Richard Eastell

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. doi request reprint Effects of 3 years of lasofoxifene treatment on bone turnover markers in women with postmenopausal osteoporosis
    Richard Eastell
    Centre for Biomedical Research, Northern General Hospital, Herries Road, Sheffield, South Yorkshire, S5 7AU, UK
    Bone 50:1135-40. 2012
  2. doi request reprint Reference intervals of bone turnover markers in healthy premenopausal women: results from a cross-sectional European study
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    Bone 50:1141-7. 2012
  3. ncbi request reprint Long-term effects of aromatase inhibitors on bone
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Herries Road, Sheffield, South Yorkshire, S5 7AU, UK
    J Steroid Biochem Mol Biol 95:151-4. 2005
  4. doi request reprint Bisphosphonates for postmenopausal osteoporosis
    Richard Eastell
    National Institute for Health Research Biomedical Research Unit for Bone Disease, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, England, UK
    Bone 49:82-8. 2011
  5. doi request reprint Bone turnover markers and bone mineral density response with risedronate therapy: relationship with fracture risk and patient adherence
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 26:1662-9. 2011
  6. doi request reprint Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: the OCEAN study
    Richard Eastell
    University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 26:1303-12. 2011
  7. doi request reprint Effects of denosumab on bone turnover markers in postmenopausal osteoporosis
    Richard Eastell
    National Institute for Health Research Bone Biomedical Research Unit, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 26:530-7. 2011
  8. doi request reprint Effects of raloxifene and alendronate on bone turnover as assessed by procollagen type I N-terminal propeptide
    R Eastell
    NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Osteoporos Int 22:1927-34. 2011
  9. doi request reprint Cardiovascular disease and bone
    Richard Eastell
    National Institute for Health Research Biomedical Research Unit for Bone Disease, Northern General Hospital, Sheffield, South Yorkshire S5 7AU, UK
    Arch Biochem Biophys 503:78-83. 2010
  10. doi request reprint Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: results of the HORIZON Pivotal Fracture Trial
    R Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    Osteoporos Int 21:1277-85. 2010

Detail Information

Publications138 found, 100 shown here

  1. doi request reprint Effects of 3 years of lasofoxifene treatment on bone turnover markers in women with postmenopausal osteoporosis
    Richard Eastell
    Centre for Biomedical Research, Northern General Hospital, Herries Road, Sheffield, South Yorkshire, S5 7AU, UK
    Bone 50:1135-40. 2012
    ..BTMs may prove useful in the monitoring of the response to lasofoxifene treatment for women with postmenopausal osteoporosis early in the course of treatment...
  2. doi request reprint Reference intervals of bone turnover markers in healthy premenopausal women: results from a cross-sectional European study
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    Bone 50:1141-7. 2012
    ..8-38.8U/L for bone ALP, and 19.5-75.2ng/mL for PINP, respectively. The clinical interpretation of the BTMs of a subject should be based on comparison with a BTM reference interval, measured with the same assay method...
  3. ncbi request reprint Long-term effects of aromatase inhibitors on bone
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Herries Road, Sheffield, South Yorkshire, S5 7AU, UK
    J Steroid Biochem Mol Biol 95:151-4. 2005
    ..Current clinical practice should include the measurement of bone mineral density in postmenopausal women taking these drugs and commencement of antiresorptive therapy if osteoporosis is already present...
  4. doi request reprint Bisphosphonates for postmenopausal osteoporosis
    Richard Eastell
    National Institute for Health Research Biomedical Research Unit for Bone Disease, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, England, UK
    Bone 49:82-8. 2011
    ..Uncertainties still exist around the optimum duration of treatment and treatment holidays, how best to use bisphosphonates with anabolic treatments, and the benefits of treatment in patients who do not have a BMD T-score below -2.5...
  5. doi request reprint Bone turnover markers and bone mineral density response with risedronate therapy: relationship with fracture risk and patient adherence
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 26:1662-9. 2011
    ..Changes greater than the LSC in BTMs and BMD reflect better treatment adherence, were associated with fracture risk reduction, and identify differences in individual responsiveness to risedronate...
  6. doi request reprint Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: the OCEAN study
    Richard Eastell
    University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 26:1303-12. 2011
    ..With a significant increase in BMD, ONO-5334 also demonstrated a new mode of action as a potential agent for treating osteoporosis. Further clinical studies are warranted to investigate long-term efficacy as well as safety of ONO-5334...
  7. doi request reprint Effects of denosumab on bone turnover markers in postmenopausal osteoporosis
    Richard Eastell
    National Institute for Health Research Bone Biomedical Research Unit, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 26:530-7. 2011
    ..24 to -0.44). The BTM response pattern with denosumab is unique and should be appreciated by physicians to monitor this treatment effectively...
  8. doi request reprint Effects of raloxifene and alendronate on bone turnover as assessed by procollagen type I N-terminal propeptide
    R Eastell
    NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Osteoporos Int 22:1927-34. 2011
    ....
  9. doi request reprint Cardiovascular disease and bone
    Richard Eastell
    National Institute for Health Research Biomedical Research Unit for Bone Disease, Northern General Hospital, Sheffield, South Yorkshire S5 7AU, UK
    Arch Biochem Biophys 503:78-83. 2010
    ..However, there is now strong evidence indicating that these conditions are associated with one another. Furthermore, there are common pathways in the pathophysiology of these two conditions...
