Dylan R Edwards

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. doi request reprint The ADAM metalloproteinases
    Dylan R Edwards
    Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Mol Aspects Med 29:258-89. 2008
  2. pmc Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms
    Rachael A Hancox
    Department of Cancer Studies and Molecular Medicine, Infirmary Close, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Breast Cancer Res 11:R24. 2009
  3. ncbi request reprint TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges
    Dylan R Edwards
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    J Pathol 202:391-4. 2004
  4. ncbi request reprint Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes
    Clara L Sampieri
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Matrix Biol 27:128-38. 2008
  5. pmc Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
    David A Young
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Arthritis Res Ther 7:R503-12. 2005
  6. ncbi request reprint Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma
    Sarah Porter
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Clin Cancer Res 10:2429-40. 2004
  7. ncbi request reprint Metalloproteinases and their inhibitors in tumor angiogenesis
    Madeleine M Handsley
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Int J Cancer 115:849-60. 2005
  8. ncbi request reprint Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression
    David A Young
    School of Biological Sciences, University of East Anglia, Norwich, UK
    FEBS J 272:1912-26. 2005
  9. ncbi request reprint Expression profiling of metalloproteinases and their inhibitors in cartilage
    Lara Kevorkian
    University of East Anglia, Norwich, UK
    Arthritis Rheum 50:131-41. 2004
  10. doi request reprint Real-time PCR expression profiling of MMPs and TIMPs
    Caroline J Pennington
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Methods Mol Biol 622:159-73. 2010

Collaborators

Detail Information

Publications63

  1. doi request reprint The ADAM metalloproteinases
    Dylan R Edwards
    Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Mol Aspects Med 29:258-89. 2008
    ..This review will provide an overview of current knowledge of the human ADAMs, discussing their structure, function, regulation and disease involvement...
  2. pmc Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms
    Rachael A Hancox
    Department of Cancer Studies and Molecular Medicine, Infirmary Close, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, UK
    Breast Cancer Res 11:R24. 2009
    ..The ECM protein tenascin-C (TNC) is frequently up-regulated in breast cancer and we have previously identified two novel isoforms - one containing exon 16 (TNC-16) and one containing exons 14 plus 16 (TNC-14/16)...
  3. ncbi request reprint TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges
    Dylan R Edwards
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    J Pathol 202:391-4. 2004
    ..New data suggest that high levels of TIMP-3 mRNAs in human breast tumours are associated with success of adjuvant endocrine therapy, but not chemotherapy...
  4. ncbi request reprint Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes
    Clara L Sampieri
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Matrix Biol 27:128-38. 2008
    ..The definition of clusters of co-regulated genes among the two gene families will aid in bioinformatic dissection of control mechanisms...
  5. pmc Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
    David A Young
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Arthritis Res Ther 7:R503-12. 2005
    ..HDAC inhibitors may therefore be novel chondroprotective therapeutic agents in arthritis by virtue of their ability to inhibit the expression of destructive metalloproteinases by chondrocytes...
  6. ncbi request reprint Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma
    Sarah Porter
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Clin Cancer Res 10:2429-40. 2004
    ..ADAMTS15 has emerged as being an independent predictor of survival, with RNA expression levels significantly lower (P = 0.007) in grade 3 breast carcinoma compared with grade 1 and 2 breast carcinoma...
  7. ncbi request reprint Metalloproteinases and their inhibitors in tumor angiogenesis
    Madeleine M Handsley
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Int J Cancer 115:849-60. 2005
    ....
  8. ncbi request reprint Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression
    David A Young
    School of Biological Sciences, University of East Anglia, Norwich, UK
    FEBS J 272:1912-26. 2005
    ....
  9. ncbi request reprint Expression profiling of metalloproteinases and their inhibitors in cartilage
    Lara Kevorkian
    University of East Anglia, Norwich, UK
    Arthritis Rheum 50:131-41. 2004
    ..To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage and cartilage from patients with osteoarthritis (OA)...
