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Genomes and GenesSpecies | George C EbersSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Environmental factors and multiple sclerosisGeorge C Ebers
University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
Lancet Neurol 7:268-77. 2008..Although these could be independent additive risk factors, it seems more likely that susceptibility is mediated by direct interactions between the environment and genes...
Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 geneDavid A Dyment
The Department of Medical Genetics, University of Ottawa, Ottawa, Canada
Neurology 79:406-11. 2012..To identify rare variants contributing to multiple sclerosis (MS) susceptibility in a family we have previously reported with up to 15 individuals affected across 4 generations...- Reducing the probability of false positive research findings by pre-publication validation - experience with a large multiple sclerosis databaseMartin Daumer
Sylvia Lawry Centre for MS Research, Hohenlindener Str, 1, 81677 Munich, Germany
BMC Med Res Methodol 8:18. 2008..We have assessed the utility to work with a pre-publication validation policy after several years of research in the context of a large multiple sclerosis database... 
The natural history of multiple sclerosis: a geographically based study: 8: familial multiple sclerosisG C Ebers
Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada
Brain 123:641-9. 2000..5%, much as projected. These results validate the recurrence risks which have previously been derived from age-corrected data for these first-degree relatives...- Long-term follow-up of the original interferon-beta1b trial in multiple sclerosis: design and lessons from a 16-year observational studyGeorge C Ebers
Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
Clin Ther 31:1724-36. 2009.... - Prognostic factors for multiple sclerosis: the importance of natural history studiesGeorge C Ebers
Department of Clinical Neurology, Radcliffe Infirmary University of Oxford, Woodstock Road, Oxford OX2 6HE, UK
J Neurol 252:iii15-iii20. 2005..There is reason to believe that magnetic resonance imaging (MRI) activity (when appropriately controlled for other unequally distributed factors, such as age) will be found to be very similar... - Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trialG C Ebers
University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
J Neurol Neurosurg Psychiatry 81:907-12. 2010..Evidence for efficacy of disease-modifying drugs in multiple sclerosis (MS) comes from trials of short duration. We report results from a 16 y, retrospective follow-up of the pivotal interferon beta-1b (IFNB-1b) study... - Disability as an outcome in MS clinical trialsG C Ebers
University of Oxford Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
Neurology 71:624-31. 2008..Since there have been no treatment claims for improving unremitting disability, worsening of disability in the placebo/control arm must occur for effectiveness on this outcome to be shown... - William Osler (1849-1919)G C Ebers
Clinical Neurology, University of Oxford Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6HE, UK
J Neurol 253:127-8. 2006 - Age and disability accumulation in multiple sclerosisA Scalfari
University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford, UK, OX3 9DU
Neurology 77:1246-52. 2011..We tested the hypothesis that age is a prognostic factor with respect to long-term accumulation of disability in multiple sclerosis (MS)... - Rare variants in the CYP27B1 gene are associated with multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Ann Neurol 70:881-6. 2011..Genetic linkage analysis and genotyping of candidate genes in families with 4 or more affected individuals more heavily loaded for susceptibility genes has not fully explained familial disease clustering... - HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibilityMichael J Chao
Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 105:13069-74. 2008.... - Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Hum Genet 54:547-9. 2009..4 years, paternal=30.3 years; P=0.009). HLA-DRB1*1501 exerts a modest, but significant effect on the AO of all forms of MS. Parent-of-origin effects at the MHC are further implicated in MS disease pathogenesis... - Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibilityMatthew R Lincoln
University Department of Clinical Neurology, Third Floor, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 106:7542-7. 2009..MHC disease associations may be more generally haplotypic or diplotypic... - Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Neuroimmunol 196:170-2. 2008..No significant transmission differences between mothers and fathers were found, suggesting that non-inherited resistance alleles do not appear to play a role in MS... - Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin DSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Genet 5:e1000369. 2009..These findings support a connection between the main epidemiological and genetic features of this disease with major practical implications for studies of disease mechanism and prevention... - No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5Adam E Handel
