Emrah Duzel

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Brain oscillations and memory
    Emrah Duzel
    UCL Institute of Cognitive Neuroscience, University College London, WC1N 3AR London, United Kingdom
    Curr Opin Neurobiol 20:143-9. 2010
  2. doi request reprint Functional phenotyping of successful aging in long-term memory: Preserved performance in the absence of neural compensation
    Emrah Duzel
    Institute of Cognitive Neurology and Dementia Research, Otto von Guericke Universitat Magdeburg, Germany
    Hippocampus 21:803-14. 2011
  3. doi request reprint NOvelty-related motivation of anticipation and exploration by dopamine (NOMAD): implications for healthy aging
    Emrah Duzel
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17 Queen Square, London WC1N 3AR, UK
    Neurosci Biobehav Rev 34:660-9. 2010
  4. doi request reprint Functional imaging of the human dopaminergic midbrain
    Emrah Duzel
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC13 NAR, UK
    Trends Neurosci 32:321-8. 2009
  5. pmc Anticipation of novelty recruits reward system and hippocampus while promoting recollection
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, UK
    Neuroimage 38:194-202. 2007
  6. pmc Synchronization of medial temporal lobe and prefrontal rhythms in human decision making
    Marc Guitart-Masip
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 33:442-51. 2013
  7. pmc Dopamine modulates episodic memory persistence in old age
    Rumana Chowdhury
    Institute of Cognitive Neuroscience, University College London, London, WC1N 3AR, United Kingdom
    J Neurosci 32:14193-204. 2012
  8. pmc Go and no-go learning in reward and punishment: interactions between affect and effect
    Marc Guitart-Masip
    Institute of Cognitive Neuroscience, University College London, London, W1CN 4AR, UK
    Neuroimage 62:154-66. 2012
  9. pmc Population level inference for multivariate MEG analysis
    Anna Jafarpour
    Institute of Cognitive Neuroscience, University College London, London, United Kingdom
    PLoS ONE 8:e71305. 2013
  10. ncbi request reprint Category-specific organization of prefrontal response-facilitation during priming
    Nico Bunzeck
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC1N 3AR, UK
    Neuropsychologia 44:1765-76. 2006

Detail Information

Publications37

  1. doi request reprint Brain oscillations and memory
    Emrah Duzel
    UCL Institute of Cognitive Neuroscience, University College London, WC1N 3AR London, United Kingdom
    Curr Opin Neurobiol 20:143-9. 2010
    ..This correspondence between species opens new perspectives for a mechanistic investigation of human memory function...
  2. doi request reprint Functional phenotyping of successful aging in long-term memory: Preserved performance in the absence of neural compensation
    Emrah Duzel
    Institute of Cognitive Neurology and Dementia Research, Otto von Guericke Universitat Magdeburg, Germany
    Hippocampus 21:803-14. 2011
    ..Thus, for some individuals successful aging in long-term memory reflects the preservation of a functionally specific memory network, and can occur in the absence of compensatory brain activity...
  3. doi request reprint NOvelty-related motivation of anticipation and exploration by dopamine (NOMAD): implications for healthy aging
    Emrah Duzel
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17 Queen Square, London WC1N 3AR, UK
    Neurosci Biobehav Rev 34:660-9. 2010
    ..We propose that maximizing the use of this mechanism by maintaining mobility and exploration of novel environments could be a potential mechanism to slow age-related decline of memory...
  4. doi request reprint Functional imaging of the human dopaminergic midbrain
    Emrah Duzel
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC13 NAR, UK
    Trends Neurosci 32:321-8. 2009
    ..We outline how systematic investigation of the functional parcellation of the SN/VTA in animals, new developments in fMRI analysis and combined PET-fMRI studies can narrow the gap between fMRI and dopaminergic neurotransmission...
  5. pmc Anticipation of novelty recruits reward system and hippocampus while promoting recollection
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, UK
    Neuroimage 38:194-202. 2007
    ..In more general terms, the data suggest that dopaminergic processing of novelty might be important in driving exploration of new environments...
  6. pmc Synchronization of medial temporal lobe and prefrontal rhythms in human decision making
    Marc Guitart-Masip
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 33:442-51. 2013
    ..Our results indicate a mnemonic guidance of human decision making, beyond anticipation of expected reward, is supported by hippocampal-prefrontal theta synchronization...
  7. pmc Dopamine modulates episodic memory persistence in old age
    Rumana Chowdhury
    Institute of Cognitive Neuroscience, University College London, London, WC1N 3AR, United Kingdom
    J Neurosci 32:14193-204. 2012
    ..This lasting improvement even for weakly encoded events supports a role for dopamine in human episodic memory consolidation, albeit operating within a narrow dose range...
  8. pmc Go and no-go learning in reward and punishment: interactions between affect and effect
    Marc Guitart-Masip
    Institute of Cognitive Neuroscience, University College London, London, W1CN 4AR, UK
    Neuroimage 62:154-66. 2012
    ....
