Sharon L Eastwood

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development
    Sharon L Eastwood
    University of Oxford, Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 22:3017-24. 2005
  2. ncbi Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons
    S L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Neurosciences Building, Oxford OX3 7JX, UK
    Schizophr Res 73:159-72. 2005
  3. ncbi Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, United Kingdom
    Biol Psychiatry 57:702-10. 2005
  4. ncbi Interstitial white matter neuron density in the dorsolateral prefrontal cortex and parahippocampal gyrus in schizophrenia
    S L Eastwood
    University of Oxford, Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Schizophr Res 79:181-8. 2005
  5. pmc Does the CAPON gene confer susceptibility to schizophrenia?
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS Med 2:e348. 2005
  6. ncbi Cellular basis of reduced cortical reelin expression in schizophrenia
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
    Am J Psychiatry 163:540-2. 2006
  7. ncbi Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice
    Sharon L Eastwood
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 21:635-44. 2007
  8. ncbi Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Synapse 36:167-77. 2000
  9. pmc Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder
    Sharon L Eastwood
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:933-45. 2008
  10. pmc The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Hum Mol Genet 19:2487-96. 2010

Detail Information

Publications31

  1. ncbi Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development
    Sharon L Eastwood
    University of Oxford, Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 22:3017-24. 2005
    ..The data also suggest a potential importance of calcineurin Agamma in neurodevelopment, and in the genetically influenced neurodevelopmental disturbance that is thought to underlie schizophrenia...
  2. ncbi Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons
    S L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Neurosciences Building, Oxford OX3 7JX, UK
    Schizophr Res 73:159-72. 2005
    ..The impairment of synaptic transmission implied by the synaptic protein reductions may contribute to the dysfunction of cortical neural circuits that characterises the disorder...
  3. ncbi Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, United Kingdom
    Biol Psychiatry 57:702-10. 2005
    ..However, the distribution of CaN A gamma is not established, nor whether its expression changes in schizophrenia...
  4. ncbi Interstitial white matter neuron density in the dorsolateral prefrontal cortex and parahippocampal gyrus in schizophrenia
    S L Eastwood
    University of Oxford, Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Schizophr Res 79:181-8. 2005
    ..As interstitial white matter neurons are presumed to be remnants of the embryonic cortical subplate, these findings provide additional evidence supportive of an early developmental abnormality in schizophrenia...
  5. pmc Does the CAPON gene confer susceptibility to schizophrenia?
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS Med 2:e348. 2005
  6. ncbi Cellular basis of reduced cortical reelin expression in schizophrenia
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK
    Am J Psychiatry 163:540-2. 2006
    ..The authors' goals were to establish the cellular origin of the reduced cortical reelin expression that occurs in schizophrenia and to relate it to markers of synaptic pathology...
  7. ncbi Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice
    Sharon L Eastwood
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 21:635-44. 2007
    ..Together the data provide supporting evidence for a role for microtubules in synaptic function, and suggest that STOP, or other microtubule proteins, may contribute to the synaptic pathology of schizophrenia...
  8. ncbi Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Synapse 36:167-77. 2000
    ..In summary, the data have implications both for understanding the effects of antipsychotic medication on synaptic organization, and for synaptic protein expression studies in patients treated with the drugs...
  9. pmc Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder
    Sharon L Eastwood
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:933-45. 2008
    ....
  10. pmc The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Hum Mol Genet 19:2487-96. 2010
    ..Whether this influence of DISC1 genotype extends to other centrosomal proteins and DISC1 binding partners remains to be determined...
  11. pmc Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder
    Sharon L Eastwood
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 67:1010-6. 2010
    ..We also measured netrin-G1 and netrin-G2 messenger RNAs because these genes are involved in the formation and plasticity of glutamatergic connections...
  12. pmc Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype
    Greg C Bristow
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res 1301:197-206. 2009
    ....
  13. ncbi Cerebellar synaptic protein expression in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroscience 105:219-29. 2001
    ..We conclude that there is synaptic pathology in the cerebellum in schizophrenia. By disrupting neural circuits, the alterations may contribute to the cerebellar dysfunction thought to occur in the disorder...
  14. pmc Reduced myelin basic protein and actin-related gene expression in visual cortex in schizophrenia
    Paul R Matthews
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e38211. 2012
