Omer Dushek

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint An induced rebinding model of antigen discrimination
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK Wolfson Centre for Mathematical Biology, University of Oxford, Oxford, UK Electronic address
    Trends Immunol 35:153-8. 2014
  2. pmc Elementary steps in T cell receptor triggering
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford Oxford, UK
    Front Immunol 2:91. 2011
  3. pmc Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Biophys J 100:1189-97. 2011
  4. doi request reprint Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Sci Signal 4:ra39. 2011
  5. pmc Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
    Hao Zhang
    The Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:19323-8. 2011
  6. pmc Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
    Milos Aleksic
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Immunity 32:163-74. 2010
  7. pmc Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity
    Himadri Mukhopadhyay
    Sir William Dunn School of Pathology, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS Comput Biol 9:e1003004. 2013
  8. doi request reprint Non-catalytic tyrosine-phosphorylated receptors
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, UK
    Immunol Rev 250:258-76. 2012
  9. doi request reprint Mechanisms for T cell receptor triggering
    P Anton van der Merwe
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Nat Rev Immunol 11:47-55. 2011
  10. pmc Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation
    Mariolina Salio
    Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 110:E4753-61. 2013

Collaborators

Detail Information

Publications12

  1. ncbi request reprint An induced rebinding model of antigen discrimination
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK Wolfson Centre for Mathematical Biology, University of Oxford, Oxford, UK Electronic address
    Trends Immunol 35:153-8. 2014
    ..Moreover, induced rebinding is able to reproduce the striking, and hitherto unexplained, 2D membrane-binding properties recently reported for the TCR. ..
  2. pmc Elementary steps in T cell receptor triggering
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford Oxford, UK
    Front Immunol 2:91. 2011
    ..Once these elementary steps are understood, they can be recombined to build a unified model of TCR triggering...
  3. pmc Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Biophys J 100:1189-97. 2011
    ..We propose a new role, to our knowledge, for multisite membrane-anchored proteins, discuss experiments that can be used to probe the model, and relate our findings to previous theoretical work...
  4. doi request reprint Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Sci Signal 4:ra39. 2011
    ..Thus, we propose that the activity of an antigen is determined by both its potency (EC50) and maximal efficacy (Emax)...
  5. pmc Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
    Hao Zhang
    The Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:19323-8. 2011
    ..This study reveals that tyrosine phosphorylation of the TCRζ cytoplasmic domain regulates its association with the plasma membrane and highlights the functional importance of TCRζ BRS motifs...
  6. pmc Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
    Milos Aleksic
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Immunity 32:163-74. 2010
    ..This confinement time model clarifies the role of k(on) in T cell activation and reconciles apparently contradictory reports on the role of TCR-pMHC binding kinetics and affinity in T cell activation...
  7. pmc Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity
    Himadri Mukhopadhyay
    Sir William Dunn School of Pathology, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS Comput Biol 9:e1003004. 2013
    ..We propose that highly regulated TCR phosphorylation is achieved by an emergent switch-like response and use the systems model to design novel chimeric antigen receptors for therapy...
  8. doi request reprint Non-catalytic tyrosine-phosphorylated receptors
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, UK
    Immunol Rev 250:258-76. 2012
    ....
  9. doi request reprint Mechanisms for T cell receptor triggering
    P Anton van der Merwe
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Nat Rev Immunol 11:47-55. 2011
    ....
  10. pmc Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation
    Mariolina Salio
    Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 110:E4753-61. 2013
    ..These results have important implications in understanding how to optimize lipid-loading onto antigen-presenting cells, to better harness iNKT cells central role at the interface between innate and adaptive immunity. ..
  11. pmc Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
    Konstantina Nika
    T Cell Signaling Laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Immunity 32:766-77. 2010
    ..Our findings suggest a dynamic regulation of Lck activity that can be promptly utilized to initiate T cell activation and have implications for signaling by other immune receptors...
  12. pmc Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation
    Mogjiborahman Salek
    T Cell Signaling Laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e77423. 2013
    ..Phosphorylation kinetics data resulting from this investigation is documented in a database (phosphoTCR) accessible online. The MS data have been deposited to the ProteomeXchange with identifier PXD000341. ..