S B Dunnett

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Medial prefrontal and neostriatal lesions disrupt performance in an operant delayed alternation task in rats
    S B Dunnett
    MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, UK
    Behav Brain Res 106:13-28. 1999
  2. ncbi request reprint Basic neural transplantation techniques. I. Dissociated cell suspension grafts of embryonic ventral mesencephalon in the adult rat brain
    S B Dunnett
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Res Brain Res Protoc 1:91-9. 1997
  3. ncbi request reprint A lateralised grip strength test to evaluate unilateral nigrostriatal lesions in rats
    S B Dunnett
    MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, UK
    Neurosci Lett 246:1-4. 1998
  4. ncbi request reprint Repair of the damaged brain. The Alfred Meyer Memorial Lecture 1998
    S B Dunnett
    University of Cambridge, Cambridge, UK
    Neuropathol Appl Neurobiol 25:351-62. 1999
  5. ncbi request reprint Effects of surgical anaesthesia on the viability of nigral grafts in the rat striatum
    S B Dunnett
    MRC Cambridge Centre for Brain Repair, and the Department of Experimental Psychology, University of Cambridge, UK
    Cell Transplant 7:567-72. 1998
  6. ncbi request reprint Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease
    R J Armstrong
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Cell Transplant 9:55-64. 2000
  7. ncbi request reprint Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease
    C Watts
    MRC Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    Exp Neurol 163:85-97. 2000
  8. ncbi request reprint Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activation
    C B Hurelbrink
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Exp Neurol 171:46-58. 2001
  9. ncbi request reprint Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease
    C B Hurelbrink
    Cambridge Centre for Brain Repair, University of Cambridge, UK
    Cell Transplant 9:743-9. 2000
  10. ncbi request reprint Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers
    P J Brasted
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Res Bull 46:487-93. 1998

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Medial prefrontal and neostriatal lesions disrupt performance in an operant delayed alternation task in rats
    S B Dunnett
    MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, UK
    Behav Brain Res 106:13-28. 1999
    ..We conclude that the operant delayed alternation task should assist analysis of fronto-striatal function in rats as well as be useful for the analysis of strategies for fronto-striatal repair...
  2. ncbi request reprint Basic neural transplantation techniques. I. Dissociated cell suspension grafts of embryonic ventral mesencephalon in the adult rat brain
    S B Dunnett
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Res Brain Res Protoc 1:91-9. 1997
    ..This is the first of a series of methodological reports on the basic methodology and refinements of neural transplantation techniques in the mammalian central nervous system...
  3. ncbi request reprint A lateralised grip strength test to evaluate unilateral nigrostriatal lesions in rats
    S B Dunnett
    MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, UK
    Neurosci Lett 246:1-4. 1998
    ..The lateralised nature of the deficit excludes explanation based on global activational changes; rather the unilateral deficit may provide a simple test of unilateral 'rigidity' in a widely used rodent model of Parkinson's disease...
  4. ncbi request reprint Repair of the damaged brain. The Alfred Meyer Memorial Lecture 1998
    S B Dunnett
    University of Cambridge, Cambridge, UK
    Neuropathol Appl Neurobiol 25:351-62. 1999
    ....
  5. ncbi request reprint Effects of surgical anaesthesia on the viability of nigral grafts in the rat striatum
    S B Dunnett
    MRC Cambridge Centre for Brain Repair, and the Department of Experimental Psychology, University of Cambridge, UK
    Cell Transplant 7:567-72. 1998
    ..We therefore conclude that anaesthesia per se is not a major contributory factor in the relatively poor survival of dopamine neurons following transplantation into the rat striatum...
  6. ncbi request reprint Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease
    R J Armstrong
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Cell Transplant 9:55-64. 2000
    ..This study supports the contention that propagated human neural precursors may ultimately be of use in therapeutic neural transplantation paradigms for diseases such as Huntington's disease...
  7. ncbi request reprint Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease
    C Watts
    MRC Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    Exp Neurol 163:85-97. 2000
    ..These results suggest that MGE tissue as well as LGE plays a role in the structural and functional integration of striatal grafts...
  8. ncbi request reprint Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activation
    C B Hurelbrink
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Exp Neurol 171:46-58. 2001
    ..This implies that strategies to improve dopaminergic cell survival in clinical programmes of transplantation for PD will need to target other pathways of cell death...
  9. ncbi request reprint Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease
    C B Hurelbrink
    Cambridge Centre for Brain Repair, University of Cambridge, UK
    Cell Transplant 9:743-9. 2000
    ..This has important implications for the practical implementation of clinical neural transplant programs in HD...
  10. ncbi request reprint Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers
    P J Brasted
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Res Bull 46:487-93. 1998
    ..Rather, the pattern of reaction time deficit after striatal lesions depends critically on the apparatus used and the precise response requirements for each task...