  10. doi request reprint Effect of once-yearly zoledronic acid on the spine and hip as measured by quantitative computed tomography: results of the HORIZON Pivotal Fracture Trial
    R Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    Osteoporos Int 21:1277-85. 2010
    ..ZOL treatment increased spine and hip BMD vs placebo, assessed by QCT and DXA. Changes in trabecular bone resulted in increased bone strength...
  11. ncbi request reprint Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate
    R Eastell
    Bone Metabolism Group, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 18:1051-6. 2003
    ..The decrease in bone resorption in patients taking risedronate accounts for a large proportion of the reduction in fracture risk. There may be a level of bone resorption reduction below which there is no further fracture benefit...
  12. ncbi request reprint Management of osteoporosis due to ovarian failure
    Richard Eastell
    University of Sheffield, Sheffield, United Kingdom
    Med Pediatr Oncol 41:222-7. 2003
    ..It works by stimulation of bone formation rather than by inhibition of bone resorption. However, it has to be given by daily injection. Thus, we have a wide choice of therapies for the woman with osteoporosis due to ovarian failure...
  13. ncbi request reprint Role of oestrogen in the regulation of bone turnover at the menarche
    Richard Eastell
    Academic Unit of Bone Metabolism, Division of Clinical Sciences North, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    J Endocrinol 185:223-34. 2005
    ..A late menarche is a consistent risk factor for fracture and low bone mineral density in the postmenopausal period; models that might explain this association are considered...
  14. doi request reprint Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop
    R Eastell
    University of Sheffield, Sheffield, United Kingdom
    J Clin Endocrinol Metab 94:340-50. 2009
    ..Asymptomatic primary hyperparathyroidism (PHPT) is a common clinical problem. The purpose of this report is to guide the use of diagnostic tests for this condition in clinical practice...
  15. doi request reprint Effect of once-yearly zoledronic acid five milligrams on fracture risk and change in femoral neck bone mineral density
    Richard Eastell
    Academic Unit of Bone Metabolism, Metabolic Bone Centre, Sorby Wing, Northern General Hospital, Herries Road, Sheffield, South Yorkshire S5 7AU, United Kingdom
    J Clin Endocrinol Metab 94:3215-25. 2009
    ..In the Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly - Pivotal Fracture Trial (HORIZON-PFT), zoledronic acid (ZOL) 5 mg significantly reduced fracture risk...
  16. doi request reprint Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, UK
    J Clin Oncol 26:1051-7. 2008
    ..It is therefore important to understand the effects of long-term aromatase inhibitor therapy on BMD...
  17. doi request reprint Biomarkers of bone health and osteoporosis risk
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Metabolic Bone Centre, Sorby Wing, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Proc Nutr Soc 67:157-62. 2008
    ....
  18. ncbi request reprint Strategies for skeletal health in the elderly
    Richard Eastell
    Division of Clinical Sciences, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Proc Nutr Soc 61:173-80. 2002
    ..Thus, strategies for enhancing skeletal health in the elderly must begin in early childhood, and continue throughout life...
  19. doi request reprint Bone formation markers in patients with glucocorticoid-induced osteoporosis treated with teriparatide or alendronate
    Richard Eastell
    University of Sheffield Bone Metabolism Group, Metabolic Bone Centre, Sorby Wing, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK
    Bone 46:929-34. 2010
    ..We conclude that bone formation as determined by surrogate markers was increased in teriparatide-treated patients with GIO and decreased in alendronate-treated patients with GIO...
  20. ncbi request reprint Prevention of bone loss with risedronate in glucocorticoid-treated rheumatoid arthritis patients
    R Eastell
    Department of Human Metabolism and Clinical Biochemistry, University of Sheffield, UK
    Osteoporos Int 11:331-7. 2000
    ..Thus risedronate preserves bone mass in postmenopausal women with rheumatoid arthritis receiving glucocorticoids while patients receiving a placebo have significant bone loss...
  21. doi request reprint Long-term effects of anastrozole on bone mineral density: 7-year results from the ATAC trial
    R Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    Ann Oncol 22:857-62. 2011
    ..This 'Arimidex', Tamoxifen, Alone or in Combination (ATAC) trial sub-study examined the effects of anastrozole and tamoxifen on bone mineral density (BMD) following 5 years of treatment...
  22. ncbi request reprint Development of an algorithm for using PINP to monitor treatment of patients with teriparatide
    Richard Eastell
    University of Sheffield, Sheffield, UK
    Curr Med Res Opin 22:61-6. 2006
    ..Teriparatide effects are mediated via the preferential stimulation of osteoblastic activity over osteoclastic activity. Amino-terminal propeptide of type I procollagen (PINP) is an indicator of osteoblastic activity...
  23. ncbi request reprint Effect of an aromatase inhibitor on bmd and bone turnover markers: 2-year results of the Anastrozole, Tamoxifen, Alone or in Combination (ATAC) trial (18233230)
    Richard Eastell
    Bone Metabolism Group, Division of Clinical Sciences North, University of Sheffield, UK
    J Bone Miner Res 21:1215-23. 2006
    ..Residual estrogen is an important determinant of bone turnover. Adjuvant anastrozole was associated with significant BMD loss and increased bone remodeling, whereas tamoxifen reduced bone marker levels...
