George C Ebers

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Environmental factors and multiple sclerosis
    George C Ebers
    University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Lancet Neurol 7:268-77. 2008
  2. pmc The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability
    Antonio Scalfari
    Imperial College, Division of Neuroscience, London, UK
    Brain 133:1914-29. 2010
  3. pmc Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000369. 2009
  4. ncbi request reprint Interactions of environment and genes in multiple sclerosis
    George Ebers
    Nuffield Dept of Clinical Neurosciences Clinical Neurology, University of Oxford, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom Electronic address
    J Neurol Sci 334:161-3. 2013
  5. pmc Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene
    David A Dyment
    The Department of Medical Genetics, University of Ottawa, Ottawa, Canada
    Neurology 79:406-11. 2012
  6. pmc Reducing the probability of false positive research findings by pre-publication validation - experience with a large multiple sclerosis database
    Martin Daumer
    Sylvia Lawry Centre for MS Research, Hohenlindener Str, 1, 81677 Munich, Germany
    BMC Med Res Methodol 8:18. 2008
  7. ncbi request reprint William Osler (1849-1919)
    G C Ebers
    Clinical Neurology, University of Oxford Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6HE, UK
    J Neurol 253:127-8. 2006
  8. doi request reprint Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial
    G C Ebers
    University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 81:907-12. 2010
  9. ncbi request reprint Long-term follow-up of the original interferon-beta1b trial in multiple sclerosis: design and lessons from a 16-year observational study
    George C Ebers
    Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
    Clin Ther 31:1724-36. 2009
  10. pmc Age and disability accumulation in multiple sclerosis
    A Scalfari
    University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford, UK, OX3 9DU
    Neurology 77:1246-52. 2011

Detail Information

Publications117 found, 100 shown here

  1. doi request reprint Environmental factors and multiple sclerosis
    George C Ebers
    University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Lancet Neurol 7:268-77. 2008
    ..Although these could be independent additive risk factors, it seems more likely that susceptibility is mediated by direct interactions between the environment and genes...
  2. pmc The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability
    Antonio Scalfari
    Imperial College, Division of Neuroscience, London, UK
    Brain 133:1914-29. 2010
    ..The prevention or delay of the progressive phase of the disease is implicated as a key therapeutic target in relapsing-remitting patients...
  3. pmc Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000369. 2009
    ..These findings support a connection between the main epidemiological and genetic features of this disease with major practical implications for studies of disease mechanism and prevention...
  4. ncbi request reprint Interactions of environment and genes in multiple sclerosis
    George Ebers
    Nuffield Dept of Clinical Neurosciences Clinical Neurology, University of Oxford, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom Electronic address
    J Neurol Sci 334:161-3. 2013
    ..MS susceptibility is comprised of both genetic and environmental factors and it has become increasingly clear that these interact. The major histocompatiblity complex is the major site of the interactions which determine MS risk. ..
  5. pmc Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene
    David A Dyment
    The Department of Medical Genetics, University of Ottawa, Ottawa, Canada
    Neurology 79:406-11. 2012
    ..To identify rare variants contributing to multiple sclerosis (MS) susceptibility in a family we have previously reported with up to 15 individuals affected across 4 generations...
  6. pmc Reducing the probability of false positive research findings by pre-publication validation - experience with a large multiple sclerosis database
    Martin Daumer
    Sylvia Lawry Centre for MS Research, Hohenlindener Str, 1, 81677 Munich, Germany
    BMC Med Res Methodol 8:18. 2008
    ..We have assessed the utility to work with a pre-publication validation policy after several years of research in the context of a large multiple sclerosis database...
  7. ncbi request reprint William Osler (1849-1919)
    G C Ebers
    Clinical Neurology, University of Oxford Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6HE, UK
    J Neurol 253:127-8. 2006
  8. doi request reprint Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial
    G C Ebers
    University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 81:907-12. 2010
    ..Evidence for efficacy of disease-modifying drugs in multiple sclerosis (MS) comes from trials of short duration. We report results from a 16 y, retrospective follow-up of the pivotal interferon beta-1b (IFNB-1b) study...