  11. ncbi request reprint Fetal porcine dopaminergic cell survival in vitro and its relationship to embryonic age
    R A Barker
    MRC Cambridge Centre for Brain Repair, UK
    Cell Transplant 8:593-9. 1999
    ..E26-E27 embryos gave the highest yield of such cells at both survival time points, suggesting that this will be the optimal age for harvesting tissues whether for experimental or clinical nigral xenograft programs...
  12. ncbi request reprint The morphological development of neurons derived from EGF- and FGF-2-driven human CNS precursors depends on their site of integration in the neonatal rat brain
    A E Rosser
    Cambridge Centre for Brain Repair, Cambridge, UK
    Eur J Neurosci 12:2405-13. 2000
    ..This is important for the application of such cells in CNS repair strategies, in particular neural transplantation...
  13. ncbi request reprint Volume and differentiation of striatal grafts in rats: relationship to the number of cells implanted
    C Watts
    MRC Cambridge Centre for Brain Repair, and the Department of Neurosurgery, University of Cambridge, UK
    Cell Transplant 9:65-72. 2000
    ..These results have important practical implications in determining the optimum number of LGE cells to implant and hence in the design of any surgical protocol for the clinical application of this technique...
  14. ncbi request reprint The morphology, integration, and functional efficacy of striatal grafts differ between cell suspensions and tissue pieces
    C Watts
    MRC Cambridge Centre for Brain Repair, Department of Neurosurgery, University of Cambridge, UK
    Cell Transplant 9:395-407. 2000
    ..No relationship was observed between functional effect and the graft anatomy. These results suggest that local graft host interaction may also be involved in graft-mediated functional recovery...
  15. ncbi request reprint Functional integration of striatal allografts in a primate model of Huntington's disease
    A L Kendall
    Department of Experimental Psychology and the MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Nat Med 4:727-9. 1998
    ..Long-term graft survival in primates indicates probable success for clinical transplants in Huntington's disease; in addition, our data suggest that graft placement has a direct influence on the pattern and extent of functional recovery...
  16. ncbi request reprint The influence of excitotoxic basal ganglia lesions on motor performance in the common marmoset
    A L Kendall
    Department of Experimental Psychology and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Brain 123:1442-58. 2000
    ..The stability and the reproducibility of the unilateral putamen lesion in the marmoset provide a suitable tool for the investigation of potential treatments for neurodegenerative disorders that attack this region of the brain...
  17. ncbi request reprint Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells
    A E Rosser
    MRC Cambridge Centre for Brain Repair, Cambridge University Forvie Site, UK
    Brain Res Dev Brain Res 98:291-5. 1997
    ..Thus, certain critical signals important for full neuronal differentiation may be missing from this system...
  18. ncbi request reprint Porcine neural xenografts in the immunocompetent rat: immune response following grafting of expanded neural precursor cells
    R J Armstrong
    Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Neuroscience 106:201-16. 2001
    ..The implications of these findings in the development of novel xenogeneic cellular therapies for neurodegenerative conditions such as Parkinson's disease are discussed...
  19. ncbi request reprint Towards a protocol for the preparation and delivery of striatal tissue for clinical trials of transplantation in Huntington's disease
    C Watts
    MRC Cambridge Centre for Brain Repair, Department of Neurosurgery, University of Cambridge, UK
    Cell Transplant 9:223-34. 2000
    ..Strategies aimed at minimizing the variability of tissue preparation should reduce the variability of functional outcome of striatal transplantation observed in animal models of Huntington's disease...
  20. ncbi request reprint Striatal grafts alleviate deficits in response execution in a lateralised reaction time task
    M D Döbrössy
    MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, UK
    Brain Res Bull 47:585-93. 1998
    ..Control grafts of cortical tissues also increased task accuracy and reduced the ipsilateral bias in responding, but were without effect on the RT deficit...
  21. ncbi request reprint Unilateral striatal lesions impair response execution on a lateralised choice reaction time task
    M D Döbrössy
    MRC Cambridge Centre for Brain Repair, UK
    Behav Brain Res 87:159-71. 1997
    ..Conversely, striatal lesions induce lateralised defects in executive, rather than sensory, processes, and impair the animals' ability to execute movement towards the contralateral side...
  22. ncbi request reprint Antioxidant strategy to counteract the side effects of antipsychotic therapy: an in vivo study in rats
    L Besret
    Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Eur J Pharmacol 408:35-9. 2000
    ..Moreover, the current study has shown the effect of the antioxidant vitamin C in protecting haloperidol effects on tyrosine hydroxylase-immunostaining...
  23. ncbi request reprint Neural transplantation in Huntington's disease: the NEST-UK donor tissue microbiological screening program and review of the literature
    M Farrington
    Clinical Microbiology and Public Health Laboratory, Health Protection Agency and Addenbrooke s Hospital, Cambridge, UK
    Cell Transplant 15:279-94. 2006
    ..This article therefore presents a comprehensive, logical yet pragmatic screening program that could be employed in any clinical studies that use human fetal tissue for neurotransplantation...