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
J Neuroimmunol 223:120-3. 2010..We found no significant effect of DNA methylation across HLA-DRB1*1501 and HLA-DRB5 on severity, although we cannot rule out time- or tissue-specific effects of DNA methylation... - Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
BMC Med Genet 9:63. 2008..In this study we sought to assess whether or not methylation of the MHC2TA promoter pIV could contribute to MS disease aetiology... - Parental transmission of HLA-DRB1*15 in multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Hum Genet 122:661-3. 2008..A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS... - A genome-wide scan in forty large pedigrees with multiple sclerosisCristen J Willer
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Hum Genet 52:955-62. 2007..30. The inability to find significant linkage in these highly penetrant families suggests that linkage is not the optimal tool for dissecting the inheritance of MS... - Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complexMichael J Chao
Department of Clinical Neurology, Level 3 West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 7BN, UK
Hum Mol Genet 18:261-6. 2009..The comparison of transmission of the same allele in vertically affected pedigrees (AUNN) to collinear sibling pairs (ASP) may provide a useful screen for putative epigenetic marks... - Analysis of 45 candidate genes for disease modifying activity in multiple sclerosisSreeram V Ramagopalan
Dept of Clinical Neurology, University of Oxford, Level 3, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK
J Neurol 255:1215-9. 2008.... - Parent-of-origin effects at the major histocompatibility complex in multiple sclerosisMichael J Chao
Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
Hum Mol Genet 19:3679-89. 2010.... - No effect of birth weight on the risk of multiple sclerosis. A population-based studySreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Neuroepidemiology 31:181-4. 2008..In a population-based Canadian cohort, we investigated whether there is any difference in birth weight for MS index cases compared to spousal controls... - The inheritance of resistance alleles in multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Genet 3:1607-13. 2007..Restriction of antigen presentation by HLA-DRB1*15 seems an improbably simple mechanism of major histocompatibility complex-associated susceptibility... - Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibriumMichael J Chao
Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
Hum Mol Genet 16:1951-8. 2007..The frequency of allelic associations not being replicated emphasizes the requirement for constructing multi-locus haplotypes in dissecting associations in regions of tight LD... - Vitamin D metabolic pathway genes and risk of multiple sclerosis in CanadiansSarah Michelle Orton
Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
J Neurol Sci 305:116-20. 2011..Previous studies have shown that serum 25-hydroxyvitamin D (25(OH)D) levels are genetically influenced. Polymorphisms in vitamin D pathway genes are candidates for association with MS susceptibility... - No effect of parental age on risk of multiple sclerosis: a population-based studySreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, Oxford, UK
Neuroepidemiology 34:106-9. 2010..In a population-based Canadian cohort, we investigated whether there is any difference in parental age at birth for MS index cases compared to spouse controls... - A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosisDavid Alexandre Dyment
The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
Am J Med Genet B Neuropsychiatr Genet 147:467-72. 2008..Additional genotyping to refine the haplotypes followed by screening for potential variants may lead to the identification of a novel MS susceptibility gene(s) in this unique population... - Childhood cow's milk allergy and the risk of multiple sclerosis: a population based studySreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Neurol Sci 291:86-8. 2010..Frequency of CMA was compared between index cases and controls. No significant differences were found. Childhood CMA thus does not appear to be a risk factor for MS... - Early life child exposure and the risk of multiple sclerosis: a population based studySreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Neurol Sci 307:162-3. 2011..Frequency of infant day care attendance was compared for index cases and controls and the results were not statistically significant. Exposure to other infants during early childhood thus does not appear to be a risk factor for MS... - No effect of preterm birth on the risk of multiple sclerosis: a population based studySreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
BMC Neurol 8:30. 2008..Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS... - An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 geneSreeram V Ramagopalan
1Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
BMC Med Genet 10:10. 2009..Given the role of this locus in antigen presentation it has been suggested that variations in the peptide binding site of the allele may underlie allelic variation in disease risk... - Mutations in the hemochromatosis gene and the clinical outcome of multiple sclerosisSreeram V Ramagopalan