  9. pmc Population level inference for multivariate MEG analysis
    Anna Jafarpour
    Institute of Cognitive Neuroscience, University College London, London, United Kingdom
    PLoS ONE 8:e71305. 2013
    ..We illustrate the method by identifying feature sets based on variable-dimension MEG power spectra in the primary visual cortex and fusiform gyrus that are maximally discriminative of data epochs before versus after visual stimulation. ..
  10. ncbi request reprint Category-specific organization of prefrontal response-facilitation during priming
    Nico Bunzeck
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC1N 3AR, UK
    Neuropsychologia 44:1765-76. 2006
    ..These data reveal that response-facilitation in prefrontal cortex is organized according to stimulus-properties, compatible with learning of stimulus-response mapping rather than response learning in general...
  11. pmc Dopamine restores reward prediction errors in old age
    Rumana Chowdhury
    Institute of Cognitive Neuroscience, University College London, London, UK
    Nat Neurosci 16:648-53. 2013
    ..This drug effect was linked to restoration of a canonical neural RPE. Our results identify a neurochemical signature underlying abnormal reward processing in older adults and indicate that this can be modulated by L-DOPA...
  12. pmc Action controls dopaminergic enhancement of reward representations
    Marc Guitart-Masip
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 109:7511-6. 2012
    ..These findings highlight a key role for dopamine in the generation of appetitively motivated actions...
  13. pmc Theta-coupled periodic replay in working memory
    Lluis Fuentemilla
    Institute of Cognitive Neuroscience, University College London, London, UK
    Curr Biol 20:606-12. 2010
    ..By confirming the predictions of a mechanistic model and linking these to behavioral performance in humans, these findings identify theta-coupled replay as a mechanism of working memory maintenance...
  14. pmc Structural integrity of the substantia nigra and subthalamic nucleus predicts flexibility of instrumental learning in older-age individuals
    Rumana Chowdhury
    Institute of Cognitive Neuroscience, University College London, London, UK Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neurobiol Aging 34:2261-70. 2013
    ..We show that interindividual variability among healthy older adults of the structural integrity within the SN/VTA and subthalamic nucleus relates to effective acquisition of competing instrumental responses. ..
  15. pmc Parcellation of the human substantia nigra based on anatomical connectivity to the striatum
    Rumana Chowdhury
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK
    Neuroimage 81:191-8. 2013
    ....
  16. doi request reprint Alleviating memory impairment through distraction
    Nathan Cashdollar
    Institute of Neurology and National Hospital for Neurology and Neurosurgery, University College London, London WC1N 3BG, United Kingdom, Institute for Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom, Center for Mind Brain Sciences, University of Trento, Trento, Italy 38060, Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University, Magdeburg, Germany 39120, and German Centre for Neurodegenerative Diseases, Magdeburg, Germany 39120
    J Neurosci 33:19012-22. 2013
    ..Our results highlight circumstances where active memory rehearsal may paradoxically increase memory impairments and distraction alleviates these memory deficits in patients with hippocampal injury and healthy adults. ..
  17. ncbi request reprint Absolute coding of stimulus novelty in the human substantia nigra/VTA
    Nico Bunzeck
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC1N 3AR, United Kingdom
    Neuron 51:369-79. 2006
    ..Thus, the human SN/VTA can code absolute stimulus novelty and might contribute to enhancing learning in the context of novelty...
  18. ncbi request reprint Mesolimbic novelty processing in older adults
    Nico Bunzeck
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17 Queen Square, London, WC1N 3AR, UK
    Cereb Cortex 17:2940-8. 2007
    ....
  19. pmc An MEG signature corresponding to an axiomatic model of reward prediction error
    Deborah Talmi
    Wellcome Trust Centre for Neuroimaging, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 59:635-45. 2012
    ..Our findings motivate an explicit examination of the critical issue of timing embodied in computational models of prediction errors as seen in human electrophysiological data...
  20. pmc Action dominates valence in anticipatory representations in the human striatum and dopaminergic midbrain
    Marc Guitart-Masip
    Institute of Cognitive Neuroscience, University College London, London, W1CN 4AR, United Kingdom
    J Neurosci 31:7867-75. 2011
    ..This dominant influence of action requires an enriched notion of opponency between reward and punishment...
  21. pmc Replay of very early encoding representations during recollection
    Anna Jafarpour
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom Institute of Cognitive Neurology and Dementia Research, Medizinische Fakultat, 39120 Magdeburg Otto von Guericke, Germany Cognition and Brain Plasticity Unit, Institute of Biomedicine Research of Bellvitge, Hospital Duran i Reynals, 08908 Hospitalet de Llobregat, Barcelona, Spain Department of Basic Psychology, University of Barcelona, Secretaria 08035 Barcelona, Spain and Institute of Neurology and Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 34:242-8. 2014
    ..These novel insights into the nature of the memory engram provide constraints for mechanistic models of long-term memory function...