  24. ncbi request reprint Secondary prevention of osteoporosis: when should a non-vertebral fracture be a trigger for action?
    R Eastell
    University of Sheffield Medical School, Sheffield, UK
    QJM 94:575-97. 2001
    ..Treatment options for patients presenting with hip fracture include HRT, bisphosphonates, and calcium plus vitamin D, and for Colles' fracture include general measures, HRT, bisphosphonates, or calcitonin plus calcium...
  25. ncbi request reprint A UK Consensus Group on management of glucocorticoid-induced osteoporosis: an update
    R Eastell
    University of Sheffield Medical School, UK
    J Intern Med 244:271-92. 1998
    ..5 mg day(-1) or more for 6 months or more. General measures, e.g. alternative GCs and routes of administration, and therapeutic interventions, e.g. cyclical etidronate and hormone replacement, are recommended...
  26. ncbi request reprint Aromatase inhibitors and bone
    Richard Eastell
    The Academic Unit of Bone Metabolism, Musculoskeletal Section, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    J Steroid Biochem Mol Biol 106:157-61. 2007
    ..We have a number of proven treatments for the treatment of postmenopausal osteoporosis and it is likely that some of these, particularly bisphosphonates, could be effective at preventing bone loss with aromatase inhibitors...
  27. ncbi request reprint Diet and healthy bones
    Richard Eastell
    Division of Clinical Sciences, Northern General Hospital, Sheffield, England S5 7AU
    Calcif Tissue Int 70:400-4. 2002
  28. pmc Effect of stopping risedronate after long-term treatment on bone turnover
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Herries Road, Sheffield S5 7AU, United Kingdom
    J Clin Endocrinol Metab 96:3367-73. 2011
    ..Determining how quickly bisphosphonate treatment effects begin to regress is crucial when considering termination of treatment...
  29. ncbi request reprint Management of bone health in postmenopausal women
    Richard Eastell
    Academic Unit of Bone Metabolism, Section of Human Metabolism, Division of Clinical Sciences North, University of Sheffield, Sheffield, UK
    Horm Res 64:76-80. 2005
    ..The efficacy of these agents can be evaluated in the individual by monitoring changes in bone mineral density or bone turnover markers...
  30. ncbi request reprint Octreotide abolishes the acute decrease in bone turnover in response to oral glucose
    Jackie A Clowes
    Bone Metabolism Group, Clinical Sciences North, University of Sheffield, Sheffield, United Kingdom S5 7AU
    J Clin Endocrinol Metab 88:4867-73. 2003
    ..We conclude that octreotide completely abolishes the bone turnover response to glucose intake and increases PTH secretion. The apparent bone turnover response to feeding is probably mediated by an octreotide-inhibitable endocrine factor...
  31. doi request reprint Establishing a reference interval for bone turnover markers in 637 healthy, young, premenopausal women from the United Kingdom, France, Belgium, and the United States
    Sarah J Glover
    University of Sheffield, Sheffield, UK
    J Bone Miner Res 24:389-97. 2009
    ..Countries differed by these characteristics, and once allowed for in the statistical model, any country differences were attenuated or removed...
  32. ncbi request reprint Effects of third generation aromatase inhibitors on bone health and other safety parameters: results of an open, randomised, multi-centre study of letrozole, exemestane and anastrozole in healthy postmenopausal women
    Eugene V McCloskey
    Academic Unit of Bone Metabolism, University of Sheffield, Sorby Wing, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK
    Eur J Cancer 43:2523-31. 2007
    ..Further, long-term clinical studies are required to determine the impact, if any, of the differences observed between the AIs..
  33. ncbi request reprint Effect of pamidronate on bone turnover and implant migration after total hip arthroplasty: a randomized trial
    J Mark Wilkinson
    Academic Unit of Bone Metabolism, Division of Clinical Sciences North, Northern General Hospital, University of Sheffield, Sheffield S5 7AU, UK
    J Orthop Res 23:1-8. 2005
    ..Bisphosphonate therapy reduces femoral calcar bone loss and bone turnover after THA, but did not influence cup migration in this study. Acute changes in biochemical markers predict femoral periprosthetic bone loss...
  34. ncbi request reprint Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption
    Rosemary A Hannon
    Bone Metabolism Group, Section of Human Metabolism, Division of Clinical Sciences North, University of Sheffield, Sheffield, UK
    Bone 34:187-94. 2004
    ..TRACP 5b may provide useful additional information about bone resorption...
  35. doi request reprint Hormonal determinants of bone turnover before and after attainment of peak bone mass
    Jennifer S Walsh
    Academic Unit of Bone Metabolism, Northern General Hospital, University of Sheffield, Sheffield, UK
    Clin Endocrinol (Oxf) 72:320-7. 2010
    ..Biochemical markers of bone turnover reflect different processes before and after peak bone mass, so hormonal influences on bone turnover may differ before and after peak bone mass...
  36. doi request reprint FRAX(®) Clinical Task Force of the 2010 Joint International Society for Clinical Densitometry & International Osteoporosis Foundation Position Development Conference
    Eugene V McCloskey
    University of Sheffield, Sheffield, UK
    J Clin Densitom 14:181-3. 2011
    ..This synthesis was presented to the expert panel and constitutes the data on which the subsequent Official Positions are predicated. A summary of the Clinical Task Force composition and charge is presented here...