  9. ncbi request reprint Long-term follow-up of the original interferon-beta1b trial in multiple sclerosis: design and lessons from a 16-year observational study
    George C Ebers
    Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
    Clin Ther 31:1724-36. 2009
    ....
  10. pmc Age and disability accumulation in multiple sclerosis
    A Scalfari
    University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford, UK, OX3 9DU
    Neurology 77:1246-52. 2011
    ..We tested the hypothesis that age is a prognostic factor with respect to long-term accumulation of disability in multiple sclerosis (MS)...
  11. ncbi request reprint The natural history of multiple sclerosis: a geographically based study: 8: familial multiple sclerosis
    G C Ebers
    Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada
    Brain 123:641-9. 2000
    ..5%, much as projected. These results validate the recurrence risks which have previously been derived from age-corrected data for these first-degree relatives...
  12. ncbi request reprint Prognostic factors for multiple sclerosis: the importance of natural history studies
    George C Ebers
    Department of Clinical Neurology, Radcliffe Infirmary University of Oxford, Woodstock Road, Oxford OX2 6HE, UK
    J Neurol 252:iii15-iii20. 2005
    ..There is reason to believe that magnetic resonance imaging (MRI) activity (when appropriately controlled for other unequally distributed factors, such as age) will be found to be very similar...
  13. ncbi request reprint Disability as an outcome in MS clinical trials
    G C Ebers
    University of Oxford Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Neurology 71:624-31. 2008
    ..Since there have been no treatment claims for improving unremitting disability, worsening of disability in the placebo/control arm must occur for effectiveness on this outcome to be shown...
  14. doi request reprint Rare variants in the CYP27B1 gene are associated with multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Ann Neurol 70:881-6. 2011
    ..Genetic linkage analysis and genotyping of candidate genes in families with 4 or more affected individuals more heavily loaded for susceptibility genes has not fully explained familial disease clustering...
  15. pmc HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility
    Michael J Chao
    Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 105:13069-74. 2008
    ....
  16. pmc Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
    Matthew R Lincoln
    University Department of Clinical Neurology, Third Floor, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7542-7. 2009
    ..MHC disease associations may be more generally haplotypic or diplotypic...
  17. doi request reprint Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neuroimmunol 196:170-2. 2008
    ..No significant transmission differences between mothers and fathers were found, suggesting that non-inherited resistance alleles do not appear to play a role in MS...
  18. doi request reprint Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 54:547-9. 2009
    ..4 years, paternal=30.3 years; P=0.009). HLA-DRB1*1501 exerts a modest, but significant effect on the AO of all forms of MS. Parent-of-origin effects at the MHC are further implicated in MS disease pathogenesis...
  19. doi request reprint Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis
    Sreeram V Ramagopalan
    Dept of Clinical Neurology, University of Oxford, Level 3, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    J Neurol 255:1215-9. 2008
    ....
  20. doi request reprint Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex
    Michael J Chao
    Department of Clinical Neurology, Level 3 West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 7BN, UK
    Hum Mol Genet 18:261-6. 2009
    ..The comparison of transmission of the same allele in vertically affected pedigrees (AUNN) to collinear sibling pairs (ASP) may provide a useful screen for putative epigenetic marks...
  21. ncbi request reprint No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Neuroimmunol 223:120-3. 2010
    ..We found no significant effect of DNA methylation across HLA-DRB1*1501 and HLA-DRB5 on severity, although we cannot rule out time- or tissue-specific effects of DNA methylation...
  22. pmc Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Med Genet 9:63. 2008
    ..In this study we sought to assess whether or not methylation of the MHC2TA promoter pIV could contribute to MS disease aetiology...
  23. ncbi request reprint A genome-wide scan in forty large pedigrees with multiple sclerosis
    Cristen J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 52:955-62. 2007
    ..30. The inability to find significant linkage in these highly penetrant families suggests that linkage is not the optimal tool for dissecting the inheritance of MS...
  24. ncbi request reprint Parental transmission of HLA-DRB1*15 in multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Genet 122:661-3. 2008
    ..A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS...