    ..The findings confirm that the primary visual cortex shows molecular alterations in schizophrenia and extend the evidence for a widespread, rather than focal, cortical pathophysiology...
  15. ncbi Anomalies of asymmetry of pyramidal cell density and structure in dorsolateral prefrontal cortex in schizophrenia
    Thomas J Cullen
    Prince of Wales International Centre for SANE Research, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 188:26-31. 2006
    ..Studies suggest that neuronal density in left dorsolateral prefrontal cortex is increased in schizophrenia...
  16. ncbi Synaptophysin protein and mRNA expression in the human hippocampal formation from birth to old age
    Sharon L Eastwood
    Department of Psychiatry of the University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, United Kingdom
    Hippocampus 16:645-54. 2006
    ....
  17. ncbi Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res Bull 55:569-78. 2001
    ..The reductions may be progressive...
  18. ncbi The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology
    S L Eastwood
    Departments of Psychiatry and Clinical Neurology, Warneford Hospital, University of Oxford, Oxford OX3 7JX, UK
    Mol Psychiatry 8:148-55. 2003
    ....
  19. doi Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies
    Elizabeth M Tunbridge
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 69:173-9. 2011
    ..We end by making several recommendations toward a more flexible, transparent, and comprehensive approach to data presentation and analysis. We illustrate the review with examples from studies of schizophrenia and mood disorder...
  20. ncbi Gene expression and neuronal activity in schizophrenia: a study of polyadenylated mRNA in the hippocampal formation and cerebral cortex
    P J Harrison
    Department of Psychiatry, Warneford Hospital, University of Oxford, UK
    Schizophr Res 26:93-102. 1997
    ..It also provides a further indication that the differential expression of individual transcripts reported in the disease is not merely reflecting changes in overall gene expression...
  21. ncbi Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia
    P J Harrison
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Lancet 352:1669-73. 1998
    ..These findings suggest that the complexins might be useful in the investigation of the synaptic pathology of schizophrenia...
  22. ncbi Hippocampal and cortical growth-associated protein-43 messenger RNA in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroscience 86:437-48. 1998
    ..The data support the emerging view that the disease pathophysiology is one which affects the hippocampal and cortical circuitry and that the abnormalities are reflected in the altered expression of specific neuronal genes...
  23. ncbi Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis
    S L Eastwood
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Mol Psychiatry 8:769, 821-31. 2003
    ..The alterations may contribute to the aberrant synaptic connectivity seen in schizophrenia. However, the functional implications of the abnormalities, as well as the mechanisms involved, remain to be fully elucidated...
  24. pmc Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (β2M) and TATA-binding protein (TBP)
    P J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropathol Appl Neurobiol 36:498-504. 2010
    ..Many variables affect mRNA measurements in post mortem human brain tissue. Brain weight has not hitherto been considered to be such a factor. This study examined whether there is any relationship between brain weight and mRNA abundance...
  25. ncbi Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia
    P J Harrison
    Department of Psychiatry, University of Oxford, UK
    Hippocampus 11:508-19. 2001
    ..The data, their interpretation, and their limitations are discussed, with particular emphasis upon molecular and immunological studies of synaptic protein gene expression...
  26. ncbi Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia
    R H Porter
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res 751:217-31. 1997
    ..These deficits are likely to contribute to the glutamatergic component of the disease pathophysiology...
  27. ncbi Laser-assisted microdissection: methods for the molecular analysis of psychiatric disorders at a cellular resolution
    Philip W J Burnet
    Department of Psychiatry, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 55:107-11. 2004
    ..Laser-assisted microdissection techniques provide such a tool. Here we briefly discuss the principles, applications, and limitations of laser-assisted microdissection in psychiatric research...
  28. ncbi Glutamate receptors and transporters in the hippocampus in schizophrenia
    Paul J Harrison
    Department of Psychiatry, Neurosciences Building, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, United Kingdom
    Ann N Y Acad Sci 1003:94-101. 2003
    ..The recently described susceptibility genes for schizophrenia all act upon glutamatergic synaptic transmission, which may, therefore, be part of the core pathophysiology of the disorder...
  29. ncbi Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Synapse 42:104-14. 2001
    ..Measurement of multiple parameters is necessary to give a clear picture of the normal situation and to show the profile of alterations in a disease...
  30. ncbi AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuroreport 5:1325-8. 1994
    ....
  31. ncbi The synaptic pathology of schizophrenia: is aberrant neurodevelopment and plasticity to blame?
    Sharon L Eastwood
    Department of Psychiatry University of Oxford, Warneford Hospital Oxford, OX3 7JX, UK
    Int Rev Neurobiol 59:47-72. 2004
    ..A brief discussion on the possible origins of the synaptic pathology of schizophrenia, and possible future studies, concludes the review...