  10. doi request reprint Real-time PCR expression profiling of MMPs and TIMPs
    Caroline J Pennington
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Methods Mol Biol 622:159-73. 2010
    ..In this chapter, we describe the use of Taqman((R)) technology to measure expression of matrix metalloproteinases and related genes...
  11. ncbi request reprint Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes
    David A Young
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem Biophys Res Commun 322:759-65. 2004
    ..The genes subdivide into eight groups based upon their expression profile. Their expression was both qualitatively and quantitatively highly homologous to that seen during mouse heart development...
  12. ncbi request reprint MMP and TIMP expression in quiescent, dividing, and differentiating human lens cells
    Lisa M Hodgkinson
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Invest Ophthalmol Vis Sci 48:4192-9. 2007
    ..Hence, a gene expression analysis was undertaken in epithelial and fiber cells dissected from clear human donor lenses...
  13. doi request reprint MMP2 activity is critical for TGFβ2-induced matrix contraction--implications for fibrosis
    Julie A Eldred
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk, UK
    Invest Ophthalmol Vis Sci 53:4085-98. 2012
    ..The pro-fibrotic cytokine transforming growth factor beta (TGFβ) is central to PCO development. This study aimed to elucidate the role of the ECM modulators matrix metalloproteinases (MMPs) in TGFβ-mediated PCO formation...
  14. pmc The ADAMTS metalloproteinases
    Sarah Porter
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem J 386:15-27. 2005
    ..This review highlights progress in understanding the structural organization and functional roles of the ADAMTSs in normal and pathological conditions...
  15. ncbi request reprint Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia
    Robert K Nuttall
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Glia 55:516-26. 2007
    ..The results have implications for the regulation of neuroinflammation and its outcomes following CNS injuries...
  16. doi request reprint Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma
    Angela Stokes
    Biomedical Research Centre, University of East Anglia
    Clin Cancer Res 16:2022-35. 2010
    ..Proteinases have been implicated in several aspects of tumor growth and metastasis in a broad range of tumors including HNSCC...
  17. pmc Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells
    Sally Thirkettle
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, United Kingdom
    J Biol Chem 288:16282-94. 2013
    ..This axis may be relevant to the recognized ability of MMP-8 to orchestrate the innate immune system in inflammation in vivo...
  18. doi request reprint New insights into the plasticity of the endothelial phenotype
    Lindsay S Cooley
    School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK
    Biochem Soc Trans 39:1639-43. 2011
    ..Therapeutic control of endothelial plasticity will allow greater understanding of the genesis and treatment of several vascular diseases...
  19. pmc ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells
    Lisa M Hodgkinson
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Mol Vis 16:2765-76. 2010
    ..Gene expression profiling was undertaken to better understand the role of the ADAM and ADAMTS families in the clear native human lenses and following surgical injury with particular relevance to posterior capsule opacification...
  20. ncbi request reprint Expression analysis of the entire MMP and TIMP gene families during mouse tissue development
    Robert K Nuttall
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    FEBS Lett 563:129-34. 2004
    ....
  21. doi request reprint The regulation of matrix metalloproteinases and their inhibitors
    Ian M Clark
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Int J Biochem Cell Biol 40:1362-78. 2008
    ..This article aims to review current knowledge across these gene families and use a bioinformatic approach to fill the gaps where no functional data are available...
  22. ncbi request reprint Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3
    Robert J R Singh
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Cardiovasc Res 67:39-49. 2005
    ..Here we investigate mechanisms involved in sVCAM-1 generation in response to cytokine stimulation...
  23. doi request reprint Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma
    Julia L Zhong
    Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom
    Mol Cancer Res 6:383-94. 2008
    ..These data indicate that selective expression of ADAM-15 variants in breast cancers could play an important role in determining tumor aggressiveness by interplay with intracellular signaling pathways...