  25. ncbi request reprint Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium
    Michael J Chao
    Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 16:1951-8. 2007
    ..The frequency of allelic associations not being replicated emphasizes the requirement for constructing multi-locus haplotypes in dissecting associations in regions of tight LD...
  26. pmc The inheritance of resistance alleles in multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 3:1607-13. 2007
    ..Restriction of antigen presentation by HLA-DRB1*15 seems an improbably simple mechanism of major histocompatibility complex-associated susceptibility...
  27. doi request reprint Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis
    Michael J Chao
    Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Hum Mol Genet 19:3679-89. 2010
    ....
  28. doi request reprint No effect of birth weight on the risk of multiple sclerosis. A population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Neuroepidemiology 31:181-4. 2008
    ..In a population-based Canadian cohort, we investigated whether there is any difference in birth weight for MS index cases compared to spousal controls...
  29. ncbi request reprint Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance
    David A Dyment
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Mol Genet 14:2019-26. 2005
    ..These studies demonstrate that it is the Class II genotype that determines susceptibility and resistance to MS. By analogy with celiac disease and type I diabetes, the pattern of susceptibility strongly supports an autoimmune aetiology...
  30. doi request reprint Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
    J Neurol Sci 305:116-20. 2011
    ..Previous studies have shown that serum 25-hydroxyvitamin D (25(OH)D) levels are genetically influenced. Polymorphisms in vitamin D pathway genes are candidates for association with MS susceptibility...
  31. doi request reprint No effect of parental age on risk of multiple sclerosis: a population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Neuroepidemiology 34:106-9. 2010
    ..In a population-based Canadian cohort, we investigated whether there is any difference in parental age at birth for MS index cases compared to spouse controls...
  32. ncbi request reprint A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis
    David Alexandre Dyment
    The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
    Am J Med Genet B Neuropsychiatr Genet 147:467-72. 2008
    ..Additional genotyping to refine the haplotypes followed by screening for potential variants may lead to the identification of a novel MS susceptibility gene(s) in this unique population...
  33. doi request reprint Childhood cow's milk allergy and the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Sci 291:86-8. 2010
    ..Frequency of CMA was compared between index cases and controls. No significant differences were found. Childhood CMA thus does not appear to be a risk factor for MS...
  34. doi request reprint Seasonality of admissions with multiple sclerosis in Scotland
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Neurol 18:1109-11. 2011
    ..Vitamin D and infectious triggers are two major candidate environmental risk factors proposed to account for this effect. We aimed to assess MS admissions in Scotland for a possible effect of seasonality...
  35. doi request reprint Multiple sclerosis and the major histocompatibility complex
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, UK
    Curr Opin Neurol 22:219-25. 2009
    ..We review here some of the recent findings of MS genetics with a particular focus on genes of the major histocompatibility complex (MHC)...
  36. pmc Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease
    Adam E Handel
    Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    BMC Med 11:163. 2013
    ..We aimed to investigate VDR binding in primary CD4+ cells from healthy volunteers...
  37. ncbi request reprint A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis
    Matthew R Lincoln
    Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford, Oxford OX2 6HE, UK
    Nat Genet 37:1108-12. 2005
    ..This study therefore indicates that MHC-associated susceptibility to multiple sclerosis is determined by HLA class II alleles, their interactions and closely neighboring variants...
  38. ncbi request reprint Sex ratio of multiple sclerosis in Canada: a longitudinal study
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet Neurol 5:932-6. 2006
    ..We reasoned that if a sex-specific change in incidence was occurring, the female to male sex ratio would serve as a surrogate of incidence change...
  39. doi request reprint Early life child exposure and the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Sci 307:162-3. 2011
    ..Frequency of infant day care attendance was compared for index cases and controls and the results were not statistically significant. Exposure to other infants during early childhood thus does not appear to be a risk factor for MS...
  40. pmc No effect of preterm birth on the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Neurol 8:30. 2008
    ..Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS...
  41. pmc An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene
    Sreeram V Ramagopalan
    1Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:10. 2009
    ..Given the role of this locus in antigen presentation it has been suggested that variations in the peptide binding site of the allele may underlie allelic variation in disease risk...
