P Eggleton

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi C1q--how many functions? How many receptors?
    P Eggleton
    Dept of Biochemistry, University of Oxford, UK
    Trends Cell Biol 8:428-31. 1998
  2. ncbi Lung surfactant proteins involved in innate immunity
    P Eggleton
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, UK
    Curr Opin Immunol 11:28-33. 1999
  3. ncbi Effect of IP6 on human neutrophil cytokine production and cell morphology
    P Eggleton
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, U K
    Anticancer Res 19:3711-5. 1999
  4. pmc C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms
    L E Leigh
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U K
    Biochem J 330:247-54. 1998
  5. pmc The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexes
    U Kishore
    Department of Biochemistry, University of Oxford, UK
    Clin Exp Immunol 108:181-90. 1997
  6. pmc The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
    R Jounblat
    MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Respir Res 6:126. 2005
  7. ncbi The ins and outs of calreticulin: from the ER lumen to the extracellular space
    S Johnson
    MRC Immunochemistry Unit, University of Oxford, Oxford, UK OX1 3QU
    Trends Cell Biol 11:122-9. 2001

Collaborators

Detail Information

Publications7

  1. ncbi C1q--how many functions? How many receptors?
    P Eggleton
    Dept of Biochemistry, University of Oxford, UK
    Trends Cell Biol 8:428-31. 1998
    ..This article discusses the various activities of C1q and the evidence that these functions might be influenced by both membrane-bound and soluble C1q-binding proteins...
  2. ncbi Lung surfactant proteins involved in innate immunity
    P Eggleton
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, UK
    Curr Opin Immunol 11:28-33. 1999
    ..Recent gene-knockout, protein engineering and physiological studies have emphasised the roles that SP-A and SP-D play in acute inflammatory responses...
  3. ncbi Effect of IP6 on human neutrophil cytokine production and cell morphology
    P Eggleton
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, U K
    Anticancer Res 19:3711-5. 1999
    ..A direct effect of IP6 on cell function was to trigger a sustained assembly of F-actin. Thus, exposure of neutrophils to low levels of IP6 appears to modulate selective neutrophil functions...
  4. pmc C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms
    L E Leigh
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U K
    Biochem J 330:247-54. 1998
    ..Our results suggests C1q-mediated chemotaxis involves gC1qR as well as G-protein-coupled signal-transduction mechanisms operating downstream to neutrophil chemotaxis...
  5. pmc The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexes
    U Kishore
    Department of Biochemistry, University of Oxford, UK
    Clin Exp Immunol 108:181-90. 1997
    ..We conclude that CRT, once released from leucocytes during inflammation, may not only induce an antigenic reaction, but also interfere with C1q-mediated inflammatory processes...
  6. pmc The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
    R Jounblat
    MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Respir Res 6:126. 2005
    ..Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood...
  7. ncbi The ins and outs of calreticulin: from the ER lumen to the extracellular space
    S Johnson
    MRC Immunochemistry Unit, University of Oxford, Oxford, UK OX1 3QU
    Trends Cell Biol 11:122-9. 2001
    ..Here, we will focus on these less-well-characterized functions of calreticulin...