  24. ncbi request reprint ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma
    Sarah Porter
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    Int J Cancer 118:1241-7. 2006
    ..In summary, ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma...
  25. doi request reprint Matrix metalloproteinases: protective roles in cancer
    Julie Decock
    School of Biological Sciences, University of East Anglia, Norwich, UK
    J Cell Mol Med 15:1254-65. 2011
    ..This review will provide a focussed overview of the published data on the tumour-suppressive behaviour of MMPs...
  26. doi request reprint ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding?
    Rosemary Bass
    Cellular Protease Group, School of Biological Sciences, University of East Anglia, Norwich NR47TJ, UK
    Biochem J 428:e3-5. 2010
    ..This is a novel and exciting finding that could help to unlock the actions of ADAM sheddases, as well as a host of other mechanisms that rely upon rapid alterations in protein conformation on the cell surface...
  27. doi request reprint Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro
    Lindsay S Cooley
    Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    J Cell Sci 123:3808-16. 2010
    ..These data reveal an unexpected plasticity in endothelial phenotype, which is regulated by contact with the ECM environment and/or cues from supporting cells...
  28. pmc G-helix of maspin mediates effects on cell migration and adhesion
    Lorna Ravenhill
    School of Biological Sciences, Biomedical Research Centre, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Biol Chem 285:36285-92. 2010
    ..These data reveal that the major extracellular functions associated with the tumor suppressive action of maspin likely involve interactions in which the G-helix plays a key role...
  29. pmc Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP)
    Joanna R Worley
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem J 372:799-809. 2003
    ....
  30. ncbi request reprint Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells
    Robert K Nuttall
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk, United Kingdom
    Mol Cancer Res 1:333-45. 2003
    ..Concurrent elevation of signaling molecules suggests potential bidirectional relationships that enhance tumor aggressiveness...
  31. ncbi request reprint The role of chondrocyte senescence in osteoarthritis
    Jo S Price
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Aging Cell 1:57-65. 2002
    ..e. no correlation was found between senescent cells and proteinase/ inhibitor expression)...
  32. ncbi request reprint Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid
    Joanna R Worley
    School of Biological Sciences, University of East Anglia, and Bertram Diabetes Research Unit, Norfolk and Norwich University Hospital NHS Trust, Norwich, United Kingdom
    J Biol Chem 278:51340-6. 2003
    ..These results indicate that PPAR gamma and RXR agonists have complex effects on monocyte metalloproteinase expression, which may have implications for therapeutic strategies...
  33. pmc Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene
    David A Young
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U K
    Biochem J 364:89-99. 2002
    ....
  34. doi request reprint Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates
    Tanya Stuchinskaya
    School of Chemistry, University of East Anglia, Norwich, Norfolk, UK
    Photochem Photobiol Sci 10:822-31. 2011
    ..Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents...
  35. ncbi request reprint Quantitative reverse transcription-polymerase chain reaction (RT-PCR): a comparison of primer-dropping, competitive, and real-time RT-PCRs
    Steven J Wall
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    Anal Biochem 300:269-73. 2002
  36. ncbi request reprint Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
    Zaruhi Poghosyan
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Biol Chem 277:4999-5007. 2002
    ..These data demonstrate selective, phosphorylation-dependent interactions of ADAM15 with Src family PTKs and Grb2, which highlight the potential for integration of ADAM functions and cellular signaling...
  37. ncbi request reprint Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix
    Karen M Yeow
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk NR4 7TJ, UK
    Matrix Biol 21:75-88. 2002
    ....
  38. ncbi request reprint Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse
    Steven J Wall
    School of Biological Sciences, University of East Anglia, Norwich, U K
    J Invest Dermatol 119:91-8. 2002
    ....
  39. ncbi request reprint Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue
    Heidi Palosaari
    Institute of Dentistry, University of Oulu, Oulu, Finland
    Eur J Oral Sci 111:117-27. 2003
    ....