  42. doi request reprint Mutations in the hemochromatosis gene and the clinical outcome of multiple sclerosis
    Sreeram V Ramagopalan
    Department of Clinical Neurology, University of Oxford, UK
    J Neuroimmunol 203:104-7. 2008
    ..The frequency of HFE mutations was not different in MS compared to the general population...
  43. doi request reprint Association of infectious mononucleosis with multiple sclerosis. A population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Neuroepidemiology 32:257-62. 2009
    ..Here in a population-based Canadian cohort, we investigate the relationship between prior clinical infection or vaccination and the risk of MS...
  44. doi request reprint Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    J Neuroimmunol 212:142-4. 2009
    ..No significant association was found in the entire sample or when stratifying by transmitting parent, indicating that this gene plays little or no role in susceptibility to MS in the Canadian population...
  45. pmc Congenital abnormalities and multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    BMC Neurol 10:115. 2010
    ..A possible marker for this intrauterine insult is the presence of a non-fatal congenital anomaly...
  46. doi request reprint The genetics of clinical outcome in multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neuroimmunol 201:183-99. 2008
    ..Recent studies implicating the role of the genotype and epistatic interactions in the MHC in determining outcome are highlighted...
  47. pmc A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
    Genome Res 20:1352-60. 2010
    ..ChIP-seq determination of transcription factor binding, in combination with GWA data, provides a powerful approach to further understanding the molecular bases of complex diseases...
  48. pmc Geography of hospital admissions for multiple sclerosis in England and comparison with the geography of hospital admissions for infectious mononucleosis: a descriptive study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 82:682-7. 2011
    ....
  49. doi request reprint Clinical prognostic factors in multiple sclerosis: a natural history review
    Alexandra Degenhardt
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Nat Rev Neurol 5:672-82. 2009
    ..Onset of progression, relapse rate and disability in the initial 5 years could be fruitful therapeutic targets; however, longer-term clinical trials will be required to justify these end points...
  50. doi request reprint Association of smoking with risk of multiple sclerosis: a population-based study
    Sreeram V Ramagopalan
    Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Neurol 260:1778-81. 2013
    ..No association was seen with maternal active or passive smoking exposure during pregnancy. Ever-smoking is associated with increased MS risk in males. Further work is needed to understand the mechanism underlying this association...
  51. pmc Vitamin D receptor binding, chromatin states and association with multiple sclerosis
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Mol Genet 21:3575-86. 2012
    ..Further analyses in other immune cell types and functional studies are warranted to fully elucidate the role of vitamin D in the immune system...
  52. pmc Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis
    Giammario Ragnedda
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e46730. 2012
    ....
  53. doi request reprint Vitamin D-gene interactions in multiple sclerosis
    Antonio J Berlanga-Taylor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK
    J Neurol Sci 311:32-6. 2011
    ..In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk...
  54. pmc Seasonal distribution of psychiatric births in England
    Giulio Disanto
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e34866. 2012
    ..48E-05; BAD p = 0.019; RDD p = 0.015). This data has implications for future strategies of disease prevention...
  55. ncbi request reprint Progress in deciphering the genetics of multiple sclerosis
    Blanca M Herrera
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Curr Opin Neurol 16:253-8. 2003
    ..Some of the studies from the extensive literature in the field of multiple sclerosis genetics published in the past year are discussed here...
  56. ncbi request reprint An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group
    David A Dyment
    The Wellcome Trust Center for Human Genetics, Oxford, UK
    Hum Mol Genet 13:1005-15. 2004
    ..This observation is most consistent with a model of genetic heterogeneity between HLA and other genetic loci. These findings offer guidance for future genetic studies including dense SNP linkage disequilibrium analysis...
  57. doi request reprint Genes for multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Lancet 371:283-5. 2008
  58. pmc Multiple sclerosis, vitamin D, and HLA-DRB1*15
    Lahiru Handunnetthi
    Wellcome Trust Centre for Human Genetics and the Department of Clinical Neurology, University of Oxford, Oxford, UK
    Neurology 74:1905-10. 2010
    ..Such interactions may hold the key for disease prevention...