Department of Clinical Neurology, University of Oxford, UK
J Neuroimmunol 203:104-7. 2008..The frequency of HFE mutations was not different in MS compared to the general population... - Association of infectious mononucleosis with multiple sclerosis. A population-based studySreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, Oxford, UK
Neuroepidemiology 32:257-62. 2009..Here in a population-based Canadian cohort, we investigate the relationship between prior clinical infection or vaccination and the risk of MS... - Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistanceDavid A Dyment
The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
Hum Mol Genet 14:2019-26. 2005..These studies demonstrate that it is the Class II genotype that determines susceptibility and resistance to MS. By analogy with celiac disease and type I diabetes, the pattern of susceptibility strongly supports an autoimmune aetiology... - Seasonality of admissions with multiple sclerosis in ScotlandAdam E Handel
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Eur J Neurol 18:1109-11. 2011..Vitamin D and infectious triggers are two major candidate environmental risk factors proposed to account for this effect. We aimed to assess MS admissions in Scotland for a possible effect of seasonality... - A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosisMatthew R Lincoln
Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford, Oxford OX2 6HE, UK
Nat Genet 37:1108-12. 2005..This study therefore indicates that MHC-associated susceptibility to multiple sclerosis is determined by HLA class II alleles, their interactions and closely neighboring variants... - Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian familiesSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, Oxford, UK
J Neuroimmunol 212:142-4. 2009..No significant association was found in the entire sample or when stratifying by transmitting parent, indicating that this gene plays little or no role in susceptibility to MS in the Canadian population... - Congenital abnormalities and multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
BMC Neurol 10:115. 2010..A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly... - A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolutionSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
Genome Res 20:1352-60. 2010..ChIP-seq determination of transcription factor binding, in combination with GWA data, provides a powerful approach to further understanding the molecular bases of complex diseases... - The genetics of clinical outcome in multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Neuroimmunol 201:183-99. 2008..Recent studies implicating the role of the genotype and epistatic interactions in the MHC in determining outcome are highlighted... - Sex ratio of multiple sclerosis in Canada: a longitudinal studySarah-Michelle Orton
Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
Lancet Neurol 5:932-6. 2006..Although the reasons why incidence of the disease is increasing are unknown, there are major implications for health-care provision because lifetime costs of multiple sclerosis exceed pound1 million per case in the UK... - Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosisGiammario Ragnedda
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS ONE 7:e46730. 2012.... - Vitamin D-gene interactions in multiple sclerosisAntonio J Berlanga-Taylor
Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK
J Neurol Sci 311:32-6. 2011..In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk... - Seasonal distribution of psychiatric births in EnglandGiulio Disanto
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS ONE 7:e34866. 2012..48E-05; BAD p = 0.019; RDD p = 0.015). This data has implications for future strategies of disease prevention... - Vitamin D receptor binding, chromatin states and association with multiple sclerosisGiulio Disanto
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Hum Mol Genet 21:3575-86. 2012..Further analyses in other immune cell types and functional studies are warranted to fully elucidate the role of vitamin D in the immune system... - Geography of hospital admissions for multiple sclerosis in England and comparison with the geography of hospital admissions for infectious mononucleosis: a descriptive studySreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Neurol Neurosurg Psychiatry 82:682-7. 2011.... - Multiple sclerosis, vitamin D, and HLA-DRB1*15Lahiru Handunnetthi
Wellcome Trust Centre for Human Genetics and the Department of Clinical Neurology, University of Oxford, Oxford, UK
Neurology 74:1905-10. 2010..Such interactions may hold the key for disease prevention... - Genes for multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, Oxford, UK
Lancet 371:283-5. 2008 - The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disabilityAntonio Scalfari
Imperial College, Division of Neuroscience, London, UK
Brain 133:1914-29. 2010..The prevention or delay of the progressive phase of the disease is implicated as a key therapeutic target in relapsing-remitting patients... - Clinical prognostic factors in multiple sclerosis: a natural history reviewAlexandra Degenhardt
