Dawn M Eagle

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task
    D M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Behav Brain Res 146:131-44. 2003
  2. ncbi request reprint Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine
    D M Eagle
    Department of Experimental Psychology, University of Cambridge, Cambridge, England, United Kingdom
    Behav Neurosci 117:1302-17. 2003
  3. pmc Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition
    Dawn M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, UK
    Neurosci Biobehav Rev 34:50-72. 2010
  4. ncbi request reprint Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol
    Dawn M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 192:193-206. 2007
  5. ncbi request reprint Stop-signal reaction-time task performance: role of prefrontal cortex and subthalamic nucleus
    Dawn M Eagle
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Cereb Cortex 18:178-88. 2008
  6. doi request reprint The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks
    Dawn M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 199:439-56. 2008
  7. doi request reprint Serotonin depletion impairs waiting but not stop-signal reaction time in rats: implications for theories of the role of 5-HT in behavioral inhibition
    Dawn M Eagle
    Department of Experimental Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 34:1311-21. 2009
  8. pmc Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats
    Andrea Bari
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Psychopharmacology (Berl) 205:273-83. 2009
  9. ncbi request reprint Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat
    Emma S J Robinson
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:1028-37. 2008
  10. pmc Prefrontal and monoaminergic contributions to stop-signal task performance in rats
    Andrea Bari
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:9254-63. 2011

Detail Information

Publications16

  1. ncbi request reprint Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task
    D M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Behav Brain Res 146:131-44. 2003
    ..These results are discussed with respect to the fronto-striatal circuitry involved in the mediation of behavioural inhibition...
  2. ncbi request reprint Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine
    D M Eagle
    Department of Experimental Psychology, University of Cambridge, Cambridge, England, United Kingdom
    Behav Neurosci 117:1302-17. 2003
    ..Medial striatal lesions also significantly slowed stop-signal reaction time. Subsequent treatment with d-amphetamine removed (0.3 mg/kg) or exacerbated (1.0 mg/kg) this deficit...
  3. pmc Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition
    Dawn M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, UK
    Neurosci Biobehav Rev 34:50-72. 2010
    ..The OF-DMStr-STN circuitry may form the basis of a control network that defines behavioral inhibition and that acts to suppress or countermand many forms of inappropriate or maladaptive behavior...
  4. ncbi request reprint Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol
    Dawn M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 192:193-206. 2007
    ..Both SSRT and go-trial reaction time (GoRT) may be sensitive to drugs such as d-amphetamine, methylphenidate and modafinil, both in normal subjects and those with ADHD...
  5. ncbi request reprint Stop-signal reaction-time task performance: role of prefrontal cortex and subthalamic nucleus
    Dawn M Eagle
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Cereb Cortex 18:178-88. 2008
    ..The STN lesion also significantly reduced accuracy of stopping at all stop-signal delays, indicative of a generalized stopping impairment that was independent of the SSRT itself...
  6. doi request reprint The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks
    Dawn M Eagle
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 199:439-56. 2008
    ..Growing evidence suggests that different 'stages' or even subtypes of action inhibition activate subtly different neuropharmacological and neuroanatomical processes...
  7. doi request reprint Serotonin depletion impairs waiting but not stop-signal reaction time in rats: implications for theories of the role of 5-HT in behavioral inhibition
    Dawn M Eagle
    Department of Experimental Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 34:1311-21. 2009
    ..This has significant implications for the treatment of conditions such as attention deficit and hyperactivity disorder, substance abuse, and affective disorders, in which inhibitory and impulse-control deficits are common...
  8. pmc Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats
    Andrea Bari
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK
    Psychopharmacology (Berl) 205:273-83. 2009
    ..While there is relative consensus regarding the anatomical substrates of behavioral inhibition, the neurochemical imbalance responsible for the deficits in stopping displayed by impulsive individuals is still a matter of debate...
  9. ncbi request reprint Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat
    Emma S J Robinson
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 33:1028-37. 2008
    ....
  10. pmc Prefrontal and monoaminergic contributions to stop-signal task performance in rats
    Andrea Bari
    Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:9254-63. 2011
    ..This study advances our understanding of the neuroanatomical and neurochemical determinants of impulsivity, which are relevant for a range of psychiatric disorders...
  11. pmc Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, UK
    Clin Psychol Rev 26:379-95. 2006
    ....
  12. pmc Contrasting roles for dopamine D1 and D2 receptor subtypes in the dorsomedial striatum but not the nucleus accumbens core during behavioral inhibition in the stop-signal task in rats
    Dawn M Eagle
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:7349-56. 2011
    ..These results suggest that DRD1 and DRD2 function within the DMStr, but not the NAcbC, may act to balance behavioral inhibition in a manner that is independent of behavioral activation...
  13. pmc Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat
    Adam C Mar
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:6398-404. 2011
    ..The findings are consistent with recent human functional imaging studies and suggest that functions of mOFC and lOFC subregions may be evolutionarily conserved and contribute differentially to decision-making processes...
  14. ncbi request reprint Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex
    Jeffrey W Dalley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neuropsychopharmacology 26:716-28. 2002
    ..These data indicate that elevated 5-HT release in the prefrontal cortex may underlie deficits in impulse control on this task. Additionally, DA dysfunction in this region may be another, possibly independent, trait marker of impulsivity...
  15. pmc The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD
    Dawn M Eagle
    Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK Electronic address
    Behav Brain Res 264:207-29. 2014
    ..These data have implications for treatment of compulsive checking in OCD, particularly for serotonin-reuptake-inhibitor treatment-refractory cases, where supplementation with dopamine receptor antagonists may be beneficial. ..
  16. doi request reprint Animal models of obsessive-compulsive spectrum disorders
    Laure Sophie Camilla d'Angelo
    1 Departments of Psychology and Psychiatry, and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    CNS Spectr 19:28-49. 2014
    ..We find that there is a burgeoning literature in these areas with important ramifications, which are considered, along with salient future lines of research. ..