  59. ncbi request reprint Genetics of multiple sclerosis
    David A Dyment
    The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
    Lancet Neurol 3:104-10. 2004
    ....
  60. ncbi request reprint Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC)
    Amy M Burrell
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom
    Discov Med 11:187-96. 2011
    ..Differences in epigenetic marks characterize monozygotic twin pairs and may explain discordance. There is promise of potential therapeutic strategies to be found in the epigenetic mechanisms at work in MS...
  61. doi request reprint Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, London Health Sciences Centre, Toronto, Ontario, Canada
    Neuroreport 23:45-8. 2012
    ..Further work using a genome-wide association study approach in familial typical migraine, consisting of those affected by MO or MA, will serve to further distinguish how and why MA differs from MO...
  62. doi request reprint Epigenetics: molecular mechanisms and implications for disease
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Trends Mol Med 16:7-16. 2010
    ..Here, we consider how growing knowledge of epigenetics is altering our understanding of biology and medicine, and its implications for future research...
  63. ncbi request reprint Association between microchimerism and multiple sclerosis in Canadian twins
    Cristen J Willer
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    J Neuroimmunol 179:145-51. 2006
    ..059). The rate of microchimerism was significantly higher in affected twins than in unaffected co-twins (p=0.0059). These observations show an association in twins between the presence of microchimerism and having MS...
  64. pmc The epidemiology of multiple sclerosis in Scotland: inferences from hospital admissions
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e14606. 2011
    ..In this study we undertook a study of medical records across Scotland on an NHS health board level of resolution to examine the epidemiology of MS in this region...
  65. doi request reprint Environmental factors and their timing in adult-onset multiple sclerosis
    Adam E Handel
    University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Neurol 6:156-66. 2010
    ..Understanding the nature of environmental influences in MS is highly relevant to the development of public health measures that are aimed at preventing this debilitating disease...
  66. doi request reprint Type 1 diabetes mellitus and multiple sclerosis: common etiological features
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Rev Endocrinol 5:655-64. 2009
    ..Similarities and differences between these two diseases draw attention to shared disease pathways but insights into each disorder are providing mutual illumination of their pathogenesis...
  67. ncbi request reprint The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome
    G C DeLuca
    University Dept of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Woodstock Rd, Oxford, OX2 6LE, UK
    J Neurol 254:1221-6. 2007
    ....
  68. pmc Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences
    Witold Czyz
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    BMC Med 10:93. 2012
    ..Here, we explore the subject of epigenetics as another component in human phenotypic variability and its links to disease focusing particularly on evidence from MZ twin studies...
  69. ncbi request reprint The contribution of demyelination to axonal loss in multiple sclerosis
    G C DeLuca
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Brain 129:1507-16. 2006
    ..Since there was little correlation between plaque load and axonal loss, the possibility that demyelination is not the primary determinant of spinal cord axonal loss warrants consideration...
  70. ncbi request reprint The extent of axonal loss in the long tracts in hereditary spastic paraplegia
    G C DeLuca
    Departments of Clinical Neurology, University of Oxford, Oxford, UK
    Neuropathol Appl Neurobiol 30:576-84. 2004
    ..The characterization of the nature of axonal loss in HSP, where this is a primary phenomenon, may help the interpretation of axonal loss in conditions such as multiple sclerosis where the sequence of events is less clear...
  71. ncbi request reprint Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts
    G C DeLuca
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Brain 127:1009-18. 2004
    ..In multiple sclerosis, axonal loss is widespread, and its extent is tract specific and size selective...
  72. doi request reprint Genetic epidemiology: the use of old and new tools for multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    Trends Neurosci 31:645-52. 2008
    ..Family-based data in multiple sclerosis are applicable to other neurological traits...
  73. ncbi request reprint An array of sunshine in multiple sclerosis
    David A Dyment
    University of Oxford, Oxford OX2 6HE, United Kingdom
    N Engl J Med 347:1445-7. 2002
  74. pmc Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosis
    Martin R Turner
    Department of Clinical Neurology, West Wing Level 3, John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, UK
    Brain 133:3470-9. 2010
    ..These 'past masters' still have much to teach us...