  24. ncbi request reprint Latency associated promoter transgene expression in the central nervous system after stereotaxic delivery of replication-defective HSV-1-based vectors
    C G Scarpini
    Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK
    Gene Ther 8:1057-71. 2001
    ....
  25. ncbi request reprint Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection
    C Baunez
    Department of Experimental Psychology, University of Cambridge, CB2 3EB Cambridge, UK
    Eur J Neurosci 13:1609-16. 2001
    ..Together, these results suggest that the STN plays an important role in response preparatory processes, including response selection and inhibitory control processes...
  26. ncbi request reprint Motor coordination and balance in rodents
    R J Carter
    University of Cambridge, Cambridge, United Kingdom
    Curr Protoc Neurosci . 2001
    ..The protocols are described in the primary context of testing mice, but modifications of the test apparatus or variations in the test parameters for assessment of rats are noted...
  27. pmc Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology
    S J Richards
    MRC Molecular Genetics Unit, Cambridge, UK
    EMBO J 10:297-303. 1991
    ..Similarly, a population of grafted cells were positively stained following incubation with an antiserum raised against components of the pathological neurofibrillary tangle and with the monoclonal antibodies Tau 6.423 and ubiquitin...
  28. ncbi request reprint Myelination and behaviour of tenascin-C null transgenic mice
    B W Kiernan
    Wellcome CRC Institute of Developmental Biology and Cancer, Cambridge, UK
    Eur J Neurosci 11:3082-92. 1999
    ..The effects on coordination are, however, not seen on a 129 genetic background. Taken together, these results significantly extend the phenotype associated with tenascin-C deficiency but argue against a role in myelination...
  29. ncbi request reprint Complement regulatory proteins are expressed at low levels in embryonic human, wild type and transgenic porcine neural tissue
    T P Harrower
    Cambridge Centre for Brain Repair, Forvie Site, Robinson, Cambridge, UK
    Xenotransplantation 11:60-71. 2004
    ..Thus alternative approaches to reducing complement activation by xenografted neural foetal tissue will be required if this process proves to be important in the rejection process...
  30. ncbi request reprint Training specificity, graft development and graft-mediated functional recovery in a rodent model of Huntington's disease
    M D Döbrössy
    Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    Neuroscience 132:543-52. 2005
    ..The results support the hypothesis that unilateral training sensitizes the striatum that subserves the motor learning, leading to exacerbated excitotoxic lesions and to an environment less conducive for graft development...
  31. ncbi request reprint The expression of Huntingtin-associated protein (HAP1) mRNA in developing, adult and ageing rat CNS: implications for Huntington's disease neuropathology
    K J Page
    The MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, UK
    Eur J Neurosci 10:1835-45. 1998
    ..These observations support the suggestion that HAP1 plays an important role in the neuropathology of HD...
  32. ncbi request reprint The role of pretraining on skilled forelimb use in an animal model of Huntington's disease
    R A Fricker-Gates
    Brain Repair Group, School of Biosciences, Cardiff University, Wales, UK
    Cell Transplant 12:257-64. 2003
    ..These results suggest that animals should be pretrained on the staircase task prior to lesion to enable maximum sensitivity in detecting both loss and recovery of function of skilled forelimb use...
  33. ncbi request reprint Staging and preparation of human fetal striatal tissue for neural transplantation in Huntington's disease
    A E Rosser
    School of Biosciences, Cardiff University, PO Box 911, Museum Av, Cardiff CF10 3US, Wales, UK
    Cell Transplant 12:679-86. 2003
    ....
  34. pmc Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475
    A E Rosser
    School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
    J Neurol Neurosurg Psychiatry 73:678-85. 2002
    ....
  35. ncbi request reprint Alpha Gal is widely expressed in embryonic porcine stem cells and neural tissue
    T P Harrower
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Neuroreport 13:481-5. 2002
    ..This study demonstrates that alphaGal expression is extensive in embryonic porcine neural cells and will be of relevance to any clinical trials using this tissue...
  36. ncbi request reprint Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease
    S P Brooks
    Cardiff University, Schools of Biological Sciences, Museum Avenue, PO Box 911, Cardiff CF10 3US, Wales, UK
    Brain Res Bull 69:452-7. 2006
    ....
  37. ncbi request reprint Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease
    A Hodges
    Department of Psychological Medicine, Wales School of Medicine, Cardiff University, Cardiff, United Kingdom
    Genes Brain Behav 7:288-99. 2008
    ..This indicates that multiple behavioral tasks assessing different behavioral domains are likely to be necessary in therapeutic trials in mouse models of HD...
  38. ncbi request reprint Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons
    V Echeverria
    Department of Pharmacology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Neuroscience 129:583-92. 2004
    ....