  40. ncbi request reprint Insulin-like growth factor-II regulates PTEN expression in the mammary gland
    Roger A Moorehead
    Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:50422-7. 2003
    ..Thus, we have identified a novel negative feedback loop within the PI3K pathway where IGF-II induces PTEN expression to modulate its physiologic effects...
  41. ncbi request reprint Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases
    Vincent Chabottaux
    Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, Center for Biomedical Integrative Genoproteomics, University of Liege, Belgium
    Cancer Res 66:5165-72. 2006
    ..t. blood vessels, and is associated with increased lung metastases. These results identify MT4-MMP as a new putative target to design anticancer strategies...
  42. ncbi request reprint Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo
    James E Harris
    Department of Infectious Diseases and Immunity, Imperial College, Du Cane Road, London, United Kingdom
    J Immunol 178:1199-207. 2007
    ..Astrocytes may contribute to a matrix degrading environment within the CNS and subsequent morbidity and mortality...
  43. ncbi request reprint Expression of Sorsby's fundus dystrophy mutations in human retinal pigment epithelial cells reduces matrix metalloproteinase inhibition and may promote angiogenesis
    Jian Hua Qi
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:13394-400. 2002
    ..These results also suggest the potential therapeutic use of TIMP-3 or synthetic MMP inhibitors in this disease...
  44. ncbi request reprint Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment
    Leon C L Van Kempen
    Cancer Research Institute, University of California, San Francisco, CA 94115, USA
    Differentiation 70:610-23. 2002
    ....
  45. pmc Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets
    Anna Radomski
    Department of Pharmacology, University of Alberta, 9 50 Medical Sciences Building, Edmonton, Ontario, Canada T6G 2H7
    Br J Pharmacol 137:1330-8. 2002
    ..11. Human rTIMP-4 exerted a biphasic effect on HT-1080 cells-induced aggregation. 12. Thus, TIMP-4 is the major intraplatelet MMP inhibitor and it is involved in regulation of platelet aggregation and recruitment...
  46. ncbi request reprint Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model
    Matthias Arlt
    Institut für Experimentelle Onkologie und Therapieforschung, Technische Universitat Munchen, D 81675 Munchen, Germany
    Cancer Res 62:5543-50. 2002
    ..MMPIs with greater selectivity/specificity for MMP-9 in vitro showed greater efficacy against liver metastasis in vivo. These data demonstrate a link between increased specificity of MMPIs and enhanced anticancer activity...
  47. ncbi request reprint Metalloproteinase inhibitors: biological actions and therapeutic opportunities
    Andrew H Baker
    BHF Blood Pressure Group, Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, UK
    J Cell Sci 115:3719-27. 2002
    ....
  48. ncbi request reprint Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption
    Jae Chang Jung
    New England Eye Center, Tufts University School of Medicine, 750 Washington Street, Box 450, Boston, MA 02111, USA
    Dev Dyn 223:402-13. 2002
    ..These findings suggest that MMPs and TIMPs act in concert to effect the dismantling of mesenchymal structures during T(3)-induced metamorphic tadpole tail resorption...
  49. ncbi request reprint Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k)
    Christopher P Denton
    Centre for Rheumatology, Royal Free and University College Medical School, Hampstead Campus, London NW3 2PF, United Kingdom
    J Biol Chem 280:16053-65. 2005
    ..Our study demonstrates that altered high affinity TGFbeta receptor function may lead to ligand-dependent activation of downstream signaling, and provides further evidence of a pivotal role for sustained TGFbeta overactivity in fibrosis...
  50. doi request reprint Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion
    Ana Gutierrez-Fernandez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Spain
    Cancer Res 68:2755-63. 2008
    ..On this basis, we propose that MMP-8 is a tumor protective factor, which also has the ability to reduce the metastatic potential of malignant cells in both mice and human...