  22. doi request reprint Mesolimbic interaction of emotional valence and reward improves memory formation
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuropsychologia 46:1000-8. 2008
    ....
  23. pmc DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, University College London, London, WC1N 3BG, UK Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA Department of Psychology, University of Giessen, 35394 Giessen, Germany Electronic address
    Neuropsychologia 51:2184-93. 2013
    ..In accordance with animal studies, these data support the idea that encoding of motivational events depends on dopaminergic processes in the hippocampus. ..
  24. doi request reprint Vigor in the face of fluctuating rates of reward: an experimental examination
    Marc Guitart-Masip
    University College London, 17 Queen Square, London, WC1N 3AR, United Kingdom
    J Cogn Neurosci 23:3933-8. 2011
    ..This validates one of the key proposals associated with the model, illuminating an apparently mandatory form of coupling that may involve tonic levels of dopamine...
  25. doi request reprint Neural generators of sustained activity differ for stimulus-encoding and delay maintenance
    Ulrike Malecki
    Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University, Magdeburg, Germany
    Eur J Neurosci 30:924-33. 2009
    ....
  26. doi request reprint The hippocampus and dopaminergic midbrain: old couple, new insights
    Dharshan Kumaran
    Wellcome Trust Centre for Neuroimaging, London, UK
    Neuron 60:197-200. 2008
    ..In this issue of Neuron, Shohamy and Wagner reveal how generalizations naturally emerge during associative learning through a partnership between putatively dopaminergic circuitry in the midbrain and the hippocampus...
  27. pmc Reward motivation accelerates the onset of neural novelty signals in humans to 85 milliseconds
    Nico Bunzeck
    UCL Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Curr Biol 19:1294-300. 2009
    ..Thus, under the contextual influence of reward motivation, behaviorally relevant novelty signals emerge much faster than previously held possible in humans...
  28. pmc Contextual novelty changes reward representations in the striatum
    Marc Guitart-Masip
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
    J Neurosci 30:1721-6. 2010
    ..These findings support a view that contextual novelty enhances neural responses underlying reward representation in the striatum and concur with the effects of novelty processing as predicted by the model of Lisman and Grace (2005)...
  29. pmc The emergence and representation of knowledge about social and nonsocial hierarchies
    Dharshan Kumaran
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, WC1N 3AR, UK
    Neuron 76:653-66. 2012
    ..Our study implicates the amygdala in the emergence and representation of knowledge about social hierarchies and distinguishes the domain-general contribution of the hippocampus...
  30. pmc Integrated Bayesian models of learning and decision making for saccadic eye movements
    Kay H Brodersen
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neural Netw 21:1247-60. 2008
    ....
  31. pmc A common mechanism for adaptive scaling of reward and novelty
    Nico Bunzeck
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
    Hum Brain Mapp 31:1380-94. 2010
    ..These findings demonstrate a new mechanism for adjusting gain and sensitivity in declarative memory in accordance with contextual probabilities and expectancies of future events...
  32. ncbi request reprint Reprint of: DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, University College London, London, WC1N 3BG, UK Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA Department of Psychology, University of Giessen, 35394 Giessen, Germany Electronic address
    Neuropsychologia 51:2469-77. 2013
    ..In accordance with animal studies, these data support the idea that encoding of motivational events depends on dopaminergic processes in the hippocampus. ..
  33. pmc A rapid, hippocampus-dependent, item-memory signal that initiates context memory in humans
    Aidan J Horner
    Institute of Cognitive Neuroscience, University College London, London, UK
    Curr Biol 22:2369-74. 2012
    ..Our results reconcile contradictory evidence concerning hippocampal involvement in item memory and show that hippocampus-dependent mnemonic processes are more rapid than previously believed...
  34. pmc Behavioral specifications of reward-associated long-term memory enhancement in humans
    Bianca C Wittmann
    Wellcome Trust Centre for Neuroimaging, University College London, London, UK
    Learn Mem 18:296-300. 2011
    ..These behavioral specifications are relevant for the functional interpretation of how reward-related activation of the SN/VTA, and more generally dopaminergic neuromodulation, contribute to long-term memory...
  35. ncbi request reprint The effect of item sequence on brain activity during recognition memory
    Emrah Duzel
    Department of Neurology II, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Brain Res Cogn Brain Res 13:115-27. 2002
    ..Due to these sequence effects, the present data question the assumption that random-mixed designs are generally favorable over block designs...
  36. pmc Action versus valence in decision making
    Marc Guitart-Masip
    Aging Research Centre, Karolinska Institute, SE 11330 Stockholm, Sweden Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK Electronic address
    Trends Cogn Sci 18:194-202. 2014
    ..They also challenge existing views that neural representations in the striatum focus on valence, showing instead a dominance of the anticipation of action. ..
  37. doi request reprint Not so uncertain at last: locus coeruleus and decision making
    Emrah Duzel
    Institute of Cognitive Neuroscience, University College London, London, WC1N 3AR, UK
    Neuron 79:9-11. 2013
    ....