Research Topics
| S P DunhamSummaryAffiliation: University of Glasgow Country: UK Publications
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Detail Information
Publications
Retroviral infections of small animalsStephen P Dunham
Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Faculty of Veterinary Medicine, Bearsden Road, Glasgow, G61 1QH, UK
Vet Clin North Am Small Anim Pract 38:879-901, ix. 2008..The seeming lack of a recognized retrovirus infection in dogs is speculated on, and current and potential future therapies are discussed...
Prime-boost vaccination using DNA and whole inactivated virus vaccines provides limited protection against virulent feline immunodeficiency virusStephen P Dunham
Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
Vaccine 24:7095-108. 2006..Therefore both DNA and WIV vaccines conferred limited protection against viral challenge but the combination of WIV and DNA in a prime-boost approach appeared to offer no significant advantage over either vaccine alone...
Lessons from the cat: development of vaccines against lentivirusesStephen P Dunham
Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
Vet Immunol Immunopathol 112:67-77. 2006..This review highlights some of the difficulties associated with the development of lentiviral vaccines and some of the lessons that have been learned in the FIV model that are of particular relevance to the development of HIV vaccines...
Isolation, expression and bioactivity of feline granulocyte-macrophage colony-stimulating factorStephen P Dunham
Department of Veterinary Pathology, Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
Gene 332:97-106. 2004..The availability of the recombinant cytokine will permit further studies, in particular, the evaluation of the role of dendritic cells in feline immunopathology and its potential as a vaccine adjuvant...
The application of nucleic acid vaccines in veterinary medicineStephen P Dunham
Department of Veterinary Pathology, Retrovirus Research Laboratory, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
Res Vet Sci 73:9-16. 2002....
Protection against feline immunodeficiency virus using replication defective proviral DNA vaccines with feline interleukin-12 and -18Stephen P Dunham
Retrovirus Research Laboratory, Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
Vaccine 20:1483-96. 2002..This study suggests that while our current DNA vaccines may not produce sterilizing immunity against more virulent isolates of FIV, they may nevertheless significantly reduce the impact of infection...
Isolation, nucleotide sequence and expression of a cDNA encoding feline granulocyte colony-stimulating factorS P Dunham
Department of Veterinary Pathology, University of Glasgow, Bearsden Road, G61 1QH, UK
Cytokine 14:347-51. 2001..Biological activity of the recombinant protein was demonstrated using the murine myeloblastic cell line GNFS-60, which showed an ED50 for fG-CSF of approximately 2 ng/ml...
The cloning and sequencing of cDNAs encoding two isoforms of feline stem cell factorS P Dunham
Department of Veterinary Pathology, University of Glasgow Veterinary School, U K
DNA Seq 6:233-7. 1996..The cDNAs encode a predicted full length fSCF protein of 274 amino-acids and a shorter isoform of 246 amino acids. Feline SCF shows a high degree of homology to the SCFs of other species at both the nucleic acid and protein level...
Limited efficacy of an inactivated feline immunodeficiency virus vaccineS P Dunham
Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH
Vet Rec 158:561-2. 2006
The isolation and sequence of canine interleukin-2S P Dunham
Department of Veterinary Pathology, University of Glasgow Veterinary School, UK
DNA Seq 5:177-80. 1995..The derived protein shows 90, 86, 85, 76 and 75% similarity to feline, human, equine, murine and bovine IL-2 homologs...
Longitudinal analysis of feline leukemia virus-specific cytotoxic T lymphocytes: correlation with recovery from infectionJ Norman Flynn
Retrovirus Research Laboratory, Department of Veterinary Pathology, University of Glasgow, Bearsden, Glasgow G61 1QH, Scotland
J Virol 76:2306-15. 2002..The results suggest an important role for FeLV-specific CTLs in retroviral immunity and demonstrate the potential to modulate disease outcome by the adoptive transfer of antigen-specific T cells in vivo...