  37. doi request reprint Relationship of changes in total hip bone mineral density to vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis treated with once-yearly zoledronic acid 5 mg: the HORIZON-Pivotal Fracture Trial (PFT)
    Richard M Jacques
    School of Health and Related Research, University of Sheffield, Sheffield, UK
    J Bone Miner Res 27:1627-34. 2012
    ..Previous studies may have underestimated the relationship between BMD change and the effect of treatment on fracture risk...
  38. doi request reprint Depot medroxyprogesterone acetate use after peak bone mass is associated with increased bone turnover but no decrease in bone mineral density
    Jennifer S Walsh
    Academic Unit of Bone Metabolism, Northern General Hospital, Herries Road, Sheffield, S5 7AU, United Kingdom
    Fertil Steril 93:697-701. 2010
    ..To ascertain whether increased bone turnover in depot medroxyprogesterone acetate (DMPA) users after peak bone mass is associated with bone mineral loss...
  39. ncbi request reprint Comparison of densitometric and radiographic vertebral fracture assessment using the algorithm-based qualitative (ABQ) method in postmenopausal women at low and high risk of fracture
    Lynne Ferrar
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 23:103-11. 2008
    ..Misdiagnosis was influenced by image quality and was more common for mild deformities...
  40. doi request reprint Shape, structural properties, and cortical stability along the femoral neck: a study using clinical QCT
    Lang Yang
    School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    J Clin Densitom 11:373-82. 2008
    ..In conclusion, multiple site measurements are required for a comprehensive assessment of FN structural properties, which can be studied based on clinical QCT...
  41. ncbi request reprint Bone mineral density and biochemical markers of bone turnover in aseptic loosening after total hip arthroplasty
    J Mark Wilkinson
    Bone Metabolism Group, Division of Clinical Sciences North, University of Sheffield, Northern General Hospital, Sheffield, UK
    J Orthop Res 21:691-6. 2003
    ..These surrogate outcome markers may be of value in monitoring response to antiresorptive therapies used to treat periprosthetic osteolysis, although the diagnosis of aseptic loosening remains clinical and radiological...
  42. ncbi request reprint Changes in bone mass and bone turnover following tibial shaft fracture
    S W Veitch
    Orthopaedic Department, Northern General Hospital, Sheffield, UK
    Osteoporos Int 17:364-72. 2006
    ..The aim of this longitudinal study was to determine the pattern and distribution of bone loss and bone turnover following a tibial shaft fracture treated with either plaster cast or intramedullary nail...
  43. ncbi request reprint The discriminative ability of peripheral and axial bone measurements to identify proximal femoral, vertebral, distal forearm and proximal humeral fractures: a case control study
    Jackie A Clowes
    Bone Metabolism Group, University of Sheffield, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK
    Osteoporos Int 16:1794-802. 2005
    ..The ability of different bone measurements to discriminate between fracture cases and controls is device- and site-specific, with additional information obtained by combining measurement sites and technologies...
  44. pmc Circulating serotonin and bone density, structure, and turnover in carcinoid syndrome
    Jennifer S Walsh
    Academic Unit of Bone Metabolism, University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, United Kingdom
    J Clin Endocrinol Metab 98:2902-7. 2013
    ..Carcinoid neuroendocrine tumors can produce very high levels of circulating serotonin and so offer a model of serotonin excess in humans...
  45. pmc Use of DXA-based structural engineering models of the proximal femur to discriminate hip fracture
    Lang Yang
    Academic Unit of Bone Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 24:33-42. 2009
    ..No index was better than total hip BMD for discriminating trochanteric fractures. In conclusion, the finite element model has the potential to replace hip BMD in discriminating hip fractures...
  46. doi request reprint Cortical consolidation of the radius and tibia in young men and women
    Jennifer S Walsh
    Academic Unit of Bone Metabolism at the University of Sheffield, and Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield S5 7AU, United Kingdom
    J Clin Endocrinol Metab 97:3342-8. 2012
    ..Bone size, geometry, density, and microarchitecture are important determinants of bone strength. By understanding how these properties change during skeletal development, we can better understand bone fragility...
  47. ncbi request reprint Algorithm-based qualitative and semiquantitative identification of prevalent vertebral fracture: agreement between different readers, imaging modalities, and diagnostic approaches
    Lynne Ferrar
    Academic Unit of Bone Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 23:417-24. 2008
    ..We compared SQ and ABQ diagnosis of VF imaged by radiography and X-ray absorptiometry. Mild ABQ VF had stronger associations with osteoporosis than mild SQ VF. Interobserver agreement (radiographic diagnosis) was better for ABQ...
  48. ncbi request reprint Risk factors for vertebral and nonvertebral fracture over 10 years: a population-based study in women
    Judith Finigan
    University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 23:75-85. 2008
    ..Factors that predicted vertebral rather than nonvertebral fractures related to physical weakness, poor health, and weight loss. Similar factors were also associated with greater bone loss at the hip...
  49. doi request reprint Use of DXA-based finite element analysis of the proximal femur in a longitudinal study of hip fracture
    Kim E Naylor
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 28:1014-21. 2013
    ..Such an approach may provide a useful tool for better assessment of bone strength to identify patients at high risk of hip fracture who may benefit from treatment to reduce fracture risk...
