Affiliation: University of Oxford
- C1q--how many functions? How many receptors?P Eggleton
Dept of Biochemistry, University of Oxford, UK
Trends Cell Biol 8:428-31. 1998..This article discusses the various activities of C1q and the evidence that these functions might be influenced by both membrane-bound and soluble C1q-binding proteins...
- Lung surfactant proteins involved in innate immunityP Eggleton
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, UK
Curr Opin Immunol 11:28-33. 1999..Recent gene-knockout, protein engineering and physiological studies have emphasised the roles that SP-A and SP-D play in acute inflammatory responses...
- Effect of IP6 on human neutrophil cytokine production and cell morphologyP Eggleton
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, U K
Anticancer Res 19:3711-5. 1999..A direct effect of IP6 on cell function was to trigger a sustained assembly of F-actin. Thus, exposure of neutrophils to low levels of IP6 appears to modulate selective neutrophil functions...
- C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanismsL E Leigh
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U K
Biochem J 330:247-54. 1998..Our results suggests C1q-mediated chemotaxis involves gC1qR as well as G-protein-coupled signal-transduction mechanisms operating downstream to neutrophil chemotaxis...
- The systemic lupus erythematosus (SLE) disease autoantigen-calreticulin can inhibit C1q association with immune complexesU Kishore
Department of Biochemistry, University of Oxford, UK
Clin Exp Immunol 108:181-90. 1997..We conclude that CRT, once released from leucocytes during inflammation, may not only induce an antigenic reaction, but also interfere with C1q-mediated inflammatory processes...
- The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumoniaR Jounblat
MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
Respir Res 6:126. 2005..Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood...
- The ins and outs of calreticulin: from the ER lumen to the extracellular spaceS Johnson
MRC Immunochemistry Unit, University of Oxford, Oxford, UK OX1 3QU
Trends Cell Biol 11:122-9. 2001..Here, we will focus on these less-well-characterized functions of calreticulin...