficient to induce renal damage...
  36. ncbi request reprint Bone marrow B-lineage cells in patients with rheumatoid arthritis following rituximab therapy
    M J Leandro
    Centre for Rheumatology, University College London, London W1T 4JF, UK
    Rheumatology (Oxford) 46:29-36. 2007
    ..To assess the presence and phenotype of B-lineage cells in the bone marrow (BM) of rheumatoid arthritis (RA) patients after rituximab therapy...
  37. ncbi request reprint Statins: immunomodulators for autoimmune rheumatic disease?
    E C Jury
    Department of Medicine, University College London, London, UK
    Lupus 14:192-6. 2005
    ..Such an anti-inflammatory effect may also benefit patients with autoimmune rheumatic disease. This overview assesses the evidence for using statins in patients with rheumatoid arthritis and systemic lupus erythematosus (SLE)...
  38. ncbi request reprint Many paths lead to lupus
    S Lawman
    University College London, London, UK
    Lupus 11:801-6. 2002
  39. ncbi request reprint Cutting edge: selection of B lymphocyte subsets is regulated by natural IgM
    Nicole Baker
    Department of Medicine, University College London, London, United Kingdom
    J Immunol 169:6686-90. 2002
    ..These results demonstrate that natural IgM regulates the selection of B lymphocyte subsets...
  40. doi request reprint Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity
    Graham P Wright
    Centre for Rheumatology, University College London, Windeyer Building, 46 Cleveland Street, London, W1T 4JF, UK
    Expert Rev Clin Immunol 7:213-25. 2011
    ..Furthermore, we will discuss the obstacles that need to be surmounted to allow adoptive Treg therapy to progress to the clinic for the benefit of autoimmune patients...
  41. doi request reprint The yin and yang of regulatory T cells and inflammation in RA
    Clare A Notley
    Centre for Rheumatology Research, Windeyer Institute of Medical Science, University College London, London W1P 4JF, UK
    Nat Rev Rheumatol 6:572-7. 2010
    ..Therapeutic approaches that enhance T(REG)-cell function whilst controlling inflammation are likely to be the most effective strategies for restoring immune tolerance in patients with this disease...
  42. doi request reprint Tuberculosis and anti-TNF treatment: experience of a central London hospital
    Satveer Mankia
    Rheumatology Department, University College Hospital, 235 Euston Road, London, NW1 2BU, UK
    Clin Rheumatol 30:399-401. 2011
    ..All patients had normal chest radiographs prior to anti-TNF treatment. Our data emphasise that country of origin is important in the determining risk of latent TB and that a normal chest radiograph does not exclude latent TB...
  43. ncbi request reprint An open study of B lymphocyte depletion in systemic lupus erythematosus
    Maria J Leandro
    Rheumatology, Middlesex Hospital, University College, 4th Floor Arthur Stanley House, 40 50 Tottenham Street, London W1T 4NJ, UK
    Arthritis Rheum 46:2673-7. 2002
    ..To gain preliminary evidence for the safety and efficacy of B lymphocyte depletion therapy in refractory systemic lupus erythematosus (SLE)...
  44. doi request reprint Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis
    Konstantia Maria Chavele
    Centre of Rheumatology, University College London, London, UK
    FEBS Lett 585:3603-10. 2011
    ..This review will discuss the phenotypic, numeric, and functional abnormalities in Tregs and their role in patients and murine models of SLE and RA...
  45. ncbi request reprint T cell-B cell interactions
    M R Ehrenstein
    Department of Medicine, Centre for Rheumatology, The Middlesex Hospital, University College London, London, UK
    Lupus 11:790-2. 2002
    ..The provenance of these peptides may be self or foreign antigens, or autoantibody idiotypes...
  46. ncbi request reprint Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice
    Helen Ferry
    Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    J Immunol 178:2916-22. 2007
    ..We show that exposure of intracellular Ag leads to the activation of conventional B cells, when there is a source of T cell help in vivo...
  47. ncbi request reprint B cell depletion in systemic lupus erythematosus
    Maria J Leandro
    University College London Hospitals
    Clin Med 7:57-9. 2007
  48. ncbi request reprint Statins for atherosclerosis--as good as it gets?
    Michael R Ehrenstein
    N Engl J Med 352:73-5. 2005
  49. pmc Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
    Qiang Pan-Hammarstrom
    Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden
    J Exp Med 201:189-94. 2005
    ..These findings link DNA ligase IV, and thus NHEJ, to CSR...
  50. ncbi request reprint Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro
    Pierre Quartier
    Rheumatology Section, Imperial College, Hammersmith Campus, London W12 ONN, UK
    Eur J Immunol 35:252-60. 2005
    ..Hence, the efficient uptake of dying cells by BMDM requires IgM antibodies and complement...