  50. ncbi request reprint Absence of marked seasonal change in bone turnover: a longitudinal and multicenter cross-sectional study
    Aubrey Blumsohn
    Bone Metabolism Group, Division of Clinical Sciences North, University of Sheffield, Northern General Hospital, Sheffield, United Kingdom
    J Bone Miner Res 18:1274-81. 2003
    ..In this study, we have been unable to confirm findings of a marked wintertime increase in bone formation and resorption within the general population. Seasonality was assessed by cosinor analysis...
  51. doi request reprint Performance of quantitative ultrasound measurements of bone for monitoring raloxifene therapy
    Margaret A Paggiosi
    Sheffield NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, UK
    J Clin Densitom 13:441-50. 2010
    ..05). Until further knowledge has been acquired, QUS measurement variables should only be used in conjunction with BMD when assessing changes in bone because of raloxifene therapy...
  52. doi request reprint Rapid and robust response of biochemical markers of bone formation to teriparatide therapy
    Sarah J Glover
    University of Sheffield, Sheffield, UK
    Bone 45:1053-8. 2009
    ..PINP is the most responsive marker. These findings have important implications for monitoring patients treated with teriparatide and may also inform the design of studies of new anabolic agents for osteoporosis...
  53. ncbi request reprint Effect of pamidronate on excretion of pyridinium crosslinks of collagen after total hip arthroplasty
    J Mark Wilkinson
    Bone Metabolism Group, Division of Clinical Sciences North, University of Sheffield, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK
    Calcif Tissue Int 73:326-31. 2003
    ..Urinary-free DPD is a poor marker of response to treatment as the ratio of free-to-total cross-links is affected by amino-bisphosphonate therapy...
  54. doi request reprint Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial
    Rosemary A Hannon
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    J Bone Miner Res 25:463-71. 2010
    ..We conclude that inhibition of Src reduces osteoclastic bone resorption in humans. Saracatinib is a potentially useful treatment for diseases characterized by increased bone resorption, such as metastatic bone disease and osteoporosis...
  55. doi request reprint Effect of ONO-5334 on Bone Mineral Density and Biochemical Markers of Bone Turnover in Postmenopausal Osteoporosis: 2-Year Results From the OCEAN Study
    Richard Eastell
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    J Bone Miner Res 29:458-66. 2014
    ..This was associated with an increase in BMD; the effect on biochemical markers was rapidly reversible on treatment cessation. © 2014 American Society for Bone and Mineral Research. ..
  56. doi request reprint Effects of Src kinase inhibition by saracatinib (AZD0530) on bone turnover in advanced malignancy in a Phase I study
    Rosemary A Hannon
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    Bone 50:885-92. 2012
    ..This result suggests that saracatinib may have therapeutic benefit in metastatic bone disease...
  57. ncbi request reprint Monitoring alendronate and estradiol therapy with quantitative ultrasound and bone mineral density
    Bridget M Ingle
    Bone Metabolism Group, Section of Medicine, Division of Clinical Sciences, University of Sheffield, Sheffield S5 7AU, UK
    J Clin Densitom 8:278-86. 2005
    ..1 and 0.6). These results indicated that changes in finger ultrasound are similar in clinical utility to dual-energy X-ray absorptiometry measurements at the femoral neck for the monitoring of antiresorptive treatments for osteoporosis...
  58. doi request reprint Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty
    Andrew Gordon
    University of Sheffield, and Academic Unit of Bone Metabolism, Northern General Hospital, Sheffield, UK
    Arthritis Rheum 58:3157-65. 2008
    ....
  59. doi request reprint Effects of Depot medroxyprogesterone acetate on bone density and bone metabolism before and after peak bone mass: a case-control study
    Jennifer S Walsh
    Academic Unit of Bone Metabolism, Sorby Wing, Northern General Hospital, Herries Road, Sheffield S5 7AU, United Kingdom
    J Clin Endocrinol Metab 93:1317-23. 2008
    ..Previous studies have found that DMPA use is associated with a bone density deficit...
  60. ncbi request reprint Calcium supplementation and bone mineral accretion in adolescent girls: an 18-mo randomized controlled trial with 2-y follow-up
    Helen L Lambert
    Academic Unit of Bone Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    Am J Clin Nutr 87:455-62. 2008
    ..A recent meta-analysis raised doubt as to whether calcium supplementation in children benefits spine and hip bone mineral density (BMD)...
  61. ncbi request reprint The impact of subcutaneous oestradiol implants on biochemical markers of bone turnover and bone mineral density in postmenopausal women
    C A Pereda
    Division of Clinical Sciences, University of Sheffield, UK
    BJOG 109:812-20. 2002
    ..To evaluate the anabolic effect of oestrogen on bone by comparing the response of markers of bone formation (and resorption) and bone mineral density (BMD) to subcutaneous oestradiol implants...
  62. doi request reprint Supine vs decubitus lateral patient positioning in vertebral fracture assessment
    Margaret Anne Paggiosi
    Sheffield NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, United Kingdom
    J Clin Densitom 15:454-60. 2012
    ..002). We conclude that there were significantly different projection effects with supine and decubitus lateral VFA, but these differences did not influence the identification of vertebral fractures in our study sample...
  63. doi request reprint Bone turnover markers: use in osteoporosis
    Kim Naylor
    Academic Unit of Bone Metabolism, University of Sheffield, Centre for Biomedical Research, Northern General Hospital, Herries Road, Sheffield, South Yorkshire S5 7AU, UK
    Nat Rev Rheumatol 8:379-89. 2012
    ..BTM changes can also be used for understanding the mechanism of action of drugs in development and identifying the correct dose; they are also potentially useful as surrogate biomarkers for fracture...