Department of Clinical Neurology, University of Oxford, Oxford, UK
Nat Rev Neurol 5:672-82. 2009..Onset of progression, relapse rate and disability in the initial 5 years could be fruitful therapeutic targets; however, longer-term clinical trials will be required to justify these end points... - Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC)Amy M Burrell
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
Discov Med 11:187-96. 2011..Differences in epigenetic marks characterize monozygotic twin pairs and may explain discordance. There is promise of potential therapeutic strategies to be found in the epigenetic mechanisms at work in MS... - Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locusMiles D Thompson
Department of Laboratory Medicine and Pathobiology, London Health Sciences Centre, Toronto, Ontario, Canada
Neuroreport 23:45-8. 2012..Further work using a genome-wide association study approach in familial typical migraine, consisting of those affected by MO or MA, will serve to further distinguish how and why MA differs from MO... - Type 1 diabetes mellitus and multiple sclerosis: common etiological featuresAdam E Handel
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Nat Rev Endocrinol 5:655-64. 2009..Similarities and differences between these two diseases draw attention to shared disease pathways but insights into each disorder are providing mutual illumination of their pathogenesis... - Epigenetics: molecular mechanisms and implications for diseaseAdam E Handel
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Trends Mol Med 16:7-16. 2010..Here, we consider how growing knowledge of epigenetics is altering our understanding of biology and medicine, and its implications for future research... - Environmental factors and their timing in adult-onset multiple sclerosisAdam E Handel
University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
Nat Rev Neurol 6:156-66. 2010..Understanding the nature of environmental influences in MS is highly relevant to the development of public health measures that are aimed at preventing this debilitating disease... - Association between microchimerism and multiple sclerosis in Canadian twinsCristen J Willer
Department of Clinical Neurology, University of Oxford, Oxford, UK
J Neuroimmunol 179:145-51. 2006..059). The rate of microchimerism was significantly higher in affected twins than in unaffected co-twins (p=0.0059). These observations show an association in twins between the presence of microchimerism and having MS... - The epidemiology of multiple sclerosis in Scotland: inferences from hospital admissionsAdam E Handel
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS ONE 6:e14606. 2011..In this study we undertook a study of medical records across Scotland on an NHS health board level of resolution to examine the epidemiology of MS in this region... - The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcomeG C DeLuca
University Dept of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6LE, UK
J Neurol 254:1221-6. 2007.... - An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study GroupDavid A Dyment
The Wellcome Trust Center for Human Genetics, Oxford, UK
Hum Mol Genet 13:1005-15. 2004..This observation is most consistent with a model of genetic heterogeneity between HLA and other genetic loci. These findings offer guidance for future genetic studies including dense SNP linkage disequilibrium analysis... - The contribution of demyelination to axonal loss in multiple sclerosisG C DeLuca
Department of Clinical Neurology, University of Oxford, Oxford, UK
Brain 129:1507-16. 2006..Since there was little correlation between plaque load and axonal loss, the possibility that demyelination is not the primary determinant of spinal cord axonal loss warrants consideration... - Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tractsG C DeLuca
Department of Clinical Neurology, University of Oxford, Oxford, UK
Brain 127:1009-18. 2004..In multiple sclerosis, axonal loss is widespread, and its extent is tract specific and size selective... - The extent of axonal loss in the long tracts in hereditary spastic paraplegiaG C DeLuca
Departments of Clinical Neurology, University of Oxford, Oxford, UK
Neuropathol Appl Neurobiol 30:576-84. 2004..The characterization of the nature of axonal loss in HSP, where this is a primary phenomenon, may help the interpretation of axonal loss in conditions such as multiple sclerosis where the sequence of events is less clear... - Genetics of multiple sclerosisDavid A Dyment
The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
Lancet Neurol 3:104-10. 2004.... - Genetic epidemiology: the use of old and new tools for multiple sclerosisSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
Trends Neurosci 31:645-52. 2008..Family-based data in multiple sclerosis are applicable to other neurological traits... - Progress in deciphering the genetics of multiple sclerosisBlanca M Herrera
Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