  51. ncbi request reprint Determinants of human B cell migration across brain endothelial cells
    Andrea Alter
    Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
    J Immunol 170:4497-505. 2003
    ....
  52. ncbi request reprint Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration
    Fazilat F Mohammed
    Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada
    Hepatology 41:857-67. 2005
    ..In conclusion, TIMP-1 is a novel negative regulator of HGF activity during liver regeneration...
  53. ncbi request reprint Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors
    Ingo J Banke
    Institut für Experimentelle Onkologie und Therapieforschung, Technische Universitat Munchen, Ismaninger Str 22, D 81675 Munchen, Germany
    Biol Chem 384:1515-25. 2003
    ..This appreciation may be important for the future rational design of new anti-proteolytic agents for cancer therapy...
  54. ncbi request reprint An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice
    Jennifer E A Wells
    Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 23:10107-15. 2003
    ..The data indicate that MMP-12 expression after spinal cord trauma is deleterious and contributes to the development of secondary injury in SCI...
  55. ncbi request reprint Metalloproteinases and their inhibitors in angiogenesis
    Marc A Lafleur
    St Vincent s Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Expert Rev Mol Med 5:1-39. 2003
    ....
  56. ncbi request reprint Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice
    Zamaneh Kassiri
    Ontario Cancer Institute, University of Toronto, University Health Network, Canada
    Circ Res 97:380-90. 2005
    ..Notably, combining TNFalpha ablation with MMP inhibition completely rescued heart disease in timp-3(-/-)-AB mice. This study provides a basis for anti-TNFalpha and MMP inhibitor combination therapy in heart disease...
  57. ncbi request reprint An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization
    Andrew Weaver
    University of Calgary, Calgary, Alberta, Canada
    FASEB J 19:1668-70. 2005
    ..These results emphasize that specific MMPs can have beneficial roles in inflammation, and they implicate MMPs in T effector polarization for the first time...
  58. ncbi request reprint Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1
    Paul T G Elkington
    Department of Infectious Diseases, Imperial College, London, UK
    Am J Respir Crit Care Med 172:1596-604. 2005
    ..However, the mechanisms of this lung destruction are poorly understood. The biochemistry of lung matrix predicts matrix metalloproteinase (MMP) involvement in immunopathology...
  59. ncbi request reprint Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon
    Gavin C Jones
    Rheumatology Research Unit, Addenbrooke s Hospital, Cambridge, UK
    Arthritis Rheum 54:832-42. 2006
    ....
  60. ncbi request reprint Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis
    Jorge García-Alvarez
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    Exp Lung Res 32:201-14. 2006
    ..Our findings suggest that TGF-beta1-induced TIMP3 may be an important mediator in lung fibrogenesis...
  61. ncbi request reprint Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis
    Jorge García-Alvarez
    Facultad de Ciencias, Universidad Nacional Autonoma de Mexico
    Sarcoidosis Vasc Diffuse Lung Dis 23:13-21. 2006
    ..Some secreted matrix metalloproteinases (MMPs) as MMP2 are highly upregulated in IPF lungs. Membrane-type (MT)-MMPs participate in the activation of pro-MMP2. However, they have not been examined in IPF...
  62. ncbi request reprint Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis
    Amit Bar-Or
    Montreal Neurological Institute, Quebec, Canada
    Brain 126:2738-49. 2003
    ....
  63. doi request reprint Distinct functionality of tumor cell-derived gelatinases during formation of liver metastases
    Michael Gerg
    Klinikum rechts der Isar der Technischen Universitat Munchen, Institut für Experimentelle Onkologie und Therapieforschung, Munich, Germany
    Mol Cancer Res 6:341-51. 2008
    ..These findings explain the efficacy of gelatinase-specific synthetic inhibitors on invasion and growth of tumor cells and attribute distinct functions of MMP-2 and MMP-9 to aspects of liver metastasis...