  64. ncbi request reprint Identification of vertebral fracture and non-osteoporotic short vertebral height in men: the MrOS study
    Lynne Ferrar
    Academic Unit of Bone Metabolism, University of Sheffield, United Kingdom
    J Bone Miner Res 22:1434-41. 2007
    ..Non-osteoporotic SVH may mimic VF but is excluded in ABQ. In men, this led to discordance between ABQ and other methods, but SVH was not linked to low bone density. Exclusion of SVH could reduce false positives...
  65. ncbi request reprint Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty
    Andrew Gordon
    Academic Unit of Bone Metabolism, University of Sheffield, Metabolic Bone Centre, Northern General Hospital, Sheffield, S5 7AU, United Kingdom
    J Orthop Res 25:1665-70. 2007
    ..09 to 2.07; p = 0.014). Our data suggest that the FRZB Arg200Trp locus may be a marker for pro-osteoblastic activity after THA. Carriage of the FRZB 200Trp allele is associated with a "positive" bone balance phenotype (osteolysis -: HO+)...
  66. doi request reprint Official Positions for FRAX® clinical regarding biochemical markers from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®
    Eugene V McCloskey
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield S5 7AU, UK
    J Clin Densitom 14:220-2. 2011
    ..More research is clearly required to address these deficiencies before biochemical markers might contribute a useful independent risk factor for inclusion in FRAX(®)...
  67. doi request reprint A randomised, double-blinded, placebo-controlled, trial to determine the individual response in bone turnover markers to lasofoxifene therapy
    A Rogers
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, UK
    Bone 45:1044-52. 2009
    ..Our results suggest that bone turnover markers are useful for monitoring response to lasofoxifene. Changes occur early and relate to the BMD response...
  68. pmc Metabolic effects of pamidronate in patients with metastatic bone disease
    J Vinholes
    YCRC Department of Clinical Oncology, Weston Park Hospital, University of Sheffield, UK
    Br J Cancer 73:1089-95. 1996
    ..Biochemical responders have the most benefit from pamidronate in terms of pain relief. This suggests that patients may benefit from more potent or repeated infusions of bisphosphonates...
  69. ncbi request reprint Effect of pamidronate in preventing local bone loss after total hip arthroplasty: a randomized, double-blind, controlled trial
    J M Wilkinson
    Division of Clinical Sciences, University of Sheffield, Northern General Hospital, United Kingdom
    J Bone Miner Res 16:556-64. 2001
    ....
  70. ncbi request reprint The impact of monitoring on adherence and persistence with antiresorptive treatment for postmenopausal osteoporosis: a randomized controlled trial
    Jackie A Clowes
    Bone Metabolism Group, University of Sheffield, Sheffield, United Kingdom S57 AU
    J Clin Endocrinol Metab 89:1117-23. 2004
    ..36; P = 0.002). In conclusion, monitoring of patients increased adherence to therapy by 57% at 1 yr. Increased adherence to therapy increased the effectiveness of raloxifene therapy determined using surrogate end points...
  71. ncbi request reprint Polyethylene wear rate and osteolysis: critical threshold versus continuous dose-response relationship
    J Mark Wilkinson
    Lower Limb Arthroplasty Unit, Department of Orthopaedics, Northern General Hospital, Sheffield, UK
    J Orthop Res 23:520-5. 2005
    ....
  72. ncbi request reprint Biochemical markers of bone turnover and fracture prediction
    Rosemary A Hannon
    Research Associate, Bone Metabolism Group, University of Sheffield, Sheffield, UK
    J Br Menopause Soc 9:10-5. 2003
    ..Prediction models have been developed to predict the 10-year risk of fracture using bone mineral density and biochemical markers of bone turnover and these could prove very useful in clinical practice...
  73. doi request reprint Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli
    Andrew Gordon
    Academic Unit of Bone Metabolism, Sorby Wing, Department of Human Metabolism, Northern General Hospital, University of Sheffield, Herries Road, Sheffield S5 7AU, United Kingdom
    J Orthop Res 28:1127-35. 2010
    ..These innate immune differences may contribute to the variation in osteolysis-susceptibility observed clinically between individuals...
  74. ncbi request reprint Precision of periprosthetic bone mineral density measurements using Hologic Windows versus DOS-based analysis software
    Nitin R Shetty
    Department of Orthopaedics, Northern General Hospital, Sheffield, United Kingdom
    J Clin Densitom 9:363-6. 2006
    ..0%; femoral region mean=1.3%; p>0.05 for both comparisons). Our results suggest that scans analyzed using each platform may be used interchangeably without the need for a calibration correction...
  75. doi request reprint Sequential treatment of severe postmenopausal osteoporosis after teriparatide: final results of the randomized, controlled European Study of Forsteo (EUROFORS)
    Richard Eastell
    University of Sheffield, Sheffield, United Kingdom
    J Bone Miner Res 24:726-36. 2009
    ..In conclusion, BMD increases progressively over 2 yr of teriparatide therapy in women with severe osteoporosis. After discontinuation of teriparatide, raloxifene maintains spine BMD and increases hip BMD...