  75. pmc Twin concordance and sibling recurrence rates in multiple sclerosis
    C J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 100:12877-82. 2003
    ..8%) for female DZ pairs. We did not demonstrate an MZ/DZ difference in males, although the sample size was small. We observed a 2-fold increase in risk to DZ twins over nontwin siblings of twins, but the difference was not significant...
  76. ncbi request reprint The natural history of multiple sclerosis: a geographically based study 9: observations on the progressive phase of the disease
    M Kremenchutzky
    Department of Clinical Neurological Sciences, University of Western Ontario London, Ontario, Canada
    Brain 129:584-94. 2006
    ..The possibility that this is the primary process in some cases must be considered...
  77. doi request reprint Risk alleles for multiple sclerosis in multiplex families
    M J D'Netto
    Wellcome Trust Centre for Human Genetics, Department of Clinical Neurology, University of Oxford, UK
    Neurology 72:1984-8. 2009
    ....
  78. ncbi request reprint Maternal - offspring HLA-DRB1 compatibility in multiple sclerosis
    C J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Tissue Antigens 66:44-7. 2005
    ..These findings do not support a role for an excess maternal - fetal HLA-DRB1 compatibility in MS susceptibility...
  79. pmc An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus
    G C DeLuca
    Department of Clinical Neurology, and Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 104:20896-901. 2007
    ..These results closely link susceptibility to long-term outcome in MS, suggesting that shared quantitative MHC-based mechanisms are common to both, emphasizing the central role of this region in pathogenesis...
  80. ncbi request reprint Parental transmission of MS in a population-based Canadian cohort
    B M Herrera
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Neurology 69:1208-12. 2007
    ..This hypothesis was tested in a population-based Canadian MS cohort...
  81. ncbi request reprint Natural history of primary progressive multiple sclerosis
    George C Ebers
    Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford, Woodstock Road, Oxford OX2 6HE, UK
    Mult Scler 10:S8-13; discussion S13-5. 2004
    ..Natural history studies provide information on likely long-term outcomes and can be used in the design and interpretation of clinical trials in PPMS. The evidence that PPMS is distinct remains weak...
  82. ncbi request reprint Hand preference and performance in 20 pairs of monozygotic twins with discordant handedness
    Jennifer M Gurd
    University Department of Clinical Neurology, University of Oxford, Oxford, UK
    Cortex 42:934-45. 2006
    ..However, no evidence was found to indicate that twins who wrote with their left hands showed poorer performance than their right-handed twin sisters...
  83. doi request reprint Parent-of-origin effects in MS: observations from avuncular pairs
    B M Herrera
    Wellcome Trust Centre for Human Genetics, Department of Clinical Neurology, University of Oxford, UK
    Neurology 71:799-803. 2008
    ..The study of aunt/uncle-niece/nephew (AUNN) pairs has potential to shed light on the on complex trait inheritance as this group can be divided into eight different pair types by gender, MS status, and parent of origin...
  84. ncbi request reprint Parent-of-origin effect in multiple sclerosis: observations in half-siblings
    G C Ebers
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Lancet 363:1773-4. 2004
    ..35% (34 affected siblings of 1859), and 1.31% for paternal half-siblings (15 of 1577), (p=0.048). The difference in risk suggests a maternal parent-of-origin effect in multiple sclerosis susceptibility...
  85. ncbi request reprint Microsatellites and genome scans-- a GAMES postscript
    D A Dyment
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neuroimmunol 190:5-7. 2007
  86. ncbi request reprint No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis
    S V Ramagopalan
    Department of Clinical Neurology, University of Oxford, UK
    J Neuroimmunol 186:156-60. 2007
    ..We conclude that APOE and PVRL2 have little or no effect on the clinical outcome of MS...
  87. ncbi request reprint A genome scan in a single pedigree with a high prevalence of multiple sclerosis
    D A Dyment
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 79:158-62. 2008
    ..Here, we present a genetic study of a large and unique kindred in which MS appears to follow an autosomal-dominant pattern of inheritance, with consistent penetrance in four generations...
