Research Topics
| Emrah DuzelSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Brain oscillations and memoryEmrah Duzel
UCL Institute of Cognitive Neuroscience, University College London, WC1N 3AR London, United Kingdom
Curr Opin Neurobiol 20:143-9. 2010..This correspondence between species opens new perspectives for a mechanistic investigation of human memory function...- Functional phenotyping of successful aging in long-term memory: Preserved performance in the absence of neural compensationEmrah Duzel
Institute of Cognitive Neurology and Dementia Research, Otto von Guericke Universitat Magdeburg, Germany
Hippocampus 21:803-14. 2011..Thus, for some individuals successful aging in long-term memory reflects the preservation of a functionally specific memory network, and can occur in the absence of compensatory brain activity... 
Anticipation of novelty recruits reward system and hippocampus while promoting recollectionBianca C Wittmann
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, UK
Neuroimage 38:194-202. 2007..In more general terms, the data suggest that dopaminergic processing of novelty might be important in driving exploration of new environments...- NOvelty-related motivation of anticipation and exploration by dopamine (NOMAD): implications for healthy agingEmrah Duzel
Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17 Queen Square, London WC1N 3AR, UK
Neurosci Biobehav Rev 34:660-9. 2010..We propose that maximizing the use of this mechanism by maintaining mobility and exploration of novel environments could be a potential mechanism to slow age-related decline of memory... - Functional imaging of the human dopaminergic midbrainEmrah Duzel
Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC13 NAR, UK
Trends Neurosci 32:321-8. 2009..We outline how systematic investigation of the functional parcellation of the SN/VTA in animals, new developments in fMRI analysis and combined PET-fMRI studies can narrow the gap between fMRI and dopaminergic neurotransmission... - Synchronization of medial temporal lobe and prefrontal rhythms in human decision makingMarc Guitart-Masip
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom, Institute of Cognitive Neuroscience, University College London, London W1CN 4AR, United Kingdom, Institute of Neurology, University College London, London W1CN 3BG, United Kingdom, and Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University and German Center for Neurodegenerative Diseases DZNE, 39120 Magdeburg, Germany
J Neurosci 33:442-51. 2013..Our results indicate a mnemonic guidance of human decision making, beyond anticipation of expected reward, is supported by hippocampal-prefrontal theta synchronization... - Dopamine modulates episodic memory persistence in old ageRumana Chowdhury
Institute of Cognitive Neuroscience, University College London, London, WC1N 3AR, United Kingdom
J Neurosci 32:14193-204. 2012..This lasting improvement even for weakly encoded events supports a role for dopamine in human episodic memory consolidation, albeit operating within a narrow dose range... - Go and no-go learning in reward and punishment: interactions between affect and effectMarc Guitart-Masip
Institute of Cognitive Neuroscience, University College London, London, W1CN 4AR, UK
Neuroimage 62:154-66. 2012.... - Action controls dopaminergic enhancement of reward representationsMarc Guitart-Masip
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
Proc Natl Acad Sci U S A 109:7511-6. 2012..These findings highlight a key role for dopamine in the generation of appetitively motivated actions... - Theta-coupled periodic replay in working memoryLluis Fuentemilla
Institute of Cognitive Neuroscience, University College London, London, UK
Curr Biol 20:606-12. 2010..By confirming the predictions of a mechanistic model and linking these to behavioral performance in humans, these findings identify theta-coupled replay as a mechanism of working memory maintenance... 
Mesolimbic novelty processing in older adultsNico Bunzeck
Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17 Queen Square, London, WC1N 3AR, UK
Cereb Cortex 17:2940-8. 2007....- An MEG signature corresponding to an axiomatic model of reward prediction errorDeborah Talmi
Wellcome Trust Centre for Neuroimaging, UCL, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 59:635-45. 2012..Our findings motivate an explicit examination of the critical issue of timing embodied in computational models of prediction errors as seen in human electrophysiological data... - Action dominates valence in anticipatory representations in the human striatum and dopaminergic midbrainMarc Guitart-Masip
Institute of Cognitive Neuroscience, University College London, London, W1CN 4AR, United Kingdom
J Neurosci 31:7867-75. 2011..This dominant influence of action requires an enriched notion of opponency between reward and punishment... - Mesolimbic interaction of emotional valence and reward improves memory formationBianca C Wittmann
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuropsychologia 46:1000-8. 2008.... - Vigor in the face of fluctuating rates of reward: an experimental examinationMarc Guitart-Masip
University College London, 17 Queen Square, London, WC1N 3AR, United Kingdom
J Cogn Neurosci 23:3933-8. 2011..This validates one of the key proposals associated with the model, illuminating an apparently mandatory form of coupling that may involve tonic levels of dopamine... - Neural generators of sustained activity differ for stimulus-encoding and delay maintenanceUlrike Malecki
Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University, Magdeburg, Germany
Eur J Neurosci 30:924-33. 2009.... - Reward motivation accelerates the onset of neural novelty signals in humans to 85 millisecondsNico Bunzeck
UCL Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
Curr Biol 19:1294-300. 2009..Thus, under the contextual influence of reward motivation, behaviorally relevant novelty signals emerge much faster than previously held possible in humans... - Contextual novelty changes reward representations in the striatumMarc Guitart-Masip
Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
J Neurosci 30:1721-6. 2010..These findings support a view that contextual novelty enhances neural responses underlying reward representation in the striatum and concur with the effects of novelty processing as predicted by the model of Lisman and Grace (2005)... - The hippocampus and dopaminergic midbrain: old couple, new insightsDharshan Kumaran
Wellcome Trust Centre for Neuroimaging, London, UK
Neuron 60:197-200. 2008..In this issue of Neuron, Shohamy and Wagner reveal how generalizations naturally emerge during associative learning through a partnership between putatively dopaminergic circuitry in the midbrain and the hippocampus... - The emergence and representation of knowledge about social and nonsocial hierarchiesDharshan Kumaran
Institute of Cognitive Neuroscience, University College London, 17 Queen Square, WC1N 3AR, UK
Neuron 76:653-66. 2012..Our study implicates the amygdala in the emergence and representation of knowledge about social hierarchies and distinguishes the domain-general contribution of the hippocampus... - Integrated Bayesian models of learning and decision making for saccadic eye movementsKay H Brodersen
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neural Netw 21:1247-60. 2008.... - A common mechanism for adaptive scaling of reward and noveltyNico Bunzeck
Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
Hum Brain Mapp 31:1380-94. 2010..These findings demonstrate a new mechanism for adjusting gain and sensitivity in declarative memory in accordance with contextual probabilities and expectancies of future events... - Behavioral specifications of reward-associated long-term memory enhancement in humansBianca C Wittmann
Wellcome Trust Centre for Neuroimaging, University College London, London, UK
Learn Mem 18:296-300. 2011..These behavioral specifications are relevant for the functional interpretation of how reward-related activation of the SN/VTA, and more generally dopaminergic neuromodulation, contribute to long-term memory... - The effect of item sequence on brain activity during recognition memoryEmrah Duzel
Department of Neurology II, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Brain Res Cogn Brain Res 13:115-27. 2002..Due to these sequence effects, the present data question the assumption that random-mixed designs are generally favorable over block designs... - A rapid, hippocampus-dependent, item-memory signal that initiates context memory in humansAidan J Horner
Institute of Cognitive Neuroscience, University College London, London, UK
Curr Biol 22:2369-74. 2012..Our results reconcile contradictory evidence concerning hippocampal involvement in item memory and show that hippocampus-dependent mnemonic processes are more rapid than previously believed...