  76. ncbi request reprint Acute changes of bone turnover and PTH induced by insulin and glucose: euglycemic and hypoglycemic hyperinsulinemic clamp studies
    Jackie A Clowes
    Bone Metabolism Group, Division of Clinical Sciences North, Northern General Hospital, University of Sheffield, Herries Road, Sheffield S5 7 AU, United Kingdom
    J Clin Endocrinol Metab 87:3324-9. 2002
    ..The reduction in bone turnover during hypoglycemia may be related to hypoglycemia itself, acute changes in PTH, or other hormones released in response to hypoglycemia...
  77. doi request reprint The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women
    K E Naylor
    University of Sheffield, UK
    Bone 46:592-7. 2010
    ..The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment...
  78. ncbi request reprint Identification of vertebral fractures: an update
    L Ferrar
    Bone Metabolism Group, Section of Human Metabolism, Division of Clinical Sciences, University of Sheffield, UK
    Osteoporos Int 16:717-28. 2005
    ..Methods of vertebral fracture definition should be validated by testing the association with clinical outcomes of vertebral fracture, in particular the prediction of incident fractures...
  79. ncbi request reprint Vertebral wedge angle measured by morphometric X-ray absorptiometry
    L Ferrar
    Division of Clinical Sciences, University of Sheffield, UK
    Osteoporos Int 12:914-21. 2001
    ..Diagnostic values for the two approaches were broadly similar. The results of this analysis do not provide strong evidence for the preferential use of the wedge angle approach...
  80. ncbi request reprint Comparison of methods for the visual identification of prevalent vertebral fracture in osteoporosis
    G Jiang
    Bone Metabolism Group, Section of Human Metabolism, Division of Clinical Sciences, University of Sheffield, Sheffield, UK
    Osteoporos Int 15:887-96. 2004
    ..Our new approach attempts to address this problem but requires further testing in a larger study population...
  81. ncbi request reprint Serum osteoprotegerin as a determinant of bone metabolism in a longitudinal study of human pregnancy and lactation
    K E Naylor
    Bone Metabolism Group, University of Sheffield, Sheffield, United Kingdom S5 7AU
    J Clin Endocrinol Metab 88:5361-5. 2003
    ..There was no correlation between change in OPG and bone turnover or bone mineral density (P > 0.05), and the physiological importance of elevated OPG in human pregnancy remains uncertain...
  82. ncbi request reprint Attainment of peak bone mass at the lumbar spine, femoral neck and radius in men and women: relative contributions of bone size and volumetric bone mineral density
    Yvette M Henry
    Bone Metabolism Group, Division of Clinical Science North, Northern General Hospital, Herries Road, S5 7AU, Sheffield, UK
    Osteoporos Int 15:263-73. 2004
    ..Skeletal growth and maturation is heterogeneous, but crucial in understanding how the origins of osteoporosis may begin during childhood and young adulthood...
  83. ncbi request reprint Effect of temperature on the longitudinal variability of quantitative ultrasound variables
    Margaret A Paggiosi
    Academic Unit of Bone Metabolism, Section of Medicine, Division of Clinical Sciences North, Northern General Hospital, University of Sheffield, Sheffield, UK
    J Clin Densitom 8:436-44. 2005
    ..Longitudinal quantitative ultrasound measurements for monitoring change in skeletal status cannot, as yet, be properly controlled...
  84. ncbi request reprint Circulating osteoprotegerin and receptor activator for nuclear factor kappaB ligand: clinical utility in metabolic bone disease assessment
    Angela Rogers
    Academic Unit of Bone Metabolism, University of Sheffield, Sheffield S5 7AU, United Kingdom
    J Clin Endocrinol Metab 90:6323-31. 2005
    ..The effects of RANKL are counteracted by osteoprotegerin (OPG), a soluble neutralizing decoy receptor...
  85. ncbi request reprint Bone markers and current laboratory assays
    Rosemary A Hannon
    Academic Unit of Bone Metabolism, Division of Clinical Sciences North, University of Sheffield Clinical Sciences Centre, Northern General Hospital, Herries Rd, Sheffield S5 7AU, UK
    Cancer Treat Rev 32:7-14. 2006
    ..In this review, we briefly discuss the biology of bone metastases as well as describe the bone turnover markers and their possible role in aiding clinicians in the treatment of patients with MBD...
  86. doi request reprint Dietary phosphate modulates atherogenesis and insulin resistance in apolipoprotein E knockout mice--brief report
    Timothy Ellam
    National Institute for Healthcare Research NIHR, Cardiovascular Biomedical Research Unit, Northern General Hospital, Sheffield, United Kingdom
    Arterioscler Thromb Vasc Biol 31:1988-90. 2011
    ..We investigated whether manipulating dietary phosphate influences atherogenesis or insulin sensitivity in mice...
  87. ncbi request reprint Comparison of two methods for measuring ultrasound properties of the heel in postmenopausal women
    B M Ingle
    Division of Clinical Sciences, University of Sheffield, UK
    Osteoporos Int 12:500-5. 2001
    ..The misclassification rate using quantitative ultrasound improves when based on duplicate measurements...
  88. ncbi request reprint Differential effects of primary hyperparathyroidism on ultrasound properties of bone
    B M Ingle
    Bone Metabolism Group, Section of Medicine, Division of Clinical Sciences, University of Sheffield, Sheffield, UK
    Osteoporos Int 13:572-8. 2002
    ..With further research the combined use of BMD and QUS could improve the assessment of skeletal status in patients with PHPT before and after surgery...
