Omer Dushek

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Biophys J 100:1189-97. 2011
  2. ncbi Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Sci Signal 4:ra39. 2011
  3. ncbi Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
    Hao Zhang
    The Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:19323-8. 2011
  4. ncbi Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
    Milos Aleksic
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Immunity 32:163-74. 2010
  5. ncbi Mechanisms for T cell receptor triggering
    P Anton van der Merwe
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Nat Rev Immunol 11:47-55. 2011
  6. ncbi Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
    Konstantina Nika
    T Cell Signaling Laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Immunity 32:766-77. 2010
  7. ncbi Non-catalytic tyrosine-phosphorylated receptors
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, UK
    Immunol Rev 250:258-76. 2012

Collaborators

Detail Information

Publications7

  1. ncbi Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Biophys J 100:1189-97. 2011
    ..We propose a new role, to our knowledge, for multisite membrane-anchored proteins, discuss experiments that can be used to probe the model, and relate our findings to previous theoretical work...
  2. ncbi Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Sci Signal 4:ra39. 2011
    ..Thus, we propose that the activity of an antigen is determined by both its potency (EC50) and maximal efficacy (Emax)...
  3. ncbi Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
    Hao Zhang
    The Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:19323-8. 2011
    ..This study reveals that tyrosine phosphorylation of the TCRζ cytoplasmic domain regulates its association with the plasma membrane and highlights the functional importance of TCRζ BRS motifs...
  4. ncbi Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
    Milos Aleksic
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Immunity 32:163-74. 2010
    ..This confinement time model clarifies the role of k(on) in T cell activation and reconciles apparently contradictory reports on the role of TCR-pMHC binding kinetics and affinity in T cell activation...
  5. ncbi Mechanisms for T cell receptor triggering
    P Anton van der Merwe
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Nat Rev Immunol 11:47-55. 2011
    ....
  6. ncbi Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
    Konstantina Nika
    T Cell Signaling Laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Immunity 32:766-77. 2010
    ..Our findings suggest a dynamic regulation of Lck activity that can be promptly utilized to initiate T cell activation and have implications for signaling by other immune receptors...
  7. ncbi Non-catalytic tyrosine-phosphorylated receptors
    Omer Dushek
    Sir William Dunn School of Pathology, University of Oxford, UK
    Immunol Rev 250:258-76. 2012
    ....