  88. ncbi request reprint Multiple sclerosis susceptibility and the X chromosome
    B M Herrera
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Mult Scler 13:856-64. 2007
    ..Complex interactions including epigenetic ones, and masking by balanced polymorphisms are mechanisms not excluded by the approach taken...
  89. ncbi request reprint A multigenerational family with multiple sclerosis
    D A Dyment
    Wellcome Trust Centre for Human Genetics, UK
    Brain 125:1474-82. 2002
    ..This family could be an important resource for the identification of a multiple sclerosis susceptibility gene...
  90. pmc Parent-of-origin effect in multiple sclerosis: observations from interracial matings
    S V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington
    Neurology 73:602-5. 2009
    ..In Canada, prevalence is high in Caucasians of Northern European ancestry and uncommon in North American Aboriginals, many of whom now have Caucasian admixture...
  91. ncbi request reprint No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative Study
    D A Dyment
    The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
    J Neuroimmunol 123:193-8. 2002
    ..CTLA-4 does not appear to be a major MS susceptibility locus in Canadian multiplex families...
  92. ncbi request reprint Genetic susceptibility to MS: a second stage analysis in Canadian MS families
    D A Dyment
    The Wellcome Trust Center for Human Genetics, Oxford, UK
    Neurogenetics 3:145-51. 2001
    ....
  93. doi request reprint HLA-DRB1 and month of birth in multiple sclerosis
    S V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK
    Neurology 73:2107-11. 2009
    ..This effect was shown to be more pronounced in familial cases of MS. In the present study, we investigated whether this month-of-birth association has any relation to the principal MS susceptibility gene, HLA-DRB1...
  94. doi request reprint Sex ratio of multiple sclerosis and clinical phenotype
    S V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Neurol 17:634-7. 2010
    ..Here, we aimed to determine whether this change in sex ratio is related to the clinical course of MS...
  95. ncbi request reprint Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosis
    Cristen J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, UK
    J Neuroimmunol 126:126-33. 2002
    ..Potential research questions regarding microchimerism, human leukocyte antigen (HLA) similarity, and autoimmune diseases in the context of multiple sclerosis (MS) are discussed...
  96. pmc MHC transmission: insights into gender bias in MS susceptibility
    M J Chao
    Department of Clinical Neurology, University of Oxford, Level 3 West Wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
    Neurology 76:242-6. 2011
    ..Given the general consensus that incidence and prevalence of MS has been rising and specifically in women, we evaluated MHC-gender interactions...
  97. pmc Association of UV radiation with multiple sclerosis prevalence and sex ratio in France
    S M Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
    Neurology 76:425-31. 2011
    ..We carried out an ecological study to evaluate the association of MS prevalence and ultraviolet (UV) radiation, a candidate climatologic risk factor...
  98. ncbi request reprint TCR beta polymorphisms and multiple sclerosis
    D A Dyment
    Wellcome Trust Center for Human Genetics, Oxford, UK
    Genes Immun 5:337-42. 2004
    ..These results show no evidence for linkage and fail to establish an association between MS susceptibility and the TCR beta locus...
  99. ncbi request reprint An autosomal dominant disorder with episodic ataxia, vertigo, and tinnitus
    J L Steckley
    Wellcome Trust Center for Human Genetics, Oxford, UK
    Neurology 57:1499-502. 2001
    ..The authors suggest EA3 for periodic vestibulocerebellar ataxia and EA4 for the disorder described here...
  100. doi request reprint Effect of immigration on multiple sclerosis sex ratio in Canada: the Canadian Collaborative Study
    S M Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 81:31-6. 2010
    ..In many regions, including Canada, rising MS incidence in women has been implied by the marked increase in F:M ratio...
  101. ncbi request reprint Follow-up investigation of 12 proposed linkage regions in multiple sclerosis
    B M Herrera
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genes Immun 7:366-71. 2006
    ..3 for all the previously suggested regions. These results again raise the possibility that the paradigm of multiple genes of small individual effect used to justify genome searches in MS is incorrect...