  89. ncbi request reprint Clinical and radiological outcome of total hip replacement five years after pamidronate therapy. A trial extension
    N Shetty
    Department of Orthopaedics, University of Sheffield, Northern General Hosital, UK
    J Bone Joint Surg Br 88:1309-15. 2006
    ..Pamidronate given as a single post-operative dose does not appear to influence the clinical outcome or prevent the development of osteolytic lesions at five years after total hip replacement...
  90. ncbi request reprint Different effects of raloxifene and estrogen on interleukin-1beta and interleukin-1 receptor antagonist production using in vitro and ex vivo studies
    A Rogers
    Clinical Sciences Centre, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK
    Bone 40:105-10. 2007
    ..This may account, at least in part for the reduced efficacy of RLX therapy compared to estrogen which has been observed in vivo on bone mineral density, bone turnover and reduction in fracture risk...
  91. ncbi request reprint Double-blind placebo-controlled study of testosterone patch therapy on bone turnover in men with borderline hypogonadism
    Z Merza
    Division of Clinical Sciences North, Sheffield University, Sheffield, UK
    Int J Androl 29:381-91. 2006
    ..However, there was evidence of suppression in bone resorption and hence longer and larger studies are needed to examine its effect on BMD...
  92. ncbi request reprint Circulating estradiol and osteoprotegerin as determinants of bone turnover and bone density in postmenopausal women
    A Rogers
    Bone Metabolism Group, University of Sheffield, Sheffield S5 7AU, UK
    J Clin Endocrinol Metab 87:4470-5. 2002
    ..We have previously reported high levels of variability in urine markers of bone resorption, and we suggest that this could account for the absence of a significant association between these markers and circulating OPG...
  93. ncbi request reprint Is short vertebral height always an osteoporotic fracture? The Osteoporosis and Ultrasound Study (OPUS)
    L Ferrar
    Academic Unit of Bone Metabolism, Division of Clinical Sciences North, University of Sheffield, Sheffield, UK
    Bone 41:5-12. 2007
    ..We aimed to determine whether ABQ classification of SVH represents true or false negative diagnosis of osteoporotic vertebral fracture, by testing the associations with clinical outcomes of osteoporosis or vertebral fracture...
  94. doi request reprint Establishing a reference range for bone turnover markers in young, healthy women
    S J Glover
    Academic Unit of Bone Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Bone 42:623-30. 2008
    ....
  95. ncbi request reprint Standardised quantitative morphometry: a modified approach for quantitative identification of prevalent vertebral deformities
    G Jiang
    Academic Unit of Bone Metabolism, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Osteoporos Int 18:1411-9. 2007
    ..In women with osteoporosis, agreement with radiological diagnosis (surrogate gold standard) was better for SQM than QM using the Eastell-Melton method...
  96. ncbi request reprint Device-specific thresholds to diagnose osteoporosis at the proximal femur: an approach to interpreting peripheral bone measurements in clinical practice
    J A Clowes
    Bone Metabolism Group, University of Sheffield, Sheffield, UK
    Osteoporos Int 17:1293-302. 2006
    ....
  97. doi request reprint Vertebral fractures in the elderly may not always be "osteoporotic"
    G Jiang
    Academic Unit of Bone Metabolism, Department of Human Metabolism, University of Sheffield, UK
    Bone 47:111-6. 2010
    ..We hypothesize that radiographic appearances can be used to differentiate between "osteoporotic" fractures of vertebrae with low BMD and strength, and "traumatic" fractures of vertebrae with normal BMD and strength...
  98. ncbi request reprint Short-term precision for morphometric X-ray absorptiometry
    L Ferrar
    Section of Medicine, Division of Clinical Sciences, University of Sheffield, UK
    Osteoporos Int 12:710-5. 2001
    ..Intraoperator variability for repeat marking was lower for MRX, but the error associated with marking MXA scans remained below the minimum change required for identification of a vertebral deformity...
  99. ncbi request reprint Influence of bone quality on the strength of internal and external fixation of tibial plateau fractures
    Ahmad M Ali
    Department of Orthopaedic and Traumatology, Oldchurch Hospital, Waterloo Road, Romford, Essex RM7 0BE, and Orthopaedic and Traumatic Surgery Research Group, Division of Clinical Sciences North, University of Sheffield, United Kingdom
    J Orthop Res 24:2080-6. 2006
    ..The two fixation methods tested performed equally well, and the choice between them depends on the soft tissue condition and surgeon preference...
  100. ncbi request reprint Adaptation of the Carter method to adjust lumbar spine bone mineral content for age and body size: application to children who were born preterm
    Christine M Smith
    Academic Unit of Bone Metabolism, Division of Clinical Sciences North, University of Sheffield, and Neonatology Unit, Jessop Wing, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Clin Densitom 9:114-9. 2006
    ....
  101. ncbi request reprint Effect of feeding on bone turnover markers and its impact on biological variability of measurements
    J A Clowes
    Bone Metabolism Group, Division of Clinical Sciences North, University of Sheffield, Northern General Hospital, UK
    Bone 30:886-90. 2002
    ..The mechanism of the acute effect of feeding on bone turnover remains uncertain...