Curr Opin Neurol 16:253-8. 2003..A variety of attempts to study more restricted populations are in progress, including rare individual pedigrees with high recurrence risk... - An array of sunshine in multiple sclerosisDavid A Dyment
University of Oxford, Oxford OX2 6HE, United Kingdom
N Engl J Med 347:1445-7. 2002 - Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosisMartin R Turner
Department of Clinical Neurology, West Wing Level 3, John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, UK
Brain 133:3470-9. 2010..These 'past masters' still have much to teach us... - Twin concordance and sibling recurrence rates in multiple sclerosisC J Willer
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Proc Natl Acad Sci U S A 100:12877-82. 2003..8%) for female DZ pairs. We did not demonstrate an MZ/DZ difference in males, although the sample size was small. We observed a 2-fold increase in risk to DZ twins over nontwin siblings of twins, but the difference was not significant... - Risk alleles for multiple sclerosis in multiplex familiesM J D'Netto
Wellcome Trust Centre for Human Genetics, Department of Clinical Neurology, University of Oxford, UK
Neurology 72:1984-8. 2009.... - The natural history of multiple sclerosis: a geographically based study 9: observations on the progressive phase of the diseaseM Kremenchutzky
Department of Clinical Neurological Sciences, University of Western Ontario London, Ontario, Canada
Brain 129:584-94. 2006..The possibility that this is the primary process in some cases must be considered... - Maternal - offspring HLA-DRB1 compatibility in multiple sclerosisC J Willer
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Tissue Antigens 66:44-7. 2005..These findings do not support a role for an excess maternal - fetal HLA-DRB1 compatibility in MS susceptibility... - Parental transmission of MS in a population-based Canadian cohortB M Herrera
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Neurology 69:1208-12. 2007..This hypothesis was tested in a population-based Canadian MS cohort... - An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locusG C DeLuca
Department of Clinical Neurology, and Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 104:20896-901. 2007..These results closely link susceptibility to long-term outcome in MS, suggesting that shared quantitative MHC-based mechanisms are common to both, emphasizing the central role of this region in pathogenesis... - Natural history of primary progressive multiple sclerosisGeorge C Ebers
Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford, Woodstock Road, Oxford OX2 6HE, UK
Mult Scler 10:S8-13; discussion S13-5. 2004..Natural history studies provide information on likely long-term outcomes and can be used in the design and interpretation of clinical trials in PPMS. The evidence that PPMS is distinct remains weak... - Hand preference and performance in 20 pairs of monozygotic twins with discordant handednessJennifer M Gurd
University Department of Clinical Neurology, University of Oxford, Oxford, UK
Cortex 42:934-45. 2006..However, no evidence was found to indicate that twins who wrote with their left hands showed poorer performance than their right-handed twin sisters... - Multiple sclerosis and the major histocompatibility complexSreeram V Ramagopalan
Wellcome Trust Centre for Human Genetics, UK
Curr Opin Neurol 22:219-25. 2009..We review here some of the recent findings of MS genetics with a particular focus on genes of the major histocompatibility complex (MHC)... - Genetic susceptibility to MS: a second stage analysis in Canadian MS familiesD A Dyment
The Wellcome Trust Center for Human Genetics, Oxford, UK
Neurogenetics 3:145-51. 2001.... - Microsatellites and genome scans-- a GAMES postscriptD A Dyment
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Neuroimmunol 190:5-7. 2007 - HLA-DRB1 and month of birth in multiple sclerosisS V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK
Neurology 73:2107-11. 2009..This effect was shown to be more pronounced in familial cases of MS. In the present study, we investigated whether this month-of-birth association has any relation to the principal MS susceptibility gene, HLA-DRB1... - Multiple sclerosis susceptibility and the X chromosomeB M Herrera
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, Department of Clinical Neurology, University of Oxford, Oxford, UK
Mult Scler 13:856-64. 2007..Complex interactions including epigenetic ones, and masking by balanced polymorphisms are mechanisms not excluded by the approach taken... - A multigenerational family with multiple sclerosisD A Dyment
Wellcome Trust Centre for Human Genetics, UK
Brain 125:1474-82. 2002..This family could be an important resource for the identification of a multiple sclerosis susceptibility gene... - No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative StudyD A Dyment
The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
J Neuroimmunol 123:193-8. 2002..CTLA-4 does not appear to be a major MS susceptibility locus in Canadian multiplex families... - A genome scan in a single pedigree with a high prevalence of multiple sclerosisD A Dyment
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Neurol Neurosurg Psychiatry 79:158-62. 2008..Here, we present a genetic study of a large and unique kindred in which MS appears to follow an autosomal-dominant pattern of inheritance, with consistent penetrance in four generations... - No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosisS V Ramagopalan
Department of Clinical Neurology, University of Oxford, UK
J Neuroimmunol 186:156-60. 2007..We conclude that APOE and PVRL2 have little or no effect on the clinical outcome of MS... - Parent-of-origin effects in MS: observations from avuncular pairsB M Herrera
Wellcome Trust Centre for Human Genetics, Department of Clinical Neurology, University of Oxford, UK
Neurology 71:799-803. 2008..The study of aunt/uncle-niece/nephew (AUNN) pairs has potential to shed light on the on complex trait inheritance as this group can be divided into eight different pair types by gender, MS status, and parent of origin... - Parent-of-origin effect in multiple sclerosis: observations in half-siblingsG C Ebers
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Lancet 363:1773-4. 2004..35% (34 affected siblings of 1859), and 1.31% for paternal half-siblings (15 of 1577), (p=0.048). The difference in risk suggests a maternal parent-of-origin effect in multiple sclerosis susceptibility... - Sex ratio of multiple sclerosis and clinical phenotypeS V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Eur J Neurol 17:634-7. 2010..Here, we aimed to determine whether this change in sex ratio is related to the clinical course of MS... - Parent-of-origin effect in multiple sclerosis: observations from interracial matingsS V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Headington
Neurology 73:602-5. 2009..In Canada, prevalence is high in Caucasians of Northern European ancestry and uncommon in North American Aboriginals, many of whom now have Caucasian admixture... - MHC transmission: insights into gender bias in MS susceptibilityM J Chao
Department of Clinical Neurology, University of Oxford, Level 3 West Wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
Neurology 76:242-6. 2011..Given the general consensus that incidence and prevalence of MS has been rising and specifically in women, we evaluated MHC-gender interactions... - Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosisCristen J Willer
Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, UK
J Neuroimmunol 126:126-33. 2002..Potential research questions regarding microchimerism, human leukocyte antigen (HLA) similarity, and autoimmune diseases in the context of multiple sclerosis (MS) are discussed... - Association of UV radiation with multiple sclerosis prevalence and sex ratio in FranceS M Orton
Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
Neurology 76:425-31. 2011..We carried out an ecological study to evaluate the association of MS prevalence and ultraviolet (UV) radiation, a candidate climatologic risk factor... - Multiple sclerosis in stepsiblings: recurrence risk and ascertainmentD A Dyment
The Wellcome Trust Center for Human Genetics, Oxford, UK
J Neurol Neurosurg Psychiatry 77:258-9. 2006..This adds to existing data showing that the action of environment in influencing MS risk is operative at a population level... - An autosomal dominant disorder with episodic ataxia, vertigo, and tinnitusJ L Steckley
Wellcome Trust Center for Human Genetics, Oxford, UK
Neurology 57:1499-502. 2001..The authors suggest EA3 for periodic vestibulocerebellar ataxia and EA4 for the disorder described here... - TCR beta polymorphisms and multiple sclerosisD A Dyment
Wellcome Trust Center for Human Genetics, Oxford, UK
Genes Immun 5:337-42. 2004..These results show no evidence for linkage and fail to establish an association between MS susceptibility and the TCR beta locus... - Effect of immigration on multiple sclerosis sex ratio in Canada: the Canadian Collaborative StudyS M Orton
Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
J Neurol Neurosurg Psychiatry 81:31-6. 2010..In many regions, including Canada, rising MS incidence in women has been implied by the marked increase in F:M ratio... - Follow-up investigation of 12 proposed linkage regions in multiple sclerosisB M Herrera
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Genes Immun 7:366-71. 2006..3 for all the previously suggested regions. These results again raise the possibility that the paradigm of multiple genes of small individual effect used to justify genome searches in MS is incorrect... - Age of puberty and the risk of multiple sclerosis: a population based studyS V Ramagopalan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Eur J Neurol 16:342-7. 2009..Given a potential role for sex hormones in MS, we have investigated whether or not the age of puberty influences the risk of developing MS in a population-based cohort... - Genetic loading in familial migraine with auraS E Noble-Topham
Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
J Neurol Neurosurg Psychiatry 74:1128-30. 2003.... - A genome-wide screen and linkage mapping for a large pedigree with episodic ataxiaM Z Cader
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Neurology 65:156-8. 2005..65. Haplotype analysis and fine mapping yielded a peak 2-point lod score of 4.14 and indicated a 4-cM region on 1q42 that is likely to harbor an